Mucosal Immunity and Protective Efficacy of Intranasal Inactivated Influenza Vaccine Is Improved by Chitosan Nanoparticle Delivery in Pigs
Dhakal, Santosh, Renu, Sankar, Ghimire, Shristi, Shaan Lakshmanappa, Yashavanth, Hogshead, Bradley T, Feliciano-Ruiz, Ninoshkaly, Lu, Fangjia, HogenEsch, Harm, Krakowka, Steven, Lee, Chang Won, Renukaradhya, Gourapura J
Published in Frontiers in immunology (02.05.2018)
Published in Frontiers in immunology (02.05.2018)
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SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
Shaan Lakshmanappa, Yashavanth, Elizaldi, Sonny R, Roh, Jamin W, Schmidt, Brian A, Carroll, Timothy D, Weaver, Kourtney D, Smith, Justin C, Verma, Anil, Deere, Jesse D, Dutra, Joseph, Stone, Mars, Franz, Sergej, Sammak, Rebecca Lee, Olstad, Katherine J, Rachel Reader, J, Ma, Zhong-Min, Nguyen, Nancy K, Watanabe, Jennifer, Usachenko, Jodie, Immareddy, Ramya, Yee, JoAnn L, Weiskopf, Daniela, Sette, Alessandro, Hartigan-O'Connor, Dennis, McSorley, Stephen J, Morrison, John H, Tran, Nam K, Simmons, Graham, Busch, Michael P, Kozlowski, Pamela A, Van Rompay, Koen K A, Miller, Christopher J, Iyer, Smita S
Published in Nature communications (22.01.2021)
Published in Nature communications (22.01.2021)
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SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma
Deere, Jesse D, Carroll, Timothy D, Dutra, Joseph, Fritts, Linda, Sammak, Rebecca Lee, Yee, JoAnn L, Olstad, Katherine J, Reader, J Rachel, Kistler, Amy, Kamm, Jack, Di Germanio, Clara, Shaan Lakshmanappa, Yashavanth, Elizaldi, Sonny R, Roh, Jamin W, Simmons, Graham, Watanabe, Jennifer, Pollard, Rachel E, Usachenko, Jodie, Immareddy, Ramya, Schmidt, Brian A, O'Connor, Shelby L, DeRisi, Joseph, Busch, Michael P, Iyer, Smita S, Van Rompay, Koen K A, Hartigan-O'Connor, Dennis J, Miller, Christopher J
Published in Microbiology spectrum (22.12.2021)
Published in Microbiology spectrum (22.12.2021)
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Chronic SIV-Induced neuroinflammation disrupts CCR7+ CD4+ T cell immunosurveillance in the rhesus macaque brain
Elizaldi, Sonny R, Hawes, Chase E, Verma, Anil, Shaan Lakshmanappa, Yashavanth, Dinasarapu, Ashok R, Schlegel, Brent T, Rajasundaram, Dhivyaa, Li, Jie, Durbin-Johnson, Blythe P, Ma, Zhong-Min, Pal, Pabitra B, Beckman, Danielle, Ott, Sean, Raeman, Reben, Lifson, Jeffrey, Morrison, John H, Iyer, Smita S
Published in The Journal of clinical investigation (01.05.2024)
Published in The Journal of clinical investigation (01.05.2024)
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Deep analysis of CD4 T cells in the rhesus CNS during SIV infection
Elizaldi, Sonny R, Verma, Anil, Ma, Zhong-Min, Ott, Sean, Rajasundaram, Dhivyaa, Hawes, Chase E, Lakshmanappa, Yashavanth Shaan, Cottrell, Mackenzie L, Kashuba, Angela D M, Ambrose, Zandrea, Lifson, Jeffrey D, Morrison, John H, Iyer, Smita S
Published in PLoS pathogens (07.12.2023)
Published in PLoS pathogens (07.12.2023)
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Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection
Hawes, Chase E, Elizaldi, Sonny R, Beckman, Danielle, Diniz, Giovanne B, Shaan Lakshmanappa, Yashavanth, Ott, Sean, Durbin-Johnson, Blythe P, Dinasarapu, Ashok R, Gompers, Andrea, Morrison, John H, Iyer, Smita S
Published in Journal of neuroinflammation (06.10.2022)
Published in Journal of neuroinflammation (06.10.2022)
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Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung inflammation
Van Rompay, Koen K A, Olstad, Katherine J, Sammak, Rebecca L, Dutra, Joseph, Watanabe, Jennifer K, Usachenko, Jodie L, Immareddy, Ramya, Roh, Jamin W, Verma, Anil, Shaan Lakshmanappa, Yashavanth, Schmidt, Brian A, Di Germanio, Clara, Rizvi, Nabeela, Liu, Hongwei, Ma, Zhong-Min, Stone, Mars, Simmons, Graham, Dumont, Larry J, Allen, A Mark, Lockwood, Sarah, Pollard, Rachel E, Ramiro de Assis, Rafael, Yee, JoAnn L, Nham, Peter B, Ardeshir, Amir, Deere, Jesse D, Jain, Aarti, Felgner, Philip L, Coffey, Lark L, Iyer, Smita S, Hartigan-O'Connor, Dennis J, Busch, Michael P, Reader, J Rachel
Published in PLoS pathogens (01.04.2022)
Published in PLoS pathogens (01.04.2022)
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Liposomal nanoparticle-based conserved peptide influenza vaccine and monosodium urate crystal adjuvant elicit protective immune response in pigs
