Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
Yu, Y Joy, Zhang, Yin, Kenrick, Margaret, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Atwal, Jasvinder, Elliott, J Michael, Prabhu, Saileta, Watts, Ryan J, Dennis, Mark S
Published in Science translational medicine (25.05.2011)
Published in Science translational medicine (25.05.2011)
Get more information
Journal Article
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
Bien-Ly, Nga, Yu, Y Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S, Weimer, Robby M, Chung, Inhee, Watts, Ryan J
Published in The Journal of experimental medicine (10.02.2014)
Published in The Journal of experimental medicine (10.02.2014)
Get full text
Journal Article
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
Jonsson, Thorlakur, Atwal, Jasvinder K., Steinberg, Stacy, Snaedal, Jon, Jonsson, Palmi V., Bjornsson, Sigurbjorn, Stefansson, Hreinn, Sulem, Patrick, Gudbjartsson, Daniel, Maloney, Janice, Hoyte, Kwame, Gustafson, Amy, Liu, Yichin, Lu, Yanmei, Bhangale, Tushar, Graham, Robert R., Huttenlocher, Johanna, Bjornsdottir, Gyda, Andreassen, Ole A., Jönsson, Erik G., Palotie, Aarno, Behrens, Timothy W., Magnusson, Olafur T., Kong, Augustine, Thorsteinsdottir, Unnur, Watts, Ryan J., Stefansson, Kari
Published in Nature (London) (02.08.2012)
Published in Nature (London) (02.08.2012)
Get full text
Journal Article
Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
Zuchero, Y. Joy Yu, Chen, Xiaocheng, Bien-Ly, Nga, Bumbaca, Daniela, Tong, Raymond K., Gao, Xiaoying, Zhang, Shuo, Hoyte, Kwame, Luk, Wilman, Huntley, Melanie A., Phu, Lilian, Tan, Christine, Kallop, Dara, Weimer, Robby M., Lu, Yanmei, Kirkpatrick, Donald S., Ernst, James A., Chih, Ben, Dennis, Mark S., Watts, Ryan J.
Published in Neuron (Cambridge, Mass.) (06.01.2016)
Published in Neuron (Cambridge, Mass.) (06.01.2016)
Get full text
Journal Article
Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies
Bien-Ly, Nga, Boswell, C. Andrew, Jeet, Surinder, Beach, Thomas G., Hoyte, Kwame, Luk, Wilman, Shihadeh, Vera, Ulufatu, Sheila, Foreman, Oded, Lu, Yanmei, DeVoss, Jason, van der Brug, Marcel, Watts, Ryan J.
Published in Neuron (Cambridge, Mass.) (21.10.2015)
Published in Neuron (Cambridge, Mass.) (21.10.2015)
Get full text
Journal Article
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Yu, Y Joy, Atwal, Jasvinder K, Zhang, Yin, Tong, Raymond K, Wildsmith, Kristin R, Tan, Christine, Bien-Ly, Nga, Hersom, Maria, Maloney, Janice A, Meilandt, William J, Bumbaca, Daniela, Gadkar, Kapil, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Ernst, James A, Scearce-Levie, Kimberly, Couch, Jessica A, Dennis, Mark S, Watts, Ryan J
Published in Science translational medicine (05.11.2014)
Published in Science translational medicine (05.11.2014)
Get more information
Journal Article
Superior In vivo Efficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer
JUNTTILA, Teemu T, PARSONS, Kathryn, TOTPAL, Klara, KELLEY, Robert F, SLIWKOWSKI, Mark X, OLSSON, Christine, YANMEI LU, YAN XIN, THERIAULT, Julie, CROCKER, Lisa, PABONAN, Oliver, BAGINSKI, Tomasz, MENG, Gloria
Published in Cancer research (Chicago, Ill.) (01.06.2010)
Published in Cancer research (Chicago, Ill.) (01.06.2010)
Get full text
Journal Article
Vagus nerve stimulation reduces ventricular arrhythmias and increases ventricular electrical stability
Nasi‐Er, Buajieer‐guli, Wenhui, Zhang, HuaXin, Sun, Xianhui, Zhou, Yaodong, Li, Yanmei, Lu, Hongli, Wang, TuEr‐Hong, ZuKe‐la, Qina, Zhou, BaoPeng, Tang
Published in Pacing and clinical electrophysiology (01.02.2019)
Published in Pacing and clinical electrophysiology (01.02.2019)
Get full text
Journal Article
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Junutula, Jagath R, Mallet, William, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S, Lu, Yanmei, Meng, Y Gloria, Ng, Carl, Yang, Jihong, Lee, Chien C, Duenas, Eileen, Gorrell, Jeffrey, Katta, Viswanatham, Kim, Amy, McDorman, Kevin, Flagella, Kelly, Venook, Rayna, Ross, Sarajane, Spencer, Susan D, Lee Wong, Wai, Lowman, Henry B, Vandlen, Richard, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul
