The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update
Lu, Meng-Chen, Ji, Jian-Ai, Jiang, Zheng-Yu, You, Qi-Dong
Published in Medicinal research reviews (01.09.2016)
Published in Medicinal research reviews (01.09.2016)
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Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions
Li, Li, Wang, Lei, You, Qi-Dong, Xu, Xiao-Li
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
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Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions
Jiang, Zheng-Yu, Lu, Meng-Chen, You, Qi-Dong
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress
Xu, Li-Li, Wu, Yu-Feng, Yan, Fang, Li, Cui-Cui, Dai, Zhen, You, Qi-Dong, Jiang, Zheng-Yu, Di, Bin
Published in Free radical biology & medicine (01.04.2019)
Published in Free radical biology & medicine (01.04.2019)
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CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation
Lu, Meng-Chen, Zhao, Jing, Liu, Yu-Ting, Liu, Tian, Tao, Meng-Min, You, Qi-Dong, Jiang, Zheng-Yu
Published in Redox biology (01.09.2019)
Published in Redox biology (01.09.2019)
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Wogonin prevents lipopolysaccharide‐induced acute lung injury and inflammation in mice via peroxisome proliferator‐activated receptor gamma‐mediated attenuation of the nuclear factor‐kappaB pathway
Yao, Jing, Pan, Di, Zhao, Yue, Zhao, Li, Sun, Jie, Wang, Yu, You, Qi‐Dong, Xi, Tao, Guo, Qing‐Long, Lu, Na
Published in Immunology (01.10.2014)
Published in Immunology (01.10.2014)
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Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions
Lu, Meng-Chen, Shao, Hong-Li, Liu, Tian, You, Qi-Dong, Jiang, Zheng-Yu
Published in European journal of medicinal chemistry (01.12.2020)
Published in European journal of medicinal chemistry (01.12.2020)
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An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis
Lu, Meng-Chen, Ji, Jian-Ai, Jiang, Yong-Lin, Chen, Zhi-Yun, Yuan, Zhen-Wei, You, Qi-Dong, Jiang, Zheng-Yu
Published in Scientific reports (24.05.2016)
Published in Scientific reports (24.05.2016)
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Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response
Zhong, Yan, Zhang, Fengyi, Sun, Zhongying, Zhou, Wei, Li, Zhi-Yu, You, Qi-Dong, Guo, Qing-Long, Hu, Rong
Published in Molecular carcinogenesis (01.10.2013)
Published in Molecular carcinogenesis (01.10.2013)
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Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway
Wang, Hu, Zhao, Li, Zhu, Li-Tao, Wang, Yu, Pan, Di, Yao, Jing, You, Qi-Dong, Guo, Qing-Long
Published in Molecular carcinogenesis (01.02.2014)
Published in Molecular carcinogenesis (01.02.2014)
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Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways
Zhao, Kai, Wei, Libin, Hui, Hui, Dai, Qinsheng, You, Qi-Dong, Guo, Qing-Long, Lu, Na
Published in PloS one (09.09.2014)
Published in PloS one (09.09.2014)
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Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor
Jiang, Zheng-Yu, Xu, Li−Li, Lu, Meng-Chen, Chen, Zhi-Yun, Yuan, Zhen-Wei, Xu, Xiao-Li, Guo, Xiao-Ke, Zhang, Xiao-Jin, Sun, Hao-Peng, You, Qi-Dong
Published in Journal of medicinal chemistry (27.08.2015)
Published in Journal of medicinal chemistry (27.08.2015)
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Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells
Ling, Yun, Yang, Yong, Lu, Na, You, Qi-dong, Wang, Sen, Gao, Ying, Chen, Yan, Guo, Qing-Long
Published in Biochemical and biophysical research communications (14.09.2007)
Published in Biochemical and biophysical research communications (14.09.2007)
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Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner
Yang, Yong, Li, Xian-Jing, Chen, Zhen, Zhu, Xuan-Xuan, Wang, Jing, Zhang, Lin-bo, Qiang, Lei, Ma, Yan-Jun, Li, Zhi-yu, Guo, Qing-Long, You, Qi-Dong
Published in PloS one (12.12.2012)
Published in PloS one (12.12.2012)
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Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway
Zhao, Yue, Yao, Jing, Wu, Xiao-Ping, Zhao, Li, Zhou, Yu-Xin, Zhang, Yi, You, Qi-Dong, Guo, Qing-Long, Lu, Na
Published in Molecular carcinogenesis (01.06.2015)
Published in Molecular carcinogenesis (01.06.2015)
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Isolation and characterization of cancer stem like cells in human glioblastoma cell lines
Qiang, Lei, Yang, Yong, Ma, Yan-Jun, Chen, Fei-Hong, Zhang, Ling-Bo, Liu, Wei, Qi, Qi, Lu, Na, Tao, Lei, Wang, Xiao-Tang, You, Qi-Dong, Guo, Qing-Long
Published in Cancer letters (28.06.2009)
Published in Cancer letters (28.06.2009)
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Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation
Jiang, Zheng-Yu, Chu, Hong-Xi, Xi, Mei-Yang, Yang, Ting-Ting, Jia, Jian-Min, Huang, Jing-Jie, Guo, Xiao-Ke, Zhang, Xiao-Jin, You, Qi-Dong, Sun, Hao-Peng
Published in PloS one (16.09.2013)
Published in PloS one (16.09.2013)
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Oroxylin a prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling
Yao, Jing, Hu, Rong, Sun, Jie, Lin, Biqi, Zhao, Li, Sha, Yunying, Zhu, Binbin, You, Qi-Dong, Yan, Tianhua, Guo, Qing-Long
Published in Molecular carcinogenesis (01.02.2014)
Published in Molecular carcinogenesis (01.02.2014)
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Gambogic Acid Inhibits Proliferation of Human Lung Carcinoma SPC-A1 Cells in Vivo and in Vitro and Represses Telomerase Activity and Telomerase Reverse Transcriptase mRNA Expression in the Cells
Wu, Zhao-Qiu, Guo, Qing-Long, You, Qi-Dong, Zhao, Li, Gu, Hong-Yan
Published in Biological & pharmaceutical bulletin (01.11.2004)
Published in Biological & pharmaceutical bulletin (01.11.2004)
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