Survey of venous thromboembolism prophylaxis in trauma patients: current prescribing practices and concordance with clinical practice guidelines
Alexander, Kaitlin M, Butts, Charles Caleb, Lee, Yan-Leei Larry, Kutcher, Matthew E, Polite, Nathan, Haut, Elliott R, Spain, David, Berndtson, Allison E, Costantini, Todd W, Simmons, Jon D
Published in Trauma surgery & acute care open (12.05.2023)
Published in Trauma surgery & acute care open (12.05.2023)
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Bilateral juvenile open angle glaucoma in two Chinese children: case report
Ng, Larry Hou-yan, Lung, Jenny Chun-yee
Published in Clinical and experimental optometry (01.07.2008)
Published in Clinical and experimental optometry (01.07.2008)
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Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction
Ketcham, John M., Haling, Jacob, Khare, Shilpi, Bowcut, Vickie, Briere, David M., Burns, Aaron C., Gunn, Robin J., Ivetac, Anthony, Kuehler, Jon, Kulyk, Svitlana, Laguer, Jade, Lawson, J. David, Moya, Krystal, Nguyen, Natalie, Rahbaek, Lisa, Saechao, Barbara, Smith, Christopher R., Sudhakar, Niranjan, Thomas, Nicole C., Vegar, Laura, Vanderpool, Darin, Wang, Xiaolun, Yan, Larry, Olson, Peter, Christensen, James G., Marx, Matthew A.
Published in Journal of medicinal chemistry (28.07.2022)
Published in Journal of medicinal chemistry (28.07.2022)
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The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading
Sudhakar, Niranjan, Yan, Larry, Qiryaqos, Fadia, Engstrom, Lars D, Laguer, Jade, Calinisan, Andrew, Hebbert, Allan, Waters, Laura, Moya, Krystal, Bowcut, Vickie, Vegar, Laura, Ketcham, John M, Ivetac, Anthony, Smith, Christopher R, Lawson, J David, Rahbaek, Lisa, Clarine, Jeffrey, Nguyen, Natalie, Saechao, Barbara, Parker, Cody, Elliott, Adam J, Vanderpool, Darin, He, Leo, Hover, Laura D, Fernandez-Banet, Julio, Coma, Silvia, Pachter, Jonathan A, Hallin, Jill, Marx, Matthew A, Briere, David M, Christensen, James G, Olson, Peter, Haling, Jacob, Khare, Shilpi
Published in Molecular cancer therapeutics (01.10.2024)
Published in Molecular cancer therapeutics (01.10.2024)
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Journal Article
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading
Sudhakar, Niranjan, Yan, Larry, Qiryaqos, Fadia, Engstrom, Lars D, Laguer, Jade, Calinisan, Andrew, Hebbert, Allan, Waters, Laura, Moya, Krystal, Bowcut, Vickie, Vegar, Laura, Ketcham, John M, Ivetac, Anthony, Smith, Christopher R, Lawson, J David, Rahbaek, Lisa, Clarine, Jeffrey, Nguyen, Natalie, Saechao, Barbara, Parker, Cody, Elliott, Adam J, Vanderpool, Darin, He, Leo, Hover, Laura D, Fernandez-Banet, Julio, Coma, Silvia, Pachter, Jonathan A, Hallin, Jill, Marx, Matthew A, Briere, David M, Christensen, James G, Olson, Peter, Haling, Jacob, Khare, Shilpi
Published in Molecular cancer therapeutics (21.06.2024)
Published in Molecular cancer therapeutics (21.06.2024)
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Abstract 7268: The SOS1 inhibitor MRTX0902 demonstrates activity across cancer models with mutations in proximal components of the RAS-MAPK pathway
Sudhakar, Niranjan, Yan, Larry, Qiryaqos, Fadia, Laguer, Jade, Briere, David, Hebbert, Allan, Calinisan, Andrew, Coma, Silvia, Pachter, Jonathan, Christensen, James G., Olson, Peter, Khare, Shilpi
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 3499: Inhibition of SOS1 by MRTX0902 augments the anti-tumor response of the targeted EGFR inhibitor osimertinib in NSCLC
Khare, Shilpi, Sudhakar, Niranjan, Laguer, Jade, Briere, David M., Yan, Larry, Hebbert, Allan, Calinisan, Andrew, Engstrom, Lars D., Qiryaqos, Fadia, Olson, Peter, Christensen, James G., Haling, Jacob R.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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The effects of overnight piggyback orthokeratology on lens centration, comfort, myopia reduction, and central corneal integrity
Ng, Larry Hou-Yan, OD, FAAO, FBCLA, Mok, Tsz-Ching, Optometry Student, Chan, Becky Wing-Yan, Optometry Student, Wong, Chun-Kit, Optometry Student
Published in Contact lens & anterior eye (01.12.2013)
Published in Contact lens & anterior eye (01.12.2013)
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Abstract 4448: Effects of adagrasib on cholesterol, lipid and glucose gene expression regulation in tumor xenograft models and patient samples
Shelton, Fabiola, Hoffman, Natalie, Trinh, David, Helu, Xousaen M., Calinisan, Andrew, Hebbert, Allan, Yan, Larry, Briere, David M., Hover, Laura, Fernandez-Benet, Julio, Anderes, Kenna, Christensen, James G., Hallin, Jill, Olson, Peter
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 1943: Discovery and characterization of potential drivers of resistance to the KRAS G12D inhibitor, MRTX1133, in cancer cell line models
Helu, Xousaen M., Griffiths, Ellie, Calinisan, Andrew, Hebbert, Allan, Yan, Larry, Hoffman, Natalie, Trinh, David, Hover, Laura, Fernandez-Banet, Julio, Briere, David M., Lifset, Ella, Olson, Peter, Christensen, James G., Hallin, Jill
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract LB193: Chemical genomics identify novel druggable nodes and resistance pathways in the presence of concomitant SOS1 and KRAS inhibition
Khare, Shilpi, Sudhakar, Niranjan, Briere, David M., Yan, Larry, Engstrom, Lars D., Laguer, Jade, Medwid, James, Vegar, Laura, Vanderpool, Darin, Marx, Matthew A., Ketcham, John M., Christensen, James G., Olson, Peter, Haling, Jacob R.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract ND02: MRTX0902: A SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers
Ketcham, John M., Khare, Shilpi, Sudhakar, Niranjan, Briere, David M., Yan, Larry, Laguer, Jade, Vegar, Laura, Vanderpool, Darin, Hallin, Jill, Hargis, Lauren, Bowcut, Vickie, Lawson, David, Gunn, Robin J., Ivetac, Anthony, Thomas, Nicole C., Saechao, Barbara, Nguyen, Natalie, Clarine, Jeffrey, Rahbaek, Lisa, Smith, Christopher R., Burns, Aaron C., Marx, Matthew A., Christensen, James G., Olson, Peter, Haling, Jacob R.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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