Published in Nature biotechnology (01.08.2008)
Published in Nature biotechnology (01.08.2008)
Get full text
Journal Article
Reference values of brachial-ankle pulse wave velocity according to age and blood pressure in a central Asia population
Yiming, Gulinuer, Zhou, Xianhui, Lv, Wenkui, Peng, Yi, Zhang, Wenhui, Cheng, Xinchun, Li, Yaodong, Xing, Qiang, Zhang, Jianghua, Zhou, Qina, Zhang, Ling, Lu, Yanmei, Wang, Hongli, Tang, Baopeng
Published in PloS one (12.04.2017)
Published in PloS one (12.04.2017)
Get full text
Journal Article
Assessing the impact and safety of implantable cardioverter defibrillators in treating catecholaminergic polymorphic ventricular tachycardia: a systematic review and meta-analysis protocol
Dong, Zhenyu, Shang, Shuai, Mu, Yali, Yusup, Rukiya, Li, Yaodong, Zhou, Xianhui, Lu, Yanmei, Tang, Baopeng
Published in BMJ open (13.08.2024)
Published in BMJ open (13.08.2024)
Get full text
Journal Article
Postcardiac injury syndrome caused by radiofrequency catheter ablation of persistent atrial fibrillation: severe pulmonary arterial hypertension with severe tricuspid regurgitation: a rare case report and literature review
Shi, Jia, Shao, Mengjiao, Zhou, Xianhui, Lu, Yanmei, Tang, Baopeng
Published in BMC cardiovascular disorders (13.04.2023)
Published in BMC cardiovascular disorders (13.04.2023)
Get full text
Journal Article
Establishing a glutamine metabolism-based model for predicting the prognosis of low-grade glioma
Zhang, Mingshi, Li, Mingjun, Liu, Jinrui, Gu, Zhicheng, Lu, Yanmei, Long, Yu, Hou, Yuyi
Published in Frontiers in genetics (22.11.2022)
Published in Frontiers in genetics (22.11.2022)
Get full text
Journal Article
Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement
Lee, Seung-Hye, Le Pichon, Claire E., Adolfsson, Oskar, Gafner, Valérie, Pihlgren, Maria, Lin, Han, Solanoy, Hilda, Brendza, Robert, Ngu, Hai, Foreman, Oded, Chan, Ruby, Ernst, James A., DiCara, Danielle, Hotzel, Isidro, Srinivasan, Karpagam, Hansen, David V., Atwal, Jasvinder, Lu, Yanmei, Bumbaca, Daniela, Pfeifer, Andrea, Watts, Ryan J., Muhs, Andreas, Scearce-Levie, Kimberly, Ayalon, Gai
Published in Cell reports (Cambridge) (09.08.2016)
Published in Cell reports (Cambridge) (09.08.2016)
Get full text
Journal Article
Breakthrough infection evokes the nasopharyngeal innate immune responses established by SARS-CoV-2-inactivated vaccine
He, Xiaomeng, Cao, Yingyin, Lu, Yanmei, Qi, Furong, Wang, Haiyan, Liao, Xuejiao, Xu, Gang, Yang, Biao, Ma, Junhua, Li, Dapeng, Tang, Xian, Zhang, Zheng
Published in Frontiers in immunology (29.06.2023)
Published in Frontiers in immunology (29.06.2023)
Get full text
Journal Article
A case of endocardial dissection caused by Micra implantation
Zhang, Jianghua, Shang, Shuai, Dong, Zhenyu, Zhou, Xianhui, Li, Yaodong, Lu, Yanmei, Xing, Qiang, Tuerhong, Zukela, Guo, Yankai, Xiaokereti, Jiasuoer, Tang, Baopeng
Published in BMC cardiovascular disorders (02.01.2024)
Published in BMC cardiovascular disorders (02.01.2024)
Get full text
Journal Article
Desmosomal Junctions and Connexin-43 Remodeling in High-Pacing-Induced Heart Failure Dogs
Wang, Qing, Xiaoyan, Liang, Shang, Shuai, Fan, Yongqiang, Lv, Huasheng, Tang, Baopeng, Lu, Yanmei
Published in Anatolian journal of cardiology (01.08.2023)
Published in Anatolian journal of cardiology (01.08.2023)
Get full text
Journal Article
Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies
Lu, Yanmei, Elango, Chinnasamy, Purushothama, Shobha, Partridge, Michael A.
Published in Journal of Immunology Research (01.01.2016)
Published in Journal of Immunology Research (01.01.2016)
Get full text
Journal Article
A sensitive AAV transduction inhibition assay assists evaluation of critical factors for detection and concordance of pre-existing antibodies
Pan, Yonghua, Rohde, Michelle, Zeitler, Jennifer, Namburi, Sai Valli Srujana, Cao, Liching, Hu, Jing, Meyer, Kathleen, Lu, Yanmei
Published in Molecular therapy. Methods & clinical development (14.12.2023)
Published in Molecular therapy. Methods & clinical development (14.12.2023)
Get full text
Journal Article