Evaluation of off‐target effects of gapmer antisense oligonucleotides using human cells
Yoshida, Tokuyuki, Naito, Yuki, Yasuhara, Hidenori, Sasaki, Kiyomi, Kawaji, Hideya, Kawai, Jun, Naito, Mikihiko, Okuda, Haruhiro, Obika, Satoshi, Inoue, Takao
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.12.2019)
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.12.2019)
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Journal Article
Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2′‑OMe-RNA and scpBNA Bearing a 5‑Hydroxycytosine Nucleobase
Sakurai, Yota, Yamaguchi, Takao, Yoshida, Tokuyuki, Horiba, Masahiko, Inoue, Takao, Obika, Satoshi
Published in Journal of organic chemistry (06.01.2023)
Published in Journal of organic chemistry (06.01.2023)
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Journal Article
Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation
Yoshida, Tokuyuki, Hagihara, Tomoko, Uchida, Yasunori, Horiuchi, Yoshiyuki, Sasaki, Kiyomi, Yamamoto, Takenori, Yamashita, Takuma, Goda, Yukihiro, Saito, Yoshiro, Yamaguchi, Takao, Obika, Satoshi, Yamamoto, Seiji, Inoue, Takao
Published in Scientific reports (21.05.2024)
Published in Scientific reports (21.05.2024)
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Journal Article
Estimated number of off‐target candidate sites for antisense oligonucleotides in human mRNA sequences
Yoshida, Tokuyuki, Naito, Yuki, Sasaki, Kiyomi, Uchida, Eriko, Sato, Yoji, Naito, Mikihiko, Kawanishi, Toru, Obika, Satoshi, Inoue, Takao
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.06.2018)
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.06.2018)
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Journal Article
Genetic Background Affects Properties of Satellite Cells and mdx Phenotypes
Fukada, So-ichiro, Morikawa, Daisuke, Yamamoto, Yukiko, Yoshida, Tokuyuki, Sumie, Noriaki, Yamaguchi, Masahiko, Ito, Takahito, Miyagoe-Suzuki, Yuko, Takeda, Shin'ichi, Tsujikawa, Kazutake, Yamamoto, Hiroshi
Published in The American journal of pathology (01.05.2010)
Published in The American journal of pathology (01.05.2010)
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Journal Article
Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application
Nabeshi, Hiromi, Yoshikawa, Tomoaki, Matsuyama, Keigo, Nakazato, Yasutaro, Matsuo, Kazuhiko, Arimori, Akihiro, Isobe, Masaaki, Tochigi, Saeko, Kondoh, Sayuri, Hirai, Toshiro, Akase, Takanori, Yamashita, Takuya, Yamashita, Kohei, Yoshida, Tokuyuki, Nagano, Kazuya, Abe, Yasuhiro, Yoshioka, Yasuo, Kamada, Haruhiko, Imazawa, Takayoshi, Itoh, Norio, Nakagawa, Shinsaku, Mayumi, Tadanori, Tsunoda, Shin-ichi, Tsutsumi, Yasuo
Published in Biomaterials (01.04.2011)
Published in Biomaterials (01.04.2011)
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Journal Article
Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice
Yoshida, Tokuyuki, Yoshioka, Yasuo, Morishita, Yuki, Aoyama, Michihiko, Tochigi, Saeko, Hirai, Toshiro, Tanaka, Kota, Nagano, Kazuya, Kamada, Haruhiko, Tsunoda, Shin-ichi, Nabeshi, Hiromi, Yoshikawa, Tomoaki, Higashisaka, Kazuma, Tsutsumi, Yasuo
Published in Nanotechnology (19.06.2015)
Published in Nanotechnology (19.06.2015)
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Journal Article
Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material
Tanaka, Hiroki, Takata, Nae, Sakurai, Yu, Yoshida, Tokuyuki, Inoue, Takao, Tamagawa, Shinya, Nakai, Yuta, Tange, Kota, Yoshioka, Hiroki, Maeki, Masatoshi, Tokeshi, Manabu, Akita, Hidetaka
Published in Pharmaceutics (13.04.2021)
Published in Pharmaceutics (13.04.2021)
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Journal Article
Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection
Hirai, Toshiro, Yoshikawa, Tomoaki, Nabeshi, Hiromi, Yoshida, Tokuyuki, Tochigi, Saeko, Ichihashi, Ko-ichi, Uji, Miyuki, Akase, Takanori, Nagano, Kazuya, Abe, Yasuhiro, Kamada, Haruhiko, Itoh, Norio, Tsunoda, Shin-ichi, Yoshioka, Yasuo, Tsutsumi, Yasuo
Published in Particle and fibre toxicology (02.02.2012)
Published in Particle and fibre toxicology (02.02.2012)
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Journal Article
Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes
Nagano, Takashi, Nagano, Kazuya, Nabeshi, Hiromi, Yoshida, Tokuyuki, Kamada, Haruhiko, Tsunoda, Shin-ichi, Gao, Jian-Qing, Higashisaka, Kazuma, Yoshioka, Yasuo, Tsutsumi, Yasuo
Published in Biological & pharmaceutical bulletin (2017)
