Restoring Dystrophin Expression in Duchenne Muscular Dystrophy: Current Status of Therapeutic Approaches
Shimizu-Motohashi, Yuko, Komaki, Hirofumi, Motohashi, Norio, Takeda, Shin'ichi, Yokota, Toshifumi, Aoki, Yoshitsugu
Published in Journal of personalized medicine (07.01.2019)
Published in Journal of personalized medicine (07.01.2019)
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Efficacy of Multi-exon Skipping Treatment in Duchenne Muscular Dystrophy Dog Model Neonates
Lim, Kenji Rowel Q., Echigoya, Yusuke, Nagata, Tetsuya, Kuraoka, Mutsuki, Kobayashi, Masanori, Aoki, Yoshitsugu, Partridge, Terence, Maruyama, Rika, Takeda, Shin’ichi, Yokota, Toshifumi
Published in Molecular therapy (02.01.2019)
Published in Molecular therapy (02.01.2019)
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eSkip-Finder: a machine learning-based web application and database to identify the optimal sequences of antisense oligonucleotides for exon skipping
Chiba, Shuntaro, Lim, Kenji Rowel Q, Sheri, Narin, Anwar, Saeed, Erkut, Esra, Shah, Md Nur Ahad, Aslesh, Tejal, Woo, Stanley, Sheikh, Omar, Maruyama, Rika, Takano, Hiroaki, Kunitake, Katsuhiko, Duddy, William, Okuno, Yasushi, Aoki, Yoshitsugu, Yokota, Toshifumi
Published in Nucleic acids research (02.07.2021)
Published in Nucleic acids research (02.07.2021)
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Establishment of a Triple Quadrupole HPLC-MS Quantitation Method for Dystrophin Protein in Mouse and Human Skeletal Muscle
Tominari, Tsukasa, Takatoya, Masaru, Matsubara, Toshiya, Matsunobe, Michio, Arai, Daichi, Matsumoto, Chiho, Hirata, Michiko, Yoshinouchi, Shosei, Miyaura, Chisato, Itoh, Yoshifumi, Komaki, Hirofumi, Takeda, Shin'ichi, Aoki, Yoshitsugu, Inada, Masaki
Published in International journal of molecular sciences (25.12.2023)
Published in International journal of molecular sciences (25.12.2023)
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Truncated dystrophin ameliorates the dystrophic phenotype of mdx mice by reducing sarcolipin-mediated SERCA inhibition
Tanihata, Jun, Nagata, Tetsuya, Ito, Naoki, Saito, Takashi, Nakamura, Akinori, Minamisawa, Susumu, Aoki, Yoshitsugu, Ruegg, Urs T., Takeda, Shin'ichi
Published in Biochemical and biophysical research communications (20.10.2018)
Published in Biochemical and biophysical research communications (20.10.2018)
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Severe cardiac involvement with preserved truncated dystrophin expression in Becker muscular dystrophy by +1G>A DMD splice-site mutation: a case report
Komaki, Ryouhei, Hashimoto, Yasumasa, Mori-Yoshimura, Madoka, Oya, Yasushi, Takizawa, Hotake, Minami, Narihiro, Nishino, Ichizo, Aoki, Yoshitsugu, Takahashi, Yuji
Published in Journal of human genetics (01.10.2020)
Published in Journal of human genetics (01.10.2020)
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Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy
van Westering, Tirsa L.E., Johansson, Henrik J., Hanson, Britt, Coenen-Stass, Anna M.L., Lomonosova, Yulia, Tanihata, Jun, Motohashi, Norio, Yokota, Toshifumi, Takeda, Shin'ichi, Lehtiö, Janne, Wood, Matthew J.A., EL Andaloussi, Samir, Aoki, Yoshitsugu, Roberts, Thomas C.
