Spiroindolones, a Potent Compound Class for the Treatment of Malaria
Rottmann, Matthias, McNamara, Case, Yeung, Bryan K.S, Lee, Marcus C.S, Zou, Bin, Russell, Bruce, Seitz, Patrick, Plouffe, David M, Dharia, Neekesh V, Tan, Jocelyn, Cohen, Steven B, Spencer, Kathryn R, González-Páez, Gonzalo E, Lakshminarayana, Suresh B, Goh, Anne, Suwanarusk, Rossarin, Jegla, Timothy, Schmitt, Esther K, Beck, Hans-Peter, Brun, Reto, Nosten, Francois, Renia, Laurent, Dartois, Veronique, Keller, Thomas H, Fidock, David A, Winzeler, Elizabeth A, Diagana, Thierry T
Published in Science (American Association for the Advancement of Science) (03.09.2010)
Published in Science (American Association for the Advancement of Science) (03.09.2010)
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Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria
Yeung, Bryan K. S, Zou, Bin, Rottmann, Matthias, Lakshminarayana, Suresh B, Ang, Shi Hua, Leong, Seh Yong, Tan, Jocelyn, Wong, Josephine, Keller-Maerki, Sonja, Fischli, Christoph, Goh, Anne, Schmitt, Esther K, Krastel, Philipp, Francotte, Eric, Kuhen, Kelli, Plouffe, David, Henson, Kerstin, Wagner, Trixie, Winzeler, Elizabeth A, Petersen, Frank, Brun, Reto, Dartois, Veronique, Diagana, Thierry T, Keller, Thomas H
Published in Journal of medicinal chemistry (22.07.2010)
Published in Journal of medicinal chemistry (22.07.2010)
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PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites
Zeeman, Anne-Marie, Lakshminarayana, Suresh B, van der Werff, Nicole, Klooster, Els J, Voorberg-van der Wel, Annemarie, Kondreddi, Ravinder R, Bodenreider, Christophe, Simon, Oliver, Sauerwein, Robert, Yeung, Bryan K S, Diagana, Thierry T, Kocken, Clemens H M
Published in Antimicrobial agents and chemotherapy (01.05.2016)
Published in Antimicrobial agents and chemotherapy (01.05.2016)
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KAI407, a Potent Non-8-Aminoquinoline Compound That Kills Plasmodium cynomolgi Early Dormant Liver Stage Parasites In Vitro
ZEEMAN, Anne-Marie, VAN AMSTERDAM, Sandra M, SAUERWEIN, Robert, GAGARING, Kerstin, BORBOA, Rachel, ZHONG CHEN, KUHEN, Kelli, GLYNNE, Richard J, CHATTERJEE, Arnab K, NAGLE, Advait, ROLAND, Jason, WINZELER, Elizabeth A, MCNAMARA, Case W, LEROY, Didier, CAMPO, Brice, DIAGANA, Thierry T, YEUNG, Bryan K. S, THOMAS, Alan W, KOCKEN, Clemens H. M, VOORBERG-VAN DER WEL, Annemarie, KLOOSTER, Els J, VAN DEN BERG, Alexander, REMARQUE, Edmond J, PLOUFFE, David M, VAN GEMERT, Geert-Jan, LUTY, Adrian
Published in Antimicrobial Agents and Chemotherapy (01.03.2014)
Published in Antimicrobial Agents and Chemotherapy (01.03.2014)
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Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model
Lakshminarayana, Suresh B, Freymond, Céline, Fischli, Christoph, Yu, Jing, Weber, Sebastian, Goh, Anne, Yeung, Bryan K S, Ho, Paul C, Dartois, Véronique, Diagana, Thierry T, Rottmann, Matthias, Blasco, Francesca
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Published in Antimicrobial agents and chemotherapy (01.02.2015)
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Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages
Chua, Adeline C. Y., Ong, Jessica Jie Ying, Malleret, Benoit, Suwanarusk, Rossarin, Kosaisavee, Varakorn, Zeeman, Anne-Marie, Cooper, Caitlin A., Tan, Kevin S. W., Zhang, Rou, Tan, Bee Huat, Abas, Siti Nurdiana, Yip, Andy, Elliot, Anne, Joyner, Chester J., Cho, Jee Sun, Breyer, Kate, Baran, Szczepan, Lange, Amber, Maher, Steven P., Nosten, François, Bodenreider, Christophe, Yeung, Bryan K. S., Mazier, Dominique, Galinski, Mary R., Dereuddre-Bosquet, Nathalie, Le Grand, Roger, Kocken, Clemens H. M., Rénia, Laurent, Kyle, Dennis E., Diagana, Thierry T., Snounou, Georges, Russell, Bruce, Bifani, Pablo
Published in Nature communications (12.08.2019)
Published in Nature communications (12.08.2019)
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Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design
Harbut, Michael B., Patel, Bhumit A., Yeung, Bryan K. S., McNamara, Case W., Bright, A. Taylor, Ballard, Jaime, Supek, Frantisek, Golde, Todd E., Winzeler, Elizabeth A., Diagana, Thierry T., Greenbaum, Doron C.
