Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men
Irie, Junichiro, Inagaki, Emi, Fujita, Masataka, Nakaya, Hideaki, Mitsuishi, Masanori, Yamaguchi, Shintaro, Yamashita, Kazuya, Shigaki, Shuhei, Ono, Takashi, Yukioka, Hideo, Okano, Hideyuki, Nabeshima, Yo-ichi, Imai, Shin-ichiro, Yasui, Masato, Tsubota, Kazuo, Itoh, Hiroshi
Published in ENDOCRINE JOURNAL (01.01.2020)
Published in ENDOCRINE JOURNAL (01.01.2020)
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The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease
Takahashi, Rina, Kanda, Takeshi, Komatsu, Motoaki, Itoh, Tomoaki, Minakuchi, Hitoshi, Urai, Hidenori, Kuroita, Tomohiro, Shigaki, Shuhei, Tsukamoto, Tasuku, Higuchi, Naoko, Ikeda, Minoru, Yamanaka, Risa, Yoshimura, Norito, Ono, Takashi, Yukioka, Hideo, Hasegawa, Kazuhiro, Tokuyama, Hirobumi, Wakino, Shu, Itoh, Hiroshi
Published in Scientific reports (16.04.2022)
Published in Scientific reports (16.04.2022)
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NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism
Komatsu, Motoaki, Kanda, Takeshi, Urai, Hidenori, Kurokochi, Arata, Kitahama, Rina, Shigaki, Shuhei, Ono, Takashi, Yukioka, Hideo, Hasegawa, Kazuhiro, Tokuyama, Hirobumi, Kawabe, Hiroshi, Wakino, Shu, Itoh, Hiroshi
Published in Scientific reports (05.06.2018)
Published in Scientific reports (05.06.2018)
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An insurmountable NPY Y5 receptor antagonist exhibits superior anti-obesity effects in high-fat diet-induced obese mice
Fukasaka, Yumiko, Nambu, Hirohide, Tanioka, Hideki, Obata, Atsushi, Tonomura, Misato, Okuno, Takayuki, Yukioka, Hideo
Published in Neuropeptides (Edinburgh) (01.08.2018)
Published in Neuropeptides (Edinburgh) (01.08.2018)
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Diacylglycerol acyltransferase 1/2 inhibition induces dysregulation of fatty acid metabolism and leads to intestinal barrier failure and diarrhea in mice
Takemoto, Kosuke, Fukasaka, Yumiko, Yoshimoto, Ryo, Nambu, Hirohide, Yukioka, Hideo
Published in Physiological reports (01.08.2020)
Published in Physiological reports (01.08.2020)
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Ghrelin O-acyltransferase knockout mice show resistance to obesity when fed high-sucrose diet
Kouno, Tetsuya, Akiyama, Nobuteru, Ito, Takahito, Okuda, Tomohiko, Nanchi, Isamu, Notoya, Mitsuru, Oka, Shogo, Yukioka, Hideo
Published in Journal of endocrinology (01.02.2016)
Published in Journal of endocrinology (01.02.2016)
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Reduced intake of carbohydrate prevents the development of obesity and impaired glucose metabolism in ghrelin O-acyltransferase knockout mice
Kouno, Tetsuya, Akiyama, Nobuteru, Fujieda, Kumiko, Nanchi, Isamu, Okuda, Tomohiko, Iwasaki, Takanori, Oka, Shogo, Yukioka, Hideo
Published in Peptides (New York, N.Y. : 1980) (01.12.2016)
Published in Peptides (New York, N.Y. : 1980) (01.12.2016)
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Acetyl-CoA carboxylase 2 inhibition reduces skeletal muscle bioactive lipid content and attenuates progression of type 2 diabetes in Zucker diabetic fatty rats
Takagi, Hiroyuki, Ikehara, Tatsuya, Hashimoto, Kumi, Tanimoto, Keiichi, Shimazaki, Atsuyuki, Kashiwagi, Yuto, Sakamoto, Shingo, Yukioka, Hideo
Published in European journal of pharmacology (05.11.2021)
Published in European journal of pharmacology (05.11.2021)
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Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice
Kato, Ayumi, Ito, Mana, Sanaki, Takao, Okuda, Tomohiko, Tsuchiya, Noriko, Yoshimoto, Ryo, Yukioka, Hideo
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.02.2022)
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.02.2022)
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A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways
Takagi, Hiroyuki, Tanimoto, Keiichi, Shimazaki, Atsuyuki, Tonomura, Yutaka, Momosaki, Sotaro, Sakamoto, Shingo, Abe, Kohji, Notoya, Mitsuru, Yukioka, Hideo
Published in The Journal of pharmacology and experimental therapeutics (01.03.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2020)
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ACC2 Deletion Enhances IMCL Reduction Along With Acetyl-CoA Metabolism and Improves Insulin Sensitivity in Male Mice
Takagi, Hiroyuki, Ikehara, Tatsuya, Kashiwagi, Yuto, Hashimoto, Kumi, Nanchi, Isamu, Shimazaki, Atsuyuki, Nambu, Hirohide, Yukioka, Hideo
Published in Endocrinology (Philadelphia) (01.08.2018)
Published in Endocrinology (Philadelphia) (01.08.2018)
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1775-P: Impact of Acetyl-CoA Carboxylase 2 Inhibition on Skeletal Muscle Diacylglycerol and Ceramide Levels and Its Potential Contribution to Improved Glucose Metabolism
TAKAGI, HIROYUKI, IKEHARA, TATSUYA, HASHIMOTO, KUMI, SHIMAZAKI, ATSUYUKI, KASHIWAGI, YUTO, NISHIURA, YUJI, NOTOYA, MITSURU, YUKIOKA, HIDEO
Published in Diabetes (New York, N.Y.) (01.06.2019)
Published in Diabetes (New York, N.Y.) (01.06.2019)
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N-methyl-2-pyridone-5-carboxamide (N-Me-2PY) has potent anti-fibrotic and anti-inflammatory activity in a fibrotic kidney model: is it an old uremic toxin?
Yoshimura, Norito, Yamada, Katsutoshi, Ono, Takashi, Notoya, Mitsuru, Yukioka, Hideo, Takahashi, Rina, Wakino, Shu, Kanda, Takeshi, Itoh, Hiroshi
Published in Clinical and experimental nephrology (01.11.2023)
Published in Clinical and experimental nephrology (01.11.2023)
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Chronic hyperinsulinemia contributes to insulin resistance under dietary restriction in association with altered lipid metabolism in Zucker diabetic fatty rats
Morita, Ippei, Tanimoto, Keiichi, Akiyama, Nobuteru, Naya, Noriyuki, Fujieda, Kumiko, Iwasaki, Takanori, Yukioka, Hideo
Published in American journal of physiology: endocrinology and metabolism (01.04.2017)
Published in American journal of physiology: endocrinology and metabolism (01.04.2017)
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Sphingomyelin synthase 2 loss suppresses steatosis but exacerbates fibrosis in the liver of mice fed with choline-deficient, L-amino acid-defined, high-fat diet
Sugimoto, Masayuki, Hamada, Tadateru, Wakabayasi, Masato, Yoshioka, Takeshi, Kato, Hideaki, Konishi, Haruyo, Nagai, Ryohei, Suzuki, Minoru, Numata, Yoshito, Igarashi, Yasuyuki, Yukioka, Hideo
Published in Biochemical and biophysical research communications (17.12.2020)
Published in Biochemical and biophysical research communications (17.12.2020)
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