Published in Molecular & cellular proteomics (01.12.2020)
Published in Molecular & cellular proteomics (01.12.2020)
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Ensemble-Learning and Feature Selection Techniques for Enhanced Antisense Oligonucleotide Efficacy Prediction in Exon Skipping
Zhu, Alex, Chiba, Shuntaro, Shimizu, Yuki, Kunitake, Katsuhiko, Okuno, Yasushi, Aoki, Yoshitsugu, Yokota, Toshifumi
Published in Pharmaceutics (24.06.2023)
Published in Pharmaceutics (24.06.2023)
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Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes
Sato, Mitsuto, Shiba, Naoko, Miyazaki, Daigo, Shiba, Yuji, Echigoya, Yusuke, Yokota, Toshifumi, Takizawa, Hotake, Aoki, Yoshitsugu, Takeda, Shin’ichi, Nakamura, Akinori
Published in Biochemical and biophysical research communications (26.11.2019)
Published in Biochemical and biophysical research communications (26.11.2019)
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Emerging Oligonucleotide Therapeutics for Rare Neuromuscular Diseases
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Book Review
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Novel EGFP reporter cell and mouse models for sensitive imaging and quantification of exon skipping
Hara, Yuko, Mizobe, Yoshitaka, Inoue, Yukiko U., Hashimoto, Yasumasa, Motohashi, Norio, Masaki, Yoshiaki, Seio, Kohji, Takeda, Shin’ichi, Nagata, Tetsuya, Wood, Matthew J. A., Inoue, Takayoshi, Aoki, Yoshitsugu
Published in Scientific reports (22.06.2020)
Published in Scientific reports (22.06.2020)
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Identification of Disease Specific Pathways Using in Vivo SILAC Proteomics in Dystrophin Deficient mdx Mouse
Rayavarapu, Sree, Coley, William, Cakir, Erdinc, Jahnke, Vanessa, Takeda, Shin'ichi, Aoki, Yoshitsugu, Grodish-Dressman, Heather, Jaiswal, Jyoti K., Hoffman, Eric P., Brown, Kristy J., Hathout, Yetrib, Nagaraju, Kanneboyina
Published in Molecular & cellular proteomics (01.05.2013)
Published in Molecular & cellular proteomics (01.05.2013)
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Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy
Maruyama, Rika, Echigoya, Yusuke, Caluseriu, Oana, Aoki, Yoshitsugu, Takeda, Shin'ichi, Yokota, Toshifumi
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2017)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2017)
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Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride
Takizawa, Hotake, Hara, Yuko, Mizobe, Yoshitaka, Ohno, Taisuke, Suzuki, Sadafumi, Inoue, Ken, Takeshita, Eri, Shimizu-Motohashi, Yuko, Ishiyama, Akihiko, Hoshino, Mikio, Komaki, Hirofumi, Takeda, Shin’ichi, Aoki, Yoshitsugu
Published in Scientific reports (07.03.2019)
Published in Scientific reports (07.03.2019)
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Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy
Chesshyre, Mary, Ridout, Deborah, Hashimoto, Yasumasa, Ookubo, Yoko, Torelli, Silvia, Maresh, Kate, Ricotti, Valeria, Abbott, Lianne, Gupta, Vandana Ayyar, Main, Marion, Ferrari, Giulia, Kowala, Anna, Lin, Yung‐Yao, Tedesco, Francesco Saverio, Scoto, Mariacristina, Baranello, Giovanni, Manzur, Adnan, Aoki, Yoshitsugu, Muntoni, Francesco
Published in Journal of cachexia, sarcopenia and muscle (01.04.2022)
Published in Journal of cachexia, sarcopenia and muscle (01.04.2022)
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Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle
Tsoumpra, Maria K, Sawatsubashi, Shun, Imamura, Michihiro, Fukumoto, Seiji, Takeda, Shin’ichi, Matsumoto, Toshio, Aoki, Yoshitsugu
Published in Journal of molecular endocrinology (01.04.2020)
Published in Journal of molecular endocrinology (01.04.2020)
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The nSMase2/Smpd3 gene modulates the severity of muscular dystrophy and the emotional stress response in mdx mice
Matsuzaka, Yasunari, Tanihata, Jun, Ooshima, Yoshiko, Yamada, Daisuke, Sekiguchi, Masayuki, Miyatake, Shouta, Aoki, Yoshitsugu, Terumitsu, Mika, Yashiro, Ryu, Komaki, Hirofumi, Ishiyama, Akihiko, Oya, Yasushi, Inoue, Yukiko U, Inoue, Takayoshi, Takeda, Shin'ichi, Hashido, Kazuo
Published in BMC medicine (19.11.2020)
Published in BMC medicine (19.11.2020)
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Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot
Suzuki, Hitoshi, Aoki, Yoshitsugu, Kameyama, Toshiki, Saito, Takashi, Masuda, Satoru, Tanihata, Jun, Nagata, Tetsuya, Mayeda, Akila, Takeda, Shin'ichi, Tsukahara, Toshifumi
Published in International journal of molecular sciences (13.10.2016)
Published in International journal of molecular sciences (13.10.2016)
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Exon Skipping Therapy Using Phosphorodiamidate Morpholino Oligomers in the mdx52 Mouse Model of Duchenne Muscular Dystrophy
Miyatake, Shouta, Mizobe, Yoshitaka, Takizawa, Hotake, Hara, Yuko, Yokota, Toshifumi, Takeda, Shin'ichi, Aoki, Yoshitsugu
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2018)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2018)
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