The future of EPAC-targeted therapies: agonism versus antagonism
Parnell, Euan, Palmer, Timothy M, Yarwood, Stephen J
Published in Trends in pharmacological sciences (Regular ed.) (01.04.2015)
Published in Trends in pharmacological sciences (Regular ed.) (01.04.2015)
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Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
Chen, Suet Ching, Brooks, Rebecca, Houskeeper, Jessica, Bremner, Shaun K., Dunlop, Julia, Viollet, Benoit, Logan, Pamela J., Salt, Ian P., Ahmed, S. Faisal, Yarwood, Stephen J.
Published in Molecular and cellular endocrinology (15.01.2017)
Published in Molecular and cellular endocrinology (15.01.2017)
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Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation
Roberts, Jemma N, Sahoo, Jugal Kishore, McNamara, Laura E, Burgess, Karl V, Yang, Jingli, Alakpa, Enateri V, Anderson, Hilary J, Hay, Jake, Turner, Lesley-Anne, Yarwood, Stephen J, Zelzer, Mischa, Oreffo, Richard O. C, Ulijn, Rein V, Dalby, Matthew J
Published in ACS nano (26.07.2016)
Published in ACS nano (26.07.2016)
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EPAC proteins transduce diverse cellular actions of cAMP
Borland, Gillian, Smith, Brian O, Yarwood, Stephen J
Published in British journal of pharmacology (01.09.2009)
Published in British journal of pharmacology (01.09.2009)
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The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs)
Wiejak, Jolanta, van Basten, Boy, Luchowska-Stańska, Urszula, Hamilton, Graham, Yarwood, Stephen J.
Published in Biochimica et biophysica acta. Molecular cell research (01.02.2019)
Published in Biochimica et biophysica acta. Molecular cell research (01.02.2019)
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Selective small-molecule EPAC activators
Luchowska-Stańska, Urszula, Morgan, David, Yarwood, Stephen J, Barker, Graeme
Published in Biochemical Society transactions (31.10.2019)
Published in Biochemical Society transactions (31.10.2019)
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Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells
Wiejak, Jolanta, Dunlop, Julia, Mackay, Simon P, Yarwood, Stephen J
Published in Biochemical journal (01.09.2013)
Published in Biochemical journal (01.09.2013)
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Journal Article
Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators
Wang, Pingyuan, Luchowska-Stańska, Urszula, van Basten, Boy, Chen, Haiying, Liu, Zhiqing, Wiejak, Jolanta, Whelan, Padraic, Morgan, David, Lochhead, Emma, Barker, Graeme, Rehmann, Holger, Yarwood, Stephen J, Zhou, Jia
Published in Journal of medicinal chemistry (28.05.2020)
Published in Journal of medicinal chemistry (28.05.2020)
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Protein interaction, cytotoxic, transcriptomic and proteomic responses to structurally distinct EPAC1 activators in HUVECs
Wiejak, Jolanta, Luchowska-Stańska, Urszula, Wang, Pingyuan, Zhou, Jia, Maffia, Pasquale, Morgan, David, Barker, Graeme, Yarwood, Stephen J.
Published in Scientific reports (05.10.2022)
Published in Scientific reports (05.10.2022)
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Journal Article
Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1
Parnell, Euan, McElroy, Stuart P., Wiejak, Jolanta, Baillie, Gemma L., Porter, Alison, Adams, David R., Rehmann, Holger, Smith, Brian O., Yarwood, Stephen J.
Published in Scientific reports (22.03.2017)
Published in Scientific reports (22.03.2017)
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Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4
Watterson, Kenneth R, Hansen, Steffen V F, Hudson, Brian D, Alvarez-Curto, Elisa, Raihan, Sheikh Zahir, Azevedo, Carlos M G, Martin, Gabriel, Dunlop, Julia, Yarwood, Stephen J, Ulven, Trond, Milligan, Graeme
Published in Molecular pharmacology (01.06.2017)
Published in Molecular pharmacology (01.06.2017)
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Journal Article
The RACK1 scaffold protein: a dynamic cog in cell response mechanisms
McCahill, Angela, Warwicker, Jim, Bolger, Graeme B, Houslay, Miles D, Yarwood, Stephen J
Published in Molecular pharmacology (01.12.2002)
Published in Molecular pharmacology (01.12.2002)
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Identification of CCAAT/Enhancer-binding Proteins as Exchange Protein Activated by cAMP-activated Transcription Factors That Mediate the Induction of the SOCS-3 Gene
Yarwood, Stephen J., Borland, Gillian, Sands, William A., Palmer, Timothy M.
Published in The Journal of biological chemistry (14.03.2008)
Published in The Journal of biological chemistry (14.03.2008)
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Genome-Wide Mapping Defines a Role for C/EBPβ and c-Jun in Non-Canonical Cyclic AMP Signalling
Wiejak, Jolanta, van Basten, Boy, Hamilton, Graham, Yarwood, Stephen J
Published in Cells (Basel, Switzerland) (14.10.2019)
Published in Cells (Basel, Switzerland) (14.10.2019)
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Recent Developments in C−H Functionalisation of Benzofurans and Benzothiophenes
Morgan, David, Yarwood, Stephen J., Barker, Graeme
Published in European journal of organic chemistry (19.02.2021)
Published in European journal of organic chemistry (19.02.2021)
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Increasing Fibroblast Response to Materials Using Nanotopography: Morphological and Genetic Measurements of Cell Response to 13-nm-High Polymer Demixed Islands
Dalby, Matthew J., Yarwood, Stephen J., Riehle, Mathis O., Johnstone, Heather J.H., Affrossman, Stanley, Curtis, Adam S.G.
Published in Experimental cell research (15.05.2002)
Published in Experimental cell research (15.05.2002)
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