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Published in MedChemComm (01.04.2021)
Published in MedChemComm (01.04.2021)
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Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships
Yokoo, Katsuki, Yamawaki, Kenji, Yoshida, Yutaka, Yonezawa, Shuji, Yamano, Yoshinori, Tsuji, Masakatsu, Hori, Toshihiko, Nakamura, Rio, Ishikura, Koji
Published in European journal of medicinal chemistry (29.11.2016)
Published in European journal of medicinal chemistry (29.11.2016)
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Expansion of Antibacterial Spectrum of Muraymycins toward Pseudomonas aeruginosa
Takeoka, Yusuke, Tanino, Tetsuya, Sekiguchi, Mitsuaki, Yonezawa, Shuji, Sakagami, Masahiro, Takahashi, Fumiyo, Togame, Hiroko, Tanaka, Yoshikazu, Takemoto, Hiroshi, Ichikawa, Satoshi, Matsuda, Akira
Published in ACS medicinal chemistry letters (08.05.2014)
Published in ACS medicinal chemistry letters (08.05.2014)
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Preclinical antitumor activity of S‐222611, an oral reversible tyrosine kinase inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2
Tanaka, Hidekazu, Hirata, Michinari, Shinonome, Satomi, Wada, Toru, Iguchi, Motofumi, Dohi, Keiji, Inoue, Makiko, Ishioka, Yukichi, Hojo, Kanji, Yamada, Tomomi, Sugimoto, Tatsuya, Masuno, Koichi, Nezasa, Ken‐ichi, Sato, Norihito, Matsuo, Kenji, Yonezawa, Shuji, Frenkel, Eugene P., Shichijo, Michitaka
Published in Cancer science (01.08.2014)
Published in Cancer science (01.08.2014)
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Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β‑Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial
Koriyama, Yuji, Hori, Akihiro, Ito, Hisanori, Yonezawa, Shuji, Baba, Yoshiyasu, Tanimoto, Norihiko, Ueno, Tatsuhiko, Yamamoto, Shiho, Yamamoto, Takahiko, Asada, Naoya, Morimoto, Kenji, Einaru, Shunsuke, Sakai, Katsunori, Kanazu, Takushi, Matsuda, Akihiro, Yamaguchi, Yoshitaka, Oguma, Takuya, Timmers, Maarten, Tritsmans, Luc, Kusakabe, Ken-ichi, Kato, Akira, Sakaguchi, Gaku
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant
Kawada, Kenji, Arimura, Akinori, Tsuri, Tatsuo, Fuji, Masahiro, Komurasaki, Tadafumi, Yonezawa, Shuji, Kugimiya, Akira, Haga, Nobuhiro, Mitsumori, Susumu, Inagaki, Masanao, Nakatani, Takuji, Tamura, Yoshinori, Takechi, Shozo, Taishi, Teruhiko, Kishino, Junji, Ohtani, Mitsuaki
Published in Angewandte Chemie (International ed.) (20.04.1998)
Published in Angewandte Chemie (International ed.) (20.04.1998)
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Collaborative Virtual Screening Identifies a 2‑Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection
Tawaraishi, Taisuke, Ochida, Atsuko, Akao, Yuichiro, Itono, Sachiko, Kamaura, Masahiro, Akther, Thamina, Shimada, Mitsuyuki, Canan, Stacie, Chowdhury, Sanjoy, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Francisco, Amanda, Ghosh, Sunil, Kaki, Rina, Kelly, John M., Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shum, David, Watanabe, Nao-aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin
Published in Journal of medicinal chemistry (26.01.2023)
Published in Journal of medicinal chemistry (26.01.2023)
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Conformational Restriction Approach to β‑Secretase (BACE1) Inhibitors: Effect of a Cyclopropane Ring To Induce an Alternative Binding Mode
Yonezawa, Shuji, Yamamoto, Takahiko, Yamakawa, Hidekuni, Muto, Chie, Hosono, Motoko, Hattori, Kazunari, Higashino, Kenichi, Yutsudo, Takashi, Iwamoto, Hideo, Kondo, Yutaka, Sakagami, Masahiro, Togame, Hiroko, Tanaka, Yoshikazu, Nakano, Toru, Takemoto, Hiroshi, Arisawa, Mitsuhiro, Shuto, Satoshi
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Conformational restriction approach to β-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations
Yonezawa, Shuji, Fujiwara, Kenichiro, Yamamoto, Takahiko, Hattori, Kazunari, Yamakawa, Hidekuni, Muto, Chie, Hosono, Motoko, Tanaka, Yoshikazu, Nakano, Toru, Takemoto, Hiroshi, Arisawa, Mitsuhiro, Shuto, Satoshi
Published in Bioorganic & medicinal chemistry (01.11.2013)
Published in Bioorganic & medicinal chemistry (01.11.2013)
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Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring
Yonezawa, Shuji, Yamakawa, Hidekuni, Muto, Chie, Hosono, Motoko, Yamamoto, Takahiko, Hattori, Kazunari, Sakagami, Masahiro, Togame, Hiroko, Tanaka, Yoshikazu, Nakano, Toru, Takemoto, Hiroshi, Arisawa, Mitsuhiro, Shuto, Satoshi
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
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Journal Article
Conformational restriction approach to I2-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations
Yonezawa, Shuji, Fujiwara, Kenichiro, Yamamoto, Takahiko, Hattori, Kazunari, Yamakawa, Hidekuni, Muto, Chie, Hosono, Motoko, Tanaka, Yoshikazu, Nakano, Toru, Takemoto, Hiroshi, Arisawa, Mitsuhiro, Shuto, Satoshi
Published in Bioorganic & medicinal chemistry (01.11.2013)
Published in Bioorganic & medicinal chemistry (01.11.2013)
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Journal Article
S‐222611, an oral reversible tyrosine kinase inhibitor of EGFR and HER2. A representative histological image of the colon treated with S‐222611 (25 mg/kg)
Tanaka, Hidekazu, Hirata, Michinari, Shinonome, Satomi, Wada, Toru, Iguchi, Motofumi, Dohi, Keiji, Inoue, Makiko, Ishioka, Yukichi, Hojo, Kanji, Yamada, Tomomi, Sugimoto, Tatsuya, Masuno, Koichi, Nezasa, Ken‐ichi, Sato, Norihito, Matsuo, Kenji, Yonezawa, Shuji, Frenkel, Eugene P., Shichijo, Michitaka
Published in Cancer science (01.08.2014)
Published in Cancer science (01.08.2014)
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METHOD FOR PRODUCING PYRAZOLECARBOXYLIC ACID DERIVATIVE
OGAWA TOMOYUKI, GODA SATOSHI, UENAKA MASAAKI, TAKAKI MUTSUMI, IIDA AKIRA, FUKUDA TOMOHIRO, HIROSE YOSHIKATSU, YONEZAWA SHUJI
Year of Publication 05.02.2014
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Year of Publication 05.02.2014
Patent
SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING β-SECRETASE-INHIBITING ACTIVITY
MATSUMOTO SAE, KOORIYAMA YUUJI, UENO TATSUHIKO, HORI AKIHIRO, KATO TERUKAZU, FUJIKOSHI CHIAKI, YONEZAWA SHUJI
Year of Publication 20.02.2013
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Year of Publication 20.02.2013
Patent