Enzyme kinetics of cytochrome P450-mediated reactions
Shou, M, Lin, Y, Lu, P, Tang, C, Mei, Q, Cui, D, Tang, W, Ngui, J S, Lin, C C, Singh, R, Wong, B K, Yergey, J A, Lin, J H, Pearson, P G, Baillie, T A, Rodrigues, A D, Rushmore, T H
Published in Current drug metabolism (01.03.2001)
Published in Current drug metabolism (01.03.2001)
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Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding
Chauret, Nathalie, Guay, Daniel, Li, Chun, Day, Stephen, Silva, José, Blouin, Marc, Ducharme, Yves, Yergey, James A., Nicoll-Griffith, Deborah A.
Published in Bioorganic & medicinal chemistry letters (19.08.2002)
Published in Bioorganic & medicinal chemistry letters (19.08.2002)
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Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists
Layton, Mark E., Kelly, Michael J., Rodzinak, Kevin J., Sanderson, Philip E., Young, Steven D., Bednar, Rodney A., DiLella, Anthony G., Mcdonald, Terrence P., Wang, Hao, Mosser, Scott D., Fay, John F., Cunningham, Michael E., Reiss, Duane R., Fandozzi, Christine, Trainor, Nicole, Liang, Annie, Lis, Edward V., Seabrook, Guy R., Urban, Mark O., Yergey, James, Koblan, Kenneth S.
Published in ACS chemical neuroscience (20.07.2011)
Published in ACS chemical neuroscience (20.07.2011)
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Diversity in the Oxidation of Substrates by Cytochrome P450 2D6: Lack of an Obligatory Role of Aspartate 301−Substrate Electrostatic Bonding
Guengerich, F. Peter, Miller, Grover P, Hanna, Imad H, Martin, Martha V, Léger, Serge, Black, Cameron, Chauret, Nathalie, Silva, José M, Trimble, Laird A, Yergey, James A, Nicoll-Griffith, Deborah A
Published in Biochemistry (Easton) (10.09.2002)
Published in Biochemistry (Easton) (10.09.2002)
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In vitro and in vivo metabolism of A potent and selective integrin αvβ3 antagonist in rats, dogs, and monkeys
CUI, Donghui, SUBRAMANIAN, Raju, SHOU, Magang, YU, Xiao, WALLACE, Michael A, BRAUN, Matthew P, ARISON, Byron H, YERGEY, James A, PRUEKSARITANONT, Thomayant
Published in Drug metabolism and disposition (01.08.2004)
Published in Drug metabolism and disposition (01.08.2004)
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In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)
Chauret, Nathalie, Yergey, James A, Brideau, Christine, Friesen, Richard W, Mancini, Joseph, Riendeau, Denis, Silva, José, Styhler, Angela, Trimble, Laird A, Nicoll-Griffith, Deborah A
Published in Bioorganic & medicinal chemistry letters (23.04.2001)
Published in Bioorganic & medicinal chemistry letters (23.04.2001)
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Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx ™)
Nicoll-Griffith, Deborah A, Yergey, James A, Trimble, Laird A, Silva, José M, Li, Chun, Chauret, Nathalie, Gauthier, Jacques Yves, Grimm, Erich, Léger, Serge, Roy, Patrick, Thérien, Michel, Wang, Zhaoyin, Prasit, Peppi, Zamboni, Robert, Young, Robert N, Brideau, Christine, Chan, Chi-Chung, Mancini, Joseph, Riendeau, Denis
Published in Bioorganic & medicinal chemistry letters (04.12.2000)
Published in Bioorganic & medicinal chemistry letters (04.12.2000)
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Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability
Delorme, Daniel, Ducharme, Yves, Brideau, Christine, Chan, Chi-Chung, Chauret, Nathalie, Desmarais, Sylvie, Dubé, Daniel, Falgueyret, Jean-Pierre, Fortin, Réjean, Guay, Jocelyne, Hamel, Pierre, Jones, Tom R, Lépine, Carole, Li, Chun, McAuliffe, Malia, McFarlane, Cyril S, Nicoll-Griffith, Deborah A, Riendeau, Denis, Yergey, James A, Girard, Yves
Published in Journal of medicinal chemistry (27.09.1996)
Published in Journal of medicinal chemistry (27.09.1996)
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In Vitro Metabolism of the COX-2 Inhibitor DFU, Including a Novel Glutathione Adduct Rearomatization
Yergey, J A, Trimble, L A, Silva, J, Chauret, N, Li, C, Therien, M, Grimm, E, Nicoll-Griffith, D A
Published in Drug metabolism and disposition (01.05.2001)
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Published in Drug metabolism and disposition (01.05.2001)
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Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile
Leblanc, Yves, Roy, Patrick, Wang, Zhaoyin, Li, Chun Sing, Chauret, Nathalie, Nicoll-Griffith, Deborah A., Silva, José M., Aubin, Yves, Yergey, James A., Chan, Chi Chung, Riendeau, Denis, Brideau, Christine, Gordon, Robert, Xu, Lijing, Webb, Janine, Visco, Denise M., Prasit, Petpiboon
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
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Description of a 96-Well Plate Assay to Measure Cytochrome P4503A Inhibition in Human Liver Microsomes Using a Selective Fluorescent Probe
Chauret, Nathalie, Tremblay, Nathalie, Lackman, Rebecca L., Gauthier, Jacques-Yves, Silva, José M., Marois, Jean, Yergey, James A., Nicoll-Griffith, Deborah A.
