The GAGOme: a cell-based library of displayed glycosaminoglycans
Chen, Yen-Hsi, Narimatsu, Yoshiki, Clausen, Thomas M., Gomes, Catarina, Karlsson, Richard, Steentoft, Catharina, Spliid, Charlotte B., Gustavsson, Tobias, Salanti, Ali, Persson, Andrea, Malmström, Anders, Willén, Daniel, Ellervik, Ulf, Bennett, Eric P., Mao, Yang, Clausen, Henrik, Yang, Zhang
Published in Nature methods (01.11.2018)
Published in Nature methods (01.11.2018)
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Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations
Tree, Julia A., Turnbull, Jeremy E., Buttigieg, Karen R., Elmore, Michael J., Coombes, Naomi, Hogwood, John, Mycroft‐West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen‐Hsi, Yang, Zhang, Spalluto, Cosma Mirella, Staples, Karl J., Yates, Edwin A., Gray, Elaine, Singh, Dave, Wilkinson, Tom, Page, Clive P., Carroll, Miles W.
Published in British Journal of Pharmacology (01.02.2021)
Published in British Journal of Pharmacology (01.02.2021)
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An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells
Narimatsu, Yoshiki, Joshi, Hiren J., Nason, Rebecca, Van Coillie, Julie, Karlsson, Richard, Sun, Lingbo, Ye, Zilu, Chen, Yen-Hsi, Schjoldager, Katrine T., Steentoft, Catharina, Furukawa, Sanae, Bensing, Barbara A., Sullam, Paul M., Thompson, Andrew J., Paulson, James C., Büll, Christian, Adema, Gosse J., Mandel, Ulla, Hansen, Lars, Bennett, Eric Paul, Varki, Ajit, Vakhrushev, Sergey Y., Yang, Zhang, Clausen, Henrik
Published in Molecular cell (25.07.2019)
Published in Molecular cell (25.07.2019)
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The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Tian, Weihua, Ye, Zilu, Wang, Shengjun, Schulz, Morten Alder, Van Coillie, Julie, Sun, Lingbo, Chen, Yen-Hsi, Narimatsu, Yoshiki, Hansen, Lars, Kristensen, Claus, Mandel, Ulla, Bennett, Eric Paul, Jabbarzadeh-Tabrizi, Siamak, Schiffmann, Raphael, Shen, Jin-Song, Vakhrushev, Sergey Y., Clausen, Henrik, Yang, Zhang
Published in Nature communications (30.04.2019)
Published in Nature communications (30.04.2019)
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A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome
Narimatsu, Yoshiki, Joshi, Hiren J, Yang, Zhang, Gomes, Catarina, Chen, Yen-Hsi, Lorenzetti, Flaminia C, Furukawa, Sanae, Schjoldager, Katrine T, Hansen, Lars, Clausen, Henrik, Bennett, Eric P, Wandall, Hans H
Published in Glycobiology (Oxford) (01.05.2018)
Published in Glycobiology (Oxford) (01.05.2018)
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Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection
Bagdonaite, Ieva, Marinova, Irina N., Rudjord-Levann, Asha M., Pallesen, Emil M. H., King-Smith, Sarah L., Karlsson, Richard, Rømer, Troels B., Chen, Yen-Hsi, Miller, Rebecca L., Olofsson, Sigvard, Nordén, Rickard, Bergström, Tomas, Dabelsteen, Sally, Wandall, Hans H.
Published in Nature communications (02.11.2023)
Published in Nature communications (02.11.2023)
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The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus
Jørgensen, Astrid Sissel, Brandum, Emma Probst, Mikkelsen, Jeppe Malthe, Orfin, Klaudia A., Boilesen, Ditte Rahbæk, Egerod, Kristoffer Lihme, Moussouras, Natasha A., Vilhardt, Frederik, Kalinski, Pawel, Basse, Per, Chen, Yen-Hsi, Yang, Zhang, Dwinell, Michael B., Volkman, Brian F., Veldkamp, Christopher T., Holst, Peter Johannes, Lahl, Katharina, Goth, Christoffer Knak, Rosenkilde, Mette Marie, Hjortø, Gertrud Malene
Published in Cellular and molecular life sciences : CMLS (01.11.2021)
Published in Cellular and molecular life sciences : CMLS (01.11.2021)
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The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models
Davies, Scott P, Mycroft-West, Courtney J, Pagani, Isabel, Hill, Harriet J, Chen, Yen-Hsi, Karlsson, Richard, Bagdonaite, Ieva, Guimond, Scott E, Stamataki, Zania, De Lima, Marcelo Andrade, Turnbull, Jeremy E, Yang, Zhang, Vicenzi, Elisa, Skidmore, Mark A, Khanim, Farhat L, Richardson, Alan
Published in Frontiers in pharmacology (06.08.2021)
Published in Frontiers in pharmacology (06.08.2021)
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Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain
Schuurs, Zachariah P., Hammond, Edward, Elli, Stefano, Rudd, Timothy R., Mycroft-West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Ahmed, Yassir A., Richard, Derek J., Turnbull, Jeremy, Ferro, Vito, Coombe, Deirdre R., Gandhi, Neha S.
