TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations
Hasako, Shinichi, Terasaka, Miki, Abe, Naomi, Uno, Takao, Ohsawa, Hirokazu, Hashimoto, Akihiro, Fujita, Ryoto, Tanaka, Kenji, Okayama, Takashige, Wadhwa, Renu, Miyadera, Kazutaka, Aoyagi, Yoshimi, Yonekura, Kazuhiko, Matsuo, Kenichi
Published in Molecular cancer therapeutics (01.08.2018)
Published in Molecular cancer therapeutics (01.08.2018)
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The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer
Watanabe, Kenta, Hirata, Michiko, Tominari, Tsukasa, Matsumoto, Chiho, Fujita, Hidenori, Yonekura, Kazuhiko, Murphy, Gillian, Nagase, Hideaki, Miyaura, Chisato, Inada, Masaki
Published in The Journal of biological chemistry (30.09.2016)
Published in The Journal of biological chemistry (30.09.2016)
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High Potency VEGFRs/MET/FMS Triple Blockade by TAS-115 Concomitantly Suppresses Tumor Progression and Bone Destruction in Tumor-Induced Bone Disease Model with Lung Carcinoma Cells
Fujita, Hidenori, Gomori, Akira, Fujioka, Yayoi, Kataoka, Yuki, Tanaka, Kenji, Hashimoto, Akihiro, Suzuki, Takamasa, Ito, Kenjiro, Haruma, Tomonori, Yamamoto-Yokoi, Hiromi, Harada, Naomoto, Sakuragi, Motomu, Oda, Nobuyuki, Matsuo, Kenichi, Inada, Masaki, Yonekura, Kazuhiko
Published in PloS one (13.10.2016)
Published in PloS one (13.10.2016)
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Triple Inhibition of EGFR, Met, and VEGF Suppresses Regrowth of HGF-Triggered, Erlotinib-Resistant Lung Cancer Harboring an EGFR Mutation
Nakade, Junya, Takeuchi, Shinji, Nakagawa, Takayuki, Ishikawa, Daisuke, Sano, Takako, Nanjo, Shigeki, Yamada, Tadaaki, Ebi, Hiromichi, Zhao, Lu, Yasumoto, Kazuo, Matsumoto, Kunio, Yonekura, Kazuhiko, Yano, Seiji
Published in Journal of thoracic oncology (01.06.2014)
Published in Journal of thoracic oncology (01.06.2014)
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Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer
Zhao, Lu, Yasumoto, Kazuo, Kawashima, Atsuhiro, Nakagawa, Takayuki, Takeuchi, Shinji, Yamada, Tadaaki, Matsumoto, Kunio, Yonekura, Kazuhiko, Yoshie, Osamu, Yano, Seiji
Published in Cancer science (01.12.2013)
Published in Cancer science (01.12.2013)
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Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators
Shirasaka, T, Shimamato, Y, Ohshimo, H, Yamaguchi, M, Kato, T, Yonekura, K, Fukushima, M
Published in Anti-cancer drugs (01.07.1996)
Published in Anti-cancer drugs (01.07.1996)
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Abstract 3600: The prominent safety profile of TAS-115, a novel c-Met + VEGFR dual kinase inhibitor can lead to potentiate the efficacy via durable inhibition of angiogenesis
Ochiiwa, Hiroaki, Fujita, Hidenori, Ito, Kimihiro, Takenaka, Toru, Huang, Jinhong, Ito, Satoko, Suzuki, Takamasa, Egami, Kousuke, Suefuji, Takashi, Sato, Ayako, Sato, Tsudoi, Fujioka, Yayoi, Kato, Masanori, Aoyagi, Yoshimi, Hashimoto, Akihiro, Kazuno, Hideki, Miyadera, Kazutaka, Suda, Yoshimitsu, Yonekura, Kazuhiko
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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UFT and Its Metabolites Inhibit the Angiogenesis Induced by Murine Renal Cell Carcinoma, as Determined by a Dorsal Air Sac Assay in Mice
