Pharmacokinetics of EDP-420 after Ascending Single Oral Doses in Healthy Adult Volunteers
JIANG, Li-Juan, WANG, Michelle, YAT SUN OR
Published in Antimicrobial Agents and Chemotherapy (01.05.2009)
Published in Antimicrobial Agents and Chemotherapy (01.05.2009)
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A novel non‐bile acid FXR agonist EDP‐305 potently suppresses liver injury and fibrosis without worsening of ductular reaction
An, Ping, Wei, Guangyan, Huang, Pinzhu, Li, Wenda, Qi, Xiaolong, Lin, Yi, Vaid, Kahini A., Wang, Jun, Zhang, Shucha, Li, Yang, Or, Yat Sun, Jiang, Li‐Juan, Popov, Yury V.
Published in Liver international (01.07.2020)
Published in Liver international (01.07.2020)
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EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model
Rhodin, Michael H J, McAllister, Nicole V, Castillo, Jonathan, Noton, Sarah L, Fearns, Rachel, Kim, In Jong, Yu, Jianming, Blaisdell, Thomas P, Panarese, Joseph, Shook, Brian C, Or, Yat Sun, Goodwin, Bryan, Lin, Kai
Published in PLoS pathogens (15.03.2021)
Published in PLoS pathogens (15.03.2021)
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The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo
Rhodin, Michael H. J., Reyes, Archie C., Balakrishnan, Anand, Bisht, Nalini, Kelly, Nicole M., Gibbons, Joyce Sweeney, Lloyd, Jonathan, Vaine, Michael, Cressey, Tessa, Crepeau, Miranda, Shen, Ruichao, Manalo, Nathan, Castillo, Jonathan, Levene, Rachel E., Leonard, Daniel, Zang, Tianzhu, Jiang, Lijuan, Daniels, Kellye, Cox, Robert M., Lieber, Carolin M., Wolf, Josef D., Plemper, Richard K., Leist, Sarah R., Scobey, Trevor, Baric, Ralph S., Wang, Guoqiang, Goodwin, Bryan, Or, Yat Sun
Published in Nature communications (01.08.2024)
Published in Nature communications (01.08.2024)
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Molecular magnetic resonance imaging accurately measures the antifibrotic effect of EDP‐305, a novel farnesoid X receptor agonist
Erstad, Derek J., Farrar, Christian T., Ghoshal, Sarani, Masia, Ricard, Ferreira, Diego S., Chen, Yin‐Ching Iris, Choi, Ji‐Kyung, Wei, Lan, Waghorn, Phillip A., Rotile, Nicholas J., Tu, Chuantao, Graham‐O'Regan, Katherine A., Sojoodi, Mozhdeh, Li, Shen, Li, Yang, Wang, Guogiang, Corey, Kathleen E., Or, Yat Sun, Jiang, Lijuan, Tanabe, Kenneth K., Caravan, Peter, Fuchs, Bryan C.
