The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA
Vukojicic, Aleksandra, Delestrée, Nicolas, Fletcher, Emily V., Pagiazitis, John G., Sankaranarayanan, Sethu, Yednock, Ted A., Barres, Ben A., Mentis, George Z.
Published in Cell reports (Cambridge) (03.12.2019)
Published in Cell reports (Cambridge) (03.12.2019)
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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease
Tóth, Gergely, Gardai, Shyra J, Zago, Wagner, Bertoncini, Carlos W, Cremades, Nunilo, Roy, Susan L, Tambe, Mitali A, Rochet, Jean-Christophe, Galvagnion, Celine, Skibinski, Gaia, Finkbeiner, Steven, Bova, Michael, Regnstrom, Karin, Chiou, San-San, Johnston, Jennifer, Callaway, Kari, Anderson, John P, Jobling, Michael F, Buell, Alexander K, Yednock, Ted A, Knowles, Tuomas P J, Vendruscolo, Michele, Christodoulou, John, Dobson, Christopher M, Schenk, Dale, McConlogue, Lisa
Published in PloS one (14.02.2014)
Published in PloS one (14.02.2014)
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Anti-JC virus antibodies: Implications for PML Risk Stratification
Gorelik, Leonid, Lerner, Michaela, Bixler, Sarah, Crossman, Mary, Schlain, Brian, Simon, Kenneth, Pace, Amy, Cheung, Anne, Chen, Ling Ling, Berman, Melissa, Zein, Fairuz, Wilson, Ewa, Yednock, Ted, Sandrock, Alfred, Goelz, Susan E., Subramanyam, Meena
Published in Annals of neurology (01.09.2010)
Published in Annals of neurology (01.09.2010)
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Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration
Jiao, Haihan, Rutar, Matt, Fernando, Nilisha, Yednock, Ted, Sankaranarayanan, Sethu, Aggio-Bruce, Riemke, Provis, Jan, Natoli, Riccardo
Published in Molecular neurodegeneration (20.08.2018)
Published in Molecular neurodegeneration (20.08.2018)
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Targeting the Intrinsically Disordered Structural Ensemble of [alpha]-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease
Tóth, Gergely, Gardai, Shyra J, Zago, Wagner, Bertoncini, Carlos W, Cremades, Nunilo, Roy, Susan L, Tambe, Mitali A, Rochet, Jean-Christophe, Galvagnion, Celine, Skibinski, Gaia, Finkbeiner, Steven, Bova, Michael, Regnstrom, Karin, Chiou, San-San, Johnston, Jennifer, Callaway, Kari, Anderson, John P, Jobling, Michael F, Buell, Alexander K, Yednock, Ted A, Knowles, Tuomas P. J, Vendruscolo, Michele, Christodoulou, John, Dobson, Christopher M, Schenk, Dale, McConlogue, Lisa
Published in PloS one (14.02.2014)
Published in PloS one (14.02.2014)
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Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms
Riley, Brigit E, Gardai, Shyra J, Emig-Agius, Dorothea, Bessarabova, Marina, Ivliev, Alexander E, Schüle, Birgitt, Schüle, Birgit, Alexander, Jeff, Wallace, William, Halliday, Glenda M, Langston, J William, Braxton, Scott, Yednock, Ted, Shaler, Thomas, Johnston, Jennifer A
Published in PloS one (29.08.2014)
Published in PloS one (29.08.2014)
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C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy
McGonigal, Rhona, Cunningham, Madeleine E, Yao, Denggao, Barrie, Jennifer A, Sankaranarayanan, Sethu, Fewou, Simon N, Furukawa, Koichi, Yednock, Ted A, Willison, Hugh J
Published in Acta neuropathologica communications (02.03.2016)
Published in Acta neuropathologica communications (02.03.2016)
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Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS
Flanagan, Ken, Fitzgerald, Kent, Baker, Jeanne, Regnstrom, Karin, Gardai, Shyra, Bard, Frederique, Mocci, Simonetta, Seto, Pui, You, Monica, Larochelle, Catherine, Prat, Alexandre, Chow, Samuel, Li, Lauri, Vandevert, Chris, Zago, Wagner, Lorenzana, Carlos, Nishioka, Christopher, Hoffman, Jennifer, Botelho, Raquel, Willits, Christopher, Tanaka, Kevin, Johnston, Jennifer, Yednock, Ted
Published in PloS one (06.07.2012)
Published in PloS one (06.07.2012)
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Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease
Gardai, Shyra J, Mao, Wenxian, Schüle, Birgitt, Babcock, Michael, Schoebel, Sue, Lorenzana, Carlos, Alexander, Jeff, Kim, Sam, Glick, Heather, Hilton, Kathryn, Fitzgerald, J Kent, Buttini, Manuel, Chiou, San-San, McConlogue, Lisa, Anderson, John P, Schenk, Dale B, Bard, Frederique, Langston, J William, Yednock, Ted, Johnston, Jennifer A
Published in PloS one (23.08.2013)
Published in PloS one (23.08.2013)
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Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye Disease
Sun, Yang, Wirta, David, Murahashi, Wendy, Mathur, Vidhu, Sankaranarayanan, Sethu, Taylor, Lori K., Yednock, Ted, Fong, Donald S., Goldberg, Jeffrey L.
