Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic Trivalent N-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo
Rajeev, Kallanthottathil G., Nair, Jayaprakash K., Jayaraman, Muthusamy, Charisse, Klaus, Taneja, Nate, O'Shea, Jonathan, Willoughby, Jennifer L. S., Yucius, Kristina, Nguyen, Tuyen, Shulga-Morskaya, Svetlana, Milstein, Stuart, Liebow, Abigail, Querbes, William, Borodovsky, Anna, Fitzgerald, Kevin, Maier, Martin A., Manoharan, Muthiah
Published in Chembiochem : a European journal of chemical biology (13.04.2015)
Published in Chembiochem : a European journal of chemical biology (13.04.2015)
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siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
Matsuda, Shigeo, Keiser, Kristofer, Nair, Jayaprakash K, Charisse, Klaus, Manoharan, Rajar M, Kretschmer, Philip, Peng, Chang G, V. Kel’in, Alexander, Kandasamy, Pachamuthu, Willoughby, Jennifer L.S, Liebow, Abigail, Querbes, William, Yucius, Kristina, Nguyen, Tuyen, Milstein, Stuart, Maier, Martin A, Rajeev, Kallanthottathil G, Manoharan, Muthiah
Published in ACS chemical biology (15.05.2015)
Published in ACS chemical biology (15.05.2015)
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Correction: Clua et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules 2022, 27 , 3944
Clua, Anna, Grijalvo, Santiago, Erande, Namrata, Gupta, Swati, Yucius, Kristina, Gargallo, Raimundo, Mazzini, Stefania, Manoharan, Muthiah, Eritja, Ramon
Published in Molecules (Basel, Switzerland) (23.12.2022)
Published in Molecules (Basel, Switzerland) (23.12.2022)
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Journal Article
Properties of Parallel Tetramolecular G-Quadruplex Carrying N -Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes
Clua, Anna, Grijalvo, Santiago, Erande, Namrata, Gupta, Swati, Yucius, Kristina, Gargallo, Raimundo, Mazzini, Stefania, Manoharan, Muthiah, Eritja, Ramon
Published in Molecules (Basel, Switzerland) (20.06.2022)
Published in Molecules (Basel, Switzerland) (20.06.2022)
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A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development
Severgnini, Mariano, Sherman, Jennifer, Sehgal, Alfica, Jayaprakash, Narayanannair K., Aubin, Justin, Wang, Gang, Zhang, Ligang, Peng, Chang G., Yucius, Kristina, Butler, Jim, Fitzgerald, Kevin
Published in Cytotechnology (Dordrecht) (01.03.2012)
Published in Cytotechnology (Dordrecht) (01.03.2012)
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Investigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis
Kusner, Linda L., Yucius, Kristina, Sengupta, Manjistha, Sprague, Andrew G., Desai, Dhruv, Nguyen, Tuyen, Charisse, Klaus, Kuchimanchi, Satya, Kallanthottathil, Rajeev, Fitzgerald, Kevin, Kaminski, Henry J., Borodovsky, Anna
Published in Molecular therapy. Methods & clinical development (14.06.2019)
Published in Molecular therapy. Methods & clinical development (14.06.2019)
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Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells
Novobrantseva, Tatiana I, Borodovsky, Anna, Wong, Jamie, Klebanov, Boris, Zafari, Mohammad, Yucius, Kristina, Querbes, William, Ge, Pei, Ruda, Vera M, Milstein, Stuart, Speciner, Lauren, Duncan, Rick, Barros, Scott, Basha, Genc, Cullis, Pieter, Akinc, Akin, Donahoe, Jessica S, Narayanannair Jayaprakash, K, Jayaraman, Muthusamy, Bogorad, Roman L, Love, Kevin, Whitehead, Katie, Levins, Chris, Manoharan, Muthiah, Swirski, Filip K, Weissleder, Ralph, Langer, Robert, Anderson, Daniel G, de Fougerolles, Antonin, Nahrendorf, Matthias, Koteliansky, Victor
Published in Molecular therapy. Nucleic acids (01.01.2012)
Published in Molecular therapy. Nucleic acids (01.01.2012)
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Journal Article
Correction: Clua et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. IMolecules/I 2022, I27/I, 3944
Clua, Anna, Grijalvo, Santiago, Erande, Namrata, Gupta, Swati, Yucius, Kristina, Gargallo, Raimundo, Mazzini, Stefania, Manoharan, Muthiah, Eritja, Ramon
Published in Molecules (Basel, Switzerland) (01.12.2022)
Published in Molecules (Basel, Switzerland) (01.12.2022)
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Properties of Parallel Tetramolecular G-Quadruplex Carrying IN/I-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes
Clua, Anna, Grijalvo, Santiago, Erande, Namrata, Gupta, Swati, Yucius, Kristina, Gargallo, Raimundo, Mazzini, Stefania, Manoharan, Muthiah, Eritja, Ramon
Published in Molecules (Basel, Switzerland) (01.06.2022)
Published in Molecules (Basel, Switzerland) (01.06.2022)
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Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression
Willoughby, Jennifer L.S., Chan, Amy, Sehgal, Alfica, Butler, James S., Nair, Jayaprakash K., Racie, Tim, Shulga-Morskaya, Svetlana, Nguyen, Tuyen, Qian, Kun, Yucius, Kristina, Charisse, Klaus, van Berkel, Theo J.C., Manoharan, Muthiah, Rajeev, Kallanthottathil G., Maier, Martin A., Jadhav, Vasant, Zimmermann, Tracy S.
