Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity
Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R., Latifi, Brandon, Leipold, Douglas D., Sing Li, Chun, Li, Ruina, Mulvihill, Melinda M., O'Donohue, Aimee, Rowntree, Rebecca K., Sadowsky, Jack D., Wai, John, Wang, Xinxin, Wu, Cong, Xu, Zijin, Yao, Hui, Yu, Shang‐Fan, Zhang, Donglu, Zang, Richard, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu, Dragovich, Peter S.
Published in ChemMedChem (07.01.2020)
Published in ChemMedChem (07.01.2020)
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Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site
Bostrom, Jenny, Yu, Shang-Fan, Kan, David, Appleton, Brent A, Lee, Chingwei V, Billeci, Karen, Man, Wenyan, Peale, Franklin, Ross, Sarajane, Wiesmann, Christian, Fuh, Germaine
Published in Science (American Association for the Advancement of Science) (20.03.2009)
Published in Science (American Association for the Advancement of Science) (20.03.2009)
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Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
Cantley, Jennifer, Ye, Xiaofen, Rousseau, Emma, Januario, Tom, Hamman, Brian D, Rose, Christopher M, Cheung, Tommy K, Hinkle, Trent, Soto, Leofal, Quinn, Connor, Harbin, Alicia, Bortolon, Elizabeth, Chen, Xin, Haskell, Roy, Lin, Eva, Yu, Shang-Fan, Del Rosario, Geoff, Chan, Emily, Dunlap, Debra, Koeppen, Hartmut, Martin, Scott, Merchant, Mark, Grimmer, Matt, Broccatelli, Fabio, Wang, Jing, Pizzano, Jennifer, Dragovich, Peter S, Berlin, Michael, Yauch, Robert L
Published in Nature communications (10.11.2022)
Published in Nature communications (10.11.2022)
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Custom-Designed Affinity Capture LC-MS F(ab′)2 Assay for Biotransformation Assessment of Site-Specific Antibody Drug Conjugates
Su, Dian, Ng, Carl, Khosraviani, Mehraban, Yu, Shang-Fan, Cosino, Ely, Kaur, Surinder, Xu, Keyang
Published in Analytical chemistry (Washington) (06.12.2016)
Published in Analytical chemistry (Washington) (06.12.2016)
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Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB-siRNA conjugates
Cuellar, Trinna L, Barnes, Dwight, Nelson, Christopher, Tanguay, Joshua, Yu, Shang-Fan, Wen, Xiaohui, Scales, Suzie J, Gesch, Julie, Davis, David, van Brabant Smith, Anja, Leake, Devin, Vandlen, Richard, Siebel, Christian W
Published in Nucleic acids research (30.01.2015)
Published in Nucleic acids research (30.01.2015)
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Evaluation and use of an anti‐cynomolgus monkey CD79b surrogate antibody–drug conjugate to enable clinical development of polatuzumab vedotin
Li, Dongwei, Lee, Donna, Dere, Randall C., Zheng, Bing, Yu, Shang‐Fan, Fuh, Franklin K., Kozak, Katherine R., Chung, Shan, Bumbaca Yadav, Daniela, Nazzal, Denise, Danilenko, Dimitry, Go, Mary Ann T., Williams, Marna, Polson, Andrew G., Poon, Kirsten Achilles, Prabhu, Saileta
Published in British journal of pharmacology (01.10.2019)
Published in British journal of pharmacology (01.10.2019)
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An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia
Zheng, Bing, Yu, Shang-Fan, Del Rosario, Geoffrey, Leong, Steven R, Lee, Genee Y, Vij, Rajesh, Chiu, Cecilia, Liang, Wei-Ching, Wu, Yan, Chalouni, Cecile, Sadowsky, Jack, Clark, Vanessa, Hendricks, Angela, Poon, Kirsten Achilles, Chu, Wayne, Pillow, Thomas, Schutten, Melissa M, Flygare, John, Polson, Andrew G
Published in Clinical cancer research (15.02.2019)
Published in Clinical cancer research (15.02.2019)
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Targeting MCL‐1 and BCL‐2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non‐Hodgkin lymphoma: Results from preclinical models and a Phase Ib study
Lasater, Elisabeth A., Amin, Dhara N., Bannerji, Rajat, Mali, Raghuveer Singh, Barrett, Kathy, Rys, Ryan N., Oeh, Jason, Lin, Eva, Sterne‐Weiler, Tim, Ingalla, Ellen Rei, Go, MaryAnn, Yu, Shang‐Fan, Krem, Maxwell M., Arthur, Chris, Hahn, Uwe, Johnston, Anna, Karur, Vinit, Khan, Nadia, Marlton, Paula, Phillips, Tycel, Gritti, Giuseppe, Seymour, John F., Tani, Monica, Yuen, Sam, Martin, Scott, Chang, Matthew T., Rose, Christopher M., Pham, Victoria C., Polson, Andrew G., Chang, YiMeng, Wever, Claudia, Johnson, Nathalie A., Jiang, Yanwen, Hirata, Jamie, Sampath, Deepak, Musick, Lisa, Flowers, Christopher R., Wertz, Ingrid E.
