Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease
Toledo-Sherman, Leticia M, Prime, Michael E, Mrzljak, Ladislav, Beconi, Maria G, Beresford, Alan, Brookfield, Frederick A, Brown, Christopher J, Cardaun, Isabell, Courtney, Stephen M, Dijkman, Ulrike, Hamelin-Flegg, Estelle, Johnson, Peter D, Kempf, Valerie, Lyons, Kathy, Matthews, Kimberly, Mitchell, William L, O’Connell, Catherine, Pena, Paula, Powell, Kendall, Rassoulpour, Arash, Reed, Laura, Reindl, Wolfgang, Selvaratnam, Suganathan, Friley, Weslyn Ward, Weddell, Derek A, Went, Naomi E, Wheelan, Patricia, Winkler, Christin, Winkler, Dirk, Wityak, John, Yarnold, Christopher J, Yates, Dawn, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (12.02.2015)
Published in Journal of medicinal chemistry (12.02.2015)
Get full text
Journal Article
Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease
Prime, Michael E, Andersen, Ole A, Barker, John J, Brooks, Mark A, Cheng, Robert K. Y, Toogood-Johnson, Ian, Courtney, Stephen M, Brookfield, Frederick A, Yarnold, Christopher J, Marston, Richard W, Johnson, Peter D, Johnsen, Siw F, Palfrey, Jordan J, Vaidya, Darshan, Erfan, Sayeh, Ichihara, Osamu, Felicetti, Brunella, Palan, Shilpa, Pedret-Dunn, Anna, Schaertl, Sabine, Sternberger, Ina, Ebneth, Andreas, Scheel, Andreas, Winkler, Dirk, Toledo-Sherman, Leticia, Beconi, Maria, Macdonald, Douglas, Muñoz-Sanjuan, Ignacio, Dominguez, Celia, Wityak, John
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
Get full text
Journal Article
A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced Obesity
Zahn, Grit, Willmes, Diana M, El-Agroudy, Nermeen N, Yarnold, Christopher, Jarjes-Pike, Richard, Schaertl, Sabine, Schreiter, Kay, Gehrmann, Wiebke, Wong, Andrea Kuan Cie, Zordan, Tommaso, König, Jörg, Jordan, Jens, Birkenfeld, Andreas L
Published in Metabolites (01.08.2022)
Published in Metabolites (01.08.2022)
Get full text
Journal Article
Discovery of a Novel Hsp90 Inhibitor by Fragment Linking
Barker, John J., Barker, Oliver, Courtney, Stephen M., Gardiner, Mihaly, Hesterkamp, Thomas, Ichihara, Osamu, Mather, Owen, Montalbetti, Christian A. G. N., Müller, Annett, Varasi, Mario, Whittaker, Mark, Yarnold, Christopher J.
Published in ChemMedChem (04.10.2010)
Published in ChemMedChem (04.10.2010)
Get full text
Journal Article
Fragment‐based Identification of Hsp90 Inhibitors
Barker, John J., Barker, Oliver, Boggio, Roberto, Chauhan, Viddhata, Cheng, Robert K. Y., Corden, Vincent, Courtney, Stephen M., Edwards, Neil, Falque, Virginie M., Fusar, Fulvia, Gardiner, Mihaly, Hamelin, Estelle M. N., Hesterkamp, Thomas, Ichihara, Osamu, Jones, Richard S., Mather, Owen, Mercurio, Ciro, Minucci, Saverio, Montalbetti, Christian A. G. N., Müller, Annett, Patel, Deepti, Phillips, Banu G., Varasi, Mario, Whittaker, Mark, Winkler, Dirk, Yarnold, Christopher J.
