Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors
Biswal, Bichitra K., Cherney, Maia M., Wang, Meitian, Chan, Laval, Yannopoulos, Constantin G., Bilimoria, Darius, Nicolas, Olivier, Bedard, Jean, James, Michael N.G.
Published in The Journal of biological chemistry (06.05.2005)
Published in The Journal of biological chemistry (06.05.2005)
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Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles
Court, John J, Poisson, Carl, Ardzinski, Andrzej, Bilimoria, Darius, Chan, Laval, Chandupatla, Kishan, Chauret, Nathalie, Collier, Philip N, Das, Sanjoy Kumar, Denis, Francois, Dorsch, Warren, Iyer, Ganesh, Lauffer, David, L’Heureux, Lucille, Li, Pan, Luisi, Brian S, Mani, Nagraj, Nanthakumar, Suganthi, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S, Tang, Qing, Waal, Nathan D, Yannopoulos, Constantin G, Green, Jeremy
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition
Wang, Meitian, Ng, Kenneth K-S, Cherney, Maia M, Chan, Laval, Yannopoulos, Constantin G, Bedard, Jean, Morin, Nicolas, Nguyen-Ba, Nghe, Alaoui-Ismaili, Moulay H, Bethell, Richard C, James, Michael N G
Published in The Journal of biological chemistry (14.03.2003)
Published in The Journal of biological chemistry (14.03.2003)
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Docking ligands into flexible and solvated macromolecules. 2. Development and application of fitted 1.5 to the virtual screening of potential HCV polymerase inhibitors
Corbeil, Christopher R, Englebienne, Pablo, Yannopoulos, Constantin G, Chan, Laval, Das, Sanjoy K, Bilimoria, Darius, L'heureux, Lucille, Moitessier, Nicolas
Published in Journal of chemical information and modeling (01.04.2008)
Published in Journal of chemical information and modeling (01.04.2008)
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Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition
Biswal, Bichitra K., Wang, Meitian, Cherney, Maia M., Chan, Laval, Yannopoulos, Constantin G., Bilimoria, Darius, Bedard, Jean, James, Michael N.G.
Published in Journal of molecular biology (04.08.2006)
Published in Journal of molecular biology (04.08.2006)
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Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency
Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Dietrich, Evelyne, Denis, Francois, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, Grey, Ronald, L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Govinda Rao, B., Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Yannopoulos, Constantin G., Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides
Chan, Laval, Pereira, Oswy, Reddy, T.Jagadeeswar, Das, Sanjoy K., Poisson, Carl, Courchesne, Marc, Proulx, Mélanie, Siddiqui, Arshad, Yannopoulos, Constantin G., Nguyen-Ba, Nghe, Roy, Caroline, Nasturica, Daniel, Moinet, Christophe, Bethell, Richard, Hamel, Martine, L'Heureux, Lucille, David, Maud, Nicolas, Olivier, Courtemanche-Asselin, Philippe, Brunette, Stéphanie, Bilimoria, Darius, Bédard, Jean
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
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Journal Article
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides
Chan, Laval, Das, Sanjoy K., Reddy, T.Jagadeeswar, Poisson, Carl, Proulx, Mélanie, Pereira, Oswy, Courchesne, Marc, Roy, Caroline, Wang, Wuyi, Siddiqui, Arshad, Yannopoulos, Constantin G., Nguyen-Ba, Nghe, Labrecque, Denis, Bethell, Richard, Hamel, Martine, Courtemanche-Asselin, Philippe, L'Heureux, Lucille, David, Maud, Nicolas, Olivier, Brunette, Stéphanie, Bilimoria, Darius, Bédard, Jean
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
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Journal Article
Identification of N,N-Disubstituted Phenylalanines as a Novel Class of Inhibitors of Hepatitis C NS5B Polymerase
Chan, Laval, Reddy, T. Jagadeeswar, Proulx, Mélanie, Das, Sanjoy K, Pereira, Oswy, Wang, Wuyi, Siddiqui, Arshad, Yannopoulos, Constantin G, Poisson, Carl, Turcotte, Nathalie, Drouin, Alexandre, Alaoui-Ismaili, M. Hicham, Bethell, Richard, Hamel, Martine, L'Heureux, Lucille, Bilimoria, Darius, Nguyen-Ba, Nghe
Published in Journal of medicinal chemistry (10.04.2003)
Published in Journal of medicinal chemistry (10.04.2003)
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Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors
Falardeau, Guy, Lachance, Hugo, St-Pierre, Annie, Yannopoulos, Constantin G., Drouin, Marc, Bédard, Jean, Chan, Laval
