Bardoxolone methyl prevents metabolic dysfunction-associated steatohepatitis by inhibiting macrophage infiltration
Onuma, Kazuhiro, Watanabe, Kenji, Isayama, Keishiro, Ogi, Sayaka, Tokunaga, Yasunori, Mizukami, Yoichi
Published in British journal of pharmacology (01.08.2024)
Published in British journal of pharmacology (01.08.2024)
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Journal Article
Preclinical in vitro and in vivo study of UD-017, a novel highly selective and orally available CDK7 inhibitor, in a variety of cancers
Onuma, Kazuhiro, Aga, Yasuhiro, Ogi, Sayaka, Matsushita, Takashi, Sunamoto, Hidetoshi, Ogawa, Ayumi, Tokunaga, Yasunori, Ushiyama, Shigeru
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Journal Article
Abstract 4835: UD-017, a novel highly selective and orally active CDK7 inhibitor, shows a significant anticancer activity in patient-derived cancers
Matsushita, Takashi, Ogi, Sayaka, Onuma, Kazuhiro, Sunamoto, Hidetoshi, Ogawa, Ayumi, Hasegawa, Toru, Tokunaga, Yasunori, Aga, Yasuhiro, Ushiyama, Shigeru
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract LB-297: In vivo anti-tumor efficacy of UD-017, a novel highly selective & orally available CDK7 inhibitor, in colorectal cancer cells xenograft models
Aga, Yasuhiro, Ogi, Sayaka, Tokunaga, Yasunori, Ogawa, Ayumi, Onuma, Kazuhiro, Matsushita, Takashi, Sunamoto, Hidetoshi, Hasegawa, Toru, Ushiyama, Shigeru
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 5707: Preclinical evaluation of KRLS-017, a potent, highly selective and reversible CDK7 inhibitor with broad antitumor effect in preclinical models, in preparation for a Phase 1 clinical trial in advanced solid tumor malignancies
Hannah, Alison L., Ritland, Steve, Steele, Thomas, Smith, Steven, Ram, Ashwin, Slingsby, BT, Dhingra, Kapil, Chrisman, James, Dua, Rajesh, Tokunaga, Yasunori, Kono, Shigeyuki, Aga, Yasuhiro
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Preclinical in vitro and in vivo evaluation of antitumor activity of UD-017, a novel selective and orally available CDK7 inhibitor, in colorectal cancer
Ogi, Sayaka, Aga, Yasuhiro, Onuma, Kazuhiro, Sunamoto, Hidetoshi, Matsushita, Takashi, Ogawa, Ayumi, Hasegawa, Tohru, Kono, Shigeyuki, Iwase, Noriaki, Tokunaga, Yasunori, Ushiyama, Shigeru
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Journal Article
Mechanism for p38α-mediated Experimental Autoimmune Encephalomyelitis
Namiki, Kana, Matsunaga, Hirofumi, Yoshioka, Kento, Tanaka, Kensuke, Murata, Kazuya, Ishida, Junji, Sakairi, Akira, Kim, Jundal, Tokuhara, Naoki, Shibakawa, Nobuhiko, Shimizu, Motohisa, Wada, Yukinori, Tokunaga, Yasunori, Shigetomi, Manabu, Hagihara, Masahiko, Kimura, Sadao, Sudo, Tatsuhiko, Fukamizu, Akiyoshi, Kasuya, Yoshitoshi
Published in The Journal of biological chemistry (13.07.2012)
Published in The Journal of biological chemistry (13.07.2012)
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ANTIBODY-DRUG CONJUGATE
TSUZAKI, Yasunori, SHIMIZU, Hayato, KIMURA, Tomio, TOKUNAGA, Yasunori, NONOUCHI, Shimpei, AGA, Yasuhiro, KASHIWAGI, Takamasa, MATSUSHITA, Takashi, MIZUNO, Gen, TANAKA, Masayuki
Year of Publication 03.10.2024
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Year of Publication 03.10.2024
Patent
1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE
MATSUSHITA Takashi, YAMADA Haruka, KOMORI Ken-ichi, OGAWA Ayumi, SHIMIZU Hayato, TOKUNAGA Yasunori, HASEGAWA Toru, AGA Yasuhiro
Year of Publication 24.04.2024
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Year of Publication 24.04.2024
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1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE
Komori, Ken-ichi, Yamada, Haruka, Tokunaga, Yasunori, Matsushita, Takashi, Shimizu, Hayato, Aga, Yasuhiro, Ogawa, Ayumi, Hasegawa, Toru
Year of Publication 22.06.2023
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Year of Publication 22.06.2023
Patent
1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE
MATSUSHITA Takashi, YAMADA Haruka, KOMORI Ken-ichi, OGAWA Ayumi, SHIMIZU Hayato, TOKUNAGA Yasunori, HASEGAWA Toru, AGA Yasuhiro
Year of Publication 22.03.2023
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Year of Publication 22.03.2023
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1, 4, 5, 6-tetrahydropyrimidine-2-amine derivative
SHIMIZU, Hayato, OGAWA, Ayumi, HASEGAWA, Toru, TOKUNAGA, Yasunori, KOMORI, Ken-ichi, YAMADA, Haruka, AGA, Yasuhiro, MATSUSHITA, Takashi
Year of Publication 22.12.2022
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Year of Publication 22.12.2022
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1,4,5,6-TETRAHYDROPYRIMIDIN-2-AMINE DERIVATIVE
AGA, YASUHIRO, MATSUSHITA, TAKASHI, OGAWA, AYUMI, HASEGAWA, TORU, KOMORI, KEN-ICHI, SHIMIZU, HAYATO, YAMADA, HARUKA, TOKUNAGA, YASUNORI
Year of Publication 18.11.2021
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Year of Publication 18.11.2021
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Double-headed protease inhibitor
Kimura, Tomio, Yamada, Haruka, Komori, Ken-ichi, Tokunaga, Yasunori, Ito, Koji, Umezaki, Satoshi, Kanda, Tomoko, Yoneda, Kenji, Shiraishi, Yusuke, Kinoshita, Naoya
Year of Publication 11.10.2022
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Year of Publication 11.10.2022
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SUBSTITUTED GUANIDINE COMPOUNDS
SHINOHARA, Masaru, KIMURA, Tomio, KOJIMA, Masahiro, ITO, Masaaki, ITO, Koji, KAWADA, Hiroyoshi, KOMORI, Ken-Ichi, NINOMIYA, Akishi, TOKUNAGA, Yasunori, KAWAGUCHI, Tetsuo, USHIYAMA, Shigeru, YAMADA, Haruka, SHIRAISHI, Yusuke
Year of Publication 06.10.2022
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Year of Publication 06.10.2022
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SUBSTITUTED GUANIDINE COMPOUND
SHINOHARA, Masaru, KIMURA, Tomio, KOJIMA, Masahiro, KOMORI, Ken-ichi, ITO, Masaaki, ITO, Koji, KAWADA, Hiroyoshi, NINOMIYA, Akishi, TOKUNAGA, Yasunori, KAWAGUCHI, Tetsuo, USHIYAMA, Shigeru, YAMADA, Haruka, SHIRAISHI, Yusuke
Year of Publication 28.07.2022
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Year of Publication 28.07.2022
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Substituted guanidine compounds
Ninomiya, Akishi, Ito, Koji, Shinohara, Masaru, Kimura, Tomio, Komori, Ken-ichi, Ushiyama, Shigeru, Yamada, Haruka, Ito, Masaaki, Tokunaga, Yasunori, Kojima, Masahiro, Kawaguchi, Tetsuo, Kawada, Hiroyoshi, Shiraishi, Yusuke
Year of Publication 26.07.2022
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Year of Publication 26.07.2022
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SUBSTITUTED GUANIDINE COMPOUND
ITO Masaaki, KOMORI Ken-ichi, NINOMIYA Akishi, SHIRAISHI Yusuke, KIMURA Tomio, KAWAGUCHI Tetsuo, TOKUNAGA Yasunori, KAWADA Hiroyoshi, SHINOHARA Masaru, YAMADA Haruka, ITO Koji, USHIYAMA Shigeru, KOJIMA Masahiro
Year of Publication 31.05.2022
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Year of Publication 31.05.2022
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SUBSTITUTED GUANIDINE COMPOUND
Ninomiya, Akishi, Ito, Koji, Shinohara, Masaru, Kimura, Tomio, Komori, Ken-ichi, Ushiyama, Shigeru, Yamada, Haruka, Ito, Masaaki, Tokunaga, Yasunori, Kojima, Masahiro, Kawaguchi, Tetsuo, Kawada, Hiroyoshi, Shiraishi, Yusuke
Year of Publication 13.05.2022
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Year of Publication 13.05.2022
Patent