In Vitro Selection of Diversely Functionalized Aptamers
Kong, Dehui, Yeung, Wayland, Hili, Ryan
Published in Journal of the American Chemical Society (11.10.2017)
Published in Journal of the American Chemical Society (11.10.2017)
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Journal Article
Mapping the glycosyltransferase fold landscape using interpretable deep learning
Taujale, Rahil, Zhou, Zhongliang, Yeung, Wayland, Moremen, Kelley W., Li, Sheng, Kannan, Natarajan
Published in Nature communications (27.09.2021)
Published in Nature communications (27.09.2021)
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Journal Article
Tracing the origin and evolution of pseudokinases across the tree of life
Kwon, Annie, Scott, Steven, Taujale, Rahil, Yeung, Wayland, Kochut, Krys J, Eyers, Patrick A, Kannan, Natarajan
Published in Science signaling (23.04.2019)
Published in Science signaling (23.04.2019)
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Journal Article
Evolution of Functional Diversity in the Holozoan Tyrosine Kinome
Yeung, Wayland, Kwon, Annie, Taujale, Rahil, Bunn, Claire, Venkat, Aarya, Kannan, Natarajan
Published in Molecular biology and evolution (09.12.2021)
Published in Molecular biology and evolution (09.12.2021)
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Journal Article
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
Garnish, Sarah E., Meng, Yanxiang, Koide, Akiko, Sandow, Jarrod J., Denbaum, Eric, Jacobsen, Annette V., Yeung, Wayland, Samson, Andre L., Horne, Christopher R., Fitzgibbon, Cheree, Young, Samuel N., Smith, Phoebe P. C., Webb, Andrew I., Petrie, Emma J., Hildebrand, Joanne M., Kannan, Natarajan, Czabotar, Peter E., Koide, Shohei, Murphy, James M.
Published in Nature communications (13.04.2021)
Published in Nature communications (13.04.2021)
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Journal Article
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
Foulkes, Daniel M, Byrne, Dominic P, Yeung, Wayland, Shrestha, Safal, Bailey, Fiona P, Ferries, Samantha, Eyers, Claire E, Keeshan, Karen, Wells, Carrow, Drewry, David H, Zuercher, William J, Kannan, Natarajan, Eyers, Patrick A
Published in Science signaling (25.09.2018)
Published in Science signaling (25.09.2018)
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Journal Article
Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases
Taujale, Rahil, Venkat, Aarya, Huang, Liang-Chin, Zhou, Zhongliang, Yeung, Wayland, Rasheed, Khaled M, Li, Sheng, Edison, Arthur S, Moremen, Kelley W, Kannan, Natarajan
Published in eLife (01.04.2020)
Published in eLife (01.04.2020)
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Journal Article
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Yeung, Wayland, Coursier, Diane, Birkinshaw, Richard W., Sandow, Jarrod J., Lehmann, Wil I. L., Liang, Lung-Yu, Lucet, Isabelle S., Chalmers, James D., Patrick, Wayne M., Kannan, Natarajan, Petrie, Emma J., Czabotar, Peter E., Murphy, James M.
Published in Nature communications (19.06.2020)
Published in Nature communications (19.06.2020)
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Journal Article
Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases
Venkat, Aarya, Watterson, Grace, Byrne, Dominic P, O'Boyle, Brady, Shrestha, Safal, Gravel, Nathan, Fairweather, Emma E, Daly, Leonard A, Bunn, Claire, Yeung, Wayland, Aggarwal, Ishan, Katiyar, Samiksha, Eyers, Claire E, Eyers, Patrick A, Kannan, Natarajan
Published in eLife (26.10.2023)
Published in eLife (26.10.2023)
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Journal Article
Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters
Berger, Brittany M, Yeung, Wayland, Goyal, Arnav, Zhou, Zhongliang, Hildebrandt, Emily R, Kannan, Natarajan, Schmidt, Walter K
Published in PloS one (24.06.2022)
Published in PloS one (24.06.2022)
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Journal Article
An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function
Cuesta-Hernández, Hipólito Nicolás, Contreras, Julia, Soriano-Maldonado, Pablo, Sánchez-Wandelmer, Jana, Yeung, Wayland, Martín-Hurtado, Ana, Muñoz, Inés G., Kannan, Natarajan, Llimargas, Marta, Muñoz, Javier, Plaza-Menacho, Iván
Published in Nature communications (17.10.2023)
Published in Nature communications (17.10.2023)
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Journal Article
KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases
Huang, Liang-Chin, Taujale, Rahil, Gravel, Nathan, Venkat, Aarya, Yeung, Wayland, Byrne, Dominic P, Eyers, Patrick A, Kannan, Natarajan
Published in BMC bioinformatics (18.09.2021)
Published in BMC bioinformatics (18.09.2021)
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Journal Article
Quantitative Structure-Mutation-Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction
Huang, Liang-Chin, Yeung, Wayland, Wang, Ye, Cheng, Huimin, Venkat, Aarya, Li, Sheng, Ma, Ping, Rasheed, Khaled, Kannan, Natarajan
Published in BMC bioinformatics (12.11.2020)
Published in BMC bioinformatics (12.11.2020)
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Journal Article
Dark kinase annotation, mining, and visualization using the Protein Kinase Ontology
Soleymani, Saber, Gravel, Nathan, Huang, Liang-Chin, Yeung, Wayland, Bozorgi, Elika, Bendzunas, Nathaniel G, Kochut, Krzysztof J, Kannan, Natarajan
Published in PeerJ (San Francisco, CA) (05.12.2023)
Published in PeerJ (San Francisco, CA) (05.12.2023)
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Journal Article
Phosformer: an explainable transformer model for protein kinase-specific phosphorylation predictions
Zhou, Zhongliang, Yeung, Wayland, Gravel, Nathan, Salcedo, Mariah, Soleymani, Saber, Li, Sheng, Kannan, Natarajan
Published in Bioinformatics (Oxford, England) (03.02.2023)
Published in Bioinformatics (Oxford, England) (03.02.2023)
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Journal Article
Informatic challenges and advances in illuminating the druggable proteome
Taujale, Rahil, Gravel, Nathan, Zhou, Zhongliang, Yeung, Wayland, Kochut, Krystof, Kannan, Natarajan
Published in Drug discovery today (01.03.2024)
Published in Drug discovery today (01.03.2024)
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Journal Article
Enzymatic Synthesis of Sequence-Defined Synthetic Nucleic Acid Polymers with Diverse Functional Groups
Kong, Dehui, Lei, Yi, Yeung, Wayland, Hili, Ryan
Published in Angewandte Chemie International Edition (10.10.2016)
Published in Angewandte Chemie International Edition (10.10.2016)
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Journal Article