Bioactivation of Lamotrigine in Vivo in Rat and in Vitro in Human Liver Microsomes, Hepatocytes, and Epidermal Keratinocytes: Characterization of Thioether Conjugates by Liquid Chromatography/Mass Spectrometry and High Field Nuclear Magnetic Resonance Spectroscopy
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Published in Chemical research in toxicology (18.01.2010)
Published in Chemical research in toxicology (18.01.2010)
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Characterization of HKI-272 Covalent Binding to Human Serum Albumin
JIANYAO WANG, LI-CHAN, Xiao Xian, CHANDRASEKARAN, Appavu, OGANESIAN, Aram, SCATINA, Joann, MUTLIB, Abdul, TALAAT, Rasmy, ATHERTON, Jim, LIN DENG, ESPINA, Robert, LINNING YU, HORWATT, Peter, ROSS, Steven, LOCKHEAD, Susan, AHMAD, Syed
Published in Drug metabolism and disposition (01.07.2010)
Published in Drug metabolism and disposition (01.07.2010)
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Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing
Espina, Robert, Yu, Linning, Wang, Jianyao, Tong, Zeen, Vashishtha, Sarvesh, Talaat, Rasmy, Scatina, JoAnn, Mutlib, Abdul
Published in Chemical research in toxicology (01.02.2009)
Published in Chemical research in toxicology (01.02.2009)
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Identification of Novel Electrophilic Metabolites of Piper methysticum Forst. (Kava)
Johnson, Benjamin M, Qiu, Sheng-Xiang, Zhang, Shide, Zhang, Fagen, Burdette, Joanna E, Yu, Linning, Bolton, Judy L, van Breemen, Richard B
Published in Chemical research in toxicology (01.06.2003)
Published in Chemical research in toxicology (01.06.2003)
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Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards
Vishwanathan, Karthick, Babalola, Kathlene, Wang, Jack, Espina, Robert, Yu, Linning, Adedoyin, Adedayo, Talaat, Rasmy, Mutlib, Abdul, Scatina, JoAnn
Published in Chemical research in toxicology (01.02.2009)
Published in Chemical research in toxicology (01.02.2009)
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Oxidation of Raloxifene to Quinoids: Potential Toxic Pathways via a Diquinone Methide and o-Quinones
Yu, Linning, Liu, Hong, Li, Wenkui, Zhang, Fagen, Luckie, Connie, van Breemen, Richard B, Thatcher, Gregory R. J, Bolton, Judy L
Published in Chemical research in toxicology (01.07.2004)
Published in Chemical research in toxicology (01.07.2004)
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A Rational Chemical Intervention Strategy To Circumvent Bioactivation Liabilities Associated with a Nonpeptidyl Thrombopoietin Receptor Agonist Containing a 2-Amino-4-arylthiazole Motif
Kalgutkar, Amit S, Driscoll, James, Zhao, Sabrina X, Walker, Gregory S, Shepard, Richard M, Soglia, John R, Atherton, James, Yu, Linning, Mutlib, Abdul E, Munchhof, Michael J, Reiter, Lawrence A, Jones, Christopher S, Doty, Johnathan L, Trevena, Kristen A, Shaffer, Christopher L, Ripp, Sharon L
Published in Chemical research in toxicology (01.12.2007)
Published in Chemical research in toxicology (01.12.2007)
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Efficient Use of the Iron Ortho-Nitrophenylporphyrin Chloride to Mimic Biological Oxidations of Dimethylaminoantipyrine
Bazin, Marc J., Shi, Helen, Delaney, Jeannine, Kline, Billie, Zhu, Zhendong, Kuhn, Cyrille, Berlioz, Francoise, Farley, Kathleen A., Fate, Gwen, Lam, Wing, Walker, Gregory S., Yu, Linning, Pollastri, Michael P.
Published in Chemical biology & drug design (01.10.2007)
Published in Chemical biology & drug design (01.10.2007)
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Equine Catechol Estrogen 4-Hydroxyequilenin Is a More Potent Inhibitor of the Variant Form of Catechol-O-Methyltransferase
Li, Yan, Yao, Jiaqin, Chang, Minsun, Nikolic, Dejan, Yu, Linning, Yager, James D, Mesecar, Andrew D, van Breemen, Richard B, Bolton, Judy L
Published in Chemical research in toxicology (01.04.2004)
Published in Chemical research in toxicology (01.04.2004)
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Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression
Cuendet, Muriel, Liu, Xuemei, Pisha, Emily, Li, Yan, Yao, Jiaqin, Yu, Linning, Bolton, Judy L
Published in Mutation research (04.06.2004)
Published in Mutation research (04.06.2004)
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Nitrosation, Nitration, and Autoxidation of the Selective Estrogen Receptor Modulator Raloxifene by Nitric Oxide, Peroxynitrite, and Reactive Nitrogen/Oxygen Species
Toader, Violeta, Xu, Xudong, Nicolescu, Adrian, Yu, Linning, Bolton, Judy L, Thatcher, Gregory R. J
Published in Chemical research in toxicology (01.10.2003)
Published in Chemical research in toxicology (01.10.2003)
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