Published in Biological & pharmaceutical bulletin (2017)
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Journal Article
Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice
Yoshida, Tokuyuki, Yoshioka, Yasuo, Tochigi, Saeko, Hirai, Toshiro, Uji, Miyuki, Ichihashi, Ko-ichi, Nagano, Kazuya, Abe, Yasuhiro, Kamada, Haruhiko, Tsunoda, Shin-Ichi, Nabeshi, Hiromi, Higashisaka, Kazuma, Yoshikawa, Tomoaki, Tsutsumi, Yasuo
Published in Particle and fibre toxicology (20.08.2013)
Published in Particle and fibre toxicology (20.08.2013)
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Journal Article
Intestinal absorption and biological effects of orally administered amorphous silica particles
Yoshida, Tokuyuki, Yoshioka, Yasuo, Takahashi, Hideki, Misato, Kazuki, Mori, Takahide, Hirai, Toshiro, Nagano, Kazuya, Abe, Yasuhiro, Mukai, Yohei, Kamada, Haruhiko, Tsunoda, Shin-ichi, Nabeshi, Hiromi, Yoshikawa, Tomoaki, Higashisaka, Kazuma, Tsutsumi, Yasuo
Published in Nanoscale research letters (26.09.2014)
Published in Nanoscale research letters (26.09.2014)
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Journal Article
Development of a bioanalytical method for an antisense therapeutic using high-resolution mass spectrometry
Sun, Yuchen, Nitta, Shin-Ichiro, Saito, Kosuke, Hosogai, Ryuta, Nakai, Keiko, Goda, Ryoya, Kakehi, Masaaki, Murata, Kazuyuki, Yamaguchi, Takeru, Okuzono, Takeshi, Yamane, Shinichi, Enoki, Yoshimasa, Kawabata, Mitsuhiko, Takahara, Kentaro, Sato, Shimpei, Yoshida, Tokuyuki, Inoue, Takao, Saito, Yoshiro
Published in Bioanalysis (01.12.2020)
Published in Bioanalysis (01.12.2020)
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Journal Article
Development and multicenter validation of an LC–MS-based bioanalytical method for antisense therapeutics
Sun, Yuchen, Nitta, Shin-ichiro, Saito, Kosuke, Hosogai, Ryuta, Nakai, Keiko, Goda, Ryoya, Shimizu, Hisao, Fujita, Hisashi, Kakehi, Masaaki, Murata, Kazuyuki, Yamaguchi, Takeru, Okuzono, Takeshi, Yamane, Shinichi, Kawabata, Mitsuhiko, Matsunuma, Takayuki, Takahara, Kentaro, Kato, Noriko, Yamada, Masaki, Yoshida, Tokuyuki, Inoue, Takao, Saito, Yoshiro
Published in Bioanalysis (01.09.2022)
Published in Bioanalysis (01.09.2022)
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Journal Article
Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure
Nabeshi, Hiromi, Yoshikawa, Tomoaki, Matsuyama, Keigo, Nakazato, Yasutaro, Arimori, Akihiro, Isobe, Masaaki, Tochigi, Saeko, Kondoh, Sayuri, Hirai, Toshiro, Akase, Takanori, Yamashita, Takuya, Yamashita, Kohei, Yoshida, Tokuyuki, Nagano, Kazuya, Abe, Yasuhiro, Yoshioka, Yasuo, Kamada, Haruhiko, Imazawa, Takayoshi, Itoh, Norio, Kondoh, Masuo, Yagi, Kiyohito, Mayumi, Tadanori, Tsunoda, Shin-ichi, Tsutsumi, Yasuo
Published in Nanotechnology (03.02.2012)
Published in Nanotechnology (03.02.2012)
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Journal Article
Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages
Nabeshi, Hiromi, Yoshikawa, Tomoaki, Arimori, Akihiro, Yoshida, Tokuyuki, Tochigi, Saeko, Hirai, Toshiro, Akase, Takanori, Nagano, Kazuya, Abe, Yasuhiro, Kamada, Haruhiko, Tsunoda, Shin-ichi, Itoh, Norio, Yoshioka, Yasuo, Tsutsumi, Yasuo
Published in Nanoscale research letters (18.01.2011)
Published in Nanoscale research letters (18.01.2011)
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Journal Article
Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice
Yoshida, Tokuyuki, Yoshioka, Yasuo, Fujimura, Maho, Yamashita, Kohei, Higashisaka, Kazuma, Morishita, Yuki, Kayamuro, Hiroyuki, Nabeshi, Hiromi, Nagano, Kazuya, Abe, Yasuhiro, Kamada, Haruhiko, Tsunoda, Shin-ichi, Itoh, Norio, Yoshikawa, Tomoaki, Tsutsumi, Yasuo
Published in Nanoscale research letters (04.03.2011)
Published in Nanoscale research letters (04.03.2011)
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Journal Article
Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice
Hirai, Toshiro, Yoshioka, Yasuo, Takahashi, Hideki, Ichihashi, Ko-ichi, Udaka, Asako, Mori, Takahide, Nishijima, Nobuo, Yoshida, Tokuyuki, Nagano, Kazuya, Kamada, Haruhiko, Tsunoda, Shin-ichi, Takagi, Tatsuya, Ishii, Ken J, Nabeshi, Hiromi, Yoshikawa, Tomoaki, Higashisaka, Kazuma, Tsutsumi, Yasuo
Published in Particle and fibre toxicology (26.06.2015)
Published in Particle and fibre toxicology (26.06.2015)
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Journal Article