Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels
Young, Gareth T., Emery, Edward C., Mooney, Elizabeth R., Tsantoulas, Christoforos, McNaughton, Peter A.
Published in Pain (Amsterdam) (01.09.2014)
Published in Pain (Amsterdam) (01.09.2014)
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Functional confirmation that the R1488 variant in SCN9A results in complete loss-of-function of Nav1.7
He, Wen, Young, Gareth T, Zhang, Baohong, Cox, Peter J, Cho, Lily Ting-Yin, John, Sally, Paciga, Sara A, Wood, Linda S, Danziger, Nicolas, Scollen, Serena, Vangjeli, Ciara
Published in BMC medical genetics (23.07.2018)
Published in BMC medical genetics (23.07.2018)
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Agonist activation of alpha 7 nicotinic acetylcholine receptors via an allosteric transmembrane site
Gill, JasKiran K, Savolainen, Mari, Young, Gareth T, Zwart, Ruud, Sher, Emanuele, Millar, Neil S
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2011)
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Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site
Gill, JasKiran K., Savolainen, Mari, Young, Gareth T., Zwart, Ruud, Sher, Emanuele, Millar, Neil S., Changeux, Jean-Pierre
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2011)
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Characterizing Human Stem Cell–derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research
Young, Gareth T, Gutteridge, Alex, Fox, Heather DE, Wilbrey, Anna L, Cao, Lishuang, Cho, Lily T, Brown, Adam R, Benn, Caroline L, Kammonen, Laura R, Friedman, Julia H, Bictash, Magda, Whiting, Paul, Bilsland, James G, Stevens, Edward B
Published in Molecular therapy (01.08.2014)
Published in Molecular therapy (01.08.2014)
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An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes
Cho, Lily T.-Y., Alexandrou, Aristos J., Torella, Rubben, Knafels, John, Hobbs, Jake, Taylor, Toni, Loucif, Alex, Konopacka, Agnieszka, Bell, Sigourney, Stevens, Edward B., Pandit, Jay, Horst, Reto, Withka, Jane M., Pryde, David C., Liu, Shenping, Young, Gareth T.
Published in Structure (London) (03.04.2018)
Published in Structure (London) (03.04.2018)
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A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV)
Shaikh, Samiha S., Chen, Ya‐Chun, Halsall, Sally‐Anne, Nahorski, Michael S., Omoto, Kiyoyuki, Young, Gareth T., Phelan, Anne, Woods, Christopher Geoffrey
Published in Human mutation (01.01.2017)
Published in Human mutation (01.01.2017)
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HCN2 ion channels: an emerging role as the pacemakers of pain
Emery, Edward C, Young, Gareth T, McNaughton, Peter A
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2012)
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2012)
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Functional confirmation that the R1488 variant in SCN9A results in complete loss-of-function of Na v 1.7
He, Wen, Young, Gareth T, Zhang, Baohong, Cox, Peter J, Cho, Lily Ting-Yin, John, Sally, Paciga, Sara A, Wood, Linda S, Danziger, Nicolas, Scollen, Serena, Vangjeli, Ciara
Published in BMC medical genetics (23.07.2018)
Published in BMC medical genetics (23.07.2018)
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Species Selectivity of a Nicotinic Acetylcholine Receptor Agonist Is Conferred by Two Adjacent Extracellular beta 4 Amino Acids that Are Implicated in the Coupling of Binding to Channel Gating
Young, Gareth T, Broad, Lisa M, Zwart, Ruud, Astles, Peter C, Bodkin, Michael, Sher, Emanuele, Millar, Neil S
Published in Molecular pharmacology (01.02.2007)
Published in Molecular pharmacology (01.02.2007)
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Transcriptional regulator PRDM12 is essential for human pain perception
Chen, Ya-Chun, Auer-Grumbach, Michaela, Matsukawa, Shinya, Zitzelsberger, Manuela, Themistocleous, Andreas C, Strom, Tim M, Samara, Chrysanthi, Moore, Adrian W, Cho, Lily Ting-Yin, Young, Gareth T, Weiss, Caecilia, Schabhüttl, Maria, Stucka, Rolf, Schmid, Annina B, Parman, Yesim, Graul-Neumann, Luitgard, Heinritz, Wolfram, Passarge, Eberhard, Watson, Rosemarie M, Hertz, Jens Michael, Moog, Ute, Baumgartner, Manuela, Valente, Enza Maria, Pereira, Diego, Restrepo, Carlos M, Katona, Istvan, Dusl, Marina, Stendel, Claudia, Wieland, Thomas, Stafford, Fay, Reimann, Frank, von Au, Katja, Finke, Christian, Willems, Patrick J, Nahorski, Michael S, Shaikh, Samiha S, Carvalho, Ofélia P, Nicholas, Adeline K, Karbani, Gulshan, McAleer, Maeve A, Cilio, Maria Roberta, McHugh, John C, Murphy, Sinead M, Irvine, Alan D, Jensen, Uffe Birk, Windhager, Reinhard, Weis, Joachim, Bergmann, Carsten, Rautenstrauss, Bernd, Baets, Jonathan, De Jonghe, Peter, Reilly, Mary M, Kropatsch, Regina, Kurth, Ingo, Chrast, Roman, Michiue, Tatsuo, Bennett, David L H, Woods, C Geoffrey, Senderek, Jan
Published in Nature genetics (01.07.2015)
Published in Nature genetics (01.07.2015)
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Species Selectivity of a Nicotinic Acetylcholine Receptor Agonist Is Conferred by Two Adjacent Extracellular β4 Amino Acids that Are Implicated in the Coupling of Binding to Channel Gating
Young, Gareth T., Broad, Lisa M., Zwart, Ruud, Astles, Peter C., Bodkin, Michael, Sher, Emanuele, Millar, Neil S.
Published in Molecular pharmacology (01.02.2007)
Published in Molecular pharmacology (01.02.2007)
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Journal Article
Agonist activation of [alpha]7 nicotinic acetylcholine receptors via an allosteric transmembrane site
Gill, JasKiran K, Savolainen, Mari, Young, Gareth T, Zwart, Ruud, Sher, Emanuele, Millar, Neil S
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2011)
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Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2011)
Journal Article
Characterizing Human Stem Cell-derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research super(MT)Open
Young, Gareth T, Gutteridge, Alex, Fox, Heather DE, Wilbrey, Anna L, Cao, Lishuang, Cho, Lily T, Brown, Adam R, Benn, Caroline L, Kammonen, Laura R, Friedman, Julia H, Bictash, Magda, Whiting, Paul, Bilsland, James G, Stevens, Edward B
Published in Molecular therapy (01.08.2014)
Published in Molecular therapy (01.08.2014)
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