Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids
Kubo, Keiji, Kohara, Yasuhisa, Yoshimura, Yoshinobu, Inada, Yoshiyuki, Shibouta, Yumiko, Furukawa, Yoshiyasu, Kato, Takeshi, Nishikawa, Kohei, Naka, Takehiko
Published in Journal of medicinal chemistry (01.08.1993)
Published in Journal of medicinal chemistry (01.08.1993)
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Journal Article
Application of 1-alkylamines to a liquid chromatographic/turbo ionspray tandem mass spectrometric method for quantifying metabolites of a new bone anabolic agent, TAK-778, in human serum
Teshima, Koichiro, Kondo, Takahiro, Maeda, Chie, Oda, Tsuneo, Hagimoto, Toshiaki, Tsukuda, Ryoichi, Yoshimura, Yoshinobu
Published in Journal of mass spectrometry. (01.06.2002)
Published in Journal of mass spectrometry. (01.06.2002)
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Functional Characterization of Single Nucleotide Polymorphisms with Amino Acid Substitution in CYP1A2, CYP2A6, and CYP2B6 Found in the Japanese Population
Iwasaki, Masahiko, Yoshimura, Yoshinobu, Asahi, Satoru, Saito, Kimitoshi, Sakai, Shuichi, Morita, Shigemichi, Takenaka, Osamu, Inoda, Toshio, Kashiyama, Eiji, Aoyama, Akinori, Nakabayashi, Takeshi, Omori, Satoshi, Kuwabara, Takashi, Izumi, Takashi, Nakamura, Kouichi, Takanaka, Kaoru, Nakayama, Yukiharu, Takeuchi, Mitsuaki, Nakamura, Hideki, Kametani, Shunichi, Terauchi, Yoshiaki, Hashizume, Takanori, Nagayama, Sekio, Kume, Toshiyuki, Achira, Meguru, Kawai, Hiroyuki, Kawashiro, Takashi, Nakamura, Akio, Nakai, Yasuhiro, Kagayama, Akira, Shiraga, Toshifumi, Niwa, Takuro, Yoshimura, Takuya, Morita, Jun, Ohsaw, Fukuichi, Tani, Masato, Osawa, Nobuo, Ida, Keiichi, Noguchi, Kiyoshi
Published in Drug metabolism and pharmacokinetics (2004)
Published in Drug metabolism and pharmacokinetics (2004)
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Degradation Products Generated by Sonication of Benzyl Alcohol, a Sample Preparation Solvent for the Determination of Residual Solvents in Pharmaceutical Bulks, on Capillary Gas Chromatography
URAKAMI, Koji, KOBAYASHI, Chiaki, MIYAZAKI, Yoshihiko, NISHIJIMA, Koji, YOSHIMURA, Yoshinobu, HASHIMOTO, Keiji
Published in Chemical & pharmaceutical bulletin (01.09.2000)
Published in Chemical & pharmaceutical bulletin (01.09.2000)
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NOVEL ANTICANCER AGENT
KASAI MASAYASU, YOSHIMURA YOSHINOBU, TAKEDA SHIGEMITSU, SHOJI YOSHIMICHI
Year of Publication 05.12.2019
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Year of Publication 05.12.2019
Patent
Nonlinear pharmacokinetics of TAK-044, a new endothelin antagonist, in rats
Takeuchi, Toshiyuki, Tagawa, Yoshihiko, Hagihara, Kiyoshi, Maeshiba, Yoshihiro, Yamashita, Kenji, Tsukuda, Ryoichi, Yoshimura, Yoshinobu
Published in Biopharmaceutics & drug disposition (01.09.2001)
Published in Biopharmaceutics & drug disposition (01.09.2001)
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Journal Article
NOVEL ANTICANCER AGENT
YOSHIMURA, YOSHINOBU, KASAI, MASAYASU, TAKEDA, SHIGEMITSU, SHOJI, YOSHIMICHI
Year of Publication 17.12.2015
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Year of Publication 17.12.2015
Patent
Evaluation and improvement of bioavailability of a new angiotensin II receptor antagonist, 2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl] methyl-1H-benzimidazole-7-carboxylic acid by making prodrug
Yoshimura, Yoshinobu, Tada, Norio, Kubo, Keiji, Miyamoto, Miwa, Inada, Yoshiyuki, Nishikawa, Kohei, Naka, Takehiko
Published in International journal of pharmaceutics (25.02.1994)
Published in International journal of pharmaceutics (25.02.1994)
