T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis
Brzostek, Joanna, Gautam, Namrata, Zhao, Xiang, Chen, Elijah W., Mehta, Monika, Tung, Desmond W. H., Chua, Yen Leong, Yap, Jiawei, Cho, Su H., Sankaran, Shvetha, Rybakin, Vasily, Fu, Guo, Gascoigne, Nicholas R. J.
Published in Nature immunology (01.02.2020)
Published in Nature immunology (01.02.2020)
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Journal Article
Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A11:01
Gu, Yue, Wong, Yee Hwa, Liew, Chong Wai, Chan, Conrad E. Z., Murali, Tanusya M., Yap, Jiawei, Too, Chien Tei, Purushotorman, Kiren, Hamidinia, Maryam, El Sahili, Abbas, Goh, Angeline T. H., Teo, Rachel Z. C., Wood, Kathryn J., Hanson, Brendon J., Gascoigne, Nicholas R. J., Lescar, Julien, Vathsala, Anantharaman, MacAry, Paul A.
Published in Nature communications (21.02.2019)
Published in Nature communications (21.02.2019)
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Journal Article
Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling
Zhao, Xiang, Sankaran, Shvetha, Yap, Jiawei, Too, Chien Tei, Ho, Zi Zong, Dolton, Garry, Legut, Mateusz, Ren, Ee Chee, Sewell, Andrew K., Bertoletti, Antonio, MacAry, Paul A., Brzostek, Joanna, Gascoigne, Nicholas R. J.
Published in Nature communications (13.07.2018)
Published in Nature communications (13.07.2018)
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Journal Article
Expansion of an Unusual Virtual Memory CD8 + Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice
Prasad, Mukul, Wojciech, Lukasz, Brzostek, Joanna, Hu, Jianfang, Chua, Yen Leong, Tung, Desmond Wai Hon, Yap, Jiawei, Rybakin, Vasily, Gascoigne, Nicholas R J
Published in Frontiers in immunology (07.04.2021)
Published in Frontiers in immunology (07.04.2021)
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Journal Article
Bioorthogonal Cleavage and Exchange of Major Histocompatibility Complex Ligands by Employing Azobenzene-Containing Peptides
Choo, Joanna A. L., Thong, Sock Yue, Yap, Jiawei, van Esch, Wim J. E., Raida, Manfred, Meijers, Rob, Lescar, Julien, Verhelst, Steven H. L., Grotenbreg, Gijsbert M.
Published in Angewandte Chemie International Edition (01.12.2014)
Published in Angewandte Chemie International Edition (01.12.2014)
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Journal Article
Lck bound to coreceptor is less active than free Lck
Wei, Qianru, Brzostek, Joanna, Sankaran, Shvetha, Casas, Javier, Hew, Lois Shi-Qi, Yap, Jiawei, Zhao, Xiang, Wojciech, Lukasz, Gascoigne, Nicholas R. J.
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2020)
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Journal Article
Utilizing distinct CAR and TCR signaling to generate enhanced cellular immunotherapy
Gascoigne, Nicholas R J, Wu, Ling, Brzostek, Joanna, Wei, Qianru, Vale, Previtha Dawn Sakthi, Koh, Clara K.T., Chua, Yen Long, Yap, Jiawei, Tan, Triscilla Y.Y., Lai, Junyun, MacAry, Paul A.
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
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Journal Article
Abstract 1425: Chimeric antigen receptors based on T cell receptor-like antibodies
Wu, Ling, Brzostek, Joanna, Sankaran, Shvetha, Tan, Triscilla, Chan, Conrad, Yap, Jiawei, Lai, Junyun, MacAry, Paul, Gascoigne, Nicholas
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Themis-associated phosphatase activity controls signaling in T cell development
Mehta, Monika, Brzostek, Joanna, W. Chen, Elijah, Tung, Desmond W. H., Chen, Shuting, Sankaran, Shvetha, Yap, Jiawei, Rybakin, Vasily, Gascoigne, Nicholas R. J.
