Discovery of Clinical Candidate 2‑(4-(2-((1H‑Benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)‑N‑(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O‑Acyltransferase‑1 Inhibitor
Shibuya, Kimiyuki, Kawamine, Katsumi, Ozaki, Chiyoka, Ohgiya, Tadaaki, Edano, Toshiyuki, Yoshinaka, Yasunobu, Tsunenari, Yoshihiko
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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Mechanism of lipid‐lowering action of the dipeptidyl peptidase‐4 inhibitor, anagliptin, in low‐density lipoprotein receptor‐deficient mice
Yano, Wataru, Inoue, Noriyuki, Ito, Shiori, Itou, Takahiro, Yasumura, Misako, Yoshinaka, Yasunobu, Hagita, Sumihiko, Goto, Moritaka, Nakagawa, Takashi, Inoue, Keisuke, Tanabe, Sohei, Kaku, Kohei
Published in Journal of diabetes investigation (01.03.2017)
Published in Journal of diabetes investigation (01.03.2017)
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Pitavastatin Increases ABCA1 Expression by Dual Mechanisms: SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells
Maejima, Takashi, Sugano, Tomohiro, Yamazaki, Hiroyuki, Yoshinaka, Yasunobu, Doi, Takeshi, Tanabe, Sohei, Nishimaki-Mogami, Tomoko
Published in Journal of Pharmacological Sciences (2011)
Published in Journal of Pharmacological Sciences (2011)
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A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels
Ikenoya, Mami, Yoshinaka, Yasunobu, Kobayashi, Hideyuki, Kawamine, Katsumi, Shibuya, Kimiyuki, Sato, Fumiyasu, Sawanobori, Kimio, Watanabe, Takuya, Miyazaki, Akira
Published in Atherosclerosis (01.04.2007)
Published in Atherosclerosis (01.04.2007)
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A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice
Yoshinaka, Yasunobu, Shibata, Haruki, Kobayashi, Hideyuki, Kuriyama, Hiroki, Shibuya, Kimiyuki, Tanabe, Sohei, Watanabe, Takuya, Miyazaki, Akira
Published in Atherosclerosis (01.11.2010)
Published in Atherosclerosis (01.11.2010)
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Discovery of Clinical Candidate 2-(4-(2-((1H-Benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetannide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor
Shibuya, Kimiyuki, Kawamine, Katsumi, Ozaki, Chiyoka, Ohgiya, Tadaaki, Edano, Toshiyuki, Yoshinaka, Yasunobu, Tsunenari, Yoshihiko
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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Triglyceride-lowering effect of pitvastatin in a rat model of postprandial lipemia
Aoki, Taro, Yoshinaka, Yasunobu, Yamazaki, Hiroyuki, Suzuki, Hideo, Tamaki, Taro, Sato, Fumiyasu, Kitahara, Masaki, Saito, Yasushi
Published in European journal of pharmacology (24.05.2002)
Published in European journal of pharmacology (24.05.2002)
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Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors
Shibuya, Kimiyuki, Kawamine, Katsumi, Miura, Toru, Ozaki, Chiyoka, Edano, Toshiyuki, Mizuno, Ken, Yoshinaka, Yasunobu, Tsunenari, Yoshihiko
Published in Bioorganic & medicinal chemistry (07.08.2018)
Published in Bioorganic & medicinal chemistry (07.08.2018)
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Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells
Maejima, Takashi, Inoue, Tsuyoshi, Kanki, Yasuharu, Kohro, Takahide, Li, Guoliang, Ohta, Yoshihiro, Kimura, Hiroshi, Kobayashi, Mika, Taguchi, Akashi, Tsutsumi, Shuichi, Iwanari, Hiroko, Yamamoto, Shogo, Aruga, Hirofumi, Dong, Shoulian, Stevens, Junko F, Poh, Huay Mei, Yamamoto, Kazuki, Kawamura, Takeshi, Mimura, Imari, Suehiro, Jun-ichi, Sugiyama, Akira, Kaneki, Kiyomi, Shibata, Haruki, Yoshinaka, Yasunobu, Doi, Takeshi, Asanuma, Akimune, Tanabe, Sohei, Tanaka, Toshiya, Minami, Takashi, Hamakubo, Takao, Sakai, Juro, Nozaki, Naohito, Aburatani, Hiroyuki, Nangaku, Masaomi, Ruan, Xiaoan, Tanabe, Hideyuki, Ruan, Yijun, Ihara, Sigeo, Endo, Akira, Kodama, Tatsuhiko, Wada, Youichiro
Published in PloS one (05.05.2014)
Published in PloS one (05.05.2014)
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