Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir
Jiang, Xiangrui, Su, Haixia, Shang, Weijuan, Zhou, Feng, Zhang, Yan, Zhao, Wenfeng, Zhang, Qiumeng, Xie, Hang, Jiang, Lei, Nie, Tianqing, Yang, Feipu, Xiong, Muya, Huang, Xiaoxing, Li, Minjun, Chen, Ping, Peng, Shaoping, Xiao, Gengfu, Jiang, Hualiang, Tang, Renhong, Zhang, Leike, Shen, Jingshan, Xu, Yechun
Published in Nature communications (13.10.2023)
Published in Nature communications (13.10.2023)
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SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
Xia, Bingqing, Shen, Xurui, He, Yang, Pan, Xiaoyan, Liu, Feng-Liang, Wang, Yi, Yang, Feipu, Fang, Sui, Wu, Yan, Duan, Zilei, Zuo, Xiaoli, Xie, Zhuqing, Jiang, Xiangrui, Xu, Ling, Chi, Hao, Li, Shuangqu, Meng, Qian, Zhou, Hu, Zhou, Yubo, Cheng, Xi, Xin, Xiaoming, Jin, Lin, Zhang, Hai-Lin, Yu, Dan-Dan, Li, Ming-Hua, Feng, Xiao-Li, Chen, Jiekai, Jiang, Hualiang, Xiao, Gengfu, Zheng, Yong-Tang, Zhang, Lei-Ke, Shen, Jingshan, Li, Jia, Gao, Zhaobing
Published in Cell research (01.08.2021)
Published in Cell research (01.08.2021)
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Impurity study of tecovirimat
Bonku, Emmanuel Mintah, Qin, Hongjian, Odilov, Abdullajon, Abduahadi, Safomuddin, Desta Guma, Samuel, Yang, Feipu, Xing, Xinglong, Wang, Xukun, Shen, Jingshan
Published in Heliyon (15.05.2024)
Published in Heliyon (15.05.2024)
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Efficient Large-Scale Process for Tecovirimat via Reactive Distillation for the Preparation of Cycloheptatriene
Bonku, Emmanuel Mintah, Qin, Hongjian, Odilov, Abdullajon, Yang, Feipu, Xing, Xinglong, Wang, Xukun, Guma, Samuel Desta, Shen, Jingshan
Published in Organic process research & development (17.11.2023)
Published in Organic process research & development (17.11.2023)
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Design, synthesis, and evaluation of novel oxyacanthine derivatives for anti-SARS-CoV-2 activity
Lu, Jie, Cheng, Yan, Zhang, Yumin, Wang, Yi, Xia, Bingqing, Zhang, Leike, Odilov, Abdullajon, He, Yang, Jiang, Xiangrui, Yang, Feipu, Shen, Jingshan
Published in Bioorganic & medicinal chemistry letters (15.11.2024)
Published in Bioorganic & medicinal chemistry letters (15.11.2024)
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Synthesis and biological evaluation of multimodal monoaminergic arylpiperazine derivatives with potential antidepressant profile
Zheng, Jiefang, Zhou, Liping, Gong, Xudong, Yang, Feipu, Cheng, Jiaxin, Ma, Rui, Wu, Chunhui, Xu, Zhijian, Zhu, Weiliang, He, Yang, Shen, Jingshan
Published in European journal of medicinal chemistry (05.09.2024)
Published in European journal of medicinal chemistry (05.09.2024)
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Facile and Cost-Effective Route for the Synthesis of Simmerafil
Odilov, Abdullajon, Liu, Yin, Hu, Tianwen, Jiang, Xiangrui, Suo, Jin, Tian, Guanghui, Yang, Feipu, Shen, Jingshan
Published in Organic process research & development (19.11.2021)
Published in Organic process research & development (19.11.2021)
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Automated design and optimization of multitarget schizophrenia drug candidates by deep learning
Tan, Xiaoqin, Jiang, Xiangrui, He, Yang, Zhong, Feisheng, Li, Xutong, Xiong, Zhaoping, Li, Zhaojun, Liu, Xiaohong, Cui, Chen, Zhao, Qingjie, Xie, Yuanchao, Yang, Feipu, Wu, Chunhui, Shen, Jingshan, Zheng, Mingyue, Wang, Zhen, Jiang, Hualiang
Published in European journal of medicinal chemistry (15.10.2020)
Published in European journal of medicinal chemistry (15.10.2020)
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Discovery of peptidomimetic spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV -2
Guma, Samuel Desta, Zhou, Zhaoyin, Song, Kang, Yang, Feipu, Suo, Jin, Zhang, Yan, Bonku, Emmanuel Mintah, Odilov, Abdullajon, Tian, Guanghui, Xu, Zhijian, Jiang, Xiangrui, Zhang, Qiumeng, Zhu, Weiliang, Shen, Jingshan