Published in Analytical biochemistry (15.12.1999)
Published in Analytical biochemistry (15.12.1999)
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Application of Rat Hepatocyte Culture to Predict in Vivo Metabolic Auto-Induction: Studies with DFP, a Cyclooxygenase-2 Inhibitor
NICOLL-GRIFFITH, Deborah A, SILVA, Jose M, CHAURET, Nathalie, DAY, Stephen, LEBLANC, Yves, ROY, Patrick, YERGEY, James A, DIXIT, Rakesh, PATRICK, Darryl
Published in Drug metabolism and disposition (01.02.2001)
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Published in Drug metabolism and disposition (01.02.2001)
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Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status
Heyes, M P, Brew, B J, Martin, A, Price, R W, Salazar, A M, Sidtis, J J, Yergey, J A, Mouradian, M M, Sadler, A E, Keilp, J
Published in Annals of neurology (01.02.1991)
Published in Annals of neurology (01.02.1991)
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Refinement of an in Vitro Cell Model for Cytochrome P450 Induction
SILVA, J. M, MORIN, P. E, DAY, S. H, KENNEDY, B. P, PAYETTE, P, RUSHMORE, T, YERGEY, J. A, NICOLL-GRIFFITH, D. A
Published in Drug metabolism and disposition (01.05.1998)
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Published in Drug metabolism and disposition (01.05.1998)
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Characterization of the in vitro oxidative metabolites of the COX-2 selective inhibitor L-766,112
Trimble, Laird A, Chauret, Nathalie, Silva, JoséM, Nicoll-Griffith, Deborah A, Li, Chun-Sing, Yergey, James A
Published in Bioorganic & medicinal chemistry letters (07.01.1997)
Published in Bioorganic & medicinal chemistry letters (07.01.1997)
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BIOACTIVATION OF THE 3-AMINO-6-CHLOROPYRAZINONE RING IN A THROMBIN INHIBITOR LEADS TO NOVEL DIHYDRO-IMIDAZOLE AND IMIDAZOLIDINE DERIVATIVES: STRUCTURES AND MECHANISM USING 13C-LABELS, MASS SPECTROMETRY, AND NMR
SUBRAMANIAN, Raju, LIN, Charles C, HO, Jonathan Z, PITZENBERGER, Steven M, SILVA-ELIPE, Maria V, GIBSON, Christopher R, BRAUN, Matthew P, XIAO YU, YERGEY, James L, SINGH, Rominder
Published in Drug metabolism and disposition (01.11.2003)
Published in Drug metabolism and disposition (01.11.2003)
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Investigation of the in Vitro Metabolism Profile of a Phosphodiesterase-IV Inhibitor, CDP-840: Leading to Structural Optimization
Li, C, Chauret, N, Trimble, L A, Nicoll-Griffith, D A, Silva, J M, MacDonald, D, Perrier, H, Yergey, J A, Parton, T, Alexander, R P, Warrellow, G J
Published in Drug metabolism and disposition (01.03.2001)
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Published in Drug metabolism and disposition (01.03.2001)
Journal Article
Isotopic distributions in mass spectra of large molecules
Yergey, James, Heller, David, Hansen, Gordon, Cotter, Robert J, Fenselau, Catherine
Published in Analytical chemistry (Washington) (01.02.1983)
Published in Analytical chemistry (Washington) (01.02.1983)
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Integrated Application of Capillary HPLC/Continuous-Flow Liquid Secondary Ion Mass Spectrometry to Discovery Stage Metabolism Studies
Li, Chun, Chauret, Nathalie, Ducharme, Yves, Trimble, Laird A, Nicoll-Griffith, Deborah A, Yergey, James A
Published in Analytical chemistry (Washington) (01.09.1995)
Published in Analytical chemistry (Washington) (01.09.1995)
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