An Exceptionally Potent Inhibitor of Human CD73
Bowman, Christine E, da Silva, Rafael G, Pham, Amber, Young, Stephen W
Published in Biochemistry (Easton) (06.08.2019)
Published in Biochemistry (Easton) (06.08.2019)
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Discovery of AB680: A Potent and Selective Inhibitor of CD73
Lawson, Kenneth V, Kalisiak, Jaroslaw, Lindsey, Erick A, Newcomb, Eric T, Leleti, Manmohan Reddy, Debien, Laurent, Rosen, Brandon R, Miles, Dillon H, Sharif, Ehesan U, Jeffrey, Jenna L, Tan, Joanne B. L, Chen, Ada, Zhao, Sharon, Xu, Guifen, Fu, Lijuan, Jin, Lixia, Park, Tim W, Berry, Wade, Moschütz, Susanne, Scaletti, Emma, Sträter, Norbert, Walker, Nigel P, Young, Stephen W, Walters, Matthew J, Schindler, Uli, Powers, Jay P
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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Journal Article
Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity
Piovesan, Dana, Tan, Joanne B L, Becker, Annette, Banuelos, Jesus, Narasappa, Nell, DiRenzo, Daniel, Zhang, Kristen, Chen, Ada, Ginn, Elaine, Udyavar, Akshata R, Yin, Fangfang, Paprcka, Susan L, Purandare, Bhamini, Park, Timothy W, Kimura, Nikki, Kalisiak, Jaroslaw, Young, Stephen W, Powers, Jay P, Schindler, Uli, Sivick, Kelsey E, Walters, Matthew J
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Journal Article
Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73
Beatty, Joel W, Lindsey, Erick A, Thomas-Tran, Rhiannon, Debien, Laurent, Mandal, Debashis, Jeffrey, Jenna L, Tran, Anh T, Fournier, Jeremy, Jacob, Steven D, Yan, Xuelei, Drew, Samuel L, Ginn, Elaine, Chen, Ada, Pham, Amber T, Zhao, Sharon, Jin, Lixia, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Moschütz, Susanne, Sträter, Norbert, Powers, Jay P, Lawson, Kenneth V
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay
Chen, Ada, Zhao, Xiaoning, Mercer, Laina, Su, Cheng, Zalameda, Leeanne, Liu, Yichin, Lembke, Amanda, Eastwood, Heather, Dang, Son, Oung, Thim, Xia, Xiaoyang, Young, Stephen W, Xiao, Shouhua, McCarter, John D
Published in Combinatorial chemistry & high throughput screening (01.09.2013)
Published in Combinatorial chemistry & high throughput screening (01.09.2013)
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Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors
Sharif, Ehesan U., Kalisiak, Jaroslaw, Lawson, Kenneth, Miles, Dillon H., Newcomb, Eric, Lindsey, Erick A., Rosen, Brandon R., Debien, Laurent P. P., Chen, Ada, Zhao, Xiaoning, Young, Stephen W., Walker, Nigel P., Straeter, Norbert, Scaletti, Emma R., Jin, Lixia, Xu, Guifen, Leleti, Manmohan R., Powers, Jay P.
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Journal Article
Discovery of Potent and Selective PI3Kγ Inhibitors
Drew, Samuel L, Thomas-Tran, Rhiannon, Beatty, Joel W, Fournier, Jeremy, Lawson, Kenneth V, Miles, Dillon H, Mata, Guillaume, Sharif, Ehesan U, Yan, Xuelei, Mailyan, Artur K, Ginn, Elaine, Chen, Jie, Wong, Kent, Soni, Divyank, Dhanota, Puja, Chen, Pei-Yu, Shaqfeh, Stefan G, Meleza, Cesar, Pham, Amber T, Chen, Ada, Zhao, Xiaoning, Banuelos, Jesus, Jin, Lixia, Schindler, Ulrike, Walters, Matthew J, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Journal Article
Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase γ (PI3Kγ)
Mata, Guillaume, Miles, Dillon H, Drew, Samuel L, Fournier, Jeremy, Lawson, Kenneth V, Mailyan, Artur K, Sharif, Ehesan U, Yan, Xuelei, Beatty, Joel W, Banuelos, Jesus, Chen, Jie, Ginn, Elaine, Chen, Ada, Gerrick, Kimberline Y, Pham, Amber T, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G, Meleza, Cesar, Narasappa, Nell, Singh, Hema, Zhao, Xiaoning, Jin, Lixia, Schindler, Ulrike, Walters, Matthew J, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
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Journal Article
Discovery of Potent and Selective 7‑Azaindole Isoindolinone-Based PI3Kγ Inhibitors
Miles, Dillon H, Yan, Xuelei, Thomas-Tran, Rhiannon, Fournier, Jeremy, Sharif, Ehesan U, Drew, Samuel L, Mata, Guillaume, Lawson, Kenneth V, Ginn, Elaine, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G, Meleza, Cesar, Chen, Ada, Pham, Amber T, Park, Timothy, Swinarski, Debbie, Banuelos, Jesus, Schindler, Ulrike, Walters, Matthew J, Walker, Nigel P, Zhao, Xiaoning, Young, Stephen W, Chen, Jie, Jin, Lixia, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L
Published in ACS medicinal chemistry letters (12.11.2020)
Published in ACS medicinal chemistry letters (12.11.2020)
