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AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations
Cho, Eunnara, Allemang, Ashley, Audebert, Marc, Chauhan, Vinita, Dertinger, Stephen, Hendriks, Giel, Luijten, Mirjam, Marchetti, Francesco, Minocherhomji, Sheroy, Pfuhler, Stefan, Roberts, Daniel J., Trenz, Kristina, Yauk, Carole L.
Published in Environmental and molecular mutagenesis (01.03.2022)
Published in Environmental and molecular mutagenesis (01.03.2022)
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Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations
LeBlanc, Danielle P. M., Meier, Matthew, Lo, Fang Yin, Schmidt, Elizabeth, Valentine, Charles, Williams, Andrew, Salk, Jesse J., Yauk, Carole L., Marchetti, Francesco
Published in BMC genomics (28.07.2022)
Published in BMC genomics (28.07.2022)
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Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes
Labib, Sarah, Williams, Andrew, Yauk, Carole L., Nikota, Jake K., Wallin, Håkan, Vogel, Ulla, Halappanavar, Sabina
Published in Particle and fibre toxicology (15.03.2016)
Published in Particle and fibre toxicology (15.03.2016)
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A case example of a radiation-relevant adverse outcome pathway to lung cancer
Chauhan, Vinita, Sherman, Samantha, Said, Zakaria, Yauk, Carole L., Stainforth, Robert
Published in International journal of radiation biology (02.01.2021)
Published in International journal of radiation biology (02.01.2021)
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Progress in toxicogenomics to protect human health
Meier, Matthew J., Harrill, Joshua, Johnson, Kamin, Thomas, Russell S., Tong, Weida, Rager, Julia E., Yauk, Carole L.
Published in Nature reviews. Genetics (01.02.2025)
Published in Nature reviews. Genetics (01.02.2025)
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BMDExpress 2: enhanced transcriptomic dose-response analysis workflow
Phillips, Jason R, Svoboda, Daniel L, Tandon, Arpit, Patel, Shyam, Sedykh, Alex, Mav, Deepak, Kuo, Byron, Yauk, Carole L, Yang, Longlong, Thomas, Russell S, Gift, Jeff S, Davis, J Allen, Olszyk, Louis, Merrick, B Alex, Paules, Richard S, Parham, Fred, Saddler, Trey, Shah, Ruchir R, Auerbach, Scott S
Published in Bioinformatics (15.05.2019)
Published in Bioinformatics (15.05.2019)
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Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
Marchetti, Francesco, Cardoso, Renato, Chen, Connie L., Douglas, George R., Elloway, Joanne, Escobar, Patricia A., Harper Jr, Tod, Heflich, Robert H., Kidd, Darren, Lynch, Anthony M., Myers, Meagan B., Parsons, Barbara L., Salk, Jesse J., Settivari, Raja S., Smith-Roe, Stephanie L., Witt, Kristine L., Yauk, Carole, Young, Robert R., Zhang, Shaofei, Minocherhomji, Sheroy
Published in Nature reviews. Drug discovery (01.03.2023)
Published in Nature reviews. Drug discovery (01.03.2023)
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Deciphering per- and polyfluoroalkyl substances mode of action: comparative gene expression analysis in human liver spheroids
Rowan-Carroll, Andrea, Meier, Matthew J, Yauk, Carole L, Williams, Andrew, Leingartner, Karen, Bradford, Lauren, Lorusso, Luigi, Atlas, Ella
Published in Toxicological sciences (01.05.2025)
Published in Toxicological sciences (01.05.2025)
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Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver
Bourdon, Julie A, Saber, Anne T, Jacobsen, Nicklas R, Jensen, Keld A, Madsen, Anne M, Lamson, Jacob S, Wallin, Håkan, Møller, Peter, Loft, Steffen, Yauk, Carole L, Vogel, Ulla B
Published in Particle and fibre toxicology (02.02.2012)
Published in Particle and fibre toxicology (02.02.2012)
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Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio
Vera-Chang, Marilyn N., St-Jacques, Antony D., Gagné, Rémi, Martyniuk, Chris J., Yauk, Carole L., Moon, Thomas W., Trudeau, Vance L.
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2018)
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A transcriptomic biomarker predictive of cell proliferation for use in adverse outcome pathway-informed testing and assessment
Corton, J Christopher, Ledbetter, Victoria, Cohen, Samuel M, Atlas, Ella, Yauk, Carole L, Liu, Jie
Published in Toxicological sciences (01.10.2024)
Published in Toxicological sciences (01.10.2024)
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Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals
Thienpont, Anouck, Cho, Eunnara, Williams, Andrew, Meier, Matthew J., Yauk, Carole L., Rogiers, Vera, Vanhaecke, Tamara, Mertens, Birgit
Published in Chemical research in toxicology (18.03.2024)
Published in Chemical research in toxicology (18.03.2024)
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Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs
Li, Heng-Hong, Chen, Renxiang, Hyduke, Daniel R., Williams, Andrew, Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, O’Lone, Raegan, Yauk, Carole L., Aubrecht, Jiri, Fornace, Albert J.
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2017)
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Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD)
Webster, A. Francina, Chepelev, Nikolai, Gagné, Rémi, Kuo, Byron, Recio, Leslie, Williams, Andrew, Yauk, Carole L.
Published in PloS one (27.08.2015)
Published in PloS one (27.08.2015)
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Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis
Rahman, Luna, Jacobsen, Nicklas Raun, Aziz, Syed Abdul, Wu, Dongmei, Williams, Andrew, Yauk, Carole L., White, Paul, Wallin, Hakan, Vogel, Ulla, Halappanavar, Sabina
Published in Mutation research (01.11.2017)
Published in Mutation research (01.11.2017)
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Potency Ranking of Per- and Polyfluoroalkyl Substances Using High-Throughput Transcriptomic Analysis of Human Liver Spheroids
Reardon, Anthony J F, Rowan-Carroll, Andrea, Ferguson, Stephen S, Leingartner, Karen, Gagne, Remi, Kuo, Byron, Williams, Andrew, Lorusso, Luigi, Bourdon-Lacombe, Julie A, Carrier, Richard, Moffat, Ivy, Yauk, Carole L, Atlas, Ella
Published in Toxicological sciences (27.10.2021)
Published in Toxicological sciences (27.10.2021)
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