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STUDIES ON CONDENSED-HETEROCYCLIC AZOLIUM CEPHALOSPORINS: V. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 3-(CONDENSED-TRIAZOLO-PYRIDINIUM, -PYRIMIDINIUM, AND -PYRIDAZINIUM)-METHYL CEPHALOSPORINS
YOSHIMURA, YOSHINOBU, TOMIMATSU, KIMINORI, NISHIMURA, TATSUO, MIYAKE, AKIO, HASHIMOTO, NAOTO
Published in Journal of antibiotics (1992)
Published in Journal of antibiotics (1992)
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Functional Characterization of Single Nucleotide Polymorphisms with Amino Acid Substitution in CYP1A2, CYP2A6, and CYP2B6 Found in the Japanese Population
Masahiko IWASAKI, Yoshinobu YOSHIMURA, Satoru ASAHI, Kimitoshi SAITO, Shuichi SAKAI, Shigemichi MORITA, Osamu TAKENAKA, Toshio INODA, Eiji KASHIYAMA, Akinori AOYAMA, Takeshi NAKABAYASHI, Satoshi OMORI, Takashi KUWABARA, Takashi IZUMI, Kouichi NAKAMURA, Kaoru TAKANAKA, Yukiharu NAKAYAMA, Mitsuaki TAKEUCHI, Hideki NAKAMURA, Shunichi KAMETANI, Yoshiaki TERAUCHI, Takanori HASHIZUME, Sekio NAGAYAMA, Toshiyuki KUME, Meguru ACHIRA, Hiroyuki KAWAI, Takashi KAWASHIRO, Akio NAKAMURA, Yasuhiro NAKAI, Akira KAGAYAMA, Toshifumi SHIRAGA, Takuro NIWA, Takuya YOSHIMURA, Jun MORITA, Fukuichi OHSAWA, Masato TANI, Nobuo OSAWA, Keiichi IDA, Kiyoshi NOGUCHI
Published in DRUG METABOLISM AND PHARMACOKINETICS (2004)
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Published in DRUG METABOLISM AND PHARMACOKINETICS (2004)
Journal Article
ORALLY ACTIVE 1-(CYCLOHEXYLOXYCARBONYLOXY)ALKYL ESTER PRODRUGS OF CEFOTIAM
NISHIMURA, TATSUO, YOSHIMURA, YOSHINOBU, MIYAKE, AKIO, YAMAOKA, MASAYOSHI, TAKANOHASHI, KUNIO, HAMAGUCHI, NAORU, HIRAI, SHINICHIRO, YASHIKI, TAKATSUKA, NUMATA, MITSUO
Published in Journal of antibiotics (01.01.1987)
Published in Journal of antibiotics (01.01.1987)
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Studies on condensed-heterocyclic azolium cephalosporins. II. Synthesis and antibacterial activity of 7.BETA.-(2-(2-aminothiazol-4-yl)-2(Z)-alkoxyiminoacetamido)-3-(condensed-heterocyclic azolium)methyl-3-cephem-4-carboxylates
YOSHIMURA, YOSHINOBU, MIYAKE, AKIO, NISHIMURA, TATSUO, KAWAI, TATSUHIKO, YAMAOKA, MASAYOSHI
Published in Journal of antibiotics (1991)
Published in Journal of antibiotics (1991)
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Journal Article
Studies on condensed-heterocyclic azolium cephalosporins. I. Synthesis and antibacterial activity of 7.BETA.-(2-(2-aminothiazol-4-yl)-2(Z)-alkoxyiminoacetamido)-3-(imidazo(1,2-a)pyridinium-1-yl)methyl-3-cephem-4-carboxylates
NISHIMURA, TATSUO, YOSHIMURA, YOSHINOBU, YAMAOKA, MASAYOSHI, KAWAI, TATSUHIKO, MIYAKE, AKIO
Published in Journal of antibiotics (1991)
Published in Journal of antibiotics (1991)
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Journal Article
Studies on condensed-heterocyclic azolium cephalosporins. IV. Synthesis and antibacterial activity of 7.BETA.-(2-(5-amino-1,2,4-thiadizol-3-yl)-2(Z)-alkoxyiminoacetamido)-3-(condensed-heterocyclic azolium)methyl cephalosporins including SCE-2787
MIYAKE, AKIO, YOSHIMURA, YOSHINOBU, YAMAOKA, MASAYOSHI, NISHIMURA, TATSUO, HASHIMOTO, NAOTO, IMADA, AKIRA
Published in Journal of antibiotics (1992)
Published in Journal of antibiotics (1992)
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Journal Article
Preparation of 1-acyloxyethyl esters of 7-(2-(2-aminothiazol-4-yl)acetamido)-3-(((1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl)thio)methyl)ceph-3-em-4-carboxylic acid (cefotiam) and their oral absorption in mice
YOSHIMURA, YOSHINOBU, HAMAGUCHI, NAORU, YASHIKI, TAKATSUKA
Published in Journal of antibiotics (1986)
Published in Journal of antibiotics (1986)
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