Published in Molecular therapy (03.01.2018)
Published in Molecular therapy (03.01.2018)
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Metabolically Stable Anomeric Linkages Containing GalNAc–siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways
Kandasamy, Pachamuthu, Mori, Shohei, Matsuda, Shigeo, Erande, Namrata, Datta, Dhrubajyoti, Willoughby, Jennifer L. S., Taneja, Nate, O’Shea, Jonathan, Bisbe, Anna, Manoharan, Rajar M., Yucius, Kristina, Nguyen, Tuyen, Indrakanti, Ramesh, Gupta, Swati, Gilbert, Jason A., Racie, Tim, Chan, Amy, Liu, Ju, Hutabarat, Renta, Nair, Jayaprakash K., Charisse, Klaus, Maier, Martin A., Rajeev, Kallanthottathil G., Egli, Martin, Manoharan, Muthiah
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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보체 인자 B (CFB) IRNA 조성물 및 이의 사용 방법
SCHLEGEL MARK K, YUCIUS KRISTINA, MCININCH JAMES D, FISHILEVICH ELANE, CASTORENO ADAM
Year of Publication 25.06.2024
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Year of Publication 25.06.2024
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Development of Liver-Specific Thrombopoietin Targeted Sirnas: Impact on Platelet Count, Megakaryocyte Mass, and Hematopoietic Progenitors in Normal and MPN Murine Models
Desai, Dhruv, Borodovsky, Anna, Davis, Wendell P, Degaonkar, Rohan, Yucius, Kristina, D'Angelo, Kellie, Gedman, Paul, Williams, Donna Marie, Rogers, Ophelia, Zhao, Zhizhuang Joe, Spivak, Jerry L., Moliterno, Alison R.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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보체 성분 C3 iRNA 조성물 및 이의 사용 방법
YUCIUS KRISTINA, SCHLEGEL MARK K, KAITTANIS CHARALAMBOS, KEATING MARK, MCININCH JAMES D, FISHILEVICH ELANE, CASTORENO ADAM, SOLOMON SARAH
Year of Publication 21.06.2022
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Year of Publication 21.06.2022
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Development Of RNAi Therapeutics Targeting The Complement Pathway
Borodovsky, Anna, Yucius, Kristina, Sprague, Andrew, Butler, James, Fishman, Shannon, Nguyen, Tuyen, Vaishnaw, Akshay, Maier, Martin, Kallanthottathil, Rajeev, Kuchimanchi, Satya, Manoharan, Muthiah, Meyers, Rachel, Fitzgerald, Kevin
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Aln-CC5, an Investigational RNAi Therapeutic Targeting C5 for Complement Inhibition
Borodovsky, Anna, Yucius, Kristina, Sprague, Andrew, Banda, Nirmal K, Holers, V. Michael, Vaishnaw, Akshay, Maier, Martin, Kallanthottathil, Rajeev, Charisse, Klaus, Kuchimanchi, Satya, Manoharan, Muthiah, Salant, David J, Fitzgerald, Kevin, Meyers, Rachel, Sorensen, Benny
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Abstract 11936: Development of Monthly to Quarterly Subcutaneous Administration of RNAi Therapeutics Targeting the Metabolic Diseases Genes PCSK9, ApoC3 and ANGPTL3
Borodovsky, Anna, Querbes, William, Sutherland, Jessica, Hutabarat, Renta, Milstein, Stuart, Kuchimanchi, Satya, Kuchimanchi, Rajeev, Charisse, Klaus, Yucius, Kristina, Liebow, Abigail, Sprague, Andrew, Maier, Martin, Kallend, David, Simon, Amy, Horton, Jay, Fitzgerald, Kevin
Published in Circulation (New York, N.Y.) (25.11.2014)
Published in Circulation (New York, N.Y.) (25.11.2014)
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Cover Picture: Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic Trivalent N-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo (ChemBioChem 6/2015)
Rajeev, Kallanthottathil G., Nair, Jayaprakash K., Jayaraman, Muthusamy, Charisse, Klaus, Taneja, Nate, O'Shea, Jonathan, Willoughby, Jennifer L. S., Yucius, Kristina, Nguyen, Tuyen, Shulga-Morskaya, Svetlana, Milstein, Stuart, Liebow, Abigail, Querbes, William, Borodovsky, Anna, Fitzgerald, Kevin, Maier, Martin A., Manoharan, Muthiah
Published in Chembiochem : a European journal of chemical biology (13.04.2015)
Published in Chembiochem : a European journal of chemical biology (13.04.2015)
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Journal Article