The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)
Hamdouchi, Chafiq, Kahl, Steven D, Patel Lewis, Anjana, Cardona, Guemalli R, Zink, Richard W, Chen, Keyue, Eessalu, Thomas E, Ficorilli, James V, Marcelo, Marialuisa C, Otto, Keith A, Wilbur, Kelly L, Lineswala, Jayana P, Piper, Jared L, Coffey, D. Scott, Sweetana, Stephanie A, Haas, Joseph V, Brooks, Dawn A, Pratt, Edward J, Belin, Ruth M, Deeg, Mark A, Ma, Xiaosu, Cannady, Ellen A, Johnson, Jason T, Yumibe, Nathan P, Chen, Qi, Maiti, Pranab, Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Reifel Miller, Anne
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
Get full text
Journal Article
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus
Hamdouchi, Chafiq, Maiti, Pranab, Warshawsky, Alan M, DeBaillie, Amy C, Otto, Keith A, Wilbur, Kelly L, Kahl, Steven D, Patel Lewis, Anjana, Cardona, Guemalli R, Zink, Richard W, Chen, Keyue, CR, Siddaramaiah, Lineswala, Jayana P, Neathery, Grace L, Bouaichi, Cecilia, Diseroad, Benjamin A, Campbell, Alison N, Sweetana, Stephanie A, Adams, Lisa A, Cabrera, Over, Ma, Xiaosu, Yumibe, Nathan P, Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Miller, Anne Reifel
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
Get full text
Journal Article
Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
Zhou, Xin, Rougée, Luc R A, Bedwell, David W, Cramer, Jeff W, Mohutsky, Michael A, Calvert, Nathan A, Moulton, Richard D, Cassidy, Kenneth C, Yumibe, Nathan P, Adams, Lisa A, Ruterbories, Kenneth J
Published in Drug metabolism and disposition (01.08.2016)
Published in Drug metabolism and disposition (01.08.2016)
Get full text
Journal Article
Fabp3 as a Biomarker of Skeletal Muscle Toxicity in the Rat: Comparison with Conventional Biomarkers
Pritt, Michael L., Hall, David Greg, Recknor, Justin, Credille, Kelly M., Brown, Donna D., Yumibe, Nathan P., Schultze, Albert Eric, Watson, David E.
Published in Toxicological sciences (01.06.2008)
Published in Toxicological sciences (01.06.2008)
Get full text
Journal Article
In Vivo Metabolism-Based Discovery of a Potent Cholesterol Absorption Inhibitor, SCH58235, in the Rat and Rhesus Monkey through the Identification of the Active Metabolites of SCH48461
Van Heek, M, France, C F, Compton, D S, McLeod, R L, Yumibe, N P, Alton, K B, Sybertz, E J, Davis, Jr, H R
Published in The Journal of pharmacology and experimental therapeutics (01.10.1997)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.10.1997)
Journal Article
Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist
Xu, Yanping, Mayhugh, Daniel, Saeed, Ashraf, Wang, Xiaodong, Thompson, Richard C, Dominianni, Samuel J, Kauffman, Raymond F, Singh, Jaipal, Bean, James S, Bensch, William R, Barr, Robert J, Osborne, John, Montrose-Rafizadeh, Chahrzad, Zink, Richard W, Yumibe, Nathan P, Huang, Naijia, Luffer-Atlas, Debra, Rungta, Deepa, Maise, Dale E, Mantlo, Nathan B
Published in Journal of medicinal chemistry (20.11.2003)
Published in Journal of medicinal chemistry (20.11.2003)
Get full text
Journal Article
Design and synthesis of novel and potent amide linked PPARγ/δ dual agonists
Shi, Qing, Canada, Emily J., Xu, Yanping, Warshawsky, Alan M., Etgen, Garret J., Broderick, Carol L., Clutinger, Cathleen K., Irwin, Lynnie A., Laurila, Michael E., Montrose-Rafizadeh, Chahrzad, Oldham, Brian A., Wang, Minmin, Winneroski, Leonard L., Xie, Chaoyu, York, Jeremy S., Yumibe, Nathan P., Zink, Richard W., Mantlo, Nathan
