Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development
Crawford, James J, Johnson, Adam R, Misner, Dinah L, Belmont, Lisa D, Castanedo, Georgette, Choy, Regina, Coraggio, Melis, Dong, Liming, Eigenbrot, Charles, Erickson, Rebecca, Ghilardi, Nico, Hau, Jonathan, Katewa, Arna, Kohli, Pawan Bir, Lee, Wendy, Lubach, Joseph W, McKenzie, Brent S, Ortwine, Daniel F, Schutt, Leah, Tay, Suzanne, Wei, BinQing, Reif, Karin, Liu, Lichuan, Wong, Harvey, Young, Wendy B
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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Drug Annotations for a New Decade
Young, Wendy B, Georg, Gunda I, Wang, Shaomeng
Published in Journal of medicinal chemistry (13.02.2020)
Published in Journal of medicinal chemistry (13.02.2020)
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Medicinal Chemistry: Where Are All the Women?
Huryn, Donna M, Bolognesi, Maria Laura, Young, Wendy B
Published in ACS medicinal chemistry letters (14.09.2017)
Published in ACS medicinal chemistry letters (14.09.2017)
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Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL
Reiff, Sean D., Muhowski, Elizabeth M., Guinn, Daphne, Lehman, Amy, Fabian, Catherine A., Cheney, Carolyn, Mantel, Rose, Smith, Lisa, Johnson, Amy J., Young, Wendy B., Johnson, Adam R., Liu, Lichuan, Byrd, John C., Woyach, Jennifer A.
Published in Blood (06.09.2018)
Published in Blood (06.09.2018)
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Journal Article
Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations
Johnson, Adam R, Kohli, Pawan Bir, Katewa, Arna, Gogol, Emily, Belmont, Lisa D, Choy, Regina, Penuel, Elicia, Burton, Luciana, Eigenbrot, Charles, Yu, Christine, Ortwine, Daniel F, Bowman, Krista, Franke, Yvonne, Tam, Christine, Estevez, Alberto, Mortara, Kyle, Wu, Jiansheng, Li, Hong, Lin, May, Bergeron, Philippe, Crawford, James J, Young, Wendy B
Published in ACS chemical biology (21.10.2016)
Published in ACS chemical biology (21.10.2016)
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Journal Article
Strategies to Mitigate the Bioactivation of Aryl Amines
Zhang, Chenghong, Crawford, James J, Landry, Matthew L, Chen, Huifen, Kenny, Jane R, Khojasteh, S. Cyrus, Lee, Wendy, Ma, Shuguang, Young, Wendy B
Published in Chemical research in toxicology (20.07.2020)
Published in Chemical research in toxicology (20.07.2020)
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Journal Article
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis
Reif, Karin, Currie, Kevin S, Di Paolo, Julie A, Huang, Tao, Balazs, Mercedesz, Barbosa, James, Barck, Kai H, Bravo, Brandon J, Carano, Richard A D, Darrow, James, Davies, Douglas R, DeForge, Laura E, Diehl, Lauri, Ferrando, Ronald, Gallion, Steven L, Giannetti, Anthony M, Gribling, Peter, Hurez, Vincent, Hymowitz, Sarah G, Jones, Randall, Kropf, Jeffrey E, Lee, Wyne P, Maciejewski, Patricia M, Mitchell, Scott A, Rong, Hong, Staker, Bart L, Whitney, J Andrew, Yeh, Sherry, Young, Wendy B, Yu, Christine, Zhang, Juan
Published in Nature chemical biology (01.01.2011)
Published in Nature chemical biology (01.01.2011)
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Journal Article
Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834
Young, Wendy B., Barbosa, James, Blomgren, Peter, Bremer, Meire C., Crawford, James J., Dambach, Donna, Gallion, Steve, Hymowitz, Sarah G., Kropf, Jeffrey E., Lee, Seung H., Liu, Lichuan, Lubach, Joseph W., Macaluso, Jen, Maciejewski, Pat, Maurer, Brigitte, Mitchell, Scott A., Ortwine, Daniel F., Di Paolo, Julie, Reif, Karin, Scheerens, Heleen, Schmitt, Aaron, Sowell, C. Gregory, Wang, Xiaojing, Wong, Harvey, Xiong, Jin-Ming, Xu, Jianjun, Zhao, Zhongdong, Currie, Kevin S.
