Mechanisms of age-related macular degeneration and therapeutic opportunities
van Lookeren Campagne, Menno, LeCouter, Jennifer, Yaspan, Brian L, Ye, Weilan
Published in The Journal of pathology (01.01.2014)
Published in The Journal of pathology (01.01.2014)
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Rare CIDEC coding variants enriched in age-related macular degeneration patients with small low-luminance deficit cause lipid droplet and fat storage defects
Kim, Sehyun, Stockwell, Amy, Qin, Han, Gao, Simon S, Sagolla, Meredith, Stoilov, Ivaylo, Wuster, Arthur, Lai, Phillip, Yaspan, Brian L, Jeanne, Marion
Published in PloS one (20.04.2023)
Published in PloS one (20.04.2023)
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Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis
Ley, Brett, Torgerson, Dara G, Oldham, Justin M, Adegunsoye, Ayodeji, Liu, Shuo, Li, Jie, Elicker, Brett M, Henry, Travis S, Golden, Jeffrey A, Jones, Kirk D, Dressen, Amy, Yaspan, Brian L, Arron, Joseph R, Noth, Imre, Hoffmann, Thomas J, Wolters, Paul J
Published in American journal of respiratory and critical care medicine (01.11.2019)
Published in American journal of respiratory and critical care medicine (01.11.2019)
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Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration
Yaspan, Brian L, Williams, David F, Holz, Frank G, Regillo, Carl D, Li, Zhengrong, Dressen, Amy, van Lookeren Campagne, Menno, Le, Kha N, Graham, Robert R, Beres, Tatiana, Bhangale, Tushar R, Honigberg, Lee A, Smith, Ashley, Henry, Erin C, Ho, Carole, Strauss, Erich C
Published in Science translational medicine (21.06.2017)
Published in Science translational medicine (21.06.2017)
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Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease
Yang, Chiao-Wen, Hojer, Caroline D., Zhou, Meijuan, Wu, Xiumin, Wuster, Arthur, Lee, Wyne P., Yaspan, Brian L., Chan, Andrew C.
Published in Cell (14.01.2016)
Published in Cell (14.01.2016)
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Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration
Orozco, Luz D., Chen, Hsu-Hsin, Cox, Christian, Katschke, Kenneth J., Arceo, Rommel, Espiritu, Carmina, Caplazi, Patrick, Nghiem, Sarajane Saturnio, Chen, Ying-Jiun, Modrusan, Zora, Dressen, Amy, Goldstein, Leonard D., Clarke, Christine, Bhangale, Tushar, Yaspan, Brian, Jeanne, Marion, Townsend, Michael J., van Lookeren Campagne, Menno, Hackney, Jason A.
Published in Cell reports (Cambridge) (28.01.2020)
Published in Cell reports (Cambridge) (28.01.2020)
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Age-related macular degeneration: Complement in action
van Lookeren Campagne, Menno, Strauss, Erich C, Yaspan, Brian L
Published in Immunobiology (1979) (01.06.2016)
Published in Immunobiology (1979) (01.06.2016)
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Apolipoprotein L1 (APOL1) renal risk variant-mediated podocyte cytotoxicity depends on African haplotype and surface expression
Gupta, Nidhi, Waas, Bridget, Austin, Daniel, De Mazière, Ann M., Kujala, Pekka, Stockwell, Amy D., Li, Tianbo, Yaspan, Brian L., Klumperman, Judith, Scales, Suzie J.
