The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
Murphy, James M., Czabotar, Peter E., Hildebrand, Joanne M., Lucet, Isabelle S., Zhang, Jian-Guo, Alvarez-Diaz, Silvia, Lewis, Rowena, Lalaoui, Najoua, Metcalf, Donald, Webb, Andrew I., Young, Samuel N., Varghese, Leila N., Tannahill, Gillian M., Hatchell, Esme C., Majewski, Ian J., Okamoto, Toru, Dobson, Renwick C.J., Hilton, Douglas J., Babon, Jeffrey J., Nicola, Nicos A., Strasser, Andreas, Silke, John, Alexander, Warren S.
Published in Immunity (Cambridge, Mass.) (19.09.2013)
Published in Immunity (Cambridge, Mass.) (19.09.2013)
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Journal Article
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
Samson, Andre L., Zhang, Ying, Geoghegan, Niall D., Gavin, Xavier J., Davies, Katherine A., Mlodzianoski, Michael J., Whitehead, Lachlan W., Frank, Daniel, Garnish, Sarah E., Fitzgibbon, Cheree, Hempel, Anne, Young, Samuel N., Jacobsen, Annette V., Cawthorne, Wayne, Petrie, Emma J., Faux, Maree C., Shield-Artin, Kristy, Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Rogers, Kelly L., Lessene, Guillaume, Hawkins, Edwin D., Murphy, James M.
Published in Nature communications (19.06.2020)
Published in Nature communications (19.06.2020)
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Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity
Babon, Jeffrey J., Kershaw, Nadia J., Murphy, James M., Varghese, Leila N., Laktyushin, Artem, Young, Samuel N., Lucet, Isabelle S., Norton, Raymond S., Nicola, Nicos A.
Published in Immunity (Cambridge, Mass.) (24.02.2012)
Published in Immunity (Cambridge, Mass.) (24.02.2012)
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Journal Article
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
Hildebrand, Joanne M., Tanzer, Maria C., Lucet, Isabelle S., Young, Samuel N., Spall, Sukhdeep K., Sharma, Pooja, Pierotti, Catia, Garnier, Jean-Marc, Dobson, Renwick C.J., Webb, Andrew I., Tripaydonis, Anne, Babon, Jeffrey J., Mulcair, Mark D., Scanlon, Martin J., Alexander, Warren S., Wilks, Andrew F., Czabotar, Peter E., Lessene, Guillaume, Murphy, James M., Silke, John
Published in Proceedings of the National Academy of Sciences - PNAS (21.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (21.10.2014)
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Journal Article
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis
Liu, Zikou, Dagley, Laura F, Shield‐Artin, Kristy, Young, Samuel N, Bankovacki, Aleksandra, Wang, Xiangyi, Tang, Michelle, Howitt, Jason, Stafford, Che A, Nachbur, Ueli, Fitzgibbon, Cheree, Garnish, Sarah E, Webb, Andrew I, Komander, David, Murphy, James M, Hildebrand, Joanne M, Silke, John
Published in The EMBO journal (01.12.2021)
Published in The EMBO journal (01.12.2021)
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A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells
Samson, André L., Fitzgibbon, Cheree, Patel, Komal M., Hildebrand, Joanne M., Whitehead, Lachlan W., Rimes, Joel S., Jacobsen, Annette V., Horne, Christopher R., Gavin, Xavier J., Young, Samuel N., Rogers, Kelly L., Hawkins, Edwin D., Murphy, James M.
Published in Cell death and differentiation (01.07.2021)
Published in Cell death and differentiation (01.07.2021)
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Journal Article
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Petrie, Emma J., Sandow, Jarrod J., Jacobsen, Annette V., Smith, Brian J., Griffin, Michael D. W., Lucet, Isabelle S., Dai, Weiwen, Young, Samuel N., Tanzer, Maria C., Wardak, Ahmad, Liang, Lung-Yu, Cowan, Angus D., Hildebrand, Joanne M., Kersten, Wilhelmus J. A., Lessene, Guillaume, Silke, John, Czabotar, Peter E., Webb, Andrew I., Murphy, James M.
Published in Nature communications (21.06.2018)
Published in Nature communications (21.06.2018)
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Journal Article
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
Garnish, Sarah E., Meng, Yanxiang, Koide, Akiko, Sandow, Jarrod J., Denbaum, Eric, Jacobsen, Annette V., Yeung, Wayland, Samson, Andre L., Horne, Christopher R., Fitzgibbon, Cheree, Young, Samuel N., Smith, Phoebe P. C., Webb, Andrew I., Petrie, Emma J., Hildebrand, Joanne M., Kannan, Natarajan, Czabotar, Peter E., Koide, Shohei, Murphy, James M.
Published in Nature communications (13.04.2021)
Published in Nature communications (13.04.2021)
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Journal Article
The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis
Davies, Katherine A., Tanzer, Maria C., Griffin, Michael D. W., Mok, Yee Foong, Young, Samuel N., Qin, Rui, Petrie, Emma J., Czabotar, Peter E., Silke, John, Murphy, James M.