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Get full text
Journal Article
Tetrahydroisoquinoline PPARγ agonists: Design of novel, highly selective non-TZD antihyperglycemic agents
Henry, James R., Li, Yihong, Warshawsky, Alan M., Brozinick, Joseph T., Hawkins, Eric D., Misener, Elizabeth A., Briere, Daniel A., Montrose-Rafizadeh, Chahrzad, Zink, Richard W., Yumibe, Nathan P., Ajamie, Rose T., Wilken, Brad, Devanarayan, Viswanath
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Get full text
Journal Article
Syn and anti bent hydrazine radical cations. Effect of .sigma.,.pi. mixing on spectral properties
Nelsen, Stephen F, Blackstock, Silas C, Yumibe, Nathan P, Frigo, Timothy B, Carpenter, John E, Weinhold, Frank
Published in Journal of the American Chemical Society (01.01.1985)
Published in Journal of the American Chemical Society (01.01.1985)
Get full text
Journal Article
The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios
YAU YI LAU, KRISHNA, Gopal, YUMIBE, Nathan P, GROTZ, Diane E, SAPIDOU, Elpida, NORTON, Laura, INHOU CHU, CHEN, Cliff, SOARES, A. D, LIN, Chin-Chung
Published in Pharmaceutical research (01.11.2002)
Published in Pharmaceutical research (01.11.2002)
Get full text
Journal Article
Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents
Henry, James R, Li, Yihong, Warshawsky, Alan M, Brozinick, Joseph T, Hawkins, Eric D, Misener, Elizabeth A, Briere, Daniel A, Montrose-Rafizadeh, Chahrzad, Zink, Richard W, Yumibe, Nathan P, Ajamie, Rose T, Wilken, Brad, Devanarayan, Viswanath
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Get full text
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Journal Article
Tetrahydroisoquinoline PPARrγ agonists : Design of novel, highly selective non-TZD antihyperglycemic agents
HENRY, James R, YIHONG LI, AJAMIE, Rose T, WILKEN, Brad, DEVANARAYAN, Viswanath, WARSHAWSKY, Alan M, BROZINICK, Joseph T, HAWKINS, Eric D, MISENER, Elizabeth A, BRIERE, Daniel A, MONTROSE-RAFIZADEH, Chahrzad, ZINK, Richard W, YUMIBE, Nathan P
Published in Bioorganic & medicinal chemistry letters (2006)
Get full text
Published in Bioorganic & medicinal chemistry letters (2006)
Journal Article
Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists
Shi, Qing, Canada, Emily J, Xu, Yanping, Warshawsky, Alan M, Etgen, Garret J, Broderick, Carol L, Clutinger, Cathleen K, Irwin, Lynnie A, Laurila, Michael E, Montrose-Rafizadeh, Chahrzad, Oldham, Brian A, Wang, Minmin, Winneroski, Leonard L, Xie, Chaoyu, York, Jeremy S, Yumibe, Nathan P, Zink, Richard W, Mantlo, Nathan
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Get full text
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Journal Article
HYPOCHOLESTEROLEMIC SUGAR-SUBSTITUTED 2-AZETIDINONES, AND PHARMACEUTICAL COMPNS. CONTG. THEM
YUMIBE, NATHAN P, VAN HEEK, MARGARET, DAVIS, HARRY R, VACCARO, WAYNE D, ALTON, KEVIN B
Year of Publication 30.11.2009
Get full text
Year of Publication 30.11.2009
Patent
Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
YUMIBE, NATHAN, P, ALTON, KEVIN, B, DAVIS, HARRY, R, HEEK VAN MARGARET, VACCARO, WAYNE, D
Year of Publication 04.06.2004
Get full text
Year of Publication 04.06.2004
Patent