Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats
GINN, John D, BOSANAC, Todd, SCHLYER, Sabine, SMITH, James D, TURNER, Michael R, WU, Frank, YOUNG, Erick R. R, CHEN, Rhonda, CYWIN, Charles, HICKEY, Eugene, KASHEM, Mohammed, KERR, Steven, KUGLER, Stanley, XIANG LI, PROKOPOWICZ, Anthony
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Get full text
Journal Article
Novel cross-talk within the IKK family controls innate immunity
Clark, Kristopher, Peggie, Mark, Plater, Lorna, Sorcek, Ronald J, Young, Erick R R, Madwed, Jeffrey B, Hough, Joanne, McIver, Edward G, Cohen, Philip
Published in Biochemical journal (15.02.2011)
Published in Biochemical journal (15.02.2011)
Get more information
Journal Article
Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 3, aryl substituted pyrrolidines
Bosanac, Todd, Hickey, Eugene R., Ginn, John, Kashem, Mohammed, Kerr, Steven, Kugler, Stanley, Li, Xiang, Olague, Alan, Schlyer, Sabine, Young, Erick R.R.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Get full text
Journal Article
Discovery of potent and selective PKC-θ inhibitors
Cywin, Charles L., Dahmann, Georg, Prokopowicz, Anthony S., Young, Erick R.R., Magolda, Ronald L., Cardozo, Mario G., Cogan, Derek A., DiSalvo, Darren, Ginn, John D., Kashem, Mohammed A., Wolak, John P., Homon, Carol A., Farrell, Thomas M., Grbic, Heather, Hu, Hanbo, Kaplita, Paul V., Liu, Lisa H., Spero, Denice M., Jeanfavre, Deborah D., O’Shea, Kathy M., White, Della M., Woska, Joseph R., Brown, Maryanne L.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
Get full text
Journal Article
Substituted 2 H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats
Ginn, John D., Bosanac, Todd, Chen, Rhonda, Cywin, Charles, Hickey, Eugene, Kashem, Mohammed, Kerr, Steven, Kugler, Stanley, Li, Xiang, Prokopowicz, Anthony, Schlyer, Sabine, Smith, James D., Turner, Michael R., Wu, Frank, Young, Erick R.R.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
Get full text
Journal Article
BI 5700, a Selective Chemical Inhibitor of IκB Kinase 2, Specifically Suppresses Epithelial-Mesenchymal Transition and Metastasis in Mouse Models of Tumor Progression
Huber, Margit A, Maier, Harald J, Alacakaptan, Memetcan, Wiedemann, Eva, Braunger, Jürgen, Boehmelt, Guido, Madwed, Jeffrey B, Young, Erick R R, Marshall, Daniel R, Pehamberger, Hubert, Wirth, Thomas, Kraut, Norbert, Beug, Hartmut
Published in Genes & cancer (01.02.2010)
Published in Genes & cancer (01.02.2010)
Get full text
Journal Article
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors
Bekkali, Younes, Thomson, David S., Betageri, Raj, Emmanuel, Michel J., Hao, Ming-Hong, Hickey, Eugene, Liu, Weimin, Patel, Usha, Ward, Yancey D., Young, Erick R.R., Nelson, Richard, Kukulka, Alison, Brown, Maryanne L., Crane, Kathy, White, Della, Freeman, Dorothy M., Labadia, Mark E., Wildeson, Jessi, Spero, Denice M.
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Get full text
Journal Article
Vinyl and Alkynyl Pyrimidines as Michael Acceptors: An Approach to a Cylindrospermopsin Substructure
Djung, Jane F, Hart, David J, Young, Erick R. R
Published in Journal of organic chemistry (08.09.2000)
Published in Journal of organic chemistry (08.09.2000)
Get full text
Journal Article
NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES
SPERO, DENICE M, HICKEY, EUGENE R, WARD, YANCEY D, LIU, WEIMIN, FRYE, LEAH L, YOUNG, ERICK R.R, EMMANUEL, MICHEL J, THOMSON, DAVID S, SUN, SANXING, MORWICK, TINA M
Year of Publication 20.10.2009
Get full text
Year of Publication 20.10.2009
Patent
CATHEPSIN S INHIBITORS
HICKEY, EUGENE R, LIU, WEIMIN, YOUNG, ERICK R.R, SUN, SANXING, WARD, YANCEY, D
Year of Publication 21.12.2005
Get full text
Year of Publication 21.12.2005
Patent
Cathepsin S inhibitors
YOUNG ERICK R.R, SUN SANXING, WARD YANCEY D, HICKEY EUGENE R, LIU WIEMEN
Year of Publication 06.10.2005
Get full text
Year of Publication 06.10.2005
Patent
Compounds useful as reversible inhibitors of cysteine proteases
YOUNG ERICK R.R, SPERO DENICE M, WARD YANCEY D, THOMSON DAVID S, LIU WEIMIN
Year of Publication 20.11.2003
Get full text
Year of Publication 20.11.2003
Patent
Pyrimidine derivatives useful as inhibitors of PKC-theta
CARDOZO MARIO G, DAHMANN GEORGE, YOUNG ERICK R.R, COGAN DEREK, SPERO DENICE M, CYWIN CHARLES L, PROKOPOWICZ ANTHONY S.III, GINN JOHN D, DISALVO DARREN
Year of Publication 09.06.2005
Get full text
Year of Publication 09.06.2005
Patent
SPIROHETEROCYCLIC NITRILES USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES
YOUNG ERICK R.R, SPERO DENICE M, SUN SANXING, WARD YANCEY D, BEKKALI YOUNES, THOMSON DAVID S, HICKEY EUGENE R, LIU WEIMIN, PATEL USHA R
Year of Publication 20.09.2004
Get full text
Year of Publication 20.09.2004
Patent
Compounds useful as reversible inhibitors of cysteine proteases
YOUNG ERICK R.R, SUN SANXING, WARD YANCEY D, BEKKALI YOUNES, THOMSON DAVID S, SPERO DENICE MARY, HICKEY EUGENE R, LIU WEIMIN, PATEL USHA R
Year of Publication 01.04.2004
Get full text
Year of Publication 01.04.2004
Patent
Novel compounds useful as reversible inhibitors of cysteine proteases
YOUNG ERICK R.R, SPERO DENICE M, SUN SANXING, WARD YANCEY D, BEKKALI YOUNES, THOMSON DAVID S, HICKEY EUGENE R, LIU WEIMIN, PATEL USHA R
Year of Publication 26.09.2002
Get full text
Year of Publication 26.09.2002
Patent