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Published in Laboratory investigation (01.05.2022)
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Design, Synthesis, and Biological Evaluation of Dimorpholine Substituted Thienopyrimidines as Potential Class I PI3K/mTOR Dual Inhibitors
Zhan, Miao, Deng, Yufang, Zhao, Lifeng, Yan, Guoyi, Wang, Fangying, Tian, Ye, Zhang, Lanxi, Jiang, Hongxia, Chen, Yuanwei
Published in Journal of medicinal chemistry (11.05.2017)
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Targeting Cysteine Located Outside the Active Site: An Effective Strategy for Covalent ALKi Design
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Synthesis and biological evaluation of novel 2,3-dihydrochromeno[3,4-d]imidazol-4(1H)-one derivatives as potent anticancer cell proliferation and migration agents
Han, Xuan, Luo, Jiang, Wu, Feng, Hou, XueYan, Yan, Guoyi, Zhou, Meng, Zhang, Mengqi, Pu, Chunlan, Li, Rui
Published in European journal of medicinal chemistry (23.05.2016)
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Design, Synthesis and Biological Evaluation of 4, 6-Coumarin Derivatives as Anti- Cancer and Apoptosis-Inducing Agents
Yan, Guoyi, Luo, Jiang, Han, Xuan, Zhang, Wenjuan, Pu, Chunlan, Zhou, Meng, Zhong, Xinxin, Hou, Xueyan, Hou, Man Zhou, Li, Rui
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Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors
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Identification of critical pathways and potential therapeutic targets in poorly differentiated duodenal papilla adenocarcinoma
Lu, Yuanxiang, Li, Wensen, Liu, Ge, Yang, Yongbo, Xiao, Erwei, Mu, Senmao, Guo, Yuqi, Li, Deyu, Yan, Guoyi
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Published in Cancer cell international (06.01.2021)
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Recent advances in dual PROTACs degrader strategies for disease treatment
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Published in European journal of medicinal chemistry (05.12.2024)
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Discovery of a PROTAC targeting ALK with in vivo activity
Yan, Guoyi, Zhong, Xinxin, Yue, Lin, Pu, Chunlan, Shan, Huifang, Lan, Suke, Zhou, Meng, Hou, Xueyan, Yang, Jie, Li, Rui
Published in European journal of medicinal chemistry (15.02.2021)
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Discovery of 2‑Methyl-2-(4-(2-methyl-8-(1H‑pyrrolo[2,3‑b]pyridin-6-yl)‑1H‑naphtho[1,2‑d]imidazol-1-yl)phenyl)propanenitrile as a Novel PI3K/mTOR Inhibitor with Enhanced Antitumor Efficacy In Vitro and In Vivo
Yang, Jie, Liu, Yuanyuan, Lan, Suke, Yu, Su, Ma, Xinyu, Luo, Dan, Shan, Huifang, Zhong, Xinxin, Yan, Guoyi, Li, Rui
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Published in Journal of medicinal chemistry (13.10.2022)
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Selective degradation of PARP2 by PROTACs via recruiting DCAF16 for triple-negative breast cancer
Pu, Chunlan, Tong, Yu, Liu, Yuanyuan, Lan, Suke, Wang, Shirui, Yan, Guoyi, Zhang, Hongjia, Luo, Dan, Ma, Xinyu, Yu, Su, Huang, Qing, Deng, Rui, Li, Rui
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Discovery of 2-Methyl-2-(4-(2-methyl-8-(1 H -pyrrolo[2,3- b ]pyridin-6-yl)-1 H -naphtho[1,2- d ]imidazol-1-yl)phenyl)propanenitrile as a Novel PI3K/mTOR Inhibitor with Enhanced Antitumor Efficacy In Vitro and In Vivo
Yang, Jie, Liu, Yuanyuan, Lan, Suke, Yu, Su, Ma, Xinyu, Luo, Dan, Shan, Huifang, Zhong, Xinxin, Yan, Guoyi, Li, Rui
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Metabolically stable diphenylamine derivatives suppress androgen receptor and BET protein in prostate cancer
Yu, Jiang, Zhou, Peiting, Du, Wu, Xu, Ruixue, Yan, Guoyi, Deng, Yufang, Li, Xinghai, Chen, Yuanwei
Published in Biochemical pharmacology (01.07.2020)
Published in Biochemical pharmacology (01.07.2020)
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Discovery and biological evaluation of darolutamide derivatives as inhibitors and down-regulators of wild-type AR and the mutants
Yu, Jiang, Zhou, Peiting, Hu, Mingxing, Yang, Liuqing, Yan, Guoyi, Xu, Ruixue, Deng, Yufang, Li, Xinghai, Chen, Yuanwei
Published in European journal of medicinal chemistry (15.11.2019)
Published in European journal of medicinal chemistry (15.11.2019)
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Discovery and biological evaluation of novel androgen receptor antagonist for castration-resistant prostate cancer
Yu, Jiang, Zhang, Lanxi, Yan, Guoyi, Zhou, Peiting, Cao, Chaoguo, Zhou, Fei, Li, Xinghai, Chen, Yuanwei
Published in European journal of medicinal chemistry (01.06.2019)
Published in European journal of medicinal chemistry (01.06.2019)
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Anti-CD133 Antibody-Targeted Therapeutic Immunomagnetic Albumin Microbeads Loaded with Vincristine-Assisted to Enhance Anti-Glioblastoma Treatment
Wang, Xueqin, Lu, Ping, Zhu, Li, Qin, Li, Zhu, Yongxia, Yan, Guoyi, Duan, Shaofeng, Guo, Yuqi
Published in Molecular pharmaceutics (04.11.2019)
Published in Molecular pharmaceutics (04.11.2019)
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