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2012)
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UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes
Lim, Michelle Yi-Xiu, LaMonte, Gregory, Lee, Marcus C. S., Reimer, Christin, Tan, Bee Huat, Corey, Victoria, Tjahjadi, Bianca F., Chua, Adeline, Nachon, Marie, Wintjens, René, Gedeck, Peter, Malleret, Benoit, Renia, Laurent, Bonamy, Ghislain M. C., Ho, Paul Chi-Lui, Yeung, Bryan K. S., Chow, Eric D., Lim, Liting, Fidock, David A., Diagana, Thierry T., Winzeler, Elizabeth A., Bifani, Pablo
Published in Nature microbiology (19.09.2016)
Published in Nature microbiology (19.09.2016)
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Lead Optimization of Imidazopyrazines: A New Class of Antimalarial with Activity on Plasmodium Liver Stages
Zou, Bin, Nagle, Advait, Chatterjee, Arnab K, Leong, Seh Yong, Tan, Liying Jocelyn, Sim, Wei Lin Sandra, Mishra, Pranab, Guntapalli, Prasuna, Tully, David C, Lakshminarayana, Suresh B, Lim, Chek Shik, Tan, Yong Cheng, Abas, Siti Nurdiana, Bodenreider, Christophe, Kuhen, Kelli L, Gagaring, Kerstin, Borboa, Rachel, Chang, Jonathan, Li, Chun, Hollenbeck, Thomas, Tuntland, Tove, Zeeman, Anne-Marie, Kocken, Clemens H. M, McNamara, Case, Kato, Nobutaka, Winzeler, Elizabeth A, Yeung, Bryan K. S, Diagana, Thierry T, Smith, Paul W, Roland, Jason
Published in ACS medicinal chemistry letters (14.08.2014)
Published in ACS medicinal chemistry letters (14.08.2014)
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Mechanistic study of the spiroindolones: a new class of antimalarials
Zou, Bin, Yap, Peiling, Sonntag, Louis-Sebastian, Leong, Seh Yong, Yeung, Bryan K S, Keller, Thomas H
Published in Molecules (Basel, Switzerland) (24.08.2012)
Published in Molecules (Basel, Switzerland) (24.08.2012)
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Targeting Plasmodium PI(4)K to eliminate malaria
McNamara, Case W., Lee, Marcus C. S., Lim, Chek Shik, Lim, Siau Hoi, Roland, Jason, Nagle, Advait, Simon, Oliver, Yeung, Bryan K. S., Chatterjee, Arnab K., McCormack, Susan L., Manary, Micah J., Zeeman, Anne-Marie, Dechering, Koen J., Kumar, T. R. Santha, Henrich, Philipp P., Gagaring, Kerstin, Ibanez, Maureen, Kato, Nobutaka, Kuhen, Kelli L., Fischli, Christoph, Rottmann, Matthias, Plouffe, David M., Bursulaya, Badry, Meister, Stephan, Rameh, Lucia, Trappe, Joerg, Haasen, Dorothea, Timmerman, Martijn, Sauerwein, Robert W., Suwanarusk, Rossarin, Russell, Bruce, Renia, Laurent, Nosten, Francois, Tully, David C., Kocken, Clemens H. M., Glynne, Richard J., Bodenreider, Christophe, Fidock, David A., Diagana, Thierry T., Winzeler, Elizabeth A.
