Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions
Steinberger, Jutta, Shen, Leo, J. Kiniry, Stephen, Naineni, Sai Kiran, Cencic, Regina, Amiri, Mehdi, Aboushawareb, Sarah A E, Chu, Jennifer, Maïga, Rayelle Itoua, Yachnin, Brahm J, Robert, Francis, Sonenberg, Nahum, Baranov, Pavel V, Pelletier, Jerry
Published in Nucleic acids research (25.09.2020)
Published in Nucleic acids research (25.09.2020)
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Journal Article
Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor
Mirza, I. Ahmad, Yachnin, Brahm J, Wang, Shaozhao, Grosse, Stephan, Bergeron, Hélène, Imura, Akihiro, Iwaki, Hiroaki, Hasegawa, Yoshie, Lau, Peter C. K, Berghuis, Albert M
Published in Journal of the American Chemical Society (01.07.2009)
Published in Journal of the American Chemical Society (01.07.2009)
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Journal Article
Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance
Volpato, Jordan P., Yachnin, Brahm J., Blanchet, Jonathan, Guerrero, Vanessa, Poulin, Lucie, Fossati, Elena, Berghuis, Albert M., Pelletier, Joelle N.
Published in The Journal of biological chemistry (24.07.2009)
Published in The Journal of biological chemistry (24.07.2009)
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Journal Article
Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues
Toulouse, Jacynthe L, Yachnin, Brahm J, Ruediger, Edward H, Deon, Daniel, Gagnon, Marc, Saint-Jacques, Kévin, Ebert, Maximilian C. C. J. C, Forge, Delphine, Bastien, Dominic, Colin, Damien Y, Vanden Eynde, Jean Jacques, Marinier, Anne, Berghuis, Albert M, Pelletier, Joelle N
Published in ACS omega (30.06.2019)
Published in ACS omega (30.06.2019)
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Journal Article
Computational Design of a Photocontrolled Cytosine Deaminase
Blacklock, Kristin M, Yachnin, Brahm J, Woolley, G. Andrew, Khare, Sagar D
Published in Journal of the American Chemical Society (10.01.2018)
Published in Journal of the American Chemical Society (10.01.2018)
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Journal Article
A Bis(imidazole)-based cysteine labeling tool for metalloprotein assembly
Ahmad, Raheel, Tyryshkin, Alexei M., Xie, Lingjun, Hansen, William A., Yachnin, Brahm J., Emge, Thomas J., Mashrai, Ashraf, Khare, Sagar D., Knapp, Spencer
Published in Journal of inorganic biochemistry (01.07.2023)
Published in Journal of inorganic biochemistry (01.07.2023)
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Journal Article
Massively parallel, computationally guided design of a proenzyme
Yachnin, Brahm J, Azouz, Laura R, White, 3rd, Ralph E, Minetti, Conceição A S A, Remeta, David P, Tan, Victor M, Drake, Justin M, Khare, Sagar D
Published in Proceedings of the National Academy of Sciences - PNAS (12.04.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (12.04.2022)
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Journal Article
The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure
Yachnin, Brahm J., Lau, Peter C.K., Berghuis, Albert M.
Published in Biochimica et biophysica acta (01.12.2016)
Published in Biochimica et biophysica acta (01.12.2016)
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Journal Article
Engineering carboxypeptidase G2 circular permutations for the design of an autoinhibited enzyme
Yachnin, Brahm J., Khare, Sagar D.
Published in Protein engineering, design and selection (01.04.2017)
Published in Protein engineering, design and selection (01.04.2017)
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Journal Article
Comprehensive characterization of ligand‐induced plasticity changes in a dimeric enzyme
Baettig, Oliver M., Shi, Kun, Yachnin, Brahm J., Burk, David L., Berghuis, Albert M.
Published in The FEBS journal (01.08.2016)
Published in The FEBS journal (01.08.2016)
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Journal Article
Lactone-Bound Structures of Cyclohexanone Monooxygenase Provide Insight into the Stereochemistry of Catalysis
Yachnin, Brahm J, McEvoy, Michelle B, MacCuish, Roderick J. D, Morley, Krista L, Lau, Peter C. K, Berghuis, Albert M
Published in ACS chemical biology (19.12.2014)
Published in ACS chemical biology (19.12.2014)
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Journal Article
Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure
Yachnin, Brahm J., Colin, Damien Y., Volpato, Jordan P., Ebert, Maximilian, Pelletier, Joelle N., Berghuis, Albert M.
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.11.2011)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.11.2011)
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Journal Article
A Bis(imidazole)-based cysteine labeling tool for metalloprotein assembly
Ahmad, Raheel, Tyryshkin, Alexei M., Xie, Lingjun, Hansen, William A., Yachnin, Brahm J., Emge, Thomas J., Mashrai, Ashraf, Khare, Sagar D., Knapp, Spencer
Published in Journal of inorganic biochemistry (01.07.2023)
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Published in Journal of inorganic biochemistry (01.07.2023)
Journal Article
Computational Design of a Photo-controlled Cytosine Deaminase
Blacklock, Kristin M., Yachnin, Brahm J., Woolley, G. Andrew, Khare, Sagar D.
Published in Journal of the American Chemical Society (28.12.2017)
Published in Journal of the American Chemical Society (28.12.2017)
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Journal Article
Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks
Koehler Leman, Julia, Lyskov, Sergey, Lewis, Steven M., Adolf-Bryfogle, Jared, Alford, Rebecca F., Barlow, Kyle, Ben-Aharon, Ziv, Farrell, Daniel, Fell, Jason, Hansen, William A., Harmalkar, Ameya, Jeliazkov, Jeliazko, Kuenze, Georg, Krys, Justyna D., Ljubetič, Ajasja, Loshbaugh, Amanda L., Maguire, Jack, Moretti, Rocco, Mulligan, Vikram Khipple, Nance, Morgan L., Nguyen, Phuong T., Ó Conchúir, Shane, Roy Burman, Shourya S., Samanta, Rituparna, Smith, Shannon T., Teets, Frank, Tiemann, Johanna K. S., Watkins, Andrew, Woods, Hope, Yachnin, Brahm J., Bahl, Christopher D., Bailey-Kellogg, Chris, Baker, David, Das, Rhiju, DiMaio, Frank, Khare, Sagar D., Kortemme, Tanja, Labonte, Jason W., Lindorff-Larsen, Kresten, Meiler, Jens, Schief, William, Schueler-Furman, Ora, Siegel, Justin B., Stein, Amelie, Yarov-Yarovoy, Vladimir, Kuhlman, Brian, Leaver-Fay, Andrew, Gront, Dominik, Gray, Jeffrey J., Bonneau, Richard
Published in Nature communications (29.11.2021)
Published in Nature communications (29.11.2021)
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