TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats
Tsujihata, Yoshiyuki, Ito, Ryo, Suzuki, Masami, Harada, Ayako, Negoro, Nobuyuki, Yasuma, Tsuneo, Momose, Yu, Takeuchi, Koji
Published in The Journal of pharmacology and experimental therapeutics (01.10.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2011)
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Journal Article
Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist
Negoro, Nobuyuki, Sasaki, Shinobu, Mikami, Satoshi, Ito, Masahiro, Suzuki, Masami, Tsujihata, Yoshiyuki, Ito, Ryo, Harada, Ayako, Takeuchi, Koji, Suzuki, Nobuhiro, Miyazaki, Junichi, Santou, Takashi, Odani, Tomoyuki, Kanzaki, Naoyuki, Funami, Miyuki, Tanaka, Toshimasa, Kogame, Akifumi, Matsunaga, Shinichiro, Yasuma, Tsuneo, Momose, Yu
Published in ACS medicinal chemistry letters (09.09.2010)
Published in ACS medicinal chemistry letters (09.09.2010)
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Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent
Negoro, Nobuyuki, Sasaki, Shinobu, Mikami, Satoshi, Ito, Masahiro, Tsujihata, Yoshiyuki, Ito, Ryo, Suzuki, Masami, Takeuchi, Koji, Suzuki, Nobuhiro, Miyazaki, Junichi, Santou, Takashi, Odani, Tomoyuki, Kanzaki, Naoyuki, Funami, Miyuki, Morohashi, Akio, Nonaka, Masami, Matsunaga, Shinichiro, Yasuma, Tsuneo, Momose, Yu
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists
Sasaki, Shinobu, Kitamura, Shuji, Negoro, Nobuyuki, Suzuki, Masami, Tsujihata, Yoshiyuki, Suzuki, Nobuhiro, Santou, Takashi, Kanzaki, Naoyuki, Harada, Masataka, Tanaka, Yasuhiro, Kobayashi, Makoto, Tada, Norio, Funami, Miyuki, Tanaka, Toshimasa, Yamamoto, Yoshio, Fukatsu, Kohji, Yasuma, Tsuneo, Momose, Yu
Published in Journal of medicinal chemistry (10.03.2011)
Published in Journal of medicinal chemistry (10.03.2011)
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Studies on Disease-Modifying Antirheumatic Drugs. IV. Synthesis of Novel Thieno[2, 3-b : 5, 4-c']dipyridine Derivatives and Their Anti-inflammatory Effect
BABA, Atsuo, MORI, Akira, YASUMA, Tsuneo, UNNO, Satoko, MAKINO, Haruhiko, SOHDA, Takashi
Published in Chemical & pharmaceutical bulletin (01.07.1999)
Published in Chemical & pharmaceutical bulletin (01.07.1999)
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Identification of Fused-Ring Alkanoic Acids with Improved Pharmacokinetic Profiles that Act as G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonists
Negoro, Nobuyuki, Sasaki, Shinobu, Ito, Masahiro, Kitamura, Shuji, Tsujihata, Yoshiyuki, Ito, Ryo, Suzuki, Masami, Takeuchi, Koji, Suzuki, Nobuhiro, Miyazaki, Junichi, Santou, Takashi, Odani, Tomoyuki, Kanzaki, Naoyuki, Funami, Miyuki, Tanaka, Toshimasa, Yasuma, Tsuneo, Momose, Yu
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
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Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure–Activity Relationships of Novel 1‑(Imidazo[1,2‑a]pyridin-6-yl)pyridin-2(1H)‑one Derivatives
Igawa, Hideyuki, Takahashi, Masashi, Kakegawa, Keiko, Kina, Asato, Ikoma, Minoru, Aida, Jumpei, Yasuma, Tsuneo, Kawata, Yayoi, Ashina, Shuntaro, Yamamoto, Syunsuke, Kundu, Mrinalkanti, Khamrai, Uttam, Hirabayashi, Hideki, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Discovery of Phenylpropanoic Acid Derivatives Containing Polar Functionalities as Potent and Orally Bioavailable G Protein-Coupled Receptor 40 Agonists for the Treatment of Type 2 Diabetes
