Total Synthesis of the Marine Alkaloid Halichlorine: Development and Use of a General Route to Chiral Piperidines
Liu, Dazhan, Acharya, Hukum P, Yu, Maolin, Wang, Jian, Yeh, Vince S. C, Kang, Shunzhen, Chiruta, Chandramouli, Jachak, Santosh M, Clive, Derrick L. J
Published in Journal of organic chemistry (02.10.2009)
Published in Journal of organic chemistry (02.10.2009)
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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease
Khare, Shilpi, Roach, Steven L, Barnes, S Whitney, Hoepfner, Dominic, Walker, John R, Chatterjee, Arnab K, Neitz, R Jeffrey, Arkin, Michelle R, McNamara, Case W, Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H, Glynne, Richard J, Supek, Frantisek
Published in PLoS pathogens (01.07.2015)
Published in PLoS pathogens (01.07.2015)
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Synthetic Chemistry of Halichlorine and the Pinnaic Acids
Clive, Derrick L. J, Yu, Maolin, Wang, Jian, Yeh, Vince S. C, Kang, Shunzhen
Published in Chemical reviews (01.12.2005)
Published in Chemical reviews (01.12.2005)
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Liver X receptor modulators: a review of recently patented compounds (2007 - 2009)
Li, Xiaolin, Yeh, Vince, Molteni, Valentina
Published in Expert opinion on therapeutic patents (01.04.2010)
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Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements
Yeh, Vince S.C., Kurukulasuriya, Ravi, Madar, David, Patel, Jyoti R., Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Jacobson, Peer, Sham, Hing L., Link, J.T.
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Identification and Preliminary Characterization of a Potent, Safe, and Orally Efficacious Inhibitor of Acyl-CoA:Diacylglycerol Acyltransferase 1
Yeh, Vince S. C, Beno, David W. A, Brodjian, Sevan, Brune, Michael E, Cullen, Steven C, Dayton, Brian D, Dhaon, Madhup K, Falls, Hugh D, Gao, Ju, Grihalde, Nelson, Hajduk, Philip, Hansen, T. Matthew, Judd, Andrew S, King, Andrew J, Klix, Russel C, Larson, Kelly J, Lau, Yau Y, Marsh, Kennan C, Mittelstadt, Scott W, Plata, Dan, Rozema, Michael J, Segreti, Jason A, Stoner, Eric J, Voorbach, Martin J, Wang, Xiaojun, Xin, Xili, Zhao, Gang, Collins, Christine A, Cox, Bryan F, Reilly, Regina M, Kym, Philip R, Souers, Andrew J
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
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Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors
Yeh, Vince S.C., Patel, Jyoti R., Yong, Hong, Kurukulasuriya, Ravi, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Stolarik, Deanne, Imade, Hovis, Beno, David, Brune, Michael, Jacobson, Peer, Sham, Hing, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Discovery of orally active butyrolactam 11β-HSD1 inhibitors
Yeh, Vince S.C., Kurukulasuriya, Ravi, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Stolarik, Deanne, Imade, Hovis, Shapiro, Robin, Knourek-Segel, Victoria, Bush, Eugene, Wilcox, Denise, Nguyen, Phong T., Brune, Michael, Jacobson, Peer, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
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A Highly Efficient Synthesis of Potent and Selective Butyrolactam Inhibitors of 11β-Hsd1
Yeh, Vince S. C, Kurukulasuriya, Ravi, Kerdesky, Francis A
Published in Organic letters (31.08.2006)
Published in Organic letters (31.08.2006)
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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Khare, Shilpi, Nagle, Advait S., Biggart, Agnes, Lai, Yin H., Liang, Fang, Davis, Lauren C., Barnes, S. Whitney, Mathison, Casey J. N., Myburgh, Elmarie, Gao, Mu-Yun, Gillespie, J. Robert, Liu, Xianzhong, Tan, Jocelyn L., Stinson, Monique, Rivera, Ianne C., Ballard, Jaime, Yeh, Vince, Groessl, Todd, Federe, Glenn, Koh, Hazel X. Y., Venable, John D., Bursulaya, Badry, Shapiro, Michael, Mishra, Pranab K., Spraggon, Glen, Brock, Ansgar, Mottram, Jeremy C., Buckner, Frederick S., Rao, Srinivasa P. S., Wen, Ben G., Walker, John R., Tuntland, Tove, Molteni, Valentina, Glynne, Richard J., Supek, Frantisek
Published in Nature (London) (08.09.2016)
Published in Nature (London) (08.09.2016)
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Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease
Khare, Shilpi, Liu, Xianzhong, Stinson, Monique, Rivera, Ianne, Groessl, Todd, Tuntland, Tove, Yeh, Vince, Wen, Ben, Molteni, Valentina, Glynne, Richard, Supek, Frantisek
Published in Antimicrobial agents and chemotherapy (01.10.2015)
Published in Antimicrobial agents and chemotherapy (01.10.2015)
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Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases
Nagle, Advait, Biggart, Agnes, Be, Celine, Srinivas, Honnappa, Hein, Andreas, Caridha, Diana, Sciotti, Richard J, Pybus, Brandon, Kreishman-Deitrick, Mara, Bursulaya, Badry, Lai, Yin H, Gao, Mu-Yun, Liang, Fang, Mathison, Casey J. N, Liu, Xiaodong, Yeh, Vince, Smith, Jeffrey, Lerario, Isabelle, Xie, Yongping, Chianelli, Donatella, Gibney, Michael, Berman, Ashley, Chen, Yen-Liang, Jiricek, Jan, Davis, Lauren C, Liu, Xianzhong, Ballard, Jaime, Khare, Shilpi, Eggimann, Fabian Kurt, Luneau, Alexandre, Groessl, Todd, Shapiro, Michael, Richmond, Wendy, Johnson, Kevin, Rudewicz, Patrick J, Rao, Srinivasa P. S, Thompson, Christopher, Tuntland, Tove, Spraggon, Glen, Glynne, Richard J, Supek, Frantisek, Wiesmann, Christian, Molteni, Valentina
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Optimization of Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for Duration of Action, as an Inhaled Therapy for Lung Remodeling in Pulmonary Arterial Hypertension
Shaw, Duncan E, Baig, Ferheen, Bruce, Ian, Chamoin, Sylvie, Collingwood, Stephen P, Cross, Sarah, Dayal, Satish, Drückes, Peter, Furet, Pascal, Furminger, Vikki, Haggart, Deborah, Hussey, Martin, Konstantinova, Irena, Loren, Jon C, Molteni, Valentina, Roberts, Sonia, Reilly, John, Saunders, Alex M, Stringer, Rowan, Sviridenko, Lilya, Thomas, Matthew, Thomson, Christopher G, Tomlins, Christine, Wen, Ben, Yeh, Vince, Pearce, Andrew C
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Lead identification to clinical candidate selection: drugs for Chagas disease
Neitz, R Jeffrey, Chen, Steven, Supek, Frantisek, Yeh, Vince, Kellar, Danielle, Gut, Jiri, Bryant, Clifford, Gallardo-Godoy, Alejandra, Molteni, Valentina, Roach, Steven L, Khare, Shilpi, Stinson, Monique, Chatterjee, Arnab K, Robertson, Stephanie, Renslo, Adam R, Arkin, Michelle, Glynne, Richard, McKerrow, James, Siqueira-Neto, Jair L
Published in Journal of biomolecular screening (01.01.2015)
Published in Journal of biomolecular screening (01.01.2015)
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