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Quantitative analysis of free fatty acids in rat plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry with meso-tetrakis porphyrin as matrix
Yu, Haiqiang, Lopez, Edwin, Young, Stephen W., Luo, Jian, Tian, Hui, Cao, Ping
Published in Analytical biochemistry (15.07.2006)
Published in Analytical biochemistry (15.07.2006)
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A homogeneous enzyme fragment complementation-based beta-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors
Zhao, Xiaoning, Jones, Adrie, Olson, Keith R, Peng, Kun, Wehrman, Tom, Park, Adam, Mallari, Rommel, Nebalasca, Danilo, Young, Stephen W, Xiao, Shou-Hua
Published in Journal of biomolecular screening (01.09.2008)
Published in Journal of biomolecular screening (01.09.2008)
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Journal Article
Development of a time-resolved fluorescence resonance energy transfer assay for cyclin-dependent kinase 4 and identification of its ATP-noncompetitive inhibitors
Lo, Mei-Chu, Ngo, Rachel, Dai, Kang, Li, Cong, Liang, Lingming, Lee, Josie, Emkey, Renee, Eksterowicz, John, Ventura, Manuel, Young, Stephen W., Xiao, Shou-Hua
Published in Analytical biochemistry (15.02.2012)
Published in Analytical biochemistry (15.02.2012)
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Journal Article
Development of a high throughput time-resolved fluorescence resonance energy transfer assay for TRAF6 ubiquitin polymerization
Hong, Catherine A, Swearingen, Elissa, Mallari, Rommel, Gao, Xiong, Cao, Zhaodan, North, Anne, Young, Stephen W, Huang, Shu-Gui
Published in Assay and drug development technologies (01.02.2003)
Published in Assay and drug development technologies (01.02.2003)
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High throughput screening for orphan and liganded GPCRs
Xiao, Shou-Hua, Reagan, Jeff D, Lee, Paul H, Fu, Angela, Schwandner, Ralf, Zhao, Xiaoning, Knop, Johannes, Beckmann, Holger, Young, Stephen W
Published in Combinatorial chemistry & high throughput screening (01.03.2008)
Published in Combinatorial chemistry & high throughput screening (01.03.2008)
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An ultrasensitive high-throughput electrochemiluminescence immunoassay for the Cdc42-associated protein tyrosine kinase ACK1
Xiao, Shou-Hua, Farrelly, Ellyn, Anzola, John, Crawford, Daniel, Jiao, XianYun, Liu, Jinqian, Ayres, Merrill, Li, Shyun, Huang, Linda, Sharma, Rajiv, Kayser, Frank, Wesche, Holger, Young, Stephen W.
Published in Analytical biochemistry (15.08.2007)
Published in Analytical biochemistry (15.08.2007)
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Journal Article
A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase
Lo, Mei-Chu, Wang, Minghan, Kim, Ki Won, Busby, James, Yamane, Harvey, Zondlo, James, Yuan, Chester, Young, Stephen W., Xiao, Shou-Hua
Published in Analytical biochemistry (01.05.2008)
Published in Analytical biochemistry (01.05.2008)
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Journal Article
A generic high-throughput screening assay for kinases: protein kinase a as an example
Mallari, Rommel, Swearingen, Elissa, Liu, Wei, Ow, Arnold, Young, Stephen W, Huang, Shu-Gui
Published in Journal of biomolecular screening (01.04.2003)
Published in Journal of biomolecular screening (01.04.2003)
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Journal Article
Abstract 4100: Receptor occupancy and neo-epitope specific T-cell repertoires in patients with solid tissue tumors following anti-PD-1 therapy
Ashok, Devika, Peng, Songming, Yuen, Benjamin, Walters, Matt, Young, Stephen W., Seitz, Lisa
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Anti-TIGIT antibodies promote immune activation relevant to targeting stem-like and tumor-specific T cells in combination with anti-PD-1
Sivick Gauthier, Kelsey E, Piovesan, Dana, de Groot, Amber E, Reiner, Gabrielle L, Schweickert, Patrick G, Soriano, Ferdie, Chen, Ada, Singh, Hema, Zhao, Xiaoning, Seitz, Lisa, Reddy, Anita, Young, Stephen W, Walker, Nigel, Walters, Matthew J
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
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Abstract 4980: Altered pan-Ras pathway and activating mutations in EGFR result in elevated CD73 in multiple cancers
Udyavar, Akshata R., DiRenzo, Daniel, Ashok, Devika, Anderson, Amy E., Young, Stephen W., Walters, Matt J., Tan, Joanne Bl
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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