Dhakal, Santosh, Cheng, Xingguo, Salcido, John, Renu, Sankar, Bondra, Kathy, Lakshmanappa, Yashavantha Shaan, Misch, Christina, Ghimire, Shristi, Feliciano-Ruiz, Ninoshkaly, Hogshead, Bradley, Krakowka, Steven, Carson, Kenneth, McDonough, Joseph, Lee, Chang Won, Renukaradhya, Gourapura J
Published in International journal of nanomedicine (01.01.2018)
Published in International journal of nanomedicine (01.01.2018)
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Amish (Rural) vs. non-Amish (Urban) Infant Fecal Microbiotas Are Highly Diverse and Their Transplantation Lead to Differences in Mucosal Immune Maturation in a Humanized Germfree Piglet Model
Dhakal, Santosh, Wang, Lingling, Antony, Linto, Rank, Jennifer, Bernardo, Pauline, Ghimire, Shristi, Bondra, Kathy, Siems, Christina, Lakshmanappa, Yashavanth Shaan, Renu, Sankar, Hogshead, Bradley, Krakowka, Steven, Kauffman, Mike, Scaria, Joy, LeJeune, Jeffrey T, Yu, Zhongtang, Renukaradhya, Gourapura J
Published in Frontiers in immunology (16.07.2019)
Published in Frontiers in immunology (16.07.2019)
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Journal Article
Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation
Verma, Anil, Hawes, Chase E., Lakshmanappa, Yashavanth Shaan, Roh, Jamin W., Schmidt, Brian A., Dutra, Joseph, Louie, William, Liu, Hongwei, Ma, Zhong-Min, Watanabe, Jennifer K., Usachenko, Jodie L., Immareddy, Ramya, Sammak, Rebecca L., Pollard, Rachel, Reader, J. Rachel, Olstad, Katherine J., Coffey, Lark L., Kozlowski, Pamela A., Hartigan-O’Connor, Dennis J., Nussenzweig, Michel, Van Rompay, Koen K.A., Morrison, John H., Iyer, Smita S.
Published in Cell reports (Cambridge) (02.11.2021)
Published in Cell reports (Cambridge) (02.11.2021)
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Dam-Infant Rhesus Macaque Pairs to Dissect Age-Dependent Responses to SARS-CoV-2 Infection
Langel, Stephanie N, Garrido, Carolina, Phan, Caroline, Travieso, Tatianna, Kirshner, Helene, DeMarco, Todd, Ma, Zhong-Min, Reader, J Rachel, Olstad, Katherine J, Sammak, Rebecca L, Shaan Lakshmanappa, Yashavanth, Roh, Jamin W, Watanabe, Jennifer, Usachenko, Jodie, Immareddy, Ramya, Pollard, Rachel, Iyer, Smita S, Permar, Sallie, Miller, Lisa A, Van Rompay, Koen K A, Blasi, Maria
Published in ImmunoHorizons (01.12.2022)
Published in ImmunoHorizons (01.12.2022)
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Journal Article
Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity reduces lung inflammation
Van Rompay, Koen K A, Olstad, Katherine J, Sammak, Rebecca L, Dutra, Joseph, Watanabe, Jennifer K, Usachenko, Jodie L, Immareddy, Ramya, Roh, Jamin W, Verma, Anil, Shaan Lakshmanappa, Yashavanth, Schmidt, Brian A, Di Germanio, Clara, Rizvi, Nabeela, Stone, Mars, Simmons, Graham, Dumont, Larry J, Allen, A Mark, Lockwood, Sarah, Pollard, Rachel E, de Assis, Rafael Ramiro, Yee, JoAnn L, Nham, Peter B, Ardeshir, Amir, Deere, Jesse D, Patterson, Jean, Jain, Aarti, Felgner, Philip L, Iyer, Smita S, Hartigan-O'Connor, Dennis J, Busch, Michael P, Reader, J Rachel
Published in bioRxiv (01.09.2021)
Published in bioRxiv (01.09.2021)
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Chronic SIV-Induced neuroinflammation disrupts [CCR7.sup.+] [CD4.sup.+] T cell immunosurveillance in the rhesus macaque brain
Elizaldi, Sonny R, Hawes, Chase E, Verma, Anil, Lakshmanappa, Yashavanth Shaan, Dinasarapu, Ashok R, Schlegel, Brent T, Rajasundaram, Dhivyaa, Li, Jie, Durbin-Johnson, Blythe P, Ma, Zhong-Min, Pal, Pabitra B, Beckman, Danielle, Ott, Sean, Raeman, Reben, Lifson, Jeffrey, Morrison, John H, Iyer, Smita S
Published in The Journal of clinical investigation (01.05.2024)
Published in The Journal of clinical investigation (01.05.2024)
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Journal Article
Oral Deliverable Mucoadhesive Chitosan- Salmonella Subunit Nanovaccine for Layer Chickens
Renu, Sankar, Markazi, Ashley D, Dhakal, Santosh, Lakshmanappa, Yashavanth S, Shanmugasundaram, Revathi, Selvaraj, Ramesh K, Renukaradhya, Gourapura J
Published in International journal of nanomedicine (01.01.2020)
Published in International journal of nanomedicine (01.01.2020)
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Journal Article
Corn-derived alpha-D-glucan nanoparticles as adjuvant for intramuscular and intranasal immunization in pigs
Dhakal, Santosh, Lu, Fangjia, Ghimire, Shristi, Renu, Sankar, Lakshmanappa, Yashavanth Shaan, Hogshead, Bradley T., Ragland, Darryl, HogenEsch, Harm, Renukaradhya, Gourapura J.
