Blockade of the fractalkine-CX3CR1 axis ameliorates experimental colitis by dislodging venous crawling monocytes
Kuboi, Yoshikazu, Nishimura, Miyuki, Ikeda, Wataru, Nakatani, Tomoya, Seki, Yukie, Yamaura, Yui, Ogawa, Kana, Hamaguchi, Akiko, Muramoto, Kenzo, Mizuno, Keiko, Ogasawara, Hideaki, Yamauchi, Toshihiko, Yasuda, Nobuyuki, Onodera, Hiroshi, Imai, Toshio
Published in International immunology (26.04.2019)
Published in International immunology (26.04.2019)
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Role of Anti‐Fractalkine Antibody in Suppression of Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis
Hoshino‐Negishi, Kana, Ohkuro, Masayoshi, Nakatani, Tomoya, Kuboi, Yoshikazu, Nishimura, Miyuki, Ida, Yoko, Kakuta, Jungo, Hamaguchi, Akiko, Kumai, Minoru, Kamisako, Tsutomu, Sugiyama, Fumihiro, Ikeda, Wataru, Ishii, Naoto, Yasuda, Nobuyuki, Imai, Toshio
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.02.2019)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.02.2019)
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Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study
Tabuchi, Hiroko, Katsurabara, Toshinori, Mori, Masahiko, Aoyama, Muneo, Obara, Takashi, Yasuda, Nobuyuki, Kawano, Tetsu, Imai, Toshio, Ieiri, Ichiro, Kumagai, Yuji
Published in Journal of clinical pharmacology (01.05.2019)
Published in Journal of clinical pharmacology (01.05.2019)
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Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis
Tanaka, Yoshiya, Takeuchi, Tsutomu, Umehara, Hisanori, Nanki, Toshihiro, Yasuda, Nobuyuki, Tago, Fumitoshi, Kawakubo, Makoto, Kitahara, Yasumi, Hojo, Seiichiro, Kawano, Tetsu, Imai, Toshio
Published in Modern rheumatology (02.01.2018)
Published in Modern rheumatology (02.01.2018)
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A phase 2 study of E6011, an anti-Fractalkine monoclonal antibody, in patients with rheumatoid arthritis inadequately responding to biological disease-modifying antirheumatic drugs
Tanaka, Yoshiya, Takeuchi, Tsutomu, Yamanaka, Hisashi, Nanki, Toshihiro, Umehara, Hisanori, Yasuda, Nobuyuki, Tago, Fumitoshi, Kitahara, Yasumi, Kawakubo, Makoto, Torii, Kentaro, Hojo, Seiichiro, Kawano, Tetsu, Imai, Toshio
Published in Modern rheumatology (04.07.2021)
Published in Modern rheumatology (04.07.2021)
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Journal Article
The Fractalkine‐CX3CR1 Axis Regulates Non‐inflammatory Osteoclastogenesis by Enhancing Precursor Cell Survival
Kuboi, Yoshikazu, Kuroda, Yukiko, Ohkuro, Masayoshi, Motoi, Sotaro, Tomimori, Yoshiya, Yasuda, Hisataka, Yasuda, Nobuyuki, Imai, Toshio, Matsuo, Koichi
Published in JBMR plus (01.10.2022)
Published in JBMR plus (01.10.2022)
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Journal Article
Emerging Role of Fractalkine in the Treatment of Rheumatic Diseases
Tanaka, Yoshiya, Hoshino-Negishi, Kana, Kuboi, Yoshikazu, Tago, Fumitoshi, Yasuda, Nobuyuki, Imai, Toshio
Published in ImmunoTargets and therapy (01.01.2020)
Published in ImmunoTargets and therapy (01.01.2020)
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Journal Article
Comparison of Medically Versus Surgically Treated Acute Type A Aortic Dissection in Patients <80 Years Old Versus Patients ≥80 Years Old
Yanagisawa, Satoshi, MD, Yuasa, Takeshi, MD, Suzuki, Noriyuki, MD, Hirai, Toshihisa, MD, Yasuda, Nobuyuki, MD, Miki, Ken, MD, Yasuura, Kenzo, MD, Horiuchi, Kazutaka, MD, Tanaka, Toshikazu, MD
Published in The American journal of cardiology (01.08.2011)
Published in The American journal of cardiology (01.08.2011)
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Does N-Acetylcysteine Reduce the Incidence of Contrast-Induced Nephropathy and Clinical Events in Patients Undergoing Primary Angioplasty for Acute Myocardial Infarction?