Published in European journal of medicinal chemistry (05.01.2025)
Published in European journal of medicinal chemistry (05.01.2025)
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Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics
Shi, Wenqiang, Wang, Yu, Wu, Chunhui, Yang, Feipu, Zheng, Wei, Wu, Song, Liu, Yongjian, Wang, Zhen, He, Yang, Shen, Jingshan
Published in Bioorganic & medicinal chemistry letters (15.04.2020)
Published in Bioorganic & medicinal chemistry letters (15.04.2020)
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TPN672: A Novel Serotonin-Dopamine Receptor Modulator for the Treatment of Schizophrenia
Wang, Yu, He, Yang, Yang, Feipu, Abame, Melkamu Alemu, Wu, Chunhui, Peng, Yanmin, Feng, Linyin, Shen, Jingshan, Wang, Zhen, He, Ling
Published in The Journal of pharmacology and experimental therapeutics (01.07.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2021)
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Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids
Zhao, Chengcheng, Jiang, Xiangrui, Peng, Liyuan, Zhang, Yan, Li, Huihui, Zhang, Qiumeng, Wang, Yinhui, Yang, Feipu, Wu, Junfang, Wen, Zheng, He, Zuowen, Shen, Jingshan, Chen, Chen, Wang, Dao Wen
Published in Journal of molecular and cellular cardiology (01.12.2023)
Published in Journal of molecular and cellular cardiology (01.12.2023)
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Synthesis and Biological Evaluation of Five‐Atom‐Linker‐Based Arylpiperazine Derivatives with an Atypical Antipsychotic Profile
Wu, Chunhui, Wang, Yu, Yang, Feipu, Shi, Wenqiang, Wang, Zhen, He, Ling, He, Yang, Shen, Jingshan
Published in ChemMedChem (17.12.2019)
Published in ChemMedChem (17.12.2019)
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Improved and ligand-free copper-catalyzed cyclization for an efficient synthesis of benzimidazoles from o -bromoarylamine and nitriles
Bonku, Emmanuel Mintah, Qin, Hongjian, Odilov, Abdullajon, Abduahadi, Safomuddin, Guma, Samuel Desta, Yang, Feipu, Zhu, Fuqiang, Aisa, Haji A, Shen, Jingshan
Published in RSC advances (21.02.2024)
Published in RSC advances (21.02.2024)
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Oxidative Aromatization of 3,4-Dihydroquinolin-2(1H)‑ones to Quinolin-2(1H)‑ones Using Transition-Metal-Activated Persulfate Salts
Chen, Weiming, Sun, Changliang, Zhang, Yan, Hu, Tianwen, Zhu, Fuqiang, Jiang, Xiangrui, Abame, Melkamu Alemu, Yang, Feipu, Suo, Jin, Shi, Jing, Shen, Jingshan, Aisa, Haji A
Published in Journal of organic chemistry (05.07.2019)
Published in Journal of organic chemistry (05.07.2019)
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A Facile Route of Synthesis for Making Flibanserin
Yang, Feipu, Wu, Chunhui, Li, Zhiqiang, Tian, Guanghui, Wu, Jianzhong, Zhu, Fuqiang, Zhang, Jian, He, Yang, Shen, Jingshan
Published in Organic process research & development (16.09.2016)
Published in Organic process research & development (16.09.2016)
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Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect
Xu, Mingshuo, Wang, Yu, Yang, Feipu, Wu, Chunhui, Wang, Zhen, Ye, Bin, Jiang, Xiangrui, Zhao, Qingjie, Li, Jianfeng, Liu, Yongjian, Zhang, Junchi, Tian, Guanghui, He, Yang, Shen, Jingshan, Jiang, Hualiang
Published in European journal of medicinal chemistry (10.02.2018)
Published in European journal of medicinal chemistry (10.02.2018)
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Improved and ligand-free copper-catalyzed cyclization for an efficient synthesis of benzimidazoles from -bromoarylamine and nitriles
Bonku, Emmanuel Mintah, Qin, Hongjian, Odilov, Abdullajon, Abduahadi, Safomuddin, Guma, Samuel Desta, Yang, Feipu, Zhu, Fuqiang, Aisa, Haji A, Shen, Jingshan
Published in RSC advances (26.02.2024)
Published in RSC advances (26.02.2024)
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