Published in Ophthalmology science (Online) (01.06.2023)
Published in Ophthalmology science (Online) (01.06.2023)
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Novel approaches to treating inflammatory bowel disease: targeting alpha-4 integrin
Sandborn, William J, Yednock, Ted A
Published in The American journal of gastroenterology (01.11.2003)
Published in The American journal of gastroenterology (01.11.2003)
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Epitope and Isotype Specificities of Antibodies to β-Amyloid Peptide for Protection against Alzheimer's Disease-like Neuropathology
Bard, Frédérique, Barbour, Robin, Cannon, Catherine, Carretto, Robert, Fox, Michael, Games, Dora, Guido, Teresa, Hoenow, Kathleen, Hu, Kang, Johnson-Wood, Kelly, Khan, Karen, Kholodenko, Dora, Lee, Celeste, Lee, Mike, Motter, Ruth, Nguyen, Minh, Reed, Amanda, Schenk, Dale, Tang, Pearl, Vasquez, Nicki, Seubert, Peter, Yednock, Ted
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2003)
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Anti-Mcam Monoclonal Antibody PRX003 Inhibits the Unique Migratory Potential of Pathogenic IL-17–Producing T Cells
Flanagan, Kenneth, Tam, Stephen J, Li, Lauri, Dolan, Philip J, Barbour, Robin M, Higaki, Jeffrey N, Liu, Yue, Nijjar, Tarlochan, Skov, Michael, Zago, Wagner, Yednock, Ted A, Kinney, Gene F, Ness, Dan
Published in Journal of allergy and clinical immunology (01.02.2016)
Published in Journal of allergy and clinical immunology (01.02.2016)
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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Prime side chromane-containing inhibitors
Ng, Raymond A., Sun, Minghua, Bowers, Simeon, Hom, Roy K., Probst, Gary D., John, Varghese, Fang, Lawrence Y., Maillard, Michel, Gailunas, Andrea, Brogley, Louis, Neitz, R. Jeffrey, Tung, Jay S., Pleiss, Michael A., Konradi, Andrei W., Sham, Hing L., Dappen, Michael S., Adler, Marc, Yao, Nanhua, Zmolek, Wes, Nakamura, David, Quinn, Kevin P., Sauer, John-Michael, Bova, Michael P., Ruslim, Lany, Artis, Dean R., Yednock, Ted A.
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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Discovery of (R)‑4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro‑1H‑pyrazolo[4,3‑c]quinoline (ELND006) and (R)‑4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro‑2H‑pyrazolo[4,3‑c]quinoline (ELND007): Metabolically Stable γ‑Secretase Inhibitors that Selectively Inhibit the Production of Amyloid‑β over Notch
Probst, Gary, Aubele, Danielle L, Bowers, Simeon, Dressen, Darren, Garofalo, Albert W, Hom, Roy K, Konradi, Andrei W, Marugg, Jennifer L, Mattson, Matthew N, Neitzel, Martin L, Semko, Chris M, Sham, Hing L, Smith, Jenifer, Sun, Minghua, Truong, Anh P, Ye, Xiaocong M, Xu, Ying-zi, Dappen, Michael S, Jagodzinski, Jacek J, Keim, Pamela S, Peterson, Brian, Latimer, Lee H, Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K, Quinn, Kevin P, Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F, Kholodenko, Dora, Hu, Kang, Kwong, Grace T, Lee, Michael, Liao, Anna, Motter, Ruth N, Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P, Hemphill, Susanna S, Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A, Basi, Guriqbal S
Published in Journal of medicinal chemistry (11.07.2013)
Published in Journal of medicinal chemistry (11.07.2013)
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Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri ®) with endogenous IgG4
Shapiro, Renée I., Plavina, Tatiana, Schlain, Brian R., Pepinsky, R. Blake, Garber, Ellen A., Jarpe, Matthew, Hochman, Paula S., Wehner, Nancy G., Bard, Frederique, Motter, Ruth, Yednock, Ted A., Taylor, Frederick R.
Published in Journal of pharmaceutical and biomedical analysis (28.04.2011)
Published in Journal of pharmaceutical and biomedical analysis (28.04.2011)
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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor
Bowers, Simeon, Truong, Anh P., Neitz, R. Jeffrey, Neitzel, Martin, Probst, Gary D., Hom, Roy K., Peterson, Brian, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergley, Pan, Hu, Yao, Nanhua, Artis, Dean R., Brigham, Elizabeth F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
Bowers, Simeon, Truong, Anh P., Jeffrey Neitz, R., Hom, Roy K., Sealy, Jennifer M., Probst, Gary D., Quincy, David, Peterson, Brian, Chan, Wayman, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergely, Pan, Hu, Lin, May, Yao, Nanhua, Artis, Dean R., Zhang, Heather, Chen, Linda, Dryer, Mark, Samant, Bhushan, Zmolek, Wes, Wong, Karina, Lorentzen, Colin, Goldbach, Erich, Tonn, George, Quinn, Kevin P., Sauer, John-Michael, Wright, Sarah, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration
Probst, Gary D., Bowers, Simeon, Sealy, Jennifer M., Truong, Anh P., Hom, Roy K., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Quincy, David A., Pan, Hu, Yao, Nanhua, Lin, May, Tóth, Gergley, Artis, Dean R., Zmolek, Wes, Wong, Karina, Qin, Ann, Lorentzen, Colin, Nakamura, David F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Wright, Sarah, Chereau, David, Ren, Zhao, Anderson, John P., Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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