The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
Akinc, Akin, Maier, Martin A, Manoharan, Muthiah, Fitzgerald, Kevin, Jayaraman, Muthusamy, Barros, Scott, Ansell, Steven, Du, Xinyao, Hope, Michael J, Madden, Thomas D, Mui, Barbara L, Semple, Sean C, Tam, Ying K, Ciufolini, Marco, Witzigmann, Dominik, Kulkarni, Jayesh A, van der Meel, Roy, Cullis, Pieter R
Published in Nature nanotechnology (01.12.2019)
Published in Nature nanotechnology (01.12.2019)
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Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
Pardi, Norbert, Tuyishime, Steven, Muramatsu, Hiromi, Kariko, Katalin, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew
Published in Journal of controlled release (10.11.2015)
Published in Journal of controlled release (10.11.2015)
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Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
McKay, Paul F, Hu, Kai, Blakney, Anna K, Samnuan, Karnyart, Brown, Jonathan C, Penn, Rebecca, Zhou, Jie, Bouton, Clément R, Rogers, Paul, Polra, Krunal, Lin, Paulo J C, Barbosa, Christopher, Tam, Ying K, Barclay, Wendy S, Shattock, Robin J
Published in Nature communications (09.07.2020)
Published in Nature communications (09.07.2020)
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Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
Pardi, Norbert, Parkhouse, Kaela, Kirkpatrick, Ericka, McMahon, Meagan, Zost, Seth J, Mui, Barbara L, Tam, Ying K, Karikó, Katalin, Barbosa, Christopher J, Madden, Thomas D, Hope, Michael J, Krammer, Florian, Hensley, Scott E, Weissman, Drew
Published in Nature communications (22.08.2018)
Published in Nature communications (22.08.2018)
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Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
Pardi, Norbert, Secreto, Anthony J, Shan, Xiaochuan, Debonera, Fotini, Glover, Joshua, Yi, Yanjie, Muramatsu, Hiromi, Ni, Houping, Mui, Barbara L, Tam, Ying K, Shaheen, Farida, Collman, Ronald G, Karikó, Katalin, Danet-Desnoyers, Gwenn A, Madden, Thomas D, Hope, Michael J, Weissman, Drew
Published in Nature communications (02.03.2017)
Published in Nature communications (02.03.2017)
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Molecular fate-mapping of serum antibody responses to repeat immunization
Schiepers, Ariën, van 't Wout, Marije F L, Greaney, Allison J, Zang, Trinity, Muramatsu, Hiromi, Lin, Paulo J C, Tam, Ying K, Mesin, Luka, Starr, Tyler N, Bieniasz, Paul D, Pardi, Norbert, Bloom, Jesse D, Victora, Gabriel D
Published in Nature (London) (16.03.2023)
Published in Nature (London) (16.03.2023)
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CAR T cells produced in vivo to treat cardiac injury
Rurik, Joel G, Tombácz, István, Yadegari, Amir, Méndez Fernández, Pedro O, Shewale, Swapnil V, Li, Li, Kimura, Toru, Soliman, Ousamah Younoss, Papp, Tyler E, Tam, Ying K, Mui, Barbara L, Albelda, Steven M, Puré, Ellen, June, Carl H, Aghajanian, Haig, Weissman, Drew, Parhiz, Hamideh, Epstein, Jonathan A
Published in Science (American Association for the Advancement of Science) (07.01.2022)
Published in Science (American Association for the Advancement of Science) (07.01.2022)
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Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
Hocker, Harrison J, Cho, Kwang-Jin, Chen, Chung-Ying K, Rambahal, Nandini, Sagineedu, Sreenivasa Rao, Shaari, Khozirah, Stanslas, Johnson, Hancock, John F, Gorfe, Alemayehu A
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2013)
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PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake
Parhiz, Hamideh, Shuvaev, Vladimir V., Pardi, Norbert, Khoshnejad, Makan, Kiseleva, Raisa Yu, Brenner, Jacob S., Uhler, Thomas, Tuyishime, Steven, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew, Muzykantov, Vladimir R.
Published in Journal of controlled release (10.12.2018)
Published in Journal of controlled release (10.12.2018)
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Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo
Jayaraman, Muthusamy, Ansell, Steven M., Mui, Barbara L., Tam, Ying K., Chen, Jianxin, Du, Xinyao, Butler, David, Eltepu, Laxman, Matsuda, Shigeo, Narayanannair, Jayaprakash K., Rajeev, Kallanthottathil G., Hafez, Ismail M., Akinc, Akin, Maier, Martin A., Tracy, Mark A., Cullis, Pieter R., Madden, Thomas D., Manoharan, Muthiah, Hope, Michael J.
