Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease
Smyth, Deborah J, Plagnol, Vincent, Walker, Neil M, Cooper, Jason D, Downes, Kate, Yang, Jennie H.M, Howson, Joanna M.M, Stevens, Helen, McManus, Ross, Wijmenga, Cisca, Heap, Graham A, Dubois, Patrick C, Clayton, David G, Hunt, Karen A, van Heel, David A, Todd, John A
Published in The New England journal of medicine (25.12.2008)
Published in The New England journal of medicine (25.12.2008)
Get full text
Journal Article
Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes
Zhang, Jia-Yuan, Hamey, Fiona, Trzupek, Dominik, Mickunas, Marius, Lee, Mercede, Godfrey, Leila, Yang, Jennie H. M., Pekalski, Marcin L., Kennet, Jane, Waldron-Lynch, Frank, Evans, Mark L., Tree, Timothy I. M., Wicker, Linda S., Todd, John A., Ferreira, Ricardo C.
Published in Nature communications (28.11.2022)
Published in Nature communications (28.11.2022)
Get full text
Journal Article
Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes
Yang, Jennie H M, Cutler, Antony J, Ferreira, Ricardo C, Reading, James L, Cooper, Nicholas J, Wallace, Chris, Clarke, Pamela, Smyth, Deborah J, Boyce, Christopher S, Gao, Guo-Jian, Todd, John A, Wicker, Linda S, Tree, Timothy I M
Published in Diabetes (New York, N.Y.) (01.11.2015)
Published in Diabetes (New York, N.Y.) (01.11.2015)
Get full text
Journal Article
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial
Tatovic, Danijela, Marwaha, Ashish, Taylor, Peter, Hanna, Stephanie J., Carter, Kym, Cheung, W. Y., Luzio, Steve, Dunseath, Gareth, Hutchings, Hayley A., Holland, Gail, Hiles, Steve, Fegan, Greg, Williams, Evangelia, Yang, Jennie H. M., Domingo-Vila, Clara, Pollock, Emily, Wadud, Muntaha, Ward-Hartstonge, Kirsten, Marques-Jones, Susie, Bowen-Morris, Jane, Stenson, Rachel, Levings, Megan K., Gregory, John W., Tree, Timothy I. M., Dayan, Colin
Published in Nature medicine (01.09.2024)
Published in Nature medicine (01.09.2024)
Get full text
Journal Article
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
Wicker, Linda S, Dendrou, Calliope A, Plagnol, Vincent, Fung, Erik, Yang, Jennie H M, Downes, Kate, Cooper, Jason D, Nutland, Sarah, Coleman, Gillian, Himsworth, Matthew, Hardy, Matthew, Burren, Oliver, Healy, Barry, Walker, Neil M, Koch, Kerstin, Ouwehand, Willem H, Bradley, John R, Wareham, Nicholas J, Todd, John A
Published in Nature genetics (01.09.2009)
Published in Nature genetics (01.09.2009)
Get full text
Journal Article
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes
WALLACE, Chris, ROTIVAL, Maxime, TODD, John A, CLAYTON, David G, BLANKENBERG, Stefan, COOPER, Jason D, RICE, Catherine M, YANG, Jennie H. M, MCNEILL, Mhairi, SMYTH, Deborah J, NIBLETT, David, CAMBIEN, François, TIRET, Laurence
Published in Human molecular genetics (15.06.2012)
Published in Human molecular genetics (15.06.2012)
Get full text
Journal Article
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing
Heap, Graham A., Yang, Jennie H.M., Downes, Kate, Healy, Barry C., Hunt, Karen A., Bockett, Nicholas, Franke, Lude, Dubois, Patrick C., Mein, Charles A., Dobson, Richard J., Albert, Thomas J., Rodesch, Matthew J., Clayton, David G., Todd, John A., van Heel, David A., Plagnol, Vincent
Published in Human molecular genetics (01.01.2010)
Published in Human molecular genetics (01.01.2010)
Get full text
Journal Article
Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes
Liu, Yuk-Fun, Powrie, Jake, Arif, Sefina, Yang, Jennie H M, Williams, Evangelia, Khatri, Leena, Joshi, Mamta, Lhuillier, Loic, Fountoulakis, Nikolaos, Smith, Emma, Beam, Craig, Lorenc, Anna, Peakman, Mark, Tree, Timothy
Published in Diabetes (New York, N.Y.) (01.04.2022)
Published in Diabetes (New York, N.Y.) (01.04.2022)
Get full text
Journal Article
Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes
BAILEY, Rebecca, COOPER, Jason D, NEJENTSEV, Sergey, TODD, John A, ZEITELS, Lauren, SMYTH, Deborah J, YANG, Jennie H. M, WALKER, Neil M, HYPPÖNEN, Elina, DUNGER, David B, RAMOS-LOPEZ, Elizabeth, BADENHOOP, Klaus
Published in Diabetes (New York, N.Y.) (01.10.2007)
Published in Diabetes (New York, N.Y.) (01.10.2007)
Get full text
Journal Article
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function
Garg, Garima, Tyler, Jennifer R, Yang, Jennie H M, Cutler, Antony J, Downes, Kate, Pekalski, Marcin, Bell, Gwynneth L, Nutland, Sarah, Peakman, Mark, Todd, John A, Wicker, Linda S, Tree, Timothy I M
Published in The Journal of immunology (1950) (01.05.2012)
Published in The Journal of immunology (1950) (01.05.2012)
Get full text
Journal Article
Clinical-grade multipotent adult progenitor cells durably control pathogenic T cell responses in human models of transplantation and autoimmunity
Reading, James L, Yang, Jennie H M, Sabbah, Shereen, Skowera, Ania, Knight, Robin R, Pinxteren, Jef, Vaes, Bart, Allsopp, Timothy, Ting, Anthony E, Busch, Sarah, Raber, Amy, Deans, Robert, Tree, Timothy I M
Published in The Journal of immunology (1950) (01.05.2013)
Published in The Journal of immunology (1950) (01.05.2013)
Get full text
Journal Article
Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans
Hanna, Stephanie J, Thayer, Terri C, Robinson, Emma J S, Vinh, Ngoc-Nga, Williams, Nigel, Landry, Laurie G, Andrews, Robert, Siah, Qi Zhuang, Leete, Pia, Wyatt, Rebecca, McAteer, Martina A, Nakayama, Maki, Wong, F Susan, Yang, Jennie H M, Tree, Timothy I M, Ludvigsson, Johnny, Dayan, Colin M, Tatovic, Danijela
Published in Frontiers in immunology (2023)
Published in Frontiers in immunology (2023)
Get full text
Journal Article
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression
Ferreira, Ricardo C., Castro Dopico, Xaquin, Oliveira, João J., Rainbow, Daniel B., Yang, Jennie H., Trzupek, Dominik, Todd, Sarah A., McNeill, Mhairi, Steri, Maristella, Orrù, Valeria, Fiorillo, Edoardo, Crouch, Daniel J. M., Pekalski, Marcin L., Cucca, Francesco, Tree, Tim I., Vyse, Tim J., Wicker, Linda S., Todd, John A.
Published in Frontiers in immunology (08.11.2019)
Published in Frontiers in immunology (08.11.2019)
Get full text
Journal Article
Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry
Yang, Jennie H M, Khatri, Leena, Mickunas, Marius, Williams, Evangelia, Tatovic, Danijela, Alhadj Ali, Mohammad, Young, Philippa, Moyle, Penelope, Sahni, Vishal, Wang, Ryan, Kaur, Rejbinder, Tannahill, Gillian M, Beaton, Andrew R, Gerlag, Danielle M, Savage, Caroline O S, Napolitano Rosen, Antonella, Waldron-Lynch, Frank, Dayan, Colin M, Tree, Timothy I M
Published in Frontiers in immunology (31.10.2019)
Published in Frontiers in immunology (31.10.2019)
Get full text
Journal Article
IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors
Whitehouse, Gavin, Gray, Elizabeth, Mastoridis, Sotiris, Merritt, Elliot, Kodela, Elisavet, Yang, Jennie H. M., Danger, Richard, Mairal, Marta, Christakoudi, Sofia, Lozano, Juan J., Macdougall, Iain C., Tree, Timothy I. M., Sanchez-Fueyo, Alberto, Martinez-Llordella, Marc
