Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes
Victor, Matheus B., Richner, Michelle, Olsen, Hannah E., Lee, Seong Won, Monteys, Alejandro M., Ma, Chunyu, Huh, Christine J., Zhang, Bo, Davidson, Beverly L., Yang, X. William, Yoo, Andrew S.
Published in Nature neuroscience (01.03.2018)
Published in Nature neuroscience (01.03.2018)
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Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain
Shirasaki, Dyna I., Greiner, Erin R., Al-Ramahi, Ismael, Gray, Michelle, Boontheung, Pinmanee, Geschwind, Daniel H., Botas, Juan, Coppola, Giovanni, Horvath, Steve, Loo, Joseph A., Yang, X. William
Published in Neuron (Cambridge, Mass.) (12.07.2012)
Published in Neuron (Cambridge, Mass.) (12.07.2012)
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Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway
Haustein, Martin D., Kracun, Sebastian, Lu, Xiao-Hong, Shih, Tiffany, Jackson-Weaver, Olan, Tong, Xiaoping, Xu, Ji, Yang, X. William, O’Dell, Thomas J., Marvin, Jonathan S., Ellisman, Mark H., Bushong, Eric A., Looger, Loren L., Khakh, Baljit S.
Published in Neuron (Cambridge, Mass.) (16.04.2014)
Published in Neuron (Cambridge, Mass.) (16.04.2014)
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Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control
Yau, Richard G., Doerner, Kerstin, Castellanos, Erick R., Haakonsen, Diane L., Werner, Achim, Wang, Nan, Yang, X. William, Martinez-Martin, Nadia, Matsumoto, Marissa L., Dixit, Vishva M., Rape, Michael
Published in Cell (02.11.2017)
Published in Cell (02.11.2017)
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DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
Lu, Ake T., Narayan, Pritika, Grant, Matthew J., Langfelder, Peter, Wang, Nan, Kwak, Seung, Wilkinson, Hilary, Chen, Richard Z., Chen, Jian, Simon Bawden, C., Rudiger, Skye R., Ciosi, Marc, Chatzi, Afroditi, Maxwell, Alastair, Hore, Timothy A., Aaronson, Jeff, Rosinski, Jim, Preiss, Alicia, Vogt, Thomas F., Coppola, Giovanni, Monckton, Darren, Snell, Russell G., William Yang, X., Horvath, Steve
Published in Nature communications (10.09.2020)
Published in Nature communications (10.09.2020)
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Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models
Lee, C.Y. Daniel, Daggett, Anthony, Gu, Xiaofeng, Jiang, Lu-Lin, Langfelder, Peter, Li, Xiaoguang, Wang, Nan, Zhao, Yingjun, Park, Chang Sin, Cooper, Yonatan, Ferando, Isabella, Mody, Istvan, Coppola, Giovanni, Xu, Huaxi, Yang, X. William
Published in Neuron (Cambridge, Mass.) (07.03.2018)
Published in Neuron (Cambridge, Mass.) (07.03.2018)
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Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
Langfelder, Peter, Cantle, Jeffrey P, Chatzopoulou, Doxa, Wang, Nan, Gao, Fuying, Al-Ramahi, Ismael, Lu, Xiao-Hong, Ramos, Eliana Marisa, El-Zein, Karla, Zhao, Yining, Deverasetty, Sandeep, Tebbe, Andreas, Schaab, Christoph, Lavery, Daniel J, Howland, David, Kwak, Seung, Botas, Juan, Aaronson, Jeffrey S, Rosinski, Jim, Coppola, Giovanni, Horvath, Steve, Yang, X William
Published in Nature neuroscience (01.04.2016)
Published in Nature neuroscience (01.04.2016)
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Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease
Wang, Nan, Gray, Michelle, Lu, Xiao-Hong, Cantle, Jeffrey P, Holley, Sandra M, Greiner, Erin, Gu, Xiaofeng, Shirasaki, Dyna, Cepeda, Carlos, Li, Yuqing, Dong, Hongwei, Levine, Michael S, Yang, X William
Published in Nature medicine (01.05.2014)
Published in Nature medicine (01.05.2014)
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Precise segmentation of densely interweaving neuron clusters using G-Cut
Li, Rui, Zhu, Muye, Li, Junning, Bienkowski, Michael S., Foster, Nicholas N., Xu, Hanpeng, Ard, Tyler, Bowman, Ian, Zhou, Changle, Veldman, Matthew B., Yang, X. William, Hintiryan, Houri, Zhang, Junsong, Dong, Hong-Wei
Published in Nature communications (04.04.2019)
Published in Nature communications (04.04.2019)
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Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
Horvath, Steve, Langfelder, Peter, Kwak, Seung, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F, Eszes, Marika, Faull, Richard L M, Curtis, Maurice A, Waldvogel, Henry J, Choi, Oi-Wa, Tung, Spencer, Vinters, Harry V, Coppola, Giovanni, Yang, X William