Published in Cell death and differentiation (01.09.2018)
Published in Cell death and differentiation (01.09.2018)
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Journal Article
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
Meng, Yanxiang, Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Horne, Christopher R., Luo, Cindy, Garnier, Jean-Marc, Liang, Lung-Yu, Cowan, Angus D., Samson, Andre L., Lessene, Guillaume, Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.
Published in Nature communications (22.11.2021)
Published in Nature communications (22.11.2021)
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Journal Article
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
Murphy, James M, Zhang, Qingwei, Young, Samuel N, Reese, Michael L, Bailey, Fiona P, Eyers, Patrick A, Ungureanu, Daniela, Hammaren, Henrik, Silvennoinen, Olli, Varghese, Leila N, Chen, Kelan, Tripaydonis, Anne, Jura, Natalia, Fukuda, Koichi, Qin, Jun, Nimchuk, Zachary, Mudgett, Mary Beth, Elowe, Sabine, Gee, Christine L, Liu, Ling, Daly, Roger J, Manning, Gerard, Babon, Jeffrey J, Lucet, Isabelle S
Published in Biochemical journal (15.01.2014)
Published in Biochemical journal (15.01.2014)
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Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance
Garcia, Laura Ramos, Tenev, Tencho, Newman, Richard, Haich, Rachel O., Liccardi, Gianmaria, John, Sidonie Wicky, Annibaldi, Alessandro, Yu, Lu, Pardo, Mercedes, Young, Samuel N., Fitzgibbon, Cheree, Fernando, Winnie, Guppy, Naomi, Kim, Hyojin, Liang, Lung-Yu, Lucet, Isabelle S., Kueh, Andrew, Roxanis, Ioannis, Gazinska, Patrycja, Sims, Martin, Smyth, Tomoko, Ward, George, Bertin, John, Beal, Allison M., Geddes, Brad, Choudhary, Jyoti S., Murphy, James M., Aurelia Ball, K., Upton, Jason W., Meier, Pascal
Published in Nature communications (07.06.2021)
Published in Nature communications (07.06.2021)
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Journal Article
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
Petrie, Emma J., Birkinshaw, Richard W., Koide, Akiko, Denbaum, Eric, Hildebrand, Joanne M., Garnish, Sarah E., Davies, Katherine A., Sandow, Jarrod J., Samson, Andre L., Gavin, Xavier, Fitzgibbon, Cheree, Young, Samuel N., Hennessy, Patrick J., Smith, Phoebe P. C., Webb, Andrew I., Czabotar, Peter E., Koide, Shohei, Murphy, James M.
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.2020)
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Journal Article
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop
Tanzer, Maria C, Tripaydonis, Anne, Webb, Andrew I, Young, Samuel N, Varghese, Leila N, Hall, Cathrine, Alexander, Warren S, Hildebrand, Joanne M, Silke, John, Murphy, James M
Published in Biochemical journal (15.10.2015)
Published in Biochemical journal (15.10.2015)
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Journal Article
Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3
Petrie, Emma J., Sandow, Jarrod J., Lehmann, Wil I.L., Liang, Lung-Yu, Coursier, Diane, Young, Samuel N., Kersten, Wilhelmus J.A., Fitzgibbon, Cheree, Samson, André L., Jacobsen, Annette V., Lowes, Kym N., Au, Amanda E., Jousset Sabroux, Hélène, Lalaoui, Najoua, Webb, Andrew I., Lessene, Guillaume, Manning, Gerard, Lucet, Isabelle S., Murphy, James M.
Published in Cell reports (Cambridge) (24.09.2019)
Published in Cell reports (Cambridge) (24.09.2019)
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Journal Article
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Yeung, Wayland, Coursier, Diane, Birkinshaw, Richard W., Sandow, Jarrod J., Lehmann, Wil I. L., Liang, Lung-Yu, Lucet, Isabelle S., Chalmers, James D., Patrick, Wayne M., Kannan, Natarajan, Petrie, Emma J., Czabotar, Peter E., Murphy, James M.
Published in Nature communications (19.06.2020)
Published in Nature communications (19.06.2020)
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Journal Article
A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes
Hildebrand, Joanne M., Lo, Bernice, Tomei, Sara, Mattei, Valentina, Young, Samuel N., Fitzgibbon, Cheree, Murphy, James M., Fadda, Abeer
Published in Cell death & disease (01.04.2021)
Published in Cell death & disease (01.04.2021)
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Journal Article
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
Murphy, James M, Lucet, Isabelle S, Hildebrand, Joanne M, Tanzer, Maria C, Young, Samuel N, Sharma, Pooja, Lessene, Guillaume, Alexander, Warren S, Babon, Jeffrey J, Silke, John, Czabotar, Peter E
Published in Biochemical journal (01.02.2014)
Published in Biochemical journal (01.02.2014)
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Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization
Meng, Yanxiang, Garnish, Sarah E., Davies, Katherine A., Black, Katrina A., Leis, Andrew P., Horne, Christopher R., Hildebrand, Joanne M., Hoblos, Hanadi, Fitzgibbon, Cheree, Young, Samuel N., Dite, Toby, Dagley, Laura F., Venkat, Aarya, Kannan, Natarajan, Koide, Akiko, Koide, Shohei, Glukhova, Alisa, Czabotar, Peter E., Murphy, James M.
Published in Nature communications (26.10.2023)
Published in Nature communications (26.10.2023)
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