YONEKURA, K, BASAKI, Y, CHIKAHISA, L, OKABE, S, HASHIMOTO, A, MIYADERA, K, WIERZBA, K, YAMADA, Y
Published in Clinical cancer research (01.08.1999)
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Published in Clinical cancer research (01.08.1999)
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TAS-108, a Novel Oral Steroidal Antiestrogenic Agent, Is a Pure Antagonist on Estrogen Receptor α and a Partial Agonist on Estrogen Receptor β with Low Uterotrophic Effect
YAMAMOTO, Yasuji, SHIBATA, Jiro, TERADA, Tadafumi, YONEKURA, Kazuhiko, SATO, Kouji, HASHIMOTO, Akihiro, AOYAGI, Yoshimi, WIERZBA, Konstanty, YANO, Shingo, ASAO, Tetsuji, BUZDAR, Aman U
Published in Clinical cancer research (01.01.2005)
Published in Clinical cancer research (01.01.2005)
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Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors
Sootome, Hiroshi, Fujita, Hidenori, Ito, Kenjiro, Ochiiwa, Hiroaki, Fujioka, Yayoi, Ito, Kimihiro, Miura, Akihiro, Sagara, Takeshi, Ito, Satoru, Ohsawa, Hirokazu, Otsuki, Sachie, Funabashi, Kaoru, Yashiro, Masakazu, Matsuo, Kenichi, Yonekura, Kazuhiko, Hirai, Hiroshi
Published in Cancer research (Chicago, Ill.) (15.11.2020)
Published in Cancer research (Chicago, Ill.) (15.11.2020)
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γ-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor
BASAKI, Yuji, CHIKAHISA, Lumi, AOYAGI, Kumio, MIYADERA, Kazutaka, YONEKURA, Kazuhiko, HASHIMOTO, Akihiro, OKABE, Soko, WIERZBA, Konstanty, YAMADA, Yuji
Published in Angiogenesis (London) (2001)
Published in Angiogenesis (London) (2001)
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TAS-116, a highly selective inhibitor of heat shock protein 90α and β, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models
Ohkubo, Shuichi, Kodama, Yasuo, Muraoka, Hiromi, Hitotsumachi, Hiroko, Yoshimura, Chihoko, Kitade, Makoto, Hashimoto, Akihiro, Ito, Kenjiro, Gomori, Akira, Takahashi, Koichi, Shibata, Yoshihiro, Kanoh, Akira, Yonekura, Kazuhiko
Published in Molecular cancer therapeutics (01.01.2015)
Published in Molecular cancer therapeutics (01.01.2015)
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Abstract 2121: MET/VEGFR/FMS signaling contributes prostate cancer-induced osteoclast differentiation and bone resorption
Watanabe, Kenta, Hirata, Michiko, Tomomi, Tsukasa, Matsumoto, Chiho, Fujita, Hidenori, Yamada, Yukari, Matsuo, Kenichi, Yonekura, Kazuhiko, Miyaura, Chisato, Inada, Masaki
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 2141: TAS-115, a novel and highly potent VEGFRMET inhibitor, shows prominent antitumor efficacy by restoring HGF-mediated hypoxia-resistant phenotype in clear cell sarcoma
Fujita, Hidenori, Yamada, Yukari, Terasaka, Miki, Fujioka, Yayoi, Harada, Naomoto, Hashimoto, Akihiro, Miyadera, Kazutaka, Matsuo, Kenichi, Yonekura, Kazuhiko
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 2141: TAS-115, a novel and highly potent VEGFR/MET inhibitor, shows prominent antitumor efficacy by restoring HGF-mediated hypoxia-resistant phenotype in clear cell sarcoma
Fujita, Hidenori, Yamada, Yukari, Terasaka, Miki, Fujioka, Yayoi, Harada, Naomoto, Hashimoto, Akihiro, Miyadera, Kazutaka, Matsuo, Kenichi, Yonekura, Kazuhiko
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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