Published in American journal of hematology (01.03.2023)
Published in American journal of hematology (01.03.2023)
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A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides
Zacharias, Neelie, Podust, Vladimir N, Kajihara, Kimberly K, Leipold, Douglas, Del Rosario, Geoffrey, Thayer, Desiree, Dong, Emily, Paluch, Maciej, Fischer, David, Zheng, Kai, Lei, Corinna, He, Jintang, Ng, Carl, Su, Dian, Liu, Luna, Masih, Shabkhaiz, Sawyer, William, Tinianow, Jeff, Marik, Jan, Yip, Victor, Li, Guangmin, Chuh, Josefa, Morisaki, J Hiroshi, Park, Summer, Zheng, Bing, Hernandez-Barry, Hilda, Loyet, Kelly M, Xu, Min, Kozak, Katherine R, Phillips, Gail Lewis, Shen, Ben-Quan, Wu, Cong, Xu, Keyang, Yu, Shang-Fan, Kamath, Amrita, Rowntree, Rebecca K, Reilly, Dorothea, Pillow, Thomas, Polson, Andrew, Schellenberger, Volker, Hazenbos, Wouter L W, Sadowsky, Jack
Published in Chemical science (Cambridge) (16.03.2022)
Published in Chemical science (Cambridge) (16.03.2022)
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Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity
Wei, BinQing, Gunzner-Toste, Janet, Yao, Hui, Wang, Tao, Wang, Jing, Xu, Zijin, Chen, Jinhua, Wai, John, Nonomiya, Jim, Tsai, Siao Ping, Chuh, Josefa, Kozak, Katherine R, Liu, Yichin, Yu, Shang-Fan, Lau, Jeff, Li, Guangmin, Phillips, Gail D, Leipold, Doug, Kamath, Amrita, Su, Dian, Xu, Keyang, Eigenbrot, Charles, Steinbacher, Stefan, Ohri, Rachana, Raab, Helga, Staben, Leanna R, Zhao, Guiling, Flygare, John A, Pillow, Thomas H, Verma, Vishal, Masterson, Luke A, Howard, Philip W, Safina, Brian
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results
Lewis, Gail D, Li, Guangmin, Guo, Jun, Yu, Shang-Fan, Fields, Carter T, Lee, Genee, Zhang, Donglu, Dragovich, Peter S, Pillow, Thomas, Wei, BinQing, Sadowsky, Jack, Leipold, Douglas, Wilson, Tim, Kamath, Amrita, Mamounas, Michael, Lee, M Violet, Saad, Ola, Choeurng, Voleak, Ungewickell, Alexander, Monemi, Sharareh, Crocker, Lisa, Kalinsky, Kevin, Modi, Shanu, Jung, Kyung Hae, Hamilton, Erika, LoRusso, Patricia, Krop, Ian, Schutten, Melissa M, Commerford, Renee, Sliwkowski, Mark X, Cho, Eunpi
Published in Nature communications (11.01.2024)
Published in Nature communications (11.01.2024)
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High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates
He, Jintang, Su, Dian, Ng, Carl, Liu, Luna, Yu, Shang-Fan, Pillow, Thomas H, Del Rosario, Geoffrey, Darwish, Martine, Lee, Byoung-Chul, Ohri, Rachana, Zhou, Hongxiang, Wang, Xueji, Lu, Jiawei, Kaur, Surinder, Xu, Keyang
Published in Analytical chemistry (Washington) (16.05.2017)
Published in Analytical chemistry (Washington) (16.05.2017)
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Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers
Pillow, Thomas H, Schutten, Melissa, Yu, Shang-Fan, Ohri, Rachana, Sadowsky, Jack, Poon, Kirsten Achilles, Solis, Willy, Zhong, Fiona, Del Rosario, Geoffrey, Go, Mary Ann T, Lau, Jeffrey, Yee, Sharon, He, Jintang, Liu, Luna, Ng, Carl, Xu, Keyang, Leipold, Douglas D, Kamath, Amrita V, Zhang, Donglu, Masterson, Luke, Gregson, Stephen J, Howard, Philip W, Fang, Fan, Chen, Jinhua, Gunzner-Toste, Janet, Kozak, Katherine K, Spencer, Susan, Polakis, Paul, Polson, Andrew G, Flygare, John A, Junutula, Jagath R