Published in Nanomedicine (01.02.2019)
Published in Nanomedicine (01.02.2019)
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Journal Article
Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques
Verma, Anil, Schmidt, Brian A, Elizaldi, Sonny R, Nguyen, Nancy K, Walter, Korey A, Beck, Zoltan, Trinh, Hung V, Dinasarapu, Ashok R, Lakshmanappa, Yashavanth Shaan, Rane, Niharika N, Matyas, Gary R, Rao, Mangala, Shen, Xiaoying, Tomaras, Georgia D, LaBranche, Celia C, Reimann, Keith A, Foehl, David H, Gach, Johannes S, thal, Donald N, Kozlowski, Pamela A, Amara, Rama R, Iyer, Smita S
Published in Journal of virology (28.02.2020)
Published in Journal of virology (28.02.2020)
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Journal Article
SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques
Elizaldi, Sonny R, Lakshmanappa, Yashavanth Shaan, Roh, Jamin W, Schmidt, Brian A, Carroll, Timothy D, Weaver, Kourtney D, Smith, Justin C, Deere, Jesse D, Dutra, Joseph, Stone, Mars, Sammak, Rebecca Lee, Olstad, Katherine J, Reader, J Rachel, Ma, Zhong-Min, Nguyen, Nancy K, Watanabe, Jennifer, Usachaenko, Jodie, Immareddy, Ramya, Yee, JoAnn L, Weiskopf, Daniela, Sette, Alessandro, Hartigan-O'Connor, Dennis, McSorley, Stephen J, Morrison, John H, Tran, Nam K, Simmons, Graham, Busch, Michael P, Kozlowski, Pamela A, Van Rompay, Koen K A, Miller, Christopher J, Iyer, Smita S
Published in bioRxiv (08.07.2020)
Published in bioRxiv (08.07.2020)
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Engineering of Targeted Mucoadhesive Chitosan Based Salmonella Nanovaccine for Oral Delivery in Poultry
Renu, Sankar, Markazi, Ashley D., Dhakal, Santosh, Lakshmanappa, Yashavanth Shaan, Shanmugasundaram, Revathi, Selvaraj, Ramesh K., Renukaradhya, Gourapura J.
Published in The Journal of immunology (1950) (01.05.2018)
Published in The Journal of immunology (1950) (01.05.2018)
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Journal Article
Mucosal immunity and protective efficacy of inactivated influenza virus vaccine is improved by intranasal chitosan nanoparticle delivery in pigs
Dhakal, Santosh, Renu, Sankar, Ghimire, Shristi, Lakshmanappa, Yashavanth Shaan, Hogshead, Bradley T., Ruiz, Ninoshkaly F., Krakowka, Steven, Lee, Chang-Won, Gourapura, Renukaradhya J.
Published in The Journal of immunology (1950) (01.05.2018)
Published in The Journal of immunology (1950) (01.05.2018)
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Journal Article
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques
Van Rompay, Koen K A, Olstad, Katherine J, Sammak, Rebecca L, Dutra, Joseph, Watanabe, Jennifer K, Usachenko, Jodie L, Immareddy, Ramya, Verma, Anil, Shaan Lakshmanappa, Yashavanth, Schmidt, Brian A, Roh, Jamin W, Elizaldi, Sonny R, Allen, A Mark, Muecksch, Frauke, Lorenzi, Julio C C, Lockwood, Sarah, Pollard, Rachel E, Yee, JoAnn L, Nham, Peter B, Ardeshir, Amir, Deere, Jesse D, Patterson, Jean, Dang, Que, Hatziioannou, Theodora, Bieniasz, Paul D, Iyer, Smita S, Hartigan-O'Connor, Dennis J, Nussenzweig, Michel C, Reader, J Rachel
Published in PLoS pathogens (06.07.2021)
Published in PLoS pathogens (06.07.2021)
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