Published in ChemMedChem (08.06.2009)
Published in ChemMedChem (08.06.2009)
Get full text
Journal Article
Potent and Selective Inhibition of Varicella-Zoster Virus (VZV) by Nucleoside Analogues with an Unusual Bicyclic Base
McGuigan, Christopher, Yarnold, Christopher J, Jones, Garry, Velázquez, Sonsoles, Barucki, Hubert, Brancale, Andrea, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik, Balzarini, Jan
Published in Journal of medicinal chemistry (04.11.1999)
Published in Journal of medicinal chemistry (04.11.1999)
Get full text
Journal Article
The carboxyterminal processing protease of D1 protein: Herbicidal activity of novel inhibitors of the recombinant and native spinach enzymes
Duff, Stephen M.G., Chen, Yun-Chia Sophia, Fabbri, Brad J., Yalamanchili, Gopichand, Hamper, Bruce C., Walker, Dan M., Brookfield, Frederick A., Boyd, Edward A., Ashton, Mark R., Yarnold, Christopher J., CaJacob, Claire A.
Published in Pesticide biochemistry and physiology (01.05.2007)
Published in Pesticide biochemistry and physiology (01.05.2007)
Get full text
Journal Article
Activities of Masked 2′,3′-Dideoxynucleoside Monophosphate Derivatives against Human Immunodeficiency Virus in Resting Macrophages
AQUARO, S, WEDGWOOD, O, YARNOLD, C, CAHARD, D, PATHINARA, R, MCGUIGAN, C, CALIO, R, DE CLERCQ, E, BALZARINI, J, PERNO, C. F
Published in Antimicrobial Agents and Chemotherapy (01.01.2000)
Published in Antimicrobial Agents and Chemotherapy (01.01.2000)
Get full text
Journal Article
신규한 페로포르틴 억제제
SHEPHERD JON, MANOLOVA VANIA, LECCI CRISTINA, REIM STEFAN, BURGERT MICHAEL, KALOGERAKIS ARIS, BOYCE SUSAN, BUHR WILM, BURCKHARDT SUSANNA, DURRENBERGER FRANZ, YARNOLD CHRISTOPHER JOHN, PENA PAULA, SCOTT JOHN, JARJES PIKE RICHARD
Year of Publication 14.06.2018
Get full text
Year of Publication 14.06.2018
Patent
NOVEL SULFONAMINOQUINOLINE HEPCIDIN ANTAGONISTS
DAWSON GRAHAM, DUERRENBERGER FRANZ, ELLENBROEK ALBERTUS ANTONIUS, GEISSER PETER OTTO, BOYCE SUSAN, RIDGILL MARK PETER, BUHR WILM, BURCKHARDT SUSANNA, DAVENPORT TARA, YARNOLD CHRISTOPHER JOHN, CORDEN VINCENT ANTHONY, COURTNEY STEPHEN MARTIN, FUNK FELIX, SLACK MARK
Year of Publication 22.01.2014
Get full text
Year of Publication 22.01.2014
Patent
CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
DE AGUIAR PENA PAULA CRISTINA, TOLEDO SHERMAN LETICIA M, WITYAK JOHN, SCHEEL ANDREAS, YARNOLD CHRISTOPHER JOHN, WINKLER DIRK, COURTNEY STEPHEN MARTIN, DOMINGUEZ CELLA
Year of Publication 17.08.2011
Get full text
Year of Publication 17.08.2011
Patent
NOVEL PYRIMIDINE AND TRIAZINE HEPCIDINE ANTAGONISTS
YAU WEI TSUNG, DUERRENBERGER FRANZ, JAEGER STEFAN, GEISSER PETER OTTO, RIDGILL MARK PETER, BUHR WILM, BURCKHARDT SUSANNA, BAINBRIDGE JULIA MARIE, DAVENPORT TARA, YARNOLD CHRISTOPHER JOHN, CORDEN VINCENT ANTHONY, COURTNEY STEPHEN MARTIN, FUNK FELIX, SLACK MARK