Published in Nature (London) (12.12.2013)
Published in Nature (London) (12.12.2013)
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Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N′6′-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate
Nzila, Alexis, Rottmann, Matthias, Chitnumsub, Penchit, Kiara, Stevens M, Kamchonwongpaisan, Sumalee, Maneeruttanarungroj, Cherdsak, Taweechai, Supannee, Yeung, Bryan K. S, Goh, Anne, Lakshminarayana, Suresh B, Zou, Bin, Wong, Josephine, Ma, Ngai Ling, Weaver, Margaret, Keller, Thomas H, Dartois, Veronique, Wittlin, Sergio, Brun, Reto, Yuthavong, Yongyuth, Diagana, Thierry T
Published in Antimicrobial Agents and Chemotherapy (01.06.2010)
Published in Antimicrobial Agents and Chemotherapy (01.06.2010)
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NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models
Moquin, Stephanie A, Simon, Oliver, Karuna, Ratna, Lakshminarayana, Suresh B, Yokokawa, Fumiaki, Wang, Feng, Saravanan, Chandra, Zhang, Jin, Day, Craig W, Chan, Katherine, Wang, Qing-Yin, Lu, Siyan, Dong, Hongping, Wan, Kah Fei, Lim, Siew Pheng, Liu, Wei, Seh, Cheah Chen, Chen, Yen-Liang, Xu, Haoying, Barkan, David T, Kounde, Cyrille S, Sim, Wei Lin Sandra, Wang, Gang, Yeo, Hui-Quan, Zou, Bin, Chan, Wai Ling, Ding, Mei, Song, Jae-Geun, Li, Min, Osborne, Colin, Blasco, Francesca, Sarko, Christopher, Beer, David, Bonamy, Ghislain M C, Sasseville, Vito G, Shi, Pei-Yong, Diagana, Thierry T, Yeung, Bryan K S, Gu, Feng
Published in Science translational medicine (03.02.2021)
Published in Science translational medicine (03.02.2021)
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Hepatic spheroids used as an in vitro model to study malaria relapse
Chua, Adeline C.Y., Ananthanarayanan, Abhishek, Ong, Jessica Jie Ying, Wong, Jen Yi, Yip, Andy, Singh, Nisha Hari, Qu, Yinghua, Dembele, Laurent, McMillian, Michael, Ubalee, Ratawan, Davidson, Silas, Tungtaeng, Anchalee, Imerbsin, Rawiwan, Gupta, Kapish, Andolina, Chiara, Lee, Fan, S-W Tan, Kevin, Nosten, François, Russell, Bruce, Lange, Amber, Diagana, Thierry T., Rénia, Laurent, Yeung, Bryan K.S., Yu, Hanry, Bifani, Pablo
Published in Biomaterials (01.09.2019)
Published in Biomaterials (01.09.2019)
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Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
Spillman, Natalie J., Allen, Richard J.W., McNamara, Case W., Yeung, Bryan K.S., Winzeler, Elizabeth A., Diagana, Thierry T., Kirk, Kiaran
Published in Cell host & microbe (13.02.2013)
Published in Cell host & microbe (13.02.2013)
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Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi
Kosaisavee, Varakorn, Suwanarusk, Rossarin, Chua, Adeline C.Y., Kyle, Dennis E., Malleret, Benoit, Zhang, Rou, Imwong, Mallika, Imerbsin, Rawiwan, Ubalee, Ratawan, Sámano-Sánchez, Hugo, Yeung, Bryan K.S., Ong, Jessica J.Y., Lombardini, Eric, Nosten, François, Tan, Kevin S.W., Bifani, Pablo, Snounou, Georges, Rénia, Laurent, Russell, Bruce
Published in Blood (14.09.2017)
Published in Blood (14.09.2017)
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Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit
Kounde, Cyrille S., Yeo, Hui-Quan, Wang, Qing-Yin, Wan, Kah Fei, Dong, Hongping, Karuna, Ratna, Dix, Ina, Wagner, Trixie, Zou, Bin, Simon, Oliver, Bonamy, Ghislain M.C., Yeung, Bryan K.S., Yokokawa, Fumiaki
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
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