Published in Angewandte Chemie (International ed.) (20.08.2012)
Published in Angewandte Chemie (International ed.) (20.08.2012)
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Plant metabolism of nematode pheromones mediates plant-nematode interactions
Manohar, Murli, Tenjo-Castano, Francisco, Chen, Shiyan, Zhang, Ying K, Kumari, Anshu, Williamson, Valerie M, Wang, Xiaohong, Klessig, Daniel F, Schroeder, Frank C
Published in Nature communications (10.01.2020)
Published in Nature communications (10.01.2020)
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Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier
Marcos-Contreras, Oscar A., Greineder, Colin F., Kiseleva, Raisa Yu, Parhiz, Hamideh, Walsh, Landis R., Zuluaga-Ramirez, Viviana, Myerson, Jacob W., Hood, Elizabeth D., Villa, Carlos H., Tombacz, Istvan, Pardi, Norbert, Seliga, Alecia, Mui, Barbara L., Tam, Ying K., Glassman, Patrick M., Shuvaev, Vladimir V., Nong, Jia, Brenner, Jacob S., Khoshnejad, Makan, Madden, Tom, Weissmann, Drew, Persidsky, Yuri, Muzykantov, Vladimir R.
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2020)
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Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses
Pardi, Norbert, Carreño, Juan Manuel, O'Dell, George, Tan, Jessica, Bajusz, Csaba, Muramatsu, Hiromi, Rijnink, Willemijn, Strohmeier, Shirin, Loganathan, Madhumathi, Bielak, Dominika, Sung, Molly M H, Tam, Ying K, Krammer, Florian, McMahon, Meagan
Published in Nature communications (09.08.2022)
Published in Nature communications (09.08.2022)
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SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation
Lederer, Katlyn, Castaño, Diana, Gómez Atria, Daniela, Oguin, Thomas H., Wang, Sidney, Manzoni, Tomaz B., Muramatsu, Hiromi, Hogan, Michael J., Amanat, Fatima, Cherubin, Patrick, Lundgreen, Kendall A., Tam, Ying K., Fan, Steven H.Y., Eisenlohr, Laurence C., Maillard, Ivan, Weissman, Drew, Bates, Paul, Krammer, Florian, Sempowski, Gregory D., Pardi, Norbert, Locci, Michela
Published in Immunity (15.12.2020)
Published in Immunity (15.12.2020)
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In vivo hematopoietic stem cell modification by mRNA delivery
Breda, Laura, Papp, Tyler E, Triebwasser, Michael P, Yadegari, Amir, Fedorky, Megan T, Tanaka, Naoto, Abdulmalik, Osheiza, Pavani, Giulia, Wang, Yongping, Grupp, Stephan A, Chou, Stella T, Ni, Houping, Mui, Barbara L, Tam, Ying K, Weissman, Drew, Rivella, Stefano, Parhiz, Hamideh
Published in Science (American Association for the Advancement of Science) (28.07.2023)
Published in Science (American Association for the Advancement of Science) (28.07.2023)
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In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
Musunuru, Kiran, Chadwick, Alexandra C, Mizoguchi, Taiji, Garcia, Sara P, DeNizio, Jamie E, Reiss, Caroline W, Wang, Kui, Iyer, Sowmya, Dutta, Chaitali, Clendaniel, Victoria, Amaonye, Michael, Beach, Aaron, Berth, Kathleen, Biswas, Souvik, Braun, Maurine C, Chen, Huei-Mei, Colace, Thomas V, Ganey, John D, Gangopadhyay, Soumyashree A, Garrity, Ryan, Kasiewicz, Lisa N, Lavoie, Jennifer, Madsen, James A, Matsumoto, Yuri, Mazzola, Anne Marie, Nasrullah, Yusuf S, Nneji, Joseph, Ren, Huilan, Sanjeev, Athul, Shay, Madeleine, Stahley, Mary R, Fan, Steven H Y, Tam, Ying K, Gaudelli, Nicole M, Ciaramella, Giuseppe, Stolz, Leslie E, Malyala, Padma, Cheng, Christopher J, Rajeev, Kallanthottathil G, Rohde, Ellen, Bellinger, Andrew M, Kathiresan, Sekar
Published in Nature (London) (20.05.2021)
Published in Nature (London) (20.05.2021)
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Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs
Tombácz, István, Laczkó, Dorottya, Shahnawaz, Hamna, Muramatsu, Hiromi, Natesan, Ambika, Yadegari, Amir, Papp, Tyler E., Alameh, Mohamad-Gabriel, Shuvaev, Vladimir, Mui, Barbara L., Tam, Ying K., Muzykantov, Vladimir, Pardi, Norbert, Weissman, Drew, Parhiz, Hamideh
Published in Molecular therapy (03.11.2021)
Published in Molecular therapy (03.11.2021)
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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Alameh, Mohamad-Gabriel, Tombácz, István, Bettini, Emily, Lederer, Katlyn, Ndeupen, Sonia, Sittplangkoon, Chutamath, Wilmore, Joel R., Gaudette, Brian T., Soliman, Ousamah Y., Pine, Matthew, Hicks, Philip, Manzoni, Tomaz B., Knox, James J., Johnson, John L., Laczkó, Dorottya, Muramatsu, Hiromi, Davis, Benjamin, Meng, Wenzhao, Rosenfeld, Aaron M., Strohmeier, Shirin, Lin, Paulo J.C., Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Jacquet, Alain, Krammer, Florian, Bates, Paul, Cancro, Michael P., Weissman, Drew, Luning Prak, Eline T., Allman, David, Igyártó, Botond Z., Locci, Michela, Pardi, Norbert
Published in Immunity (Cambridge, Mass.) (14.12.2021)
Published in Immunity (Cambridge, Mass.) (14.12.2021)
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