Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects
Yore, Mark M., Syed, Ismail, Moraes-Vieira, Pedro M., Zhang, Tejia, Herman, Mark A., Homan, Edwin A., Patel, Rajesh T., Lee, Jennifer, Chen, Shili, Peroni, Odile D., Dhaneshwar, Abha S., Hammarstedt, Ann, Smith, Ulf, McGraw, Timothy E., Saghatelian, Alan, Kahn, Barbara B.
Published in Cell (09.10.2014)
Published in Cell (09.10.2014)
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Journal Article
New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress
Sporn, Michael B, Liby, Karen T, Yore, Mark M, Fu, Liangfeng, Lopchuk, Justin M, Gribble, Gordon W
Published in Journal of natural products (Washington, D.C.) (25.03.2011)
Published in Journal of natural products (Washington, D.C.) (25.03.2011)
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Journal Article
Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism
Norseen, Julie, Hosooka, Tetsuya, Hammarstedt, Ann, Yore, Mark M., Kant, Shashi, Aryal, Pratik, Kiernan, Urban A., Phillips, David A., Maruyama, Hiroshi, Kraus, Bettina J., Usheva, Anny, Davis, Roger J., Smith, Ulf, Kahn, Barbara B.
Published in Molecular and Cellular Biology (01.05.2012)
Published in Molecular and Cellular Biology (01.05.2012)
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Journal Article
Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR
Yore, Mark M, Kettenbach, Arminja N, Sporn, Michael B, Gerber, Scott A, Liby, Karen T
Published in PloS one (27.07.2011)
Published in PloS one (27.07.2011)
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Journal Article
The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice
LIBY, Karen, ROYCE, Darlene B, WILLIAMS, Charlotte R, RISINGSONG, Renee, YORE, Mark M, HONDA, Tadashi, GRIBBLE, Gordon W, DMITROVSKY, Ethan, SPORN, Thomas A, SPORN, Michael B
Published in Cancer research (Chicago, Ill.) (15.03.2007)
Published in Cancer research (Chicago, Ill.) (15.03.2007)
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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling
LIBY, Karen, HOCK, Thomas, GRIBBLE, Gordon W, HILL-KAPTURCZAK, Nathalie, AGARWAL, Anupam, SPORN, Michael B, YORE, Mark M, SUH, Nanjoo, PLACE, Andrew E, RISINGSONG, Renee, WILLIAMS, Charlotte R, ROYCE, Darlene B, HONDA, Tadashi, HONDA, Yukiko
Published in Cancer research (Chicago, Ill.) (01.06.2005)
Published in Cancer research (Chicago, Ill.) (01.06.2005)
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Journal Article
Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole
Yates, Melinda S, Kwak, Mi-Kyoung, Egner, Patricia A, Groopman, John D, Bodreddigari, Sridevi, Sutter, Thomas R, Baumgartner, Karen J, Roebuck, B D, Liby, Karen T, Yore, Mark M, Honda, Tadashi, Gribble, Gordon W, Sporn, Michael B, Kensler, Thomas W
Published in Cancer research (Chicago, Ill.) (15.02.2006)
Published in Cancer research (Chicago, Ill.) (15.02.2006)
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Journal Article
Prevention and Treatment of Experimental Estrogen Receptor–Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268
Liby, Karen, Risingsong, Renee, Royce, Darlene B, Williams, Charlotte R, Yore, Mark M, Honda, Tadashi, Gribble, Gordon W, Lamph, William W, Vannini, Nicola, Sogno, Ilaria, Albini, Adriana, Sporn, Michael B
Published in Clinical cancer research (15.07.2008)
Published in Clinical cancer research (15.07.2008)
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Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice
Liby, Karen, Risingsong, Renee, Royce, Darlene B, Williams, Charlotte R, Ma, Tian, Yore, Mark M, Sporn, Michael B
Published in Cancer prevention research (Philadelphia, Pa.) (01.12.2009)
Published in Cancer prevention research (Philadelphia, Pa.) (01.12.2009)
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Journal Article
Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4
Moraes-Vieira, Pedro M., Yore, Mark M., Sontheimer-Phelps, Alexandra, Castoldi, Angela, Norseen, Julie, Aryal, Pratik, Sjödi, Kotryna Simonyté, Kahn, Barbara B.
Published in Proceedings of the National Academy of Sciences - PNAS (08.12.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (08.12.2020)
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Journal Article
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin
Liby, Karen, Yore, Mark M, Roebuck, Bill D, Baumgartner, Karen J, Honda, Tadashi, Sundararajan, Chitra, Yoshizawa, Hidenori, Gribble, Gordon W, Williams, Charlotte R, Risingsong, Renee, Royce, Darlene B, Dinkova-Kostova, Albena T, Stephenson, Katherine K, Egner, Patricia A, Yates, Melinda S, Groopman, John D, Kensler, Thomas W, Sporn, Michael B
Published in Cancer research (Chicago, Ill.) (15.08.2008)
Published in Cancer research (Chicago, Ill.) (15.08.2008)
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Journal Article
Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis
Syed, Ismail, Lee, Jennifer, Moraes-Vieira, Pedro M., Donaldson, Cynthia J., Sontheimer, Alexandra, Aryal, Pratik, Wellenstein, Kerry, Kolar, Matthew J., Nelson, Andrew T., Siegel, Dionicio, Mokrosinski, Jacek, Farooqi, I. Sadaf, Zhao, Juan Juan, Yore, Mark M., Peroni, Odile D., Saghatelian, Alan, Kahn, Barbara B.
Published in Cell metabolism (06.02.2018)
Published in Cell metabolism (06.02.2018)
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Journal Article
Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects
Syed, Ismail, Lee, Jennifer, Peroni, Odile D., Yore, Mark M., Moraes-Vieira, Pedro M., Santoro, Anna, Wellenstein, Kerry, Smith, Ulf, McGraw, Timothy E., Saghatelian, Alan, Kahn, Barbara B.
Published in Cell metabolism (02.10.2018)
Published in Cell metabolism (02.10.2018)
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Journal Article
Smoothened Regulates Activator and Repressor Functions of Hedgehog Signaling via Two Distinct Mechanisms
Ogden, Stacey K., Casso, David J., Ascano, Manuel, Yore, Mark M., Kornberg, Thomas B., Robbins, David J.
Published in The Journal of biological chemistry (17.03.2006)
Published in The Journal of biological chemistry (17.03.2006)
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Journal Article
The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-κB activation through direct inhibition of IκB kinase β
Yore, Mark M., Liby, Karen T., Honda, Tadashi, Gribble, Gordon W., Sporn, Michael B.
Published in Molecular cancer therapeutics (01.12.2006)
Published in Molecular cancer therapeutics (01.12.2006)
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Journal Article
The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis
Liby, Karen, Black, Candice C, Royce, Darlene B, Williams, Charlotte R, Risingsong, Renee, Yore, Mark M, Liu, Xi, Honda, Tadashi, Gribble, Gordon W, Lamph, William W, Sporn, Thomas A, Dmitrovsky, Ethan, Sporn, Michael B
Published in Molecular cancer therapeutics (01.05.2008)
Published in Molecular cancer therapeutics (01.05.2008)
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Journal Article
Platforms and networks in triterpenoid pharmacology
Sporn, Michael B., Liby, Karen, Yore, Mark M., Suh, Nanjoo, Albini, Adriana, Honda, Tadashi, Sundararajan, Chitra, Gribble, Gordon W.
Published in Drug development research (01.06.2007)
Published in Drug development research (01.06.2007)
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