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
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Synthesis of Antisense Oligonucleotides Conjugated to a Multivalent Carbohydrate Cluster for Cellular Targeting
Maier, Martin A, Yannopoulos, Constantin G, Mohamed, Nazim, Roland, Arlene, Fritz, Hans, Mohan, V, Just, George, Manoharan, Muthiah
Published in Bioconjugate chemistry (01.01.2003)
Published in Bioconjugate chemistry (01.01.2003)
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Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase
Reddy, T.Jagadeeswar, Chan, Laval, Turcotte, Nathalie, Proulx, Melanie, Pereira, Oswy Z., Das, Sanjoy K., Siddiqui, Arshad, Wang, Wuyi, Poisson, Carl, Yannopoulos, Constantin G., Bilimoria, Darius, L'Heureux, Lucille, Alaoui, Hicham M.A., Nguyen-Ba, Nghe
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
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Journal Article
HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY
YANNOPOULOS, Constantin G, PING XU, PROULX, Melanie, HALAB, Lilianne, WUYI WANG, BEDARD, Jean, MORIN, Nicolas, HAMEL, Martine, NICOLAS, Olivier, BILIMORIA, Darius, L'HEUREUX, Lucille, BETHELL, Richard, FENG NI, DIONNE, Gervais, CHAN, Laval, PEREIRA, Oswy Z, JAGADEESWAR REDDY, T, DAS, Sanjoy K, POISSON, Carl, NGUYEN-BA, Nghe, TURCOTTE, Nathalie
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
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Journal Article
Non-nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase
Wang, Meitian, Ng, Kenneth K.-S., Cherney, Maia M., Chan, Laval, Yannopoulos, Constantin G., Bedard, Jean, Morin, Nicolas, Nguyen-Ba, Nghe, Alaoui-Ismaili, Moulay H., Bethell, Richard C., James, Michael N.G.
Published in The Journal of biological chemistry (14.03.2003)
Published in The Journal of biological chemistry (14.03.2003)
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Journal Article
Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of F itted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors
Corbeil, Christopher R., Englebienne, Pablo, Yannopoulos, Constantin G., Chan, Laval, Das, Sanjoy K., Bilimoria, Darius, L’Heureux, Lucille, Moitessier, Nicolas
Published in Journal of chemical information and modeling (01.04.2008)
Published in Journal of chemical information and modeling (01.04.2008)
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Journal Article
Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors
Falardeau, Guy, Lachance, Hugo, St-Pierre, Annie, Yannopoulos, Constantin G, Drouin, Marc, Bédard, Jean, Chan, Laval
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
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Published in Bioorganic & medicinal chemistry letters (15.03.2005)
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331 Thiophene-2-carboxylic acids: a series of novel HCV polymerase inhibitors
Zhang, Ming-Qiang, Chan, Laval, Das, Sanjoy K., Reddy, Thumkunta J., Pereira, Oswy Z., Poisson, Carl, Proulx, Mélanie, Halab, Liliane, Roy, Caroline, Yannopoulos, Constantin G., Nguyen-Ba, Nghe, Bethell, Richard, David, Maud, Bédard, Jean, Hamel, Martine, Bilimoria, Darius, Nicolas, Olivier, Morin, Nicolas, Courtemanche-Asselin, Philippe, Hamelin, Bettina, Dong, Kelly, Rioux, Nathalie, Richard, Annie
Published in Hepatology (Baltimore, Md.) (2003)
Published in Hepatology (Baltimore, Md.) (2003)
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Structural basis for the RNA binding selectivity of oligonucleotide analogues containing alkylsulfide internucleoside linkages and 2′-substituted 3′-deoxyribonucleosides
Damha, Masad J., Meng, Bin, Wang, Daguang, Yannopoulos, Constantin G., Just, George
Published in Nucleic acids research (11.10.1995)
Published in Nucleic acids research (11.10.1995)
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2',3'-cyclopropanated nucleoside dimers
Yannopoulos, CG, Zhou, WQ, Nower, P, Peoch, D, Sanghvi, YS, Just, G
Published in Synlett (01.04.1997)
Published in Synlett (01.04.1997)
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Thiophene analogues for the treatment or prevention of Flavivirus infections
KUMAR DAS, SANJOY, YANNOPOULOS, CONSTANTIN G, CHAN CHUN KONG, LAVAL, POISSON, CARL
Year of Publication 28.03.2013
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Year of Publication 28.03.2013
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