Published in Aging (Albany, NY.) (01.07.2016)
Published in Aging (Albany, NY.) (01.07.2016)
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Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
Gu, Xiaofeng, Greiner, Erin R., Mishra, Rakesh, Kodali, Ravindra, Osmand, Alex, Finkbeiner, Steven, Steffan, Joan S., Thompson, Leslie Michels, Wetzel, Ronald, Yang, X. William
Published in Neuron (Cambridge, Mass.) (24.12.2009)
Published in Neuron (Cambridge, Mass.) (24.12.2009)
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An Antisense CAG Repeat Transcript at JPH3 Locus Mediates Expanded Polyglutamine Protein Toxicity in Huntington's Disease-like 2 Mice
Wilburn, Brian, Rudnicki, Dobrila D., Zhao, Jing, Weitz, Tara Murphy, Cheng, Yin, Gu, Xiaofeng, Greiner, Erin, Park, Chang Sin, Wang, Nan, Sopher, Bryce L., La Spada, Albert R., Osmand, Alex, Margolis, Russell L., Sun, Yi E., Yang, X. William
Published in Neuron (Cambridge, Mass.) (12.05.2011)
Published in Neuron (Cambridge, Mass.) (12.05.2011)
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MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice
Langfelder, Peter, Gao, Fuying, Wang, Nan, Howland, David, Kwak, Seung, Vogt, Thomas F, Aaronson, Jeffrey S, Rosinski, Jim, Coppola, Giovanni, Horvath, Steve, Yang, X William
Published in PloS one (11.01.2018)
Published in PloS one (11.01.2018)
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N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice
Gu, Xiaofeng, Cantle, Jeffrey P., Greiner, Erin R., Lee, C.Y. Daniel, Barth, Albert M., Gao, Fuying, Park, Chang Sin, Zhang, Zhiqiang, Sandoval-Miller, Susana, Zhang, Richard L., Diamond, Marc, Mody, Istvan, Coppola, Giovanni, Yang, X. William
Published in Neuron (Cambridge, Mass.) (18.02.2015)
Published in Neuron (Cambridge, Mass.) (18.02.2015)
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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
Jiang, Mali, Wang, Jiawei, Fu, Jinrong, Du, Lin, Jeong, Hyunkyung, West, Tim, Xiang, Lan, Peng, Qi, Hou, Zhipeng, Cai, Huan, Seredenina, Tamara, Arbez, Nicolas, Zhu, Shanshan, Sommers, Katherine, Qian, Jennifer, Zhang, Jiangyang, Mori, Susumu, Yang, X William, Tamashiro, Kellie L K, Aja, Susan, Moran, Timothy H, Luthi-Carter, Ruth, Martin, Bronwen, Maudsley, Stuart, Mattson, Mark P, Cichewicz, Robert H, Ross, Christopher A, Holtzman, David M, Krainc, Dimitri, Duan, Wenzhen
Published in Nature medicine (01.01.2012)
Published in Nature medicine (01.01.2012)
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Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease
Chandra, Abhishek, Sharma, Abhijeet, Calingasan, Noel Y, White, Joshua M, Shurubor, Yevgeniya, Yang, X William, Beal, M Flint, Johri, Ashu
Published in Human molecular genetics (01.06.2016)
Published in Human molecular genetics (01.06.2016)
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PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease
Morozko, Eva L., Smith-Geater, Charlene, Monteys, Alejandro Mas, Pradhan, Subrata, Lim, Ryan G., Langfelder, Peter, Kachemov, Marketta, Hill, Austin, Stocksdale, Jennifer T., Cullis, Pieter R., Wu, Jie, Ochaba, Joseph, Miramontes, Ricardo, Chakraborty, Anirban, Hazra, Tapas K., Lau, Alice, St-cyr, Sophie, Orellana, Iliana, Kopan, Lexi, Wang, Keona Q., Yeung, Sylvia, Leavitt, Blair R., Reidling, Jack C., Yang, X. William, Steffan, Joan S., Davidson, Beverly L., Sarkar, Partha S., Thompson, Leslie M.
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2021)
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Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
Cui, Yijun, Ostlund, Sean B, James, Alex S, Park, Chang Sin, Ge, Weihong, Roberts, Kristofer W, Mittal, Nitish, Murphy, Niall P, Cepeda, Carlos, Kieffer, Brigitte L, Levine, Michael S, Jentsch, James David, Walwyn, Wendy M, Sun, Yi E, Evans, Christopher J, Maidment, Nigel T, Yang, X William
Published in Nature neuroscience (01.02.2014)
Published in Nature neuroscience (01.02.2014)
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Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration
Tao, Jifang, Wu, Hao, Lin, Quan, Wei, Weizheng, Lu, Xiao-Hong, Cantle, Jeffrey P, Ao, Yan, Olsen, Richard W, Yang, X William, Mody, Istvan, Sofroniew, Michael V, Sun, Yi E
Published in The Journal of neuroscience (01.06.2011)
Published in The Journal of neuroscience (01.06.2011)
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