Published in Scientific reports (14.02.2024)
Published in Scientific reports (14.02.2024)
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Multi-ancestry GWAS analysis identifies two novel loci associated with diabetic eye disease and highlights APOL1 as a high risk locus in patients with diabetic macular edema
Stockwell, Amy D, Chang, Michael C, Mahajan, Anubha, Forrest, William, Anegondi, Neha, Pendergrass, Rion K, Selvaraj, Suresh, Reeder, Jens, Wei, Eric, Iglesias, Victor A, Creps, Natalie M, Macri, Laura, Neeranjan, Andrea N, van der Brug, Marcel P, Scales, Suzie J, McCarthy, Mark I, Yaspan, Brian L
Published in PLoS genetics (16.08.2023)
Published in PLoS genetics (16.08.2023)
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Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis
Allen, Richard J, Stockwell, Amy, Oldham, Justin M, Guillen-Guio, Beatriz, Schwartz, David A, Maher, Toby M, Flores, Carlos, Noth, Imre, Yaspan, Brian L, Jenkins, R Gisli, Wain, Louise V, Adegunsoye, Ayodeji, Allen, Richard J, Booth, Helen L, Fahy, William A, Fingerlin, Tasha E, Flores, Carlos, Guillen-Guio, Beatriz, Hall, Ian P, Hart, Simon P, Hill, Mike R, Hirani, Nik, Hubbard, Richard B, Jenkins, R Gisli, Kaminski, Naftali, Ma, Shwu-Fan, Maher, Toby M, McAnulty, Robin J, Millar, Ann B, Molina-Molina, Maria, Molyneaux, Philip L, Navaratnam, Vidya, Neighbors, Margaret, Noth, Imre, Oballa, Eunice, Oldham, Justin M, Parfrey, Helen, Saini, Gauri, Sayers, Ian, Schwartz, David A, Sheng, Xuting, Stockwell, Amy, Strek, Mary E, Tobin, Martin D, Wain, Louise V, Whyte, Moira K B, Yaspan, Brian L, Zhang, Yingze
Published in Thorax (01.08.2022)
Published in Thorax (01.08.2022)
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A genome-wide association study of chronic spontaneous urticaria risk and heterogeneity
Chang, Diana, Hammer, Christian, Holweg, Cecile T.J., Selvaraj, Suresh, Rathore, Nisha, McCarthy, Mark I., Yaspan, Brian L., Choy, David F.
Published in Journal of allergy and clinical immunology (01.05.2023)
Published in Journal of allergy and clinical immunology (01.05.2023)
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Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study
Dressen, Amy, Abbas, Alexander R, Cabanski, Christopher, Reeder, Janina, Ramalingam, Thirumalai R, Neighbors, Margaret, Bhangale, Tushar R, Brauer, Matthew J, Hunkapiller, Julie, Reeder, Jens, Mukhyala, Kiran, Cuenco, Karen, Tom, Jennifer, Cowgill, Amy, Vogel, Jan, Forrest, William F, Collard, Harold R, Wolters, Paul J, Kropski, Jonathan A, Lancaster, Lisa H, Blackwell, Timothy S, Arron, Joseph R, Yaspan, Brian L
Published in The lancet respiratory medicine (01.08.2018)
Published in The lancet respiratory medicine (01.08.2018)
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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma
Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng
Published in Cell (03.10.2019)
Published in Cell (03.10.2019)
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Identification of a Genetic Susceptibility Locus for Idiopathic Pulmonary Fibrosis in the 16p Subtelomere Using Whole-Genome Sequencing
Donoghue, Lauren J, Stockwell, Amy D, Neighbors, Margaret, Sheng, Rebecca X, Prabhakaran, Ramanandan, Wolters, Paul J, Lancaster, Lisa H, Kropski, Jonathan A, Blackwell, Timothy S, McCarthy, Mark I, Yaspan, Brian L
Published in American journal of respiratory and critical care medicine (01.04.2023)
Published in American journal of respiratory and critical care medicine (01.04.2023)
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Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA
Wiggs, Janey L., Hee Kang, Jae, Yaspan, Brian L., Mirel, Daniel B., Laurie, Cathy, Crenshaw, Andrew, Brodeur, Wendy, Gogarten, Stephanie, Olson, Lana M., Abdrabou, Wael, DelBono, Elizabeth, Loomis, Stephanie, Haines, Jonathan L., Pasquale, Louis R.