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
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Journal Article
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
Corzo, Cesar A, Varfolomeev, Eugene, Setiadi, A Francesca, Francis, Ross, Klabunde, Sha, Senger, Kate, Sujatha-Bhaskar, Swathi, Drobnick, Joy, Do, Steven, Suto, Eric, Huang, Zhiyu, Eastham-Anderson, Jeffrey, Katewa, Arna, Pang, Jodie, Domeyer, Melanie, Dela Cruz, Christopher, Paler-Martinez, Andres, Lau, Vivian W C, Hadadianpour, Azadeh, Ramirez-Carrozi, Vladimir, Sun, Yonglian, Bao, Katherine, Xu, Daqi, Hunley, Emily, Brightbill, Hans D, Warming, Soren, Roose-Girma, Merone, Wong, Alfred, Tam, Lucinda, Emson, Claire L, Crawford, James J, Young, Wendy B, Pappu, Rajita, McKenzie, Brent S, Asghari, Vida, Vucic, Domagoj, Hackney, Jason A, Austin, Cary D, Lee, Wyne P, Lekkerkerker, Annemarie, Ghilardi, Nico, Bryan, Marian C, Kiefer, James R, Townsend, Michael J, Zarrin, Ali A
Published in Science signaling (02.06.2020)
Published in Science signaling (02.06.2020)
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Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor
LICHUAN LIU, HALLADAY, Jason S, KUEBLER, Peter, DAVIS, John C, CHARLENE LIAO, X, LUBACH, Joseph W, DEESE, Alan, SOWELL, C. Gregory, CURRIE, Kevin S, YOUNG, Wendy B, KHOJASTEH, S. Cyrus, HOP, Cornelis E. C. A, SHIN, Young, WONG, Harvey, WONG, Susan, CORAGGIO, Melis, LA, Hank, BAUMGARDNER, Matthew, LE, Hoa, GOPAUL, Sashi, BOGGS, Jason
Published in Drug metabolism and disposition (01.10.2011)
Published in Drug metabolism and disposition (01.10.2011)
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Journal Article
Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity
Crawford, James J, Lee, Wendy, Johnson, Adam R, Delatorre, Kelly J, Chen, Jacob, Eigenbrot, Charles, Heidmann, Julia, Kakiuchi-Kiyota, Satoko, Katewa, Arna, Kiefer, James R, Liu, Lichuan, Lubach, Joseph W, Misner, Dinah, Purkey, Hans, Reif, Karin, Vogt, Jennifer, Wong, Harvey, Yu, Christine, Young, Wendy B
Published in ACS medicinal chemistry letters (13.08.2020)
Published in ACS medicinal chemistry letters (13.08.2020)
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Journal Article
Discovery of highly potent and selective Bruton’s tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability
Young, Wendy B., Barbosa, James, Blomgren, Peter, Bremer, Meire C., Crawford, James J., Dambach, Donna, Eigenbrot, Charles, Gallion, Steve, Johnson, Adam R., Kropf, Jeffrey E., Lee, Seung H., Liu, Lichuan, Lubach, Joseph W., Macaluso, Jen, Maciejewski, Pat, Mitchell, Scott A., Ortwine, Daniel F., Di Paolo, Julie, Reif, Karin, Scheerens, Heleen, Schmitt, Aaron, Wang, Xiaojing, Wong, Harvey, Xiong, Jin-Ming, Xu, Jianjun, Yu, Christine, Zhao, Zhongdong, Currie, Kevin S.
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
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Journal Article
Changes in Cognitive Control Following a Novel Resilience-Focused Nursing Educational Program: An Exploratory Study
Dames, Shannon, Young, Wendy, Krigolson, Olave, Zhang, Kelly, Stoller, Lincoln, Bartle, Robyn
Published in Quality advancement in nursing education (2022)
Published in Quality advancement in nursing education (2022)
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Journal Article
Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats
Erickson, Rebecca I, Schutt, Leah K, Tarrant, Jacqueline M, McDowell, Michelle, Liu, Lichuan, Johnson, Adam R, Lewin-Koh, Sock-Cheng, Hedehus, Maj, Ross, Jed, Carano, Richard A D, Staflin, Karin, Zhong, Fiona, Crawford, James J, Zhong, Shelly, Reif, Karin, Katewa, Arna, Wong, Harvey, Young, Wendy B, Dambach, Donna M, Misner, Dinah L
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2017)
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Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFN α -driven lupus nephritis
Katewa, Arna, Wang, Yugang, Hackney, Jason A, Huang, Tao, Suto, Eric, Ramamoorthi, Nandhini, Austin, Cary D, Bremer, Meire, Chen, Jacob Zhi, Crawford, James J, Currie, Kevin S, Blomgren, Peter, DeVoss, Jason, DiPaolo, Julie A, Hau, Jonathan, Johnson, Adam, Lesch, Justin, DeForge, Laura E, Lin, Zhonghua, Liimatta, Marya, Lubach, Joseph W, McVay, Sami, Modrusan, Zora, Nguyen, Allen, Poon, Chungkee, Wang, Jianyong, Liu, Lichuan, Lee, Wyne P, Wong, Harvey, Young, Wendy B, Townsend, Michael J, Reif, Karin
Published in JCI insight (06.04.2017)
Published in JCI insight (06.04.2017)
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