Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Caballero, Benjamin, Bourdenx, Mathieu, Luengo, Enrique, Diaz, Antonio, Sohn, Peter Dongmin, Chen, Xu, Wang, Chao, Juste, Yves R, Wegmann, Susanne, Patel, Bindi, Young, Zapporah T, Kuo, Szu Yu, Rodriguez-Navarro, Jose Antonio, Shao, Hao, Lopez, Manuela G, Karch, Celeste M, Goate, Alison M, Gestwicki, Jason E, Hyman, Bradley T, Gan, Li, Cuervo, Ana Maria
Published in Nature communications (14.04.2021)
Published in Nature communications (14.04.2021)
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A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities
Shao, Hao, Taguwa, Shuhei, Gilbert, Luke, Shkedi, Arielle, Sannino, Sara, Guerriero, Christopher J., Gale-Day, Zachary J., Young, Zapporah T., Brodsky, Jeffrey L., Weissman, Jonathan, Gestwicki, Jason E., Frydman, Judith
Published in Cell chemical biology (18.08.2022)
Published in Cell chemical biology (18.08.2022)
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Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy
Young, Zapporah T., Rauch, Jennifer N., Assimon, Victoria A., Jinwal, Umesh K., Ahn, Misol, Li, Xiaokai, Dunyak, Bryan M., Ahmad, Atta, Carlson, George A., Srinivasan, Sharan R., Zuiderweg, Erik R.P., Dickey, Chad A., Gestwicki, Jason E.
Published in Cell chemical biology (18.08.2016)
Published in Cell chemical biology (18.08.2016)
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Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau
Abisambra, Jose, Jinwal, Umesh K, Miyata, Yoshinari, Rogers, Justin, Blair, Laura, Li, Xiaokai, Seguin, Sandlin P, Wang, Li, Jin, Ying, Bacon, Justin, Brady, Sarah, Cockman, Matthew, Guidi, Chantal, Zhang, Juan, Koren, John, Young, Zapporah T, Atkins, Christopher A, Zhang, Bo, Lawson, Lisa Y, Weeber, Edwin J, Brodsky, Jeffrey L, Gestwicki, Jason E, Dickey, Chad A
Published in Biological psychiatry (1969) (01.09.2013)
Published in Biological psychiatry (1969) (01.09.2013)
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A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein–Protein Interactions
Rinaldi, Silvia, Assimon, Victoria A, Young, Zapporah T, Morra, Giulia, Shao, Hao, Taylor, Isabelle R, Gestwicki, Jason E, Colombo, Giorgio
Published in ACS chemical biology (16.11.2018)
Published in ACS chemical biology (16.11.2018)
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Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels
Miyata, Yoshinari, Li, Xiaokai, Lee, Hsiu-Fang, Jinwal, Umesh K, Srinivasan, Sharan R, Seguin, Sandlin P, Young, Zapporah T, Brodsky, Jeffrey L, Dickey, Chad A, Sun, Duxin, Gestwicki, Jason E
Published in ACS chemical neuroscience (19.06.2013)
Published in ACS chemical neuroscience (19.06.2013)
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Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70)
Shao, Hao, Li, Xiaokai, Moses, Michael A, Gilbert, Luke A, Kalyanaraman, Chakrapani, Young, Zapporah T, Chernova, Margarita, Journey, Sara N, Weissman, Jonathan S, Hann, Byron, Jacobson, Matthew P, Neckers, Len, Gestwicki, Jason E
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Therapeutic Strategies for Restoring Tau Homeostasis
Young, Zapporah T, Mok, Sue Ann, Gestwicki, Jason E
Published in Cold Spring Harbor perspectives in medicine (01.01.2018)
Published in Cold Spring Harbor perspectives in medicine (01.01.2018)
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Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells
Taylor, Isabelle R, Assimon, Victoria A, Kuo, Szu Yu, Rinaldi, Silvia, Li, Xiaokai, Young, Zapporah T, Morra, Giulia, Green, Keith, Nguyen, Daniel, Shao, Hao, Garneau-Tsodikova, Sylvie, Colombo, Giorgio, Gestwicki, Jason E
Published in Chemical science (Cambridge) (10.01.2020)
Published in Chemical science (Cambridge) (10.01.2020)
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Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents
Li, Xiaokai, Srinivasan, Sharan R, Connarn, Jamie, Ahmad, Atta, Young, Zapporah T, Kabza, Adam M, Zuiderweg, Erik. R. P, Sun, Duxin, Gestwicki, Jason E
Published in ACS medicinal chemistry letters (14.11.2013)
Published in ACS medicinal chemistry letters (14.11.2013)
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