Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
Park, Hye-Kyung, Yoon, Nam Gu, Lee, Ji-Eun, Hu, Sung, Yoon, Sora, Kim, So Yeon, Hong, Jun-Hee, Nam, Dougu, Chae, Young Chan, Park, Jong Bae, Kang, Byoung Heon
Published in Experimental & molecular medicine (01.01.2020)
Published in Experimental & molecular medicine (01.01.2020)
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Journal Article
Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy (Adv. Sci. 2/2024)
Kim, So‐Yeon, Yoon, Nam Gu, Im, Jin Young, Lee, Ji Hye, Kim, Juhee, Jeon, Yujin, Choi, Young Jae, Lee, Jong‐Hwa, Uemura, Akiyoshi, Park, Dong Ho, Kang, Byoung Heon
Published in Advanced science (01.01.2024)
Published in Advanced science (01.01.2024)
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Journal Article
Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy
Kim, So‐Yeon, Yoon, Nam Gu, Im, Jin Young, Lee, Ji Hye, Kim, Juhee, Jeon, Yujin, Choi, Young Jae, Lee, Jong‐Hwa, Uemura, Akiyoshi, Park, Dong Ho, Kang, Byoung Heon
Published in Advanced science (01.01.2024)
Published in Advanced science (01.01.2024)
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Journal Article
TRAP-1 TRAP-1 inhibitor
KANG BYOUNG HEON, YOON NAM GU, JUNG GONI, YANG SUJAE, K.B.HONG, KANG SOOSUNG, JEONG YONG UK, JI HOON LEE, DARONG KIM
Year of Publication 24.06.2024
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Year of Publication 24.06.2024
Patent
TRAP-1 INHIBITOR
JEONG, Yong Uk, KIM, Darong, KANG, Soosung, HONG, Ki Bum, YOON, Nam Gu, KANG, Byoung Heon, LEE, Ji Hoon, JUNG, Goni, YANG, Sujae
Year of Publication 20.06.2024
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Year of Publication 20.06.2024
Patent
COMPOUND FOR INHIBITING ANGIOGENESIS FACTOR, AND USE THEREOF
KIM, So-Yeon, PARK, Dong Ho, YOON, Nam Gu, KANG, Byoung Heon, LEE, Changwook
Year of Publication 24.06.2021
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Year of Publication 24.06.2021
Patent
Compound for inhibiting neovascularization factor and use thereof
LEE CHANGWOOK, KANG BYOUNG HEON, YOON NAM GU, PARK DONG HO, KIM SO YEON
Year of Publication 24.06.2021
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Year of Publication 24.06.2021
Patent
Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site
Yoon, Nam Gu, Lee, Hakbong, Kim, So-Yeon, Hu, Sung, Kim, Darong, Yang, Sujae, Hong, Ki Bum, Lee, Ji Hoon, Kang, Soosung, Kim, Byung-Gyu, Myung, Kyungjae, Lee, Changwook, Kang, Byoung Heon
Published in Journal of the American Chemical Society (01.12.2021)
Published in Journal of the American Chemical Society (01.12.2021)
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Journal Article
Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6-chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity
Yang, Sujae, Yoon, Nam Gu, Park, Min-A, Yun, Jisu, Im, Jin Young, Kang, Byoung Heon, Kang, Soosung
Published in Bioorganic chemistry (01.09.2022)
Published in Bioorganic chemistry (01.09.2022)
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Journal Article
Correction to “Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site”
Yoon, Nam Gu, Lee, Hakbong, Kim, So-Yeon, Hu, Sung, Kim, Darong, Yang, Sujae, Hong, Ki Bum, Lee, Ji Hoon, Kang, Soosung, Kim, Byung-Gyu, Myung, Kyungjae, Lee, Changwook, Kang, Byoung Heon
Published in Journal of the American Chemical Society (02.02.2022)
Published in Journal of the American Chemical Society (02.02.2022)
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Journal Article
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1
Jung, Sejin, Yoon, Nam Gu, Yang, Sujae, Kim, Darong, Lee, Won Seok, Hong, Ki Bum, Lee, Changwook, Kang, Byoung Heon, Lee, Ji Hoon, Kang, Soosung
Published in Bioorganic & medicinal chemistry letters (15.01.2020)
Published in Bioorganic & medicinal chemistry letters (15.01.2020)
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Journal Article
Design and Synthesis of TRAP1 Selective Inhibitors: H‑Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity
Yang, Sujae, Yoon, Nam Gu, Kim, Dongyoung, Park, Eunsun, Kim, So-Yeon, Lee, Ji Hoon, Lee, Changwook, Kang, Byoung Heon, Kang, Soosung
Published in ACS medicinal chemistry letters (08.07.2021)
Published in ACS medicinal chemistry letters (08.07.2021)
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Journal Article
Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug
Hu, Sung, Ferraro, Mariarosaria, Thomas, Ajesh P, Chung, Jeong Min, Yoon, Nam Gu, Seol, Ji-Hoon, Kim, Sangpil, Kim, Han-ul, An, Mi Young, Ok, Haewon, Jung, Hyun Suk, Ryu, Ja-Hyoung, Colombo, Giorgio, Kang, Byoung Heon
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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Journal Article
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models
Kim, Darong, Kim, So-Yeon, Kim, Dongyoung, Yoon, Nam Gu, Yun, Jisu, Hong, Ki Bum, Lee, Changwook, Lee, Ji Hoon, Kang, Byoung Heon, Kang, Soosung
Published in Bioorganic chemistry (01.08.2020)
Published in Bioorganic chemistry (01.08.2020)
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Journal Article