Published in Proceedings of the National Academy of Sciences - PNAS (27.11.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (27.11.2018)
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Journal Article
Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model
Wu, Ling, Brzostek, Joanna, Sankaran, Shvetha, Wei, Qianru, Yap, Jiawei, Tan, Triscilla Y Y, Lai, Junyun, MacAry, Paul A, Gascoigne, Nicholas R J
Published in Cancers (18.02.2021)
Published in Cancers (18.02.2021)
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Journal Article
Lymphoepithelial carcinoma of the larynx: an extremely rare tumour in a patient of Chinese descent
Yap, Jiawei Alexander, Bundele, Manish M, Lim, Ming Yann, Goh, Julian Park Nam
Published in BMJ case reports (20.10.2021)
Published in BMJ case reports (20.10.2021)
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Journal Article
Hybrid structural modeling of alloantibody binding to human leukocyte antigen with rapid and reproducible cross-linking mass spectrometry
Ser, Zheng, Gu, Yue, Yap, Jiawei, Lim, Yan Ting, Wang, Shi Mei, Hamidinia, Maryam, Murali, Tanusya Murali, Kumar, Ragini, Gascoigne, Nicholas RJ, MacAry, Paul A., Sobota, Radoslaw M.
Published in Cell reports methods (25.09.2023)
Published in Cell reports methods (25.09.2023)
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Journal Article
CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance
Wu, Ling, Brzostek, Joanna, Sakthi Vale, Previtha Dawn, Wei, Qianru, Koh, Clara K.T., Ong, June Xu Hui, Wu, Liang-zhe, Tan, Jia Chi, Chua, Yen Leong, Yap, Jiawei, Song, Yuan, Tan, Vivian Jia Yi, Tan, Triscilla Y.Y., Lai, Junyun, MacAry, Paul A., Gascoigne, Nicholas R.J.
Published in Cell reports. Medicine (21.02.2023)
Published in Cell reports. Medicine (21.02.2023)
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Journal Article
Themis controls T cell activation, effector functions, and metabolism of peripheral CD8 + T cells
Gautam, Namrata, Wojciech, Lukasz, Yap, Jiawei, Chua, Yen Leong, Ding, Eyan MW, Sim, Don CN, Tan, Alrina SM, Ahl, Patricia J, Prasad, Mukul, Tung, Desmond WH, Connolly, John E, Adriani, Giulia, Brzostek, Joanna, Gascoigne, Nicholas RJ
Published in Life science alliance (01.12.2023)
Published in Life science alliance (01.12.2023)
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Journal Article
Design and validation of conditional ligands for HLA‐B08:01, HLA‐B15:01, HLA‐B35:01, and HLA‐B44:05
Frøsig, Thomas Mørch, Yap, Jiawei, Seremet, Tina, Lyngaa, Rikke, Svane, Inge Marie, Thor Straten, Per, Heemskerk, Mirjam H. M., Grotenbreg, Gijsbert M., Hadrup, Sine Reker
Published in Cytometry. Part A (01.10.2015)
Published in Cytometry. Part A (01.10.2015)
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Journal Article
Design and validation of conditional ligands for HLA‐B 08:01, HLA‐B 15:01, HLA‐B 35:01, and HLA‐B 44:05
Frøsig, Thomas Mørch, Yap, Jiawei, Seremet, Tina, Lyngaa, Rikke, Svane, Inge Marie, Thor Straten, Per, Heemskerk, Mirjam H. M., Grotenbreg, Gijsbert M., Hadrup, Sine Reker
Published in Cytometry. Part A (01.10.2015)
Published in Cytometry. Part A (01.10.2015)
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Journal Article
Bioorthogonal Cleavage and Exchange of Major Histocompatibility Complex Ligands by Employing Azobenzene-Containing Peptides
Choo, Joanna A. L., Thong, Sock Yue, Yap, Jiawei, van Esch, Wim J. E., Raida, Manfred, Meijers, Rob, Lescar, Julien, Verhelst, Steven H. L., Grotenbreg, Gijsbert M.
Published in Angewandte Chemie (01.12.2014)
Published in Angewandte Chemie (01.12.2014)
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Journal Article
Cleavage and exchange of major histocompatibility complex ligands employing azobenzene-containing peptides
Thong, Sock Yue, Choo, Ai Ling Joanna, Grotenbreg, Gijsbert Marnix, Verhelst, Steven Hendrik Leonard, Yap, Jiawei, Van Esch, Wilhelmus Johannes Elisabeth
Year of Publication 03.09.2019
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Year of Publication 03.09.2019
Patent
CLEAVAGE AND EXCHANGE OF MAJOR HISTOCOMPATIBILITY COMPLEX LIGANDS EMPLOYING AZOBENZENE-CONTAINING PEPTIDES
Grotenbreg Gijsbert Marnix, Van Esch Wilhelmus Johannes Elisabeth, Verhelst Steven Hendrik Leonard, Choo Ai Ling Joanna, Thong Sock Yue, Yap Jiawei
Year of Publication 13.04.2017
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Year of Publication 13.04.2017
Patent