The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells
Tcheng, Matthew, Schimmer, Aaron D., Gronda, Marcela, Hurren, Rose, Khan, Shahbaz, Zhang, Lan Xin, Sarathy, Chaitra, Yan, Yongran, Arruda, Andrea, Kislinger, Thomas, Minden, Mark D.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
The Exportin, XPO2, Is a Novel Therapeutic Target in Pediatric, Adolescent and Young Adult AML
Egan, Grace, Hurren, Rose, Sarathy, Chaitra, Thomas, Geethu Emily, Khan, Dilshad H., Yan, Yongran, Feng, Yue, Brown, Brandon, Kornblau, Steven M., Schimmer, Aaron D.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
Serine Phosphorylation Marks Proteins for Degradation By the Mitochondrial Serine Protease Complex, Clpxp
Feng, Yue, Jitkova, Yulia, Keszei, Alexander, Sarathy, Chaitra, Trudel, Vincent, St-Germain, Jonathan, Tcheng, Matthew, Goncalves, Monica M, Yan, Yongran, Hurren, Rose, Schultz, Matthew, Vahidi, Siavash, Raught, Brian, Yudin, Andrei, Mazhab-Jafari, Mohammad, Schimmer, Aaron D.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
XPO2 Is Essential for a Subset of AML Cells and Is a Biomarker for Poor Response and Survival in Pediatric and AYA AML
Egan, Grace, Thomas, Geethu Emily, Hurren, Rose, Bansal, Suraj, Zeng, Andy G.X., Sarathy, Chaitra, Khan, Dilshad H., Yan, Yongran, Feng, Yue, St-Germain, Jonathan, Raught, Brian, Dick, John E., Schimmer, Aaron D.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing
Thomas, Geethu Emily, Nouri, Kazem, Lee, Jong Bok, Hurren, Rose, Yan, Yongran, Maclean, Neil, Jitkova, Yulia, Ma, Li, Wang, Xiaoming, Sarathy, Chaitra, Arruda, Andrea, Minden, Mark D., Zhang, Li, Spadavecchio, Vito, Schimmer, Aaron D.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
Inhibiting the Mitochondrial RNA Degradosome Complex SUV3 and Pnpase Increases dsRNA in the Cytoplasm, Triggers a Viral Mimicry Response and Kills AML Cells and Progenitors
Thomas, Geethu Emily, Nouri, Kazem, Hurren, Rose, Yan, Yongran, MacLean, Neil, Jitkova, Yulia, Ma, Li, Wang, Xiaoming, Sarathy, Chaitra, Arruda, Andrea, Minden, Mark D., Spadevecchio, Vito, Schimmer, Aaron D.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability
Duong, Nathan, Khan, Dilshad H., Thomas, Geethu Emily, Hurren, Rose, Lee, Jong Bok, St-Germain, Jonathan, Drimmer, Lily, Yan, Yongran, Maclean, Neil, Gronda, Marcela, Rondeau, Vincent, Brown, Brandon D., Jones, Courtney L, Chang, Hong, Arruda, Andrea, Minden, Mark D., Zhang, Li, Kornblau, Steven M., Raught, Brian, Spadavecchio, Vito, Schimmer, Aaron D.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
Intracellular IL-23 Receptor (IL-23R) Is Necessary for AML Viability and Regulates Mitotic Spindle and Centrosome Formation
Duong, Nathan, Khan, Dilshad H., Thomas, Geethu Emily, Hurren, Rose, Lee, Jong Bok, St-Germain, Jonathan, Drimmer, Lily, Yan, Yongran, MacLean, Neil, Gronda, Marcela, Brown, Brandon D, Raught, Brian, Arruda, Andrea, Minden, Mark D., Zhang, Li, Kornblau, Steven M., Spadevecchio, Vito, Schimmer, Aaron D.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
Abstract 4834: Mitochondrial ClpXP degrades serine phosphorylated protein aggregates
Feng, Yue, Jitkova, Yulia, Keszei, Alexander, St-Germain, Jonathan, Yan, Yongran, Raught, Brian, Mazhab-Jafari, Mohammad, Schimmer, Aaron
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Get full text
Journal Article
Abstract 5898: Inhibition of the LONP1 ATPase domain induces mitochondrial proteotoxic stress and is cytotoxic to acute myeloid leukemia cells
Tcheng, Matthew, Gronda, Marcela, Hurren, Rose, Zhang, Lan Xin, Sarathy, Chaitra, Yan, Yongran, Arruda, Andrea, Minden, Mark D., Schimmer, Aaron D.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Get full text
Journal Article
Abstract 7053: Serine phosphorylation marks proteins for degradation by the mitochondrial matrix protease, ClpXP
Feng, Yue, Goncalves, Monica M., Jitkova, Yulia, Keszei, Alexander, Sarathy, Chaitra, Trudel, Vincent, St-Germain, Jonathan, Tcheng, Matthew, Yan, Yongran, Hurren, Rose, Schultz, Matthew, Raught, Brian, Yudin, Andrei, Mazhab-Jafari, Mohammad, Vahidi, Siavash, Schimmer, Aaron D.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Get full text
Journal Article
Abstract 4833: Inhibiting the mitochondrial RNA degradosome complex SUV3 and PNPase increases dsRNA in the cytoplasm, triggers a viral mimicry response and kills AML cells and progenitors
Thomas, Geethu Emily, Nouri, Kazem, Lee, Jong Bok, Hurren, Rose, Yan, Yongran, MacLean, Neil, Jitkova, Yulia, Ma, Li, Wang, Xiao Ming, Sarathy, Chaitra, Arruda, Andrea, Minden, Mark D., Zhang, Li, Spadavecchio, Vito, Schimmer, Aaron
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Get full text
Journal Article
Abstract 1646: IL-23R is a regulator of the mitotic spindle and is critical for cell viability in AML
Duong, Nathan, Khan, Dilshad H., Thomas, Geethu E., Hurren, Rose, Lee, Jong Bok, St-Germain, Jonathan, Drimmer, Lily, Yan, Yongran, Maclean, Neil, Gronda, Marcela, Rondeau, Vincent, Brown, Brandon D., Jones, Courtney L., Chang, Hong, Arruda, Andrea, Minden, Mark D., Zhang, Li, Kornblau, Steven M., Raught, Brian, Spadavecchio, Vito, Schimmer, Aaron D.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Get full text
Journal Article
Abstract 333: Interleukin 23 receptor is a critical regulator of the mitotic spindle and necessary for AML viability
Duong, Nathan, Khan, Dilshad H., Thomas, Geethu E., Hurren, Rose, Lee, Jong Bok, St-Germain, Jonathan, Drimmer, Lily, Yan, Yongran, MacLean, Neil, Gronda, Marcela, Brown, Brandon D., Raught, Brian, Arruda, Andrea, Chang, Hong, Minden, Mark D., Zhang, Li, Kornblau, Steven M., Spadavecchio, Vito, Schimmer, Aaron D.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Get full text
Journal Article