Published in Human molecular genetics (01.12.2011)
Published in Human molecular genetics (01.12.2011)
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Association of CAV1/CAV2 Genomic Variants with Primary Open-Angle Glaucoma Overall and by Gender and Pattern of Visual Field Loss
Loomis, Stephanie J., MPH, Kang, Jae H., ScD, Weinreb, Robert N., MD, Yaspan, Brian L., PhD, Cooke Bailey, Jessica N., PhD, Gaasterland, Douglas, MD, Gaasterland, Terry, PhD, Lee, Richard K., MD, PhD, Lichter, Paul R., MD, Budenz, Donald L., MD, MPH, Liu, Yutao, PhD, Realini, Tony, MD, MPH, Friedman, David S., MD, PhD, McCarty, Catherine A., PhD, MPH, Moroi, Sayoko E., MD, PhD, Olson, Lana, MPH, Schuman, Joel S., MD, Singh, Kuldev, MD, MPH, Vollrath, Douglas, MD, PhD, Wollstein, Gadi, MD, Zack, Donald J., MD, PhD, Brilliant, Murray, PhD, Sit, Arthur J., MD, Christen, William G., ScD, PhD, Fingert, John, MD, PhD, Kraft, Peter, PhD, Zhang, Kang, MD, PhD, Allingham, R. Rand, MD, Pericak-Vance, Margaret A., PhD, Richards, Julia E., PhD, Hauser, Michael A., PhD, Haines, Jonathan L., PhD, Pasquale, Louis R., MD, Wiggs, Janey L., MD, PhD
Published in Ophthalmology (Rochester, Minn.) (01.02.2014)
Published in Ophthalmology (Rochester, Minn.) (01.02.2014)
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Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification
Haag, Simone M, Xie, Shiqi, Eidenschenk, Celine, Fortin, Jean-Philippe, Callow, Marinella, Costa, Mike, Lun, Aaron, Cox, Chris, Wu, Sunny Z, Pradhan, Rachana N, Lock, Jaclyn, Kuhn, Julia A, Holokai, Loryn, Thai, Minh, Freund, Emily, Nissenbaum, Ariane, Keir, Mary, Bohlen, Christopher J, Martin, Scott, Geiger-Schuller, Kathryn, Hejase, Hussein A, Yaspan, Brian L, Melo Carlos, Sandra, Turley, Shannon J, Murthy, Aditya
Published in Nature genetics (23.10.2024)
Published in Nature genetics (23.10.2024)
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PCSK6 and Survival in Idiopathic Pulmonary Fibrosis
Oldham, Justin M, Allen, Richard J, Lorenzo-Salazar, Jose M, Molyneaux, Philip L, Ma, Shwu-Fan, Joseph, Chitra, Kim, John S, Guillen-Guio, Beatriz, Hernández-Beeftink, Tamara, Kropski, Jonathan A, Huang, Yong, Lee, Cathryn T, Adegunsoye, Ayodeji, Pugashetti, Janelle Vu, Linderholm, Angela L, Vo, Vivian, Strek, Mary E, Jou, Jonathan, Muñoz-Barrera, Adrian, Rubio-Rodriguez, Luis A, Hubbard, Richard, Hirani, Nik, Whyte, Moira K B, Hart, Simon, Nicholson, Andrew G, Lancaster, Lisa, Parfrey, Helen, Rassl, Doris, Wallace, William, Valenzi, Eleanor, Zhang, Yingze, Mychaleckyj, Josyf, Stockwell, Amy, Kaminski, Naftali, Wolters, Paul J, Molina-Molina, Maria, Banovich, Nicholas E, Fahy, William A, Martinez, Fernando J, Hall, Ian P, Tobin, Martin D, Maher, Toby M, Blackwell, Timothy S, Yaspan, Brian L, Jenkins, R Gisli, Flores, Carlos, Wain, Louise V, Noth, Imre
Published in American journal of respiratory and critical care medicine (01.06.2023)
Published in American journal of respiratory and critical care medicine (01.06.2023)
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A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk
Chang, Diana, Hunkapiller, Julie, Bhangale, Tushar, Reeder, Jens, Mukhyala, Kiran, Tom, Jennifer, Cowgill, Amy, Vogel, Jan, Forrest, William F., Khan, Zia, Stockwell, Amy, McCarthy, Mark I., Staton, Tracy L., Olsson, Julie, Holweg, Cecile T. J., Cheung, Dorothy S., Chen, Hubert, Brauer, Matthew J., Graham, Robert R., Behrens, Timothy, Wilson, Mark S., Arron, Joseph R., Choy, David F., Yaspan, Brian L.
Published in Scientific reports (02.04.2022)
Published in Scientific reports (02.04.2022)
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Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis
Chavarria-Smith, Joseph, Chiu, Cecilia P C, Jackman, Janet K, Yin, Jianping, Zhang, Juan, Hackney, Jason A, Lin, Wei-Yu, Tyagi, Tulika, Sun, Yonglian, Tao, Janet, Dunlap, Debra, Morton, William D, Ghodge, Swapnil V, Maun, Henry R, Li, Hong, Hernandez-Barry, Hilda, Loyet, Kelly M, Chen, Emily, Liu, John, Tam, Christine, Yaspan, Brian L, Cai, Hao, Balazs, Mercedesz, Arron, Joseph R, Li, Jing, Wittwer, Arthur J, Pappu, Rajita, Austin, Cary D, Lee, Wyne P, Lazarus, Robert A, Sudhamsu, Jawahar, Koerber, James T, Yi, Tangsheng
Published in Science translational medicine (14.12.2022)
Published in Science translational medicine (14.12.2022)
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