Published in Proceedings of the National Academy of Sciences - PNAS (03.07.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (03.07.2017)
Get full text
Journal Article
Evidence of association with type 1 diabetes in the SLC11A1 gene region
Yang, Jennie H M, Downes, Kate, Howson, Joanna M M, Nutland, Sarah, Stevens, Helen E, Walker, Neil M, Todd, John A
Published in BMC genetics (27.04.2011)
Published in BMC genetics (27.04.2011)
Get full text
Journal Article
Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes
Alhadj Ali, Mohammad, Liu, Yuk-Fun, Arif, Sefina, Tatovic, Danijela, Shariff, Hina, Gibson, Vivienne B, Yusuf, Norkhairin, Baptista, Roman, Eichmann, Martin, Petrov, Nedyalko, Heck, Susanne, Yang, Jennie H M, Tree, Timothy I M, Pujol-Autonell, Irma, Yeo, Lorraine, Baumard, Lucas, Stenson, Rachel, Howell, Alex, Clark, Alison, Boult, Zoe, Powrie, Jake, Adams, Laura, Wong, Florence S, Luzio, Stephen, Dunseath, Gareth, Green, Kate, O'Keefe, Alison, Bayly, Graham, Thorogood, Natasha, Andrews, Robert, Leech, Nicola, Joseph, Frank, Nair, Sunil, Seal, Susan, Cheung, HoYee, Beam, Craig, Hills, Robert, Peakman, Mark, Dayan, Colin M
Published in Science translational medicine (09.08.2017)
Published in Science translational medicine (09.08.2017)
Get more information
Journal Article
Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial
Todd, John A, Evangelou, Marina, Cutler, Antony J, Pekalski, Marcin L, Walker, Neil M, Stevens, Helen E, Porter, Linsey, Smyth, Deborah J, Rainbow, Daniel B, Ferreira, Ricardo C, Esposito, Laura, Hunter, Kara M D, Loudon, Kevin, Irons, Kathryn, Yang, Jennie H, Bell, Charles J M, Schuilenburg, Helen, Heywood, James, Challis, Ben, Neupane, Sankalpa, Clarke, Pamela, Coleman, Gillian, Dawson, Sarah, Goymer, Donna, Anselmiova, Katerina, Kennet, Jane, Brown, Judy, Caddy, Sarah L, Lu, Jia, Greatorex, Jane, Goodfellow, Ian, Wallace, Chris, Tree, Tim I, Evans, Mark, Mander, Adrian P, Bond, Simon, Wicker, Linda S, Waldron-Lynch, Frank
Published in PLoS medicine (11.10.2016)
Published in PLoS medicine (11.10.2016)
Get full text
Journal Article
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
Todd, John A, Walker, Neil M, Cooper, Jason D, Smyth, Deborah J, Downes, Kate, Plagnol, Vincent, Bailey, Rebecca, Nejentsev, Sergey, Field, Sarah F, Payne, Felicity, Lowe, Christopher E, Szeszko, Jeffrey S, Hafler, Jason P, Zeitels, Lauren, Yang, Jennie H M, Vella, Adrian, Nutland, Sarah, Stevens, Helen E, Schuilenburg, Helen, Coleman, Gillian, Maisuria, Meeta, Meadows, William, Smink, Luc J, Healy, Barry, Burren, Oliver S, Lam, Alex A C, Ovington, Nigel R, Allen, James, Adlem, Ellen, Leung, Hin-Tak, Wallace, Chris, Howson, Joanna M M, Guja, Cristian, Ionescu-Tîrgovi te, Constantin, Simmonds, Matthew J, Heward, Joanne M, Gough, Stephen C L, Dunger, David B, Wicker, Linda S, Clayton, David G
Published in Nature genetics (01.07.2007)
Published in Nature genetics (01.07.2007)
Get full text
Journal Article
Guidelines for standardizing T‐cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes
Yang, Jennie H. M., Ward‐Hartstonge, Kirsten A., Perry, Daniel J., Blanchfield, J. Lori, Posgai, Amanda L., Wiedeman, Alice E., Diggins, Kirsten, Rahman, Adeeb, Tree, Timothy I. M., Brusko, Todd M., Levings, Megan K., James, Eddie A., Kent, Sally C., Speake, Cate, Homann, Dirk, Long, S. Alice
Published in European journal of immunology (01.03.2022)
Published in European journal of immunology (01.03.2022)
Get full text
Journal Article