Clinical pharmacokinetics of laninamivir, a novel long-acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy male volunteers
Ishizuka, Hitoshi, Yoshiba, Satoshi, Okabe, Hiromi, Yoshihara, Kazutaka
Published in Journal of clinical pharmacology (01.11.2010)
Published in Journal of clinical pharmacology (01.11.2010)
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Journal Article
Safety and Pharmacokinetics of DS-8500a, a Novel GPR119 Agonist, After Multiple Oral Doses in Healthy Japanese Males
Kato, Manabu, Furuie, Hidetoshi, Kamiyama, Emi, Shiosakai, Kazuhito, Yoshihara, Kazutaka, Taguchi, Takashi
Published in Clinical drug investigation (01.06.2018)
Published in Clinical drug investigation (01.06.2018)
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Journal Article
Assessment of the effects of renal impairment on the pharmacokinetic profile of laninamivir, a novel neuraminidase inhibitor, after a single inhaled dose of its Prodrug, CS-8958
Ishizuka, Hitoshi, Yoshiba, Satoshi, Yoshihara, Kazutaka, Okabe, Hiromi
Published in Journal of clinical pharmacology (01.02.2011)
Published in Journal of clinical pharmacology (01.02.2011)
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Journal Article
Population Pharmacokinetics of Laninamivir and Its Prodrug Laninamivir Octanoate in Healthy Subjects and in Adult and Pediatric Patients with Influenza Virus Infection
Yoshihara, Kazutaka, Ishizuka, Hitoshi, Kubo, Yuichi
Published in Drug metabolism and pharmacokinetics (2013)
Published in Drug metabolism and pharmacokinetics (2013)
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Journal Article
Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure
Endo, Seiko, Fukahori, Aiko, Tokuhiro, Shinya, Shinagawa, Akira, Walker, Joseph, Yoshihara, Kazutaka, Ishizuka, Hitoshi, Ieiri, Ichiro, Sugiyama, Yuichi
Published in Journal of human genetics (01.08.2012)
Published in Journal of human genetics (01.08.2012)
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Journal Article
Comparative Pharmacodynamics of Olmesartan and Azelnidipine in Patients with Hypertension: a Population Pharmacokinetic/Pharmacodynamic Analysis
Tanigawara, Yusuke, Yoshihara, Kazutaka, Kuramoto, Kizuku, Arakawa, Kikuo
Published in Drug metabolism and pharmacokinetics (01.01.2009)
Published in Drug metabolism and pharmacokinetics (01.01.2009)
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Journal Article
Population Pharmacokinetics of Laninamivir and Its Prodrug Laninamivir Octanoate in Healthy Subjects and in Adult and Pediatric Patients with Influenza Virus Infection
Kazutaka YOSHIHARA, Hitoshi ISHIZUKA, Yuichi KUBO
Published in DRUG METABOLISM AND PHARMACOKINETICS (25.10.2013)
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Published in DRUG METABOLISM AND PHARMACOKINETICS (25.10.2013)
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Population Pharmacokinetics of Trastuzumab Deruxtecan in Patients With HER2‐Positive Breast Cancer and Other Solid Tumors
Yin, Ophelia, Xiong, Yuan, Endo, Seiko, Yoshihara, Kazutaka, Garimella, Tushar, AbuTarif, Malaz, Wada, Russ, LaCreta, Frank
Published in Clinical pharmacology and therapeutics (01.05.2021)
Published in Clinical pharmacology and therapeutics (01.05.2021)
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Journal Article
Exposure-response analysis of the efficacy and safety of esaxerenone, a novel nonsteroidal mineralocorticoid receptor blocker, in hypertensive patients with or without diabetic kidney disease
Yoshihara, Kazutaka, Fukae, Masato, Kastrissios, Helen, Wada, Russell, Shimizu, Takako
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
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Trastuzumab Deruxtecan Dosing in Human Epidermal Growth Factor Receptor 2-Positive Gastric Cancer: Population Pharmacokinetic Modeling and Exposure-Response Analysis
Yoshihara, Kazutaka, Kobayashi, Yoshimasa, Endo, Seiko, Fukae, Masato, Hennig, Stefanie, Kastrissios, Helen, Kamiyama, Emi, Garimella, Tushar, Abutarif, Malaz