Mikami, Satoshi, Kitamura, Shuji, Negoro, Nobuyuki, Sasaki, Shinobu, Suzuki, Masami, Tsujihata, Yoshiyuki, Miyazaki, Takeshi, Ito, Ryo, Suzuki, Nobuhiro, Miyazaki, Junichi, Santou, Takashi, Kanzaki, Naoyuki, Funami, Miyuki, Tanaka, Toshimasa, Yasuma, Tsuneo, Momose, Yu
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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Correction to Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure–Activity Relationships of Novel 1‑(Imidazo[1,2‑a]pyridin-6-yl)pyridin-2(1H)‑one Derivatives
Igawa, Hideyuki, Takahashi, Masashi, Kakegawa, Keiko, Kina, Asato, Ikoma, Minoru, Aida, Jumpei, Yasuma, Tsuneo, Kawata, Yayoi, Ashina, Shuntaro, Yamamoto, Syunsuke, Kundu, Mrinalkanti, Khamrai, Uttam, Hirabayashi, Hideki, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition
Igawa, Hideyuki, Takahashi, Masashi, Shirasaki, Mikio, Kakegawa, Keiko, Kina, Asato, Ikoma, Minoru, Aida, Jumpei, Yasuma, Tsuneo, Okuda, Shoki, Kawata, Yayoi, Noguchi, Toshihiro, Yamamoto, Syunsuke, Fujioka, Yasushi, Kundu, Mrinalkanti, Khamrai, Uttam, Nakayama, Masaharu, Nagisa, Yasutaka, Kasai, Shizuo, Maekawa, Tsuyoshi
Published in Bioorganic & medicinal chemistry (01.06.2016)
Published in Bioorganic & medicinal chemistry (01.06.2016)
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Synthesis and structure–activity relationship of tetrahydropyrazolopyrimidine derivatives—A novel structural class of potent calcium-sensing receptor antagonists
Yoshida, Masato, Mori, Akira, Inaba, Atsuhiro, Oka, Masahiro, Makino, Haruhiko, Yamaguchi, Masashi, Fujita, Hisashi, Kawamoto, Tomohiro, Goto, Mika, Kimura, Hiroyuki, Baba, Atsuo, Yasuma, Tsuneo
Published in Bioorganic & medicinal chemistry (15.12.2010)
Published in Bioorganic & medicinal chemistry (15.12.2010)
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Journal Article
Discovery of Novel and Potent Orally Active Calcium-Sensing Receptor Antagonists that Stimulate Pulselike Parathyroid Hormone Secretion: Synthesis and Structure−Activity Relationships of Tetrahydropyrazolopyrimidine Derivatives
Yoshida, Masato, Mori, Akira, Kotani, Etsuo, Oka, Masahiro, Makino, Haruhiko, Fujita, Hisashi, Ban, Junko, Ikeda, Yukihiro, Kawamoto, Tomohiro, Goto, Mika, Kimura, Hiroyuki, Baba, Atsuo, Yasuma, Tsuneo
Published in Journal of medicinal chemistry (10.03.2011)
Published in Journal of medicinal chemistry (10.03.2011)
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Journal Article
CRYSTALLINE FORMS OF 2-[(2S)-1-AZABICYCLO[2.2.2]OCT-2-YL]-6-(3-METHYL-1H- PYRAZOL-4-YL)THIENO[3,2-d]PYRIMIDIN-4(3H)-ONE HEMIHYDRATE
SIDDHESH DINANATH PATIL, TAYA NAOHIRO, MARIANNE LANGSTON, OGURO YUYA, IWATA KENTARO, ZHU LEI, MIZUNO MASAHIRO, YASUMA TSUNEO, JOHN DANIEL BAILEY, GOUR SHRUTI, MAEDA KAZUHIRO, LILLY ROY, HOMMA MISAKI
Year of Publication 10.09.2020
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Year of Publication 10.09.2020
Patent
Novel and potent calcium-sensing receptor antagonists: Discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent
Yoshida, Masato, Mori, Akira, Morimoto, Shinji, Kotani, Etsuo, Oka, Masahiro, Notoya, Kohei, Makino, Haruhiko, Ono, Midori, Shirasaki, Mikio, Tada, Norio, Fujita, Hisashi, Ban, Junko, Ikeda, Yukihiro, Kawamoto, Tomohiro, Goto, Mika, Kimura, Hiroyuki, Baba, Atsuo, Yasuma, Tsuneo
Published in Bioorganic & medicinal chemistry (15.03.2011)
Published in Bioorganic & medicinal chemistry (15.03.2011)
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