Published in Hepatology communications (01.07.2018)
Published in Hepatology communications (01.07.2018)
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Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes
Tang, Datong, Gai, Yonghua, Polemeropoulos, Alexander, Chen, Zhigang, Wang, Zhe, Or, Yat Sun
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
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Journal Article
Synthesis of 3,6-bicyclolides: A novel class of macrolide antibiotics
Gai, Yonghua, Tang, Datong, Xu, Guoyou, Chen, Zhigang, Polemeropoulos, Alexander, Wang, Zhe, Or, Yat Sun
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
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Journal Article
Synthesis of Novel 6,11-O-Bridged Bicyclic Ketolides via a Palladium-Catalyzed Bis-allylation
Wang, Guoqiang, Niu, Deqiang, Qiu, Yao-Ling, Phan, Ly Tam, Chen, Zhigang, Polemeropoulos, Alexander, Or, Yat Sun
Published in Organic letters (25.11.2004)
Published in Organic letters (25.11.2004)
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Journal Article
Synthesis and Antibacterial Activity of a Novel Class of 4‘-Substituted 16-Membered Ring Macrolides Derived from Tylosin
Phan, Ly T, Jian, Tianying, Chen, Zhigang, Qiu, Yao-Ling, Wang, Zhaolin, Beach, Theresa, Polemeropoulos, Alex, Or, Yat Sun
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Design, Synthesis, and Antimicrobial Activity of 6-O-Substituted Ketolides Active against Resistant Respiratory Tract Pathogens
Or, Yat Sun, Clark, Richard F, Wang, Sanyi, Chu, Daniel T. W, Nilius, Angela M, Flamm, Robert K, Mitten, Michael, Ewing, Patty, Alder, Jeff, Ma, Zhenkun
Published in Journal of medicinal chemistry (23.03.2000)
Published in Journal of medicinal chemistry (23.03.2000)
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Synthesis and Biological Evaluation of Novel Cyclosporin A Analogues: Potential Soft Drugs for the Treatment of Autoimmune Diseases
Lazarova, Tsvetelina, Chen, Jason S, Hamann, Blake, Kang, Jane M, Homuth-Trombino, Daniela, Han, Feng, Hoffmann, Ethan, McClure, Christopher, Eckstein, Jens, Or, Yat Sun
Published in Journal of medicinal chemistry (27.02.2003)
Published in Journal of medicinal chemistry (27.02.2003)
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Journal Article
Synthesis of novel 4′-substituted 16-membered ring macrolide antibiotics derived from leucomycins
Wang, Zhaolin, Jian, Tianying, Phan, Ly T., Or, Yat Sun
Published in Bioorganic & medicinal chemistry letters (19.01.2004)
Published in Bioorganic & medicinal chemistry letters (19.01.2004)
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Journal Article
EDP-938 Has a High Barrier to Resistance in Healthy Adults Experimentally Infected with Respiratory Syncytial Virus
Levene, Rachel Emily, DeVincenzo, John, Conery, Annie L, Ahmed, Alaa, Or, Yat Sun, Rhodin, Michael H J
Published in The Journal of infectious diseases (23.10.2024)
Published in The Journal of infectious diseases (23.10.2024)
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Journal Article
Synthesis of New 14-Membered Macrolide Antibiotics via a Novel Ring Contraction Metathesis
Lazarova, Tsvetelina I, Binet, Sophie M, Vo, Nha H, Chen, Jason S, Phan, Ly T, Or, Yat Sun
Published in Organic letters (20.02.2003)
Published in Organic letters (20.02.2003)
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Journal Article
Su1498 - A Highly Selective and Potent Farnesoid X Receptor (FXR) Agonist EDP-305 Reduces Liver Steatosis, Ballooning, and Non-Alcoholic Fatty Liver Disease Activity (NAS) in two Murine Models of Non-Alcoholic Steatohepatitis (NASH)
Jiang, Li-Juan, Chau, Mary, Li, Yang, Or, Yat Sun
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2018)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2018)
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Journal Article
In vitro and in vivo antiviral activity and resistance profile of the hepatitis C virus NS3/4A protease inhibitor ABT-450
Pilot-Matias, Tami, Tripathi, Rakesh, Cohen, Daniel, Gaultier, Isabelle, Dekhtyar, Tatyana, Lu, Liangjun, Reisch, Thomas, Irvin, Michelle, Hopkins, Todd, Pithawalla, Ron, Middleton, Timothy, Ng, Teresa, McDaniel, Keith, Or, Yat Sun, Menon, Rajeev, Kempf, Dale, Molla, Akhteruzzaman, Collins, Christine
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Published in Antimicrobial agents and chemotherapy (01.02.2015)
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Journal Article
In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir
Ng, Teresa I, Tripathi, Rakesh, Reisch, Thomas, Lu, Liangjun, Middleton, Timothy, Hopkins, Todd A, Pithawalla, Ron, Irvin, Michelle, Dekhtyar, Tatyana, Krishnan, Preethi, Schnell, Gretja, Beyer, Jill, McDaniel, Keith F, Ma, Jun, Wang, Guoqiang, Jiang, Li-Juan, Or, Yat Sun, Kempf, Dale, Pilot-Matias, Tami, Collins, Christine
Published in Antimicrobial agents and chemotherapy (01.01.2018)
Published in Antimicrobial agents and chemotherapy (01.01.2018)
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