The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Dixit, Vishwa Deep, Vandanmagsar, Bolormaa, Youm, Yun-Hee, Ravussin, Anthony, Galgani, Jose E, Stadler, Krisztian, Mynatt, Randall L, Ravussin, Eric, Stephens, Jacqueline M
Published in Nature medicine (01.02.2011)
Published in Nature medicine (01.02.2011)
Get full text
Journal Article
IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge
Spadaro, Olga, Camell, Christina D., Bosurgi, Lidia, Nguyen, Kim Y., Youm, Yun-Hee, Rothlin, Carla V., Dixit, Vishwa Deep
Published in Cell reports (Cambridge) (11.04.2017)
Published in Cell reports (Cambridge) (11.04.2017)
Get full text
Journal Article
Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Youm, Yun-Hee, Grant, Ryan W., McCabe, Laura R., Albarado, Diana C., Nguyen, Kim Yen, Ravussin, Anthony, Pistell, Paul, Newman, Susan, Carter, Renee, Laque, Amanda, Münzberg, Heike, Rosen, Clifford J., Ingram, Donald K., Salbaum, J. Michael, Dixit, Vishwa Deep
Published in Cell metabolism (01.10.2013)
Published in Cell metabolism (01.10.2013)
Get full text
Journal Article
Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
Youm, Yun-Hee, Horvath, Tamas L., Mangelsdorf, David J., Kliewer, Steven A., Dixit, Vishwa Deep
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2016)
Get full text
Journal Article
Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice
Ryu, Seungjin, Shchukina, Irina, Youm, Yun-Hee, Qing, Hua, Hilliard, Brandon, Dlugos, Tamara, Zhang, Xinbo, Yasumoto, Yuki, Booth, Carmen J, Fernández-Hernando, Carlos, Suárez, Yajaira, Khanna, Kamal, Horvath, Tamas L, Dietrich, Marcelo O, Artyomov, Maxim, Wang, Andrew, Dixit, Vishwa Deep
Published in eLife (21.06.2021)
Published in eLife (21.06.2021)
Get full text
Journal Article
Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity
Ryu, Seungjin, Spadaro, Olga, Sidorov, Sviatoslav, Lee, Aileen H, Caprio, Sonia, Morrison, Christopher, Smith, Steven R, Ravussin, Eric, Shchukina, Irina, Artyomov, Maxim N, Youm, Yun-Hee, Dixit, Vishwa Deep
Published in The Journal of clinical investigation (01.10.2023)
Published in The Journal of clinical investigation (01.10.2023)
Get full text
Journal Article
Obesity accelerates thymic aging
Yang, Hyunwon, Youm, Yun-Hee, Vandanmagsar, Bolormaa, Rood, Jennifer, Kumar, K. Ganesh, Butler, Andrew A., Dixit, Vishwa Deep
Published in Blood (29.10.2009)
Published in Blood (29.10.2009)
Get full text
Journal Article
Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence
Spadaro, Olga, Goldberg, Emily L., Camell, Christina D., Youm, Yun-Hee, Kopchick, John J., Nguyen, Kim Y., Bartke, Andrzej, Sun, Liou Y., Dixit, Vishwa Deep
Published in Cell reports (Cambridge) (23.02.2016)
Published in Cell reports (Cambridge) (23.02.2016)
Get full text
Journal Article
The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence
Youm, Yun-Hee, Kanneganti, Thirumala-Devi, Vandanmagsar, Bolormaa, Zhu, Xuewei, Ravussin, Anthony, Adijiang, Ayinuer, Owen, John S., Thomas, Michael J., Francis, Joseph, Parks, John S., Dixit, Vishwa Deep
Published in Cell reports (Cambridge) (26.01.2012)
Published in Cell reports (Cambridge) (26.01.2012)
Get full text
Journal Article
Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity
Ravussin, Anthony, Youm, Yun-Hee, Sander, Jil, Ryu, Seungjin, Nguyen, Kim, Varela, Luis, Shulman, Gerald I., Sidorov, Sviatoslav, Horvath, Tamas L., Schultze, Joachim L., Dixit, Vishwa Deep
Published in Cell reports (Cambridge) (31.07.2018)
Published in Cell reports (Cambridge) (31.07.2018)
Get full text
Journal Article
Inactivation of C/ebp Homologous Protein-driven Immune-Metabolic Interactions Exacerbate Obesity and Adipose Tissue Leukocytosis
Grant, Ryan, Nguyen, Kim Y., Ravussin, Anthony, Albarado, Diana, Youm, Yun-Hee, Dixit, Vishwa Deep
Published in The Journal of biological chemistry (16.05.2014)
Published in The Journal of biological chemistry (16.05.2014)
Get full text
Journal Article
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
Youm, Yun-Hee, Nguyen, Kim Y, Grant, Ryan W, Goldberg, Emily L, Bodogai, Monica, Kim, Dongin, D'Agostino, Dominic, Planavsky, Noah, Lupfer, Christopher, Kanneganti, Thirumala D, Kang, Seokwon, Horvath, Tamas L, Fahmy, Tarek M, Crawford, Peter A, Biragyn, Arya, Alnemri, Emad, Dixit, Vishwa Deep
Published in Nature medicine (01.03.2015)
Published in Nature medicine (01.03.2015)
Get full text
Journal Article
Less Keratinocyte-Derived Factors Related to More Keratinocyte Apoptosis in Depigmented than Normally Pigmented Suction-Blistered Epidermis May Cause Passive Melanocyte Death in Vitiligo
Lee, Ai-Young, Kim, Nan-Hyung, Choi, Won-Ik, Youm, Yun-Hee
Published in Journal of investigative dermatology (01.05.2005)
Published in Journal of investigative dermatology (01.05.2005)
Get full text
Journal Article
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing
Camell, Christina D., Sander, Jil, Spadaro, Olga, Lee, Aileen, Nguyen, Kim Y., Wing, Allison, Goldberg, Emily L., Youm, Yun-Hee, Brown, Chester W., Elsworth, John, Rodeheffer, Matthew S., Schultze, Joachim L., Dixit, Vishwa Deep
Published in Nature (London) (05.10.2017)
Published in Nature (London) (05.10.2017)
Get full text
Journal Article
Axin expression in thymic stromal cells contributes to an age-related increase in thymic adiposity and is associated with reduced thymopoiesis independently of ghrelin signaling
Yang, Hyunwon, Youm, Yun‐Hee, Sun, Yuxiang, Rim, Jong‐Seop, Galbán, Craig J., Vandanmagsar, Bolormaa, Dixit, Vishwa Deep
Published in Journal of leukocyte biology (01.06.2009)
Published in Journal of leukocyte biology (01.06.2009)
Get full text
Journal Article
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis
Camell, Christina D., Günther, Patrick, Lee, Aileen, Goldberg, Emily L., Spadaro, Olga, Youm, Yun-Hee, Bartke, Andrzej, Hubbard, Gene B., Ikeno, Yuji, Ruddle, Nancy H., Schultze, Joachim, Dixit, Vishwa Deep
Published in Cell metabolism (03.12.2019)
Published in Cell metabolism (03.12.2019)
Get full text
Journal Article
IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2
Goldberg, Emily L., Shchukina, Irina, Youm, Yun-Hee, Ryu, Seungjin, Tsusaka, Takeshi, Young, Kyrlia C., Camell, Christina D., Dlugos, Tamara, Artyomov, Maxim N., Dixit, Vishwa Deep
Published in Cell metabolism (02.11.2021)
Published in Cell metabolism (02.11.2021)
Get full text
Journal Article