Published in Journal of clinical pharmacology (01.11.2023)
Published in Journal of clinical pharmacology (01.11.2023)
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Population pharmacokinetics of esaxerenone, a novel non-steroidal mineralocorticoid receptor blocker, in patients with essential hypertension, patients with diabetic nephropathy, and healthy volunteers
Yoshihara, Kazutaka, Fukae, Masato, Kastrissios, Helen, Wada, Russell, Shimizu, Takako, Ishizuka, Hitoshi
Published in Drug metabolism and pharmacokinetics (01.10.2023)
Published in Drug metabolism and pharmacokinetics (01.10.2023)
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Journal Article
DS-5670a, a novel mRNA-encapsulated lipid nanoparticle vaccine against severe acute respiratory syndrome coronavirus 2: Results from a phase 2 clinical study
Toyama, Kaoru, Eto, Takashi, Takazawa, Kenji, Shimizu, Shinji, Nakayama, Tetsuo, Furihata, Kei, Sogawa, Yoshitaka, Kumazaki, Masafumi, Jonai, Nao, Matsunaga, Satoko, Takeshita, Fumihiko, Yoshihara, Kazutaka, Ishizuka, Hitoshi
Published in Vaccine (31.08.2023)
Published in Vaccine (31.08.2023)
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Journal Article
Comparative Pharmacodynamics of Olmesartan and Azelnidipine in Patients with Hypertension: a Population Pharmacokinetic/Pharmacodynamic Analysis
Yusuke TANIGAWARA, Kazutaka YOSHIHARA, Kizuku KURAMOTO, Kikuo ARAKAWA
Published in DRUG METABOLISM AND PHARMACOKINETICS (2009)
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Published in DRUG METABOLISM AND PHARMACOKINETICS (2009)
Journal Article
Abstract 5049: Application of population pharmacokinetic and exposure-response modeling for DS-8201a, a HER2-targeting ADC, predicts 50% ORR in patients with heavily pretreated breast cancer
Yoshihara, Kazutaka, Endo, Seiko, Tamura, Kenji, Doi, Toshihiko, Tokui, Taro
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
THERAPY FOR DRUG-RESISTANT CANCER BY ADMINISTRATION OF ANTI-HER2 ANTIBODY/DRUG CONJUGATE
JIKO TAKAHIRO, YOSHIHARA KAZUTAKA, ENDO SEIKO, FUJISAKI YOSHIHIKO, OGITANI YUSUKE
Year of Publication 16.04.2024
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Year of Publication 16.04.2024
Patent
HER2 - THERAPY FOR DRUG-RESISTANT CANCER BY ADMINISTRATION OF ANTI-HER2 ANTIBODY/DRUG CONJUGATE
YOSHIHARA KAZUTAKA, ENDO SEIKO, FUJISAKI YOSHIHIKO, OGITANI YUSUKE, JIKOH TAKAHIRO
Year of Publication 20.11.2023
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Year of Publication 20.11.2023
Patent
Pharmacokinetics and Bioequivalence of Mirogabalin Orally Disintegrating Tablets and Conventional Tablets in Healthy Japanese Participants
Toyama, Kaoru, Eto, Takashi, Suzuki, Kanae, Shinohara, Sayaka, Yoshiba, Satoshi, Yoshihara, Kazutaka, Ishizuka, Hitoshi
Published in Clinical pharmacology in drug development (01.10.2023)
Published in Clinical pharmacology in drug development (01.10.2023)
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Population Pharmacokinetics of Edoxaban in Japanese Atrial Fibrillation Patients With Severe Renal Impairment
Shimizu, Takako, Tachibana, Masaya, Kimura, Tetsuya, Kumakura, Tomohiko, Yoshihara, Kazutaka
Published in Clinical pharmacology in drug development (01.09.2017)
Published in Clinical pharmacology in drug development (01.09.2017)
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Journal Article
Population Pharmacokinetic and Exposure-Response Modeling for the EZH1/2 Dual Inhibitor DS-3201b in Patients with Non-Hodgkin Lymphomas
Atsumi, Ryo, Yoshiba, Satoshi, Maruyama, Dai, Tobinai, Kensei, Ishida, Takashi, Ishitsuka, Kenji, Imaizumi, Yoshitaka, Takeuchi, Shogo, Tsukasaki, Kunihiro, Adachi, Nobuaki, Fujitani, Sumiaki, Tachibana, Masaya, Yoshihara, Kazutaka, Ishizuka, Hitoshi
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
항 HER2 항체-약물 콘주게이트 투여에 의한 내성암의 치료
YOSHIHARA KAZUTAKA, ENDO SEIKO, FUJISAKI YOSHIHIKO, OGITANI YUSUKE, JIKOH TAKAHIRO
Year of Publication 12.06.2019
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Year of Publication 12.06.2019
Patent