Tanaka, Akihito, Suzuki, Yoriyasu, Suzuki, Noriyuki, Hirai, Toshihisa, Yasuda, Nobuyuki, Miki, Ken, Fujita, Masaya, Tanaka, Toshikazu
Published in Internal Medicine (01.01.2011)
Published in Internal Medicine (01.01.2011)
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Metformin Causes Reduction of Food Intake and Body Weight Gain and Improvement of Glucose Intolerance in Combination with Dipeptidyl Peptidase IV Inhibitor in Zucker fa/fa Rats
Yasuda, Nobuyuki, Inoue, Takashi, Nagakura, Tadashi, Yamazaki, Kazuto, Kira, Kazunobu, Saeki, Takao, Tanaka, Isao
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2004)
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Comparison of Efficacies of a Dipeptidyl Peptidase IV Inhibitor and α-Glucosidase Inhibitors in Oral Carbohydrate and Meal Tolerance Tests and the Effects of Their Combination in Mice
Yamazaki, Kazuto, Inoue, Takashi, Yasuda, Nobuyuki, Sato, Yoshiaki, Nagakura, Tadashi, Takenaka, Osamu, Clark, Richard, Saeki, Takao, Tanaka, Isao
Published in Journal of Pharmacological Sciences (2007)
Published in Journal of Pharmacological Sciences (2007)
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Improved Glucose Tolerance via Enhanced Glucose-Dependent Insulin Secretion in Dipeptidyl Peptidase IV-Deficient Fischer Rats
Nagakura, Tadashi, Yasuda, Nobuyuki, Yamazaki, Kazuto, Ikuta, Hironori, Yoshikawa, Seiji, Asano, Osamu, Tanaka, Isao
Published in Biochemical and biophysical research communications (08.06.2001)
Published in Biochemical and biophysical research communications (08.06.2001)
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7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one Is a Novel Competitive and Selective Inhibitor of Dipeptidyl Peptidase IV with an Antihyperglycemic Activity
Yamazaki, Kazuto, Yasuda, Nobuyuki, Inoue, Takashi, Nagakura, Tadashi, Kira, Kazunobu, Shinoda, Masanobu, Saeki, Takao, Tanaka, Isao
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Effects of the Combination of a Dipeptidyl Peptidase IV Inhibitor and an Insulin Secretagogue on Glucose and Insulin Levels in Mice and Rats
Yamazaki, Kazuto, Yasuda, Nobuyuki, Inoue, Takashi, Yamamoto, Eiichi, Sugaya, Yukiko, Nagakura, Tadashi, Shinoda, Masanobu, Clark, Richard, Saeki, Takao, Tanaka, Isao
Published in The Journal of pharmacology and experimental therapeutics (01.02.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2007)
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Journal Article
Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes
Hiyoshi, Hironobu, Yanagimachi, Mamoru, Ito, Masashi, Yasuda, Nobuyuki, Okada, Toshimi, Ikuta, Hironori, Shinmyo, Daisuke, Tanaka, Keigo, Kurusu, Nobuyuki, Yoshida, Ichiro, Abe, Shinya, Saeki, Takao, Tanaka, Hiroshi
Published in Journal of lipid research (01.01.2003)
Published in Journal of lipid research (01.01.2003)
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The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight
Yamazaki, Kazuto, Yasuda, Nobuyuki, Inoue, Takashi, Nagakura, Tadashi, Kira, Kazunobu, Saeki, Takao, Tanaka, Isao
Published in European journal of pharmacology (19.03.2004)
Published in European journal of pharmacology (19.03.2004)
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Efficacy and Safety of E6011, an Anti‐Fractalkine Monoclonal Antibody, in Patients With Active Rheumatoid Arthritis With Inadequate Response to Methotrexate: Results of a Randomized, Double‐Blind, Placebo‐Controlled Phase II Study
Tanaka, Yoshiya, Takeuchi, Tsutomu, Yamanaka, Hisashi, Nanki, Toshihiro, Umehara, Hisanori, Yasuda, Nobuyuki, Tago, Fumitoshi, Kitahara, Yasumi, Kawakubo, Makoto, Torii, Kentaro, Hojo, Seiichiro, Kawano, Tetsu, Imai, Toshio
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2021)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2021)
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