Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)
Qiao, Jennifer X, Wang, Tammy C, Adam, Leonard P, Chen, Alice Ye A, Taylor, David S, Yang, Richard Z, Zhuang, Shaobin, Sleph, Paul G, Li, Julia P, Li, Danshi, Yin, Xiaohong, Chang, Ming, Chen, Xue-Qing, Shen, Hong, Li, Jianqing, Smith, Daniel, Wu, Dauh-Rurng, Leith, Leslie, Harikrishnan, Lalgudi S, Kamau, Muthoni G, Miller, Michael M, Bilder, Donna, Rampulla, Richard, Li, Yi-Xin, Xu, Carrie, Lawrence, R. Michael, Poss, Michael A, Levesque, Paul, Gordon, David A, Huang, Christine S, Finlay, Heather J, Wexler, Ruth R, Salvati, Mark E
Published in Journal of medicinal chemistry (25.11.2015)
Published in Journal of medicinal chemistry (25.11.2015)
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Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase
Kim, Soong-Hoon, Johnson, James A., Jiang, Ji, Parkhurst, Brandon, Phillips, Monique, Pi, Zulan, Qiao, Jennifer X., Tora, George, Ye Chen, Alice, Liu, Eddie, Yin, Xiaohong, Yang, Richard, Zhao, Lei, Taylor, David S., Basso, Michael, Behnia, Kamelia, Onorato, Joelle, Chen, Xue-Qing, Abell, Lynn M., Lu, Hao, Locke, Gregory, Caporuscio, Christian, Adam, Leonard P., Gordon, David, Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
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Discovery of hydroxyl 1,2-diphenylethanamine analogs as potent cholesterol ester transfer protein inhibitors
Jiang, Ji, Finlay, Heather, Johnson, James A., Harikrishnan, Lalgudi, Kamau, Muthoni, Qiao, Jennifer, Wang, Tammy, Adam, Leonard, Taylor, David, Yang, Richard, Sleph, Paul, Chen, Alice Ye A., Yin, Xiaohong, Wexler, Ruth, Salvati, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.07.2016)
Published in Bioorganic & medicinal chemistry letters (15.07.2016)
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PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor
Hangeland, Jon J., Abell, Lynn M., Adam, Leonard P., Jiang, Ji, Friends, Todd J., Haque, Lauren E., Neels, James, Onorato, Joelle M., Chen, Alice Ye A., Taylor, David S., Yin, Xiaohong, Harrity, Thomas W., Basso, Michael D., Yang, Richard, Sleph, Paul G., Gordon, David A., Huang, Christine S., Wexler, Ruth R., Finlay, Heather J., Lawrence, R. Michael
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor
Finlay, Heather J, Jiang, Ji, Rampulla, Richard, Salvati, Mark E, Qiao, Jennifer X, Wang, Tammy C, Lawrence, R. Michael, Harikrishnan, Lalgudi S, Kamau, Muthoni G, Taylor, David S, Chen, Alice Ye A, Yin, Xiaohong, Huang, Christine S, Chang, Ming, Chen, Xue-Qing, Sleph, Paul G, Xu, Carrie, Li, Julia, Levesque, Paul, Adam, Leonard P, Wexler, Ruth R
Published in ACS medicinal chemistry letters (13.06.2019)
Published in ACS medicinal chemistry letters (13.06.2019)
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Diphenylpyridylethanamine (DPPE) Derivatives as Cholesteryl Ester Transfer Protein (CETP) Inhibitors
Harikrishnan, Lalgudi S, Finlay, Heather J, Qiao, Jennifer X, Kamau, Muthoni G, Jiang, Ji, Wang, Tammy C, Li, James, Cooper, Christopher B, Poss, Michael A, Adam, Leonard P, Taylor, David S, Chen, Alice Ye A, Yin, Xiaohong, Sleph, Paul G, Yang, Richard Z, Sitkoff, Doree F, Galella, Michael A, Nirschl, David S, Van Kirk, Katy, Miller, Arthur V, Huang, Christine S, Chang, Ming, Chen, Xue-Qing, Salvati, Mark E, Wexler, Ruth R, Lawrence, R. Michael
Published in Journal of medicinal chemistry (12.07.2012)
Published in Journal of medicinal chemistry (12.07.2012)
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Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors
Miller, Michael M., Liu, Yalei, Jiang, Ji, Johnson, James A., Kamau, Muthoni, Nirschl, David S., Wang, Yufeng, Harikrishnan, Lalgudi, Taylor, David S., Chen, Alice Ye A., Yin, Xiaohong, Seethala, Ramakrishna, Peterson, Tara L., Zvyaga, Tatyana, Zhang, Jun, Huang, Christine S., Wexler, Ruth R., Poss, Michael A., Michael Lawrence, R., Adam, Leonard P., Salvati, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.10.2012)
Published in Bioorganic & medicinal chemistry letters (15.10.2012)
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Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors
Wang, Yufeng, Yang, Wu, Finlay, Heather J., Harikrishnan, Lalgudi S., Jiang, Ji, Kamau, Muthoni G., Van Kirk, Katy, Nirschl, David S., Taylor, David S., Chen, Alice Ye A., Yin, Xiaohong, Sleph, Paul G., Yang, Richard Z., Huang, Christine S., Adam, Leonard P., Lawrence, R. Michael, Wexler, Ruth R., Salvati, Mark E.
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
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2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: Optimization via array synthesis
Harikrishnan, Lalgudi S., Kamau, Muthoni G., Herpin, Timothy F., Morton, George C., Liu, Yalei, Cooper, Christopher B., Salvati, Mark E., Qiao, Jennifer X., Wang, Tammy C., Adam, Leonard P., Taylor, David S., Chen, Alice Ye A., Yin, Xiaohong, Seethala, Ramakrishna, Peterson, Tara L., Nirschl, David S., Miller, Arthur V., Weigelt, Carolyn A., Appiah, Kingsley K., O’Connell, Jonathan C., Michael Lawrence, R.
Published in Bioorganic & medicinal chemistry (15.04.2008)
Published in Bioorganic & medicinal chemistry (15.04.2008)
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Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL‑C Increase In Vivo
Tora, George, Kim, Soong-Hoon, Pi, Zulan, Johnson, James A, Jiang, Ji, Phillips, Monique, Lloyd, John, Abell, Lynn M, Lu, Hao, Locke, Gregory, Adam, Leonard P, Taylor, David S, Yin, Xiaohong, Behnia, Kamelia, Zhao, Lei, Yang, Richard, Basso, Michael, Caporuscio, Christian, Chen, Alice Ye, Liu, Eddie, Kirshgessner, Todd, Onorato, Joelle M, Ryan, Carol, Traeger, Sarah C, Gordon, David, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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Corrigendum to “Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase” [Bioorg. Med. Chem. Lett. 29 (2019) 1918–1921]
Kim, Soong-Hoon, Johnson, James A., Jiang, Ji, Parkhurst, Brandon, Phillips, Monique, Pi, Zulan, Qiao, Jennifer X., Tora, George, Ye Chen, Alice, Liu, Eddie, Yin, Xiaohong, Yang, Richard, Zhao, Lei, Taylor, David S., Basso, Michael, Behnia, Kamelia, Onorato, Joelle, Chen, Xue-Qing, Abell, Lynn M., Lu, Hao, Locke, Gregory, Caporuscio, Christian, Adam, Leonard P., Gordon, David, Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (01.09.2019)
Published in Bioorganic & medicinal chemistry letters (01.09.2019)
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