Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide
Nemoto, Tsuyoshi, Irukayama‐Tomobe, Yoko, Hirose, Yuki, Tanaka, Hiromu, Takahashi, Genki, Takahashi, Satoshi, Yanagisawa, Masashi, Kanbayashi, Takashi
Published in Journal of sleep research (01.10.2022)
Published in Journal of sleep research (01.10.2022)
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Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
Wang, Yibing, Cao, Liqin, Lee, Chia-Ying, Matsuo, Tomohiko, Wu, Kejia, Asher, Greg, Tang, Lijun, Saitoh, Tsuyoshi, Russell, Jamie, Klewe-Nebenius, Daniela, Wang, Li, Soya, Shingo, Hasegawa, Emi, Chérasse, Yoan, Zhou, Jiamin, Li, Yuwenbin, Wang, Tao, Zhan, Xiaowei, Miyoshi, Chika, Irukayama, Yoko, Cao, Jie, Meeks, Julian P., Gautron, Laurent, Wang, Zhiqiang, Sakurai, Katsuyasu, Funato, Hiromasa, Sakurai, Takeshi, Yanagisawa, Masashi, Nagase, Hiroshi, Kobayakawa, Reiko, Kobayakawa, Ko, Beutler, Bruce, Liu, Qinghua
Published in Nature communications (23.05.2018)
Published in Nature communications (23.05.2018)
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Peripherally administered orexin improves survival of mice with endotoxin shock
Ogawa, Yasuhiro, Irukayama-Tomobe, Yoko, Murakoshi, Nobuyuki, Kiyama, Maiko, Ishikawa, Yui, Hosokawa, Naoto, Tominaga, Hiromu, Uchida, Shuntaro, Kimura, Saki, Kanuka, Mika, Morita, Miho, Hamada, Michito, Takahashi, Satoru, Hayashi, Yu, Yanagisawa, Masashi
Published in eLife (30.12.2016)
Published in eLife (30.12.2016)
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Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models
Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Tominaga, Hiromu, Ishikawa, Yukiko, Hosokawa, Naoto, Ambai, Shinobu, Kawabe, Yuki, Uchida, Shuntaro, Nakajima, Ryo, Saitoh, Tsuyoshi, Kanda, Takeshi, Vogt, Kaspar, Sakurai, Takeshi, Nagase, Hiroshi, Yanagisawa, Masashi
Published in Proceedings of the National Academy of Sciences - PNAS (30.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (30.05.2017)
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Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists
Nagahara, Takashi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Kuroda, Daisuke, Gouda, Hiroaki, Kumagai, Hidetoshi, Fujii, Hideaki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy
Yamamoto, Hikari, Nagumo, Yasuyuki, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Namekawa, Yukiko, Nemoto, Tsuyoshi, Tanaka, Hiromu, Takahashi, Genki, Tokuda, Akihisa, Saitoh, Tsuyoshi, Nagase, Hiroshi, Funato, Hiromasa, Yanagisawa, Masashi
Published in PloS one (22.07.2022)
Published in PloS one (22.07.2022)
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Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring
Iio, Keita, Saitoh, Tsuyoshi, Ohshita, Ryuichiro, Hino, Tsubasa, Amezawa, Mao, Takayama, Yoshiaki, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
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Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton
Hino, Tsubasa, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
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Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives
Katoh, Koki, Kutsumura, Noriki, Yamamoto, Naoshi, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
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Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors
Katoh, Koki, Yamamoto, Naoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Kutsumura, Noriki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
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Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library
Saitoh, Tsuyoshi, Amezawa, Mao, Horiuchi, Jumpei, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Ohshita, Ryuichiro, Tokuda, Akihisa, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Hasegawa, Emi, Sakurai, Takeshi, Uchida, Yasuo, Sato, Tetsu, Gouda, Hiroaki, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in European journal of medicinal chemistry (05.10.2022)
Published in European journal of medicinal chemistry (05.10.2022)
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Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group
Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
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Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity
Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
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Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity
Ohrui, Sayaka, Yamamoto, Naoshi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, Gouda, Hiroaki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.02.2018)
Published in Bioorganic & medicinal chemistry letters (15.02.2018)
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Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring
Yamamoto, Naoshi, Ohrui, Sayaka, Okada, Takahiro, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, Gouda, Hiroaki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry (15.04.2019)
Published in Bioorganic & medicinal chemistry (15.04.2019)
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Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice
Saitoh, Akiyoshi, Tominaga, Hiromu, Ogawa, Yasuhiro, Irukayama-Tomobe, Yoko, Yamada, Mitsuhiko, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Pharmacological reports (01.04.2018)
Published in Pharmacological reports (01.04.2018)
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Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B
Irukayama-Tomobe, Yoko, Tanaka, Hirokazu, Yokomizo, Takehiko, Hashidate-Yoshida, Tomomi, Yanagisawa, Masashi, Sakurai, Takeshi
Published in Proceedings of the National Academy of Sciences - PNAS (10.03.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (10.03.2009)
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A NOVEL REARRANGEMENT REACTION OF MORPHINAN TO ARYLMORPHAN SKELETONS AND THE PHARMACOLOGIES OF ARYLMORPHAN DERIVATIVES
Yata, Masahiro, Kutsumura, Noriki, Nagumo, Yasuyuki, Yamamoto, Naoshi, Saitoh, Tsuyoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Heterocycles (01.04.2019)
Published in Heterocycles (01.04.2019)
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A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions
Watanabe, Noriya, Wada, Mari, Irukayama-Tomobe, Yoko, Ogata, Yousuke, Tsujino, Natsuko, Suzuki, Mika, Furutani, Naoki, Sakurai, Takeshi, Yamamoto, Miyuki
Published in PloS one (24.04.2012)
Published in PloS one (24.04.2012)
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Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans
Maeda, Seiji, Miyauchi, Takashi, Kakiyama, Tetsuji, Sugawara, Jun, Iemitsu, Motoyuki, Irukayama-Tomobe, Yoko, Murakami, Haruka, Kumagai, Yoshito, Kuno, Shinya, Matsuda, Mitsuo
Published in Life sciences (1973) (20.07.2001)
Published in Life sciences (1973) (20.07.2001)
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