Year of Publication 12.06.2012
Get full text
Year of Publication 12.06.2012
Patent
CITRATE TRANSPORTER MODULATORS AND USES THEREOF
CRAFT, Russell, KHOR, Someina, ZAHN, Grit, SCHREITER, Kay, SCHAERTL, Sabine, BROMIDGE, Steven Mark, YARNOLD, Christopher John, JARJES-PIKE, Richard
Year of Publication 03.08.2023
Get full text
Year of Publication 03.08.2023
Patent
Novel ferroportin inhibitors
Pena, Paula, Dürrenberger, Franz, Shepherd, Jon, Scott, John, Burgert, Michael, Manolova, Vania, Boyce, Susan, Yarnold, Christopher John, Kalogerakis, Aris, Burckhardt, Susanna, Lecci, Cristina, Buhr, Wilm, Jarjes-Pike, Richard, Reim, Stefan
Year of Publication 23.02.2024
Get full text
Year of Publication 23.02.2024
Patent
BENZIMIDAZOLYL DERIVATIVES FOR USE AS FERROPORTIN INHIBITORS
BUHR, WILM, PENA, PAULA, SCOTT, JOHN, DURRENBERGER, FRANZ, SHEPHERD, JON, REIM, STEFAN, KALOGERAKIS, ARIS, LECCI, CRISTINA, BURCKHARDT, SUSANNA, JARJES-PIKE, RICHARD, MANOLOVA, VANIA, BURGERT, MICHAEL, BOYCE, SUSAN, YARNOLD, CHRISTOPHER JOHN
Year of Publication 24.10.2023
Get full text
Year of Publication 24.10.2023
Patent
HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF
DENG, Shixian, FIORITO, Jole, DE VRIES, Luuk, Elard, LANDRY, Donald W, CALCAGNO, Elisa, JONES, Richard, Scott, ZUCCARELLO, Elisa, ROWLEY, Julian, Hugh, ARANCIO, Ottavio, YARNOLD, Christopher, John
Year of Publication 16.11.2022
Get full text
Year of Publication 16.11.2022
Patent
ANTIVIRAL COMPOUNDS
Ingram, Peter Neville, Whittaker, Mark, Amouzegh, Patricia Leonie, Chudyk, Ewa Iwona, Yarnold, Christopher John, Kerry, Mark Anthony, Fischl, Wolfgang, Morao, Inaki, Pons, Jean-Francois
Year of Publication 10.11.2022
Get full text
Year of Publication 10.11.2022
Patent
NOVEL FERROPORTIN INHIBITORS
BUHR, WILM, PENA, PAULA, SCOTT, JOHN, DURRENBERGER, FRANZ, SHEPHERD, JON, REIM, STEFAN, KALOGERAKIS, ARIS, LECCI, CRISTINA, BURCKHARDT, SUSANNA, JARJES-PIKE, RICHARD, MANOLOVA, VANIA, BURGERT, MICHAEL, BOYCE, SUSAN, YARNOLD, CHRISTOPHER JOHN
Year of Publication 03.10.2023
Get full text
Year of Publication 03.10.2023
Patent
5,6,7,8-TETRAHYDRO-2,6- AND 2,7-NAPHTHYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF DISEASES RESPONSIVE TO CITRATE TRANSPORTER MODULATION
BAINBRIDGE, Julia Marie, BERETTA, Giacomo, ARNOLD, Robert Edward, KERRY, Mark Anthony, FLANAGAN, Stuart Robert, DAVENPORT, Adam James, YARNOLD, Christopher John, DOCTON, Emily Catherine, WALKER, Patrick Ross, THEWLIS, Kevin Michael, DOWLING, Verity Nicole, ZAHN, Grit, BROMIDGE, Steven Mark, GLEAVE, Laura Jane, MACKINNON, Colin Haig, DE AGUIARPENA, Paula Cristina, LECCI, Cristina
Year of Publication 22.05.2024
Get full text
Year of Publication 22.05.2024
Patent