Published in Molecular cancer therapeutics (01.05.2017)
Published in Molecular cancer therapeutics (01.05.2017)
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Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
Dornan, David, Bennett, Fiona, Chen, Yvonne, Dennis, Mark, Eaton, Dan, Elkins, Kristi, French, Dorothy, Go, Mary Ann T., Jack, Andrew, Junutula, Jagath R., Koeppen, Hartmut, Lau, Jeffrey, McBride, Jacqueline, Rawstron, Andy, Shi, Xiaoyan, Yu, Nancy, Yu, Shang-Fan, Yue, Peng, Zheng, Bing, Ebens, Allen, Polson, Andrew G.
Published in Blood (24.09.2009)
Published in Blood (24.09.2009)
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Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates
Zhang, Donglu, Yu, Shang-Fan, Khojasteh, S Cyrus, Ma, Yong, Pillow, Thomas H, Sadowsky, Jack D, Su, Dian, Kozak, Katherine R, Xu, Keyang, Polson, Andrew G, Dragovich, Peter S, Hop, Cornelis E C A
Published in Molecular cancer therapeutics (01.03.2018)
Published in Molecular cancer therapeutics (01.03.2018)
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Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates
Staben, Leanna R, Chen, Jinhua, Cruz-Chuh, Josefa dela, del Rosario, Geoff, Go, Mary Ann, Guo, Jun, Khojasteh, S. Cyrus, Kozak, Katherine R, Li, Guangmin, Ng, Carl, Lewis Phillips, Gail D, Pillow, Thomas H, Rowntree, Rebecca K, Wai, John, Wei, BinQing, Xu, Keyang, Xu, Zijin, Yu, Shang-Fan, Zhang, Donglu, Dragovich, Peter S
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers
Gregson, Stephen J., Masterson, Luke A., Wei, Binqing, Pillow, Thomas H., Spencer, Susan D., Kang, Gyoung-Dong, Yu, Shang-Fan, Raab, Helga, Lau, Jeffrey, Li, Guangmin, Lewis Phillips, Gail D., Gunzner-Toste, Janet, Safina, Brian S., Ohri, Rachana, Darwish, Martine, Kozak, Katherine R., dela Cruz-Chuh, Josefa, Polson, Andrew, Flygare, John A., Howard, Philip W.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Development of T-cell engagers selective for cells co-expressing two antigens
Dicara, Danielle M, Bhakta, Sunil, Go, Mary Ann, Ziai, James, Firestein, Ron, Forrest, Bill, Gu, Chen, Leong, Steven R, Lee, Genee, Yu, Shang-Fan, Polson, Andrew G, Agard, Nicholas J
Published in mAbs (2022)
Published in mAbs (2022)
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Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer
Boswell, C. Andrew, Yadav, Daniela Bumbaca, Mundo, Eduardo E., Yu, Shang-Fan, Lacap, Jennifer Arca, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ferl, Gregory Z., Zhang, Crystal, Ho, Jason, Ulufatu, Sheila, Khawli, Leslie A., Lin, Kedan
Published in Oncotarget (22.10.2019)
Published in Oncotarget (22.10.2019)
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A Modified TOPSIS Method for Obtaining the Associated Weights of the OWA-Type Operators
Liu, Fang, Shang, Yu-Fan, Pan, Li-Hua
Published in International journal of intelligent systems (01.10.2015)
Published in International journal of intelligent systems (01.10.2015)
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