Published in Computational and structural biotechnology journal (01.01.2021)
Published in Computational and structural biotechnology journal (01.01.2021)
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Observation of morphology and compositional changes of magnesium alloy using liquid cell TEM
Yang, Chia-Ming, Chen, Yen-Hsi, Tsai, Meng-Hsiu, Hsu, Ben Bang-Yu, Tsai, Wen-Ta, Lin, Chiu-Feng, Tseng, Chun-Chieh, Chen, In-Gann
Published in Journal of materials research and technology (01.11.2022)
Published in Journal of materials research and technology (01.11.2022)
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A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution
Chen, Yen-Hsi, Tian, Weihua, Yasuda, Makiko, Ye, Zilu, Song, Ming, Mandel, Ulla, Kristensen, Claus, Povolo, Lorenzo, Marques, André R A, Čaval, Tomislav, Heck, Albert J R, Sampaio, Julio Lopes, Johannes, Ludger, Tsukimura, Takahiro, Desnick, Robert, Vakhrushev, Sergey Y, Yang, Zhang, Clausen, Henrik
Published in Frontiers in bioengineering and biotechnology (24.02.2023)
Published in Frontiers in bioengineering and biotechnology (24.02.2023)
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Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells
Chung, Shin-Yi, Chen, Yen-Hsi, Lin, Pei-Rong, Chao, Ta-Chung, Su, Jung-Chen, Shiau, Chung-Wai, Su, Yeu
Published in Cell death discovery (13.08.2018)
Published in Cell death discovery (13.08.2018)
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Genetic glycoengineering in mammalian cells
Narimatsu, Yoshiki, Büll, Christian, Chen, Yen-Hsi, Wandall, Hans H., Yang, Zhang, Clausen, Henrik
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Glycoengineering design options for IgG1 in CHO cells using precise gene editing
Schulz, Morten A, Tian, Weihua, Mao, Yang, Van Coillie, Julie, Sun, Lingbo, Larsen, Joachim S, Chen, Yen-Hsi, Kristensen, Claus, Vakhrushev, Sergey Y, Clausen, Henrik, Yang, Zhang
Published in Glycobiology (Oxford) (01.07.2018)
Published in Glycobiology (Oxford) (01.07.2018)
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Mammalian cell-based production of glycans, glycopeptides and glycomodules
Jaroentomeechai, Thapakorn, Karlsson, Richard, Goerdeler, Felix, Teoh, Fallen Kai Yik, Grønset, Magnus Nørregaard, de Wit, Dylan, Chen, Yen-Hsi, Furukawa, Sanae, Psomiadou, Venetia, Hurtado-Guerrero, Ramon, Vidal-Calvo, Elena Ethel, Salanti, Ali, Boltje, Thomas J., van den Bos, Leendert J., Wunder, Christian, Johannes, Ludger, Schjoldager, Katrine T., Joshi, Hiren J., Miller, Rebecca L., Clausen, Henrik, Vakhrushev, Sergey Y., Narimatsu, Yoshiki
Published in Nature communications (08.11.2024)
Published in Nature communications (08.11.2024)
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Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate
Vidal-Calvo, Elena Ethel, Martin-Salazar, Anne, Choudhary, Swati, Dagil, Robert, Raghavan, Sai Sundar Rajan, Duvnjak, Lara, Nordmaj, Mie Anemone, Clausen, Thomas Mandel, Skafte, Ann, Oberkofler, Jan, Wang, Kaituo, Agerbæk, Mette Ø, Løppke, Caroline, Jørgensen, Amalie Mundt, Ropac, Daria, Mujollari, Joana, Willis, Shona, Garcias López, Agnès, Miller, Rebecca Louise, Karlsson, Richard Torbjörn Gustav, Goerdeler, Felix, Chen, Yen-Hsi, Colaço, Ana R., Wang, Yong, Lavstsen, Thomas, Martowicz, Agnieszka, Nelepcu, Irina, Marzban, Mona, Oo, Htoo Zarni, Ørum-Madsen, Maj Sofie, Wang, Yuzhuo, Nielsen, Morten A., Clausen, Henrik, Wierer, Michael, Wolf, Dominik, Gögenur, Ismail, Theander, Thor G., Al-Nakouzi, Nader, Gustavsson, Tobias, Daugaard, Mads, Salanti, Ali
Published in Nature communications (30.08.2024)
Published in Nature communications (30.08.2024)
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Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates
Karlsson, Richard, Chopra, Pradeep, Joshi, Apoorva, Yang, Zhang, Vakhrushev, Sergey Y, Clausen, Thomas Mandel, Painter, Chelsea D, Szekeres, Gergo P, Chen, Yen-Hsi, Sandoval, Daniel R, Hansen, Lars, Esko, Jeffrey D, Pagel, Kevin, Dyer, Douglas P, Turnbull, Jeremy E, Clausen, Henrik, Boons, Geert-Jan, Miller, Rebecca L
Published in Science advances (24.12.2021)
Published in Science advances (24.12.2021)
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A novel chemosensitivity profiling platform for small acute lymphoblastic leukemia cell populations
Groth-Pedersen, Line, Chen, Yen-Hsi, Faber, Marianne, Valentin, Rebecca, Albertsen, Birgitte Klug, Wehner, Peder Skov, Rosthøj, Steen, Frandsen, Thomas Leth, Marquart, Hanne Vibeke, Schmiegelow, Kjeld
Published in Leukemia & lymphoma (01.07.2015)
Published in Leukemia & lymphoma (01.07.2015)
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Xylosyltransferase Bump-and-hole Engineering to Chemically Manipulate Proteoglycans in Mammalian Cells
Li, Zhen, Di Vagno, Lucia, Chawla, Himanshi, Ni Cheallaigh, Aisling, Critcher, Meg, Sammon, Douglas, Briggs, David C, Chung, Nara, Chang, Vincent, Mahoney, Keira E, Cioce, Anna, Murphy, Lloyd D, Chen, Yen-Hsi, Narimatsu, Yoshiki, Miller, Rebecca L, Willems, Lianne I, Malaker, Stacy A, Huang, Mia L, Miller, Gavin J, Hohenester, Erhard, Schumann, Benjamin
Published in bioRxiv (27.